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Your search keyword '"Kahl, Christoph"' showing total 15 results
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15 results on '"Kahl, Christoph"'

1. Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study

Author

Niederwieser, Dietger, Lang, Thomas, Krahl, Rainer, Heinicke, Thomas, Maschmeyer, Georg, Al-Ali, Haifa Kathrin, Schwind, Sebastian, Jentzsch, Madlen, Cross, Michael, Kahl, Christoph, Wolf, Hans-Heinrich, Sayer, Herbert, Schulze, Antje, Dreger, Peter, Hegenbart, Ute, Krämer, Alwin, Junghanss, Christian, Mügge, Lars-Olof, Hähling, Detlev, Hirt, Carsten, Späth, Christian, Peter, Norma, Opitz, Bernhard, Florschütz, Axel, Reifenrath, Kolja, Zojer, Niklas, Scholl, Sebastian, Pönisch, Wolfram, Heyn, Simone, Vucinic, Vladan, Hochhaus, Andreas, Aul, Carlo, Giagounidis, Aristoteles, Balleisen, Leopold, Oldenkott, Bernd, Staib, Peter, Kiehl, Michael, Schütte, Wolfgang, Naumann, Ralph, Eimermacher, Hartmut, Dörken, Bernd, Sauerland, Cristina, Lengfelder, Eva, Hiddemann, Wolfgang, Wörmann, Bernhard, Müller-Tidow, Carsten, Serve, Hubert, Schliemann, Christoph, Hehlmann, Rüdiger, Berdel, Wolfgang E., Pfirrmann, Markus, Krug, Utz, and Hoffmann, Verena S.

Published
2023
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2. Standard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3 / AIO KRK-0306

Author

Hofmann, Felix O., Heinemann, Volker, D’Anastasi, Melvin, Gesenhues, Alena B., Hesse, Nina, von Weikersthal, Ludwig Fischer, Decker, Thomas, Kiani, Alexander, Moehler, Markus, Kaiser, Florian, Heintges, Tobias, Kahl, Christoph, Kullmann, Frank, Scheithauer, Werner, Link, Hartmut, Modest, Dominik P., Stintzing, Sebastian, and Holch, Julian W.

Published
2023
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3. Efficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3

Author

Fischer, Laura E., Stintzing, Sebastian, von Weikersthal, Ludwig Fischer, Modest, Dominik P., Decker, Thomas, Kiani, Alexander, Kaiser, Florian, Al-Batran, Salah-Eddin, Heintges, Tobias, Lerchenmüller, Christian, Kahl, Christoph, Seipelt, Gernot, Kullmann, Frank, Stauch, Martina, Scheithauer, Werner, Giessen-Jung, Clemens, Uhlig, Jens, Peuser, Bettina, Denzlinger, Claudio, Stahler, Arndt, Weiss, Lena, Heinrich, Kathrin, Held, Swantje, Jung, Andreas, Kirchner, Thomas, and Heinemann, Volker

Published
2022
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4. Consensus molecular subtypes (CMS) as prognostic and predictive biomarkers of RAS wild-type (WT) metastatic colorectal cancer (mCRC): Pooled analysis of the randomized trials FIRE-1, FIRE-3, XELAVIRI, and PanaMa.

Author

Stahler, Arndt, primary, Modest, Dominik Paul, additional, Stintzing, Sebastian, additional, Held, Swantje, additional, Fischer von Weikersthal, Ludwig, additional, Müller, Lothar, additional, Graeven, Ullrich, additional, Decker, Thomas, additional, Heintges, Tobias, additional, Kahl, Christoph, additional, Scheithauer, Werner, additional, Kiani, Alexander, additional, Kaiser, Florian, additional, Schwaner, Ingo, additional, Fruehauf, Stefan, additional, Karthaus, Meinolf, additional, Trarbach, Tanja, additional, Klauschen, Frederik, additional, Horst, David, additional, and Heinemann, Volker, additional

Published
2024
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5. Impact of molecular alterations on quality of life and prognostic understanding over time in patients with incurable lung cancer: a multicenter, longitudinal, prospective cohort study

Author

Kuon, Jonas, Blasi, Miriam, Unsöld, Laura, Vogt, Jeannette, Mehnert, Anja, Alt-Epping, Bernd, van Oorschot, Birgitt, Sistermanns, Jochen, Ahlborn, Miriam, Ritterbusch, Ulrike, Stevens, Susanne, Kahl, Christoph, Ruellan, Anne, Matthias, Kathrin, Kubin, Thomas, Stahlhut, Kerstin, Heider, Andrea, Lordick, Florian, and Thomas, Michael

Published
2022
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6. Relevance of different prognostic scores in primary CNS lymphoma in the era of intensified treatment regimens: A retrospective, multicenter analysis of 174 patients

Author

Zeremski, Vanja, primary, Adolph, Louisa, additional, Beer, Sina, additional, Berisha, Mirjeta, additional, Jacobs, Benedikt, additional, Kahl, Christoph, additional, Koenecke, Christian, additional, Kropf, Siegfried, additional, Panse, Jens, additional, Petersen, Judith, additional, Schmidt‐Hieber, Martin, additional, Schneider, Jessica, additional, Vucinic, Vladan, additional, Walter, Jeanette, additional, Weigert, Oliver, additional, Witte, Hanno M., additional, and Mougiakakos, Dimitrios, additional

Published
2024
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7. Allogeneic hematopoietic stem cell transplantation improves long-term outcome for relapsed AML patients across all ages: results from two East German Study Group Hematology and Oncology (OSHO) trials

Author

Heinicke, Thomas, Krahl, Rainer, Kahl, Christoph, Cross, Michael, Scholl, Sebastian, Wolf, Hans-Heinrich, Hähling, Detlev, Hegenbart, Ute, Peter, Norma, Schulze, Antje, Florschütz, Axel, Schmidt, Volker, Reifenrath, Kolja, Zojer, Niklas, Junghanss, Christian, Sayer, Herbert G., Maschmeyer, Georg, Späth, Christian, Hochhaus, Andreas, Fischer, Thomas, Al-Ali, Haifa Kathrin, and Niederwieser, Dietger

Published
2021
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8. Correction to: Allogeneic hematopoietic stem cell transplantation improves long‑term outcome for relapsed AML patients across all ages: results from two East German Study Group Hematology and Oncology (OSHO) trials

Author

Heinicke, Thomas, Krahl, Rainer, Kahl, Christoph, Cross, Michael, Scholl, Sebastian, Wolf, Hans‑Heinrich, Hähling, Detlev, Hegenbart, Ute, Peter, Norma, Schulze, Antje, Florschütz, Axel, Schmidt, Volker, Reifenrath, Kolja, Zojer, Niklas, Junghanss, Christian, Sayer, Herbert G., Maschmeyer, Georg, Späth, Christian, Hochhaus, Andreas, Fischer, Thomas, Al‑Ali, Haifa Kathrin, and Niederwieser, Dietger

Published
2021
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9. Refining first-line treatment decision in RAS wildtype (RAS-WT) metastatic colorectal cancer (mCRC) by combining clinical biomarkers: Results of the randomized phase 3 trial FIRE-3 (AIO KRK0306).

Author

Holch, Julian Walter, Ohnmacht, Alexander, Stintzing, Sebastian, Heinrich, Kathrin, Westphalen, Benedikt, Weiss, Lena, von Weikersthal, Ludwig, Decker, Thomas, Kiani, Alexander, Kaiser, Florian, Heintges, Tobias, Kahl, Christoph, Kullmann, Frank, Scheithauer, Werner, Link, Hartmut, Hoeffkes, Heinz-Gert, Moehler, Markus H., Modest, Dominik Paul, Menden, Michael, and Heinemann, Volker

Published
2024
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10. FOLFOXIRI Plus Cetuximab or Bevacizumab as First-Line Treatment of BRAF V600E -Mutant Metastatic Colorectal Cancer: The Randomized Phase II FIRE-4.5 (AIO KRK0116) Study.

Author

Stintzing, Sebastian, Heinrich, Kathrin, Tougeron, David, Modest, Dominik Paul, Schwaner, Ingo, Eucker, Jan, Pihusch, Rudolf, Stauch, Martina, Kaiser, Florian, Kahl, Christoph, Karthaus, Meinolf, Müller, Christian, Burkart, Christof, Reinacher-Schick, Anke, Kasper-Virchow, Stefan, Fischer von Weikersthal, Ludwig, Krammer-Steiner, Beate, Prager, Gerald Wolfgang, Taieb, Julien, and Heinemann, Volker

Published
2023
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11. First-line Treatment With Bendamustine and Rituximab for Old and Frail Patients With Aggressive Lymphoma: Results of the B-R-ENDA Trial

Author

Braulke, Friederike, primary, Zettl, Florian, additional, Ziepert, Marita, additional, Viardot, Andreas, additional, Kahl, Christoph, additional, Prange-Krex, Gabriele, additional, Korfel, Agnieszka, additional, Dreyling, Martin, additional, Bott, Alexander, additional, Wedding, Ulrich, additional, Reichert, Dietmar, additional, de Wit, Maike, additional, Hartmann, Frank, additional, Poeschel, Viola, additional, Schmitz, Norbert, additional, Witzens-Harig, Mathias, additional, Klapper, Wolfram, additional, Rosenwald, Andreas, additional, Wulf, Gerald, additional, Altmann, Bettina, additional, and Trümper, Lorenz, additional

Published
2022
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12. Standard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3 / AIO KRK-0306

Author

Hofmann, Felix O., primary, Heinemann, Volker, additional, D’Anastasi, Melvin, additional, Gesenhues, Alena B., additional, Hesse, Nina, additional, von Weikersthal, Ludwig Fischer, additional, Decker, Thomas, additional, Kiani, Alexander, additional, Moehler, Markus, additional, Kaiser, Florian, additional, Heintges, Tobias, additional, Kahl, Christoph, additional, Kullmann, Frank, additional, Scheithauer, Werner, additional, Link, Hartmut, additional, Modest, Dominik P., additional, Stintzing, Sebastian, additional, and Holch, Julian W., additional

Published
2022
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13. Corrigendum to ‘Single-nucleotide variants, tumour mutational burden and microsatellite instability in patients with metastatic colorectal cancer: Next-generation sequencing results of the FIRE-3 trial’. [European Journal of Cancer 137 (2020) 250–259]

Author

Stahler, Arndt, primary, Stintzing, Sebastian, additional, von Einem, Jobst C., additional, Westphalen (Benedikt), Christoph B., additional, Heinrich, Kathrin, additional, Krämer, Nicole, additional, Michl, Marlies, additional, Modest, Dominik P., additional, Fischer von Weikersthal, Ludwig, additional, Decker, Thomas, additional, Kiani, Alexander, additional, Heintges, Tobias, additional, Kahl, Christoph, additional, Kullmann, Frank, additional, Scheithauer, Werner, additional, Moehler, Markus, additional, Kaiser, Florian, additional, Kirchner, Thomas, additional, Jung, Andreas, additional, and Heinemann, Volker, additional

Published
2022
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14. Early weight loss is an independent risk factor for shorter survival and increased side effects in patients with metastatic colorectal cancer undergoing first‐line treatment within the randomized Phase III trial FIRE‐3 (AIO KRK‐0306)

Author

Liu, Lian, primary, Erickson, Nicole Tonya, additional, Ricard, Ingrid, additional, von Weikersthal, Ludwig Fischer, additional, Lerch, Markus M., additional, Decker, Thomas, additional, Kiani, Alexander, additional, Kaiser, Florian, additional, Heintges, Tobias, additional, Kahl, Christoph, additional, Kullmann, Frank, additional, Scheithauer, Werner, additional, Link, Hartmut, additional, Höffkes, Heinz‐Gert, additional, Moehler, Markus, additional, Gesenhues, Alena Britta, additional, Theurich, Sebastian, additional, Michl, Marlies, additional, Modest, Dominik P., additional, Algül, Hana, additional, Stintzing, Sebastian, additional, Heinemann, Volker, additional, and Holch, Julian W., additional

Published
2021
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15. Early weight loss is an independent risk factor for shorter survival and increased side effects in patients with metastatic colorectal cancer undergoing first‐line treatment within the randomized Phase III trial FIRE‐3 (AIO KRK‐0306)

Author

Liu, Lian, Erickson, Nicole Tonya, Ricard, Ingrid, von Weikersthal, Ludwig Fischer, Lerch, Markus M., Decker, Thomas, Kiani, Alexander, Kaiser, Florian, Heintges, Tobias, Kahl, Christoph, Kullmann, Frank, Scheithauer, Werner, Link, Hartmut, Höffkes, Heinz‐Gert, Moehler, Markus, Gesenhues, Alena Britta, Theurich, Sebastian, Michl, Marlies, Modest, Dominik P., and Algül, Hana

Subjects
COLORECTAL cancer, WEIGHT loss, METASTASIS, PROGNOSIS, TREATMENT effectiveness, POSTOPERATIVE nausea & vomiting
Abstract

Body weight loss is frequently regarded as negatively related to outcomes in patients with malignancies. This retrospective analysis of the FIRE‐3 study evaluated the evolution of body weight in patients with metastatic colorectal cancer (mCRC). FIRE‐3 evaluated first‐line FOLFIRI (folinic acid, fluorouracil and irinotecan) plus cetuximab or bevacizumab in mCRC patients with RAS‐WT tumors (ie, wild‐type in KRAS and NRAS exons 2‐4). The prognostic and predictive relevance of early weight loss (EWL) regarding patient outcomes and treatment side effects were evaluated. Retrospective data on body weight during first 6 months of treatment were evaluated (N = 326). To correlate with efficacy endpoints and treatment side effects, patients were grouped according to clinically significant EWL ≥5% and <5% at Month 3. Age constituted the only significant predictor of EWL following a linear relationship with the corresponding log odds ratio (P =.016). EWL was significantly associated with the incident frequencies of diarrhea, edema, fatigue, nausea and vomiting. Further, a multivariate analysis revealed EWL to be an independent negative prognostic factor for overall survival (32.4 vs 21.1 months; hazard ratio [HR]: 1.64; 95% confidence interval [CI] = 1.13‐2.38; P =.0098) and progression‐free survival (11.8 vs 9.0 months; HR: 1.72; 95% CI = 1.18‐2.5; P =.0048). In conclusion, EWL during systemic treatment against mCRC is significantly associated with patient age. Patients exhibiting EWL had worse survival and higher frequencies of adverse events. Early preventative measures targeted at weight maintenance should be evaluated, especially in elderly patients being at highest risk of EWL. What's new? When patients with metastatic colorectal cancer (mCRC) rapidly lose weight early in the course of treatment, that often forebodes a negative outcome. Here, the authors examined changes in body weight in the first 3 months of treatment. Older patients had the highest risk of extreme early weight loss (greater than 5%). This weight loss was correlated with adverse events such as nausea, vomiting, and diarrhoea, and also with an 11‐month reduction in overall survival. These results should increase oncologists' awareness of patients' body weight change early in treatment and encourage intervention from dietitians to help prevent weight loss. [ABSTRACT FROM AUTHOR]

Published
2022
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