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Your search keyword '"Kaiser, Jan Christian"' showing total 15 results
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15 results on '"Kaiser, Jan Christian"'

1. Clinical identification of malignant pleural effusions

Author

Jia, Jianlong, Marazioti, Antonia, Voulgaridis, Apostolos, Psallidas, Ioannis, Lamort, Anne-Sophie, Iliopoulou, Marianthi, Krontira, Anthi C., Lilis, Ioannis, Asciak, Rachelle, Kanellakis, Nikolaos I., Rahman, Najib M., Karkoulias, Kyriakos, Spiropoulos, Konstantinos, Liu, Ruonan, Kaiser, Jan-Christian, and Stathopoulos, Georgios T.

Published
2024
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3. Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise

Author

Chauhan, Vinita, primary, Beaton, Danielle, additional, Tollefsen, Knut Erik, additional, Preston, Julian, additional, Burtt, Julie J., additional, Leblanc, Julie, additional, Hamada, Nobuyuki, additional, Azzam, Edouard I., additional, Armant, Olivier, additional, Bouffler, Simon, additional, Azimzadeh, Omid, additional, Moertl, Simone, additional, Yamada, Yutaka, additional, Tanaka, Ignacia B., additional, Kaiser, Jan Christian, additional, Applegate, Kimberly, additional, Laurier, Dominique, additional, and Garnier-Laplace, Jacqueline, additional

Published
2024
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8. Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

Author

Burtt, Julie J., primary, Leblanc, Julie, additional, Randhawa, Kristi, additional, Ivanova, Addie, additional, Rudd, Murray A., additional, Wilkins, Ruth, additional, Azzam, Edouard I., additional, Hecker, Markus, additional, Horemans, Nele, additional, Vandenhove, Hildegarde, additional, Adam-Guillermin, Christelle, additional, Armant, Olivier, additional, Klokov, Dmitry, additional, Audouze, Karine, additional, Kaiser, Jan Christian, additional, Moertl, Simone, additional, Lumniczky, Katalin, additional, Tanaka, Ignacia B., additional, Yamada, Yutaka, additional, Hamada, Nobuyuki, additional, Al-Nabulsi, Isaf, additional, Preston, R. Julian, additional, Bouffler, Simon, additional, Applegate, Kimberly, additional, Cool, Donald, additional, Beaton, Danielle, additional, Tollefsen, Knut Erik, additional, Garnier-Laplace, Jacqueline, additional, Laurier, Dominique, additional, and Chauhan, Vinita, additional

Published
2022
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9. Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

Author

Azimzadeh, Omid, primary, Moertl, Simone, additional, Ramadan, Raghda, additional, Baselet, Bjorn, additional, Laiakis, Evagelia C., additional, Sebastian, Soji, additional, Beaton, Danielle, additional, Hartikainen, Jaana M., additional, Kaiser, Jan Christian, additional, Beheshti, Afshin, additional, Salomaa, Sisko, additional, Chauhan, Vinita, additional, and Hamada, Nobuyuki, additional

Published
2022
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13. Prognostic phenotypes of early-stage lung adenocarcinoma

Author

Lamort, Anne-Sophie, primary, Kaiser, Jan Christian, additional, Pepe, Mario A.A., additional, Lilis, Ioannis, additional, Ntaliarda, Giannoula, additional, Somogyi, Kalman, additional, Spella, Magda, additional, Behrend, Sabine J., additional, Giotopoulou, Georgia A., additional, Kujawa, Willem, additional, Lindner, Michael, additional, Koch, Ina, additional, Hatz, Rudolf A., additional, Behr, Juergen, additional, Sotillo, Rocio, additional, Schamberger, Andrea C., additional, and Stathopoulos, Georgios T., additional

Published
2021
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14. Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation

Author

Chauhan, Vinita, primary, Hamada, Nobuyuki, additional, Monceau, Virginie, additional, Ebrahimian, Teni, additional, Adam, Nadine, additional, Wilkins, Ruth C., additional, Sebastian, Soji, additional, Patel, Zarana S., additional, Huff, Janice L., additional, Simonetto, Cristoforo, additional, Iwasaki, Toshiyasu, additional, Kaiser, Jan Christian, additional, Salomaa, Sisko, additional, Moertl, Simone, additional, and Azimzadeh, Omid, additional

Published
2021
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15. Prognostic phenotypes of early-stage lung adenocarcinoma.

Author

Lamort AS, Kaiser JC, Pepe MAA, Lilis I, Ntaliarda G, Somogyi K, Spella M, Behrend SJ, Giotopoulou GA, Kujawa W, Lindner M, Koch I, Hatz RA, Behr J, Sotillo R, Schamberger AC, and Stathopoulos GT

Subjects
Humans, Phenotype, Prognosis, Proliferating Cell Nuclear Antigen genetics, Prospective Studies, Adenocarcinoma of Lung genetics, Adenocarcinoma of Lung pathology, Lung Neoplasms pathology
Abstract

Background: Survival after curative resection of early-stage lung adenocarcinoma (LUAD) varies and prognostic biomarkers are urgently needed., Methods: Large-format tissue samples from a prospective cohort of 200 patients with resected LUAD were immunophenotyped for cancer hallmarks TP53, NF1, CD45, PD-1, PCNA, TUNEL and FVIII, and were followed for a median of 2.34 (95% CI 1.71-3.49) years., Results: Unsupervised hierarchical clustering revealed two patient subgroups with similar clinicopathological features and genotype, but with markedly different survival: "proliferative" patients (60%) with elevated TP53, NF1, CD45 and PCNA expression had 50% 5-year overall survival, while "apoptotic" patients (40%) with high TUNEL had 70% 5-year survival (hazard ratio 2.23, 95% CI 1.33-3.80; p=0.0069). Cox regression and machine learning algorithms including random forests built clinically useful models: a score to predict overall survival and a formula and nomogram to predict tumour phenotype. The distinct LUAD phenotypes were validated in The Cancer Genome Atlas and KMplotter data, and showed prognostic power supplementary to International Association for the Study of Lung Cancer tumour-node-metastasis stage and World Health Organization histologic classification., Conclusions: Two molecular subtypes of LUAD exist and their identification provides important prognostic information., Competing Interests: Conflict of interest: The authors declare no potential conflicts of interest., (Copyright ©The authors 2022. For reproduction rights and permissions contact permissions@ersnet.org.)

Published
2022
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