In radio wave hyperthermia therapy, array antenna configuration was mainly studied to generate a small spot at the diseased part. Array antennas have the flexibility in controlling radiation performance, such as spot positions, by using their numerous radiating elements. However, the flexibility is achieved at the expense of antenna structure complexity. On the other hand, a lens antenna can concentrate radio waves into a small spot by forming a lens shape. The simplicity of a lens antenna structure lends itself to easy handling in a practical application. Moreover, the frequency independence of the lens antenna allows for a more flexible selection of hyperthermia therapy frequencies. Therefore, the lens antenna is selected as a focusing antenna in this paper. The lens shaping method and the temperature increment measurement are the main contents of this paper. The designed lens has a diameter of 30 cm, a focusing distance of 30 cm, and a working frequency of 2.45 GHz. A thin lens design method is applied to reduce lens weight. Firstly, the focusing ability of the designed lens is ensured by comparing the spot size results of electromagnetic (EM) simulation with its theoretical value. A spot size of 1.77 cm is obtained in both cases. Next, the temperature increment is examined by EM simulations. The temperature at the 2 cm tumor was increased to 41 °C from the human body temperature of 37 °C by an input power of 10 Watts (W). For the temperature increment measurement, a tumor within human body phantom is utilized and the available input power is reduced to 4 W. The tumor temperature increased from 21.5 °C of room temperature to 24.4 °C, which was captured by a thermal imaging camera. As a result, the functionality of the lens antenna for hyperthermia therapy is verified., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)