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Ambient magnetic skyrmions stabilized in multilayer nanostructures are of immense interest due to their relevance to magnetic tunnel junction (MTJ) devices for memory and unconventional computing applications. However, existing skyrmionic nanostructures built using conventional metallic or oxide multilayer nanodots are unable to concurrently fulfill the requirements of nanoscale skyrmion stability and feasibility of all-electrical readout and manipulation. Here, we develop a few-repeat hybrid multilayer platform consisting of metallic [Pt/CoB/Ir]3 and oxide [Pt/CoB/MgO] components that are coupled to evolve together as a single, composite stack. Zero-field (ZF) skyrmions with sizes as small as 50 nm are stabilized in the hybrid multilayer nanodots, which are smoothly modulated by up to 2.5x by varying CoB thickness and dot sizes. Meanwhile, skyrmion multiplets are also stabilized by small bias fields. Crucially, we observe higher order 'target' skyrmions with varying magnetization rotations in moderately-sized, low anisotropy nanodots. These results provide a viable route to realize long-sought skyrmionic MTJ devices and new possibilities for multi-state skyrmionic device concepts.

Two-dimensional (2D) materials have aroused considerable research interests owing to their potential applications in nanoelectronics and optoelectronics. Thermodynamic stability of 2D structures inevitably affects the performance and power consumption of the fabricated nanodevices. Black arsenic (b-As), as a cousin of black phosphorus, has presented the extremely high anisotropy in physical properties. However, the systematic research on structural stability of b-As is still lack. Herein, we demonstrated the detailed analysis on structural metastability of the natural b-As, and determined its existence conditions in terms of two essential thermodynamic variables as hydrostatic pressure and temperature. Our results confirmed that b-As can only survive below 0.7 GPa, and then irreversibly transform to gray arsenic, in consistent with our theoretical calculations. Furthermore, thermal annealing strategy was developed to precisely control the thickness of b-As flake, and it sublimates at 300 oC. These results could pave the way for 2D b-As in many promising applications., Comment: 28 pages, 4 figures

Longitudinal tracking of skin lesions - finding correspondence, changes in morphology, and texture - is beneficial to the early detection of melanoma. However, it has not been well investigated in the context of full-body imaging. We propose a novel framework combining geometric and texture information to localize skin lesion correspondence from a source scan to a target scan in total body photography (TBP). Body landmarks or sparse correspondence are first created on the source and target 3D textured meshes. Every vertex on each of the meshes is then mapped to a feature vector characterizing the geodesic distances to the landmarks on that mesh. Then, for each lesion of interest (LOI) on the source, its corresponding location on the target is first coarsely estimated using the geometric information encoded in the feature vectors and then refined using the texture information. We evaluated the framework quantitatively on both a public and a private dataset, for which our success rates (at 10 mm criterion) are comparable to the only reported longitudinal study. As full-body 3D capture becomes more prevalent and has higher quality, we expect the proposed method to constitute a valuable step in the longitudinal tracking of skin lesions., Comment: MICCAI-2023

Lumbar spinal stenosis (LSS) is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen, and is manifested as chronic low back and leg pain. Danlu Tongdu (DLTD) tablets can relieve chronic pain caused by LSS, but the molecular mechanism remains largely unknown. In this study, the potential molecular mechanism of DLTD tablets in the treatment of LSS was firstly predicted by network pharmacology method. Results showed that DLTD functions in regulating anti-oxidative, apoptosis, and inflammation signaling pathways. Furthermore, the flow cytometry results showed that DLTD tablets efficiently reduced ROS content and inhibited rat neural stem cell apoptosis induced by hydrogen peroxide. DLTD also inhibited the mitochondrial membrane potential damage induced by hydrogen peroxide. Elisa analysis showed that DLTD induced cell cycle related protein, CDK2 and CDK4 and reduced CDKN1A protein expression level. Taken together, our study provided new insights of DLTD in treating LSS through reducing ROS content, decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.

Quantum Hall effect (QHE), the ground to construct modern conceptual electronic systems with emerging physics, is often much influenced by the interplay between the host two-dimensional electron gases and the substrate, sometimes predicted to exhibit exotic topological states. Yet the understanding of the underlying physics and the controllable engineering of this paradigm of interaction remain challenging. Here we demonstrate the observation of an unusual QHE, which differs markedly from the known picture, in graphene samples in contact with an anti-ferromagnetic insulator CrOCl equipped with dual gates. Owing to the peculiar interfacial coupling, Landau levels in monolayer graphene remain intact at negative filling fractions, but largely deviated for the positive gate-doping range. The latter QHE phase even presents in the limit of zero magnetic field, with the consequential Landau quantization following a parabolic relation between the displacement field $D$ and the magnetic field $B$. This characteristic prevails up to 100 K in a sufficiently wide effective doping range from 0 to 10$^{13}$ cm$^{-2}$. Our findings thus open up new routes for manipulating the quantum electronic states, which may find applications in such as quantum metrology., Comment: 11 pages, 5 figures