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Treatment of meningiomas refractory to surgery and irradiation is challenging and effective chemotherapies are still lacking. Recently, in vitro analyses revealed decitabine (DCT, 5-aza-2’–deoxycytidine) to be effective in high-grade meningiomas and, moreover, to induce hypomethylation of distinct oncogenes only sparsely described in meningiomas in vivo yet.Expression of the corresponding onco- and tumor suppressor genes TRIM58, FAM84B, ELOVL2, MAL2, LMO3, and DIO3 were analyzed and scored by immunohistochemical staining and RT-PCR in samples of 111 meningioma patients. Correlations with clinical and histological variables and prognosis were analyzed in uni- and multivariate analyses.All analyzed oncogenes were highly expressed in meningiomas. Expression scores of TRIM58 tended to be higher in benign than in high-grade tumors 20 vs 16 (p = .002) and all 9 samples lacking TRIM58 expression displayed WHO grade II/III histology. In contrast, median expression scores for both FAM84B (6 vs 4, p ≤ .001) and ELOVL2 (9 vs 6, p DIO3 expression was distinctly higher in all analyzed samples as compared to the reference decitabine-resistant Ben-Men 1 cell line. Increased ELOVL2 expression (score ≥ 8) correlated with tumor relapse in both uni- (HR: 2.42, 95%CI 1.18–4.94; p = .015) and multivariate (HR: 2.09, 95%CI 1.01–4.44; p = .046) analyses.All oncogenes involved in DCT efficacy in vitro are also widely expressed in vivo, and expression is partially associated with histology and prognosis. These results strongly encourage further analyses of DCT efficiency in meningiomas in vitro and in situ.

To assess the long-term hazard of tsunamis, particularly in regions with a short and fragmented historical record, sedimentary deposits of tsunamis are an essential tool. In the North Sea region, evidence of tsunamis is scarce. The Shetland Islands are an exception, as they contain abundant deposits of the Storegga tsunami (c. 8150 cal. a BP), and additionally more fragmented evidence of younger tsunami events c. 5500 and c. 1500 cal. a BP. Sediments of the youngest tsunami (the “Dury Voe” event) have only been found at two sites so far, marked by thin landward fining and landward thinning sand sheets which are vertically confined by peat. Here, we present sedimentary evidence for the youngest Shetland tsunami from the small coastal lake of Loch Flugarth, northern Mainland. Three gravity cores of up to 91.7 cm length were taken behind the barrier separating the lake from a shallow marine embayment. The cores show organic-rich background deposition with many sub-cm-scale sand layers, reflecting recurring storm overwash and a sediment source limited to the active beach and uppermost subtidal zone. A basal 13 cm-thick sand layer, dated to 426–787 cal. a CE based on 14C, 137Cs and Bayesian age-depth modelling, was found in all three cores. High-resolution grain-size analysis identified four normally graded sublayers with inversely graded traction carpets in the lower part of two sublayers. An organic-rich ‘mud’ drape and ‘mud’ cap cover the upper two sublayers, which also contain small rip-up clasts. Grain-size distributions show a difference between the basal sand layer and the coarser and better sorted thin storm layers. Principal component analysis of X-ray fluorescence core scanning data also distinguishes both sand units: Zr, Fe and Ti dominate the basal sand, while the thin storm layers are high in K and Si. The enrichment of the basal sand layer in Zr and Ti, in combination with increased magnetic susceptibility, may be related to higher heavy mineral content in the basal sand reflecting the additional marine sediment source of a tsunami deposit below the storm-wave base. Based on reinterpretation of chronological data from the two published sites and the chronostratigraphy of the present study, the Dury Voe tsunami seems to be slightly younger, i.e., closer to 1400 cal. a BP. Although the source of the tsunami remains unclear, the lack of evidence for this event outside of the Shetlands suggests that it was smaller than the older Storegga tsunami, which affected most of the North Sea basin.

The El Niño-Southern Oscillation (ENSO), known for exceptional heavy rainfalls, droughts and inundations in the Pacific and Indian Ocean realm, is one of the largest oceanic and atmospheric phenomena on Earth influencing global climate patterns. Over the last decades, a strong warming in the high latitudes of both hemispheres has been observed to coincide with the rise of a third ENSO type — “El Niño/La Niña Modoki”, also called Central Pacific ENSO. During El Niño Modoki (La Niña Modoki) events, sea-surface temperature (SST) is higher (lower) in the central equatorial Pacific, flanked by colder (warmer) SSTs in the western or eastern Pacific, associated with a twin Walker Circulation. The study aims to understand the underlying spatio-temporal dynamics and processes of Central Pacific ENSO and a possible link to anthropogenic impacts from a paleo-perspective to improve the predictability of Central Pacific ENSO variations in the future. Therefore, high-resolution (c. 1–2 kyr resolution) proxy records of SST variability are generated from marine sediment cores from the western, central, and eastern equatorial Pacific from the Middle-Pleistocene to present. The SST reconstructions are based on Mg/Ca ratios of planktic foraminifers and biomarker (alkenone) analyses. Based on preliminary and published data, a lower east–west SST gradient and colder SSTs in the central Pacific occurred during warmer periods. La Niña Modoki conditions apparently become more frequent with increasing CO2 conditions pointing at the likelihood that La Niña Modoki conditions will become more prevalent in the near future. Accordingly, an increase in precipitation on both sides of the Pacific realm could be expected.

Tsunami deposits are required to assess the long-term hazard of tsunamis, in particular in regions with a short and fragmented historical record. In the North Sea region, evidence of tsunamis is scarce. However, the Shetland Islands are an exception, as they provide abundant deposits of the Storegga tsunami c. 8150 cal. a BP, and more fragmented evidence of younger events ~5500 and ~1500 cal. a BP. Sediments of the youngest tsunami – the so-called Dury Voe event – are considered uncertain and have only been found at two sites so far, as thin landward fining and landward thinning sand sheets which are vertically confined by peat. Here, we present sedimentary evidence for a tsunami from the small coastal lake of Loch Flugarth, northern Mainland. Three gravity cores of up to 91 cm length were taken behind the barrier separating the lake from a shallow marine embayment. The cores show organic-rich background deposition with many sub-cm-scale sand layers, reflecting recurring storm overwash and a sediment source limited to the active beach and uppermost subtidal. A basal 13 cm-thick sand layer, dated to 426–787 cal. a CE based on 14C-AMS, 137Cs and Bayesian age-depth modelling, was found in all three cores. High-resolution grain-size analysis identified four normally graded sublayers with inversely graded traction carpets in the lower part of two sublayers. An organic-rich “mud” drape and “mud” cap, respectively, cover the upper two sublayers, which also contain small rip-up clasts. Grain-size distributions shows a difference between the basal sand layer and the thin storm layers, which are coarser and better sorted. Principal component analysis of XRF core scanning data also distinguishes both sand units, mostly driven by Zr, Fe and Ti in the basal sand. This, in combination with increased magnetic susceptibility, may be related to higher heavy mineral content reflecting an additional marine sediment source for the tsunami deposit. Based on reinterpretation of chronological data from the two published sites and the chronostratigraphy of the present study, the Dury Voe tsunami seems to be younger than previously estimated, i.e. closer to 1400–1300 cal. a BP. The source of the tsunami remains unclear. As there is no evidence for this event outside the Shetlands, the size of the tsunami is expected to be smaller than the Storegga tsunami, which affected most of the North Sea basin.

Synchronous or metachronous growth of multiple tumors (≥ 2) is found in up to 20% of meningioma patients. However, biological as well as histological features and prognosis are largely unexplored. Clinical and histological characteristics were retrospectively investigated in 95 patients harboring 226 multiple meningiomas (MMs) and compared with 135 cases of singular meningiomas (SM) using uni- and multivariate analyses. In MM, tumors occurred synchronously and metachronously in 62% and 38%, respectively. WHO grade was intra-individually constant in all but two MMs, and histological subtype varied in 13% of grade 1 tumors. MM occurred more commonly in convexity/parasagittal locations, while SM were more frequent at the skull base (p p = .014) and high-grade histology in MM were associated with a prolonged time to progression (p p ≥ .05, each). Multivariate analyses showed synchronous/metachronous meningioma growth (HR 4.50, 95% CI 2.26–8.96; p p = .224), but exponentially raised in patients with 3–4 (HR 3.25, 1.22–1.62; p = .018) and ≥ 5 tumors (HR 13.80, 4.06–46.96; p

About 25% of patients with intracranial meningioma display seizures at the time of initial presentation. Hence, identification of risk factors for preoperative seizures is crucial during perioperative care of meningioma patients.Associations of preoperative seizures with clinical, radiological and histological variables were analyzed in 945 patients (689 females, 73% and 256 males, 27%; median age: 58 years) who underwent surgery for primary diagnosed intracranial meningioma.Preoperative seizures were found in 189 patients (20%). In univariate analyses, male gender (OR: 1.91, 95%CI 1.37-2.68; p.001), grade II/III histology (OR: 2.24, 95%CI 1.46-3.46; p.001), brain invasion (OR: 2.59, 95%CI 1.45-4.63; p=001), non-skull base tumor location (OR: 3.07, 95%CI 2.13-4.41; p.001), heterogeneous contrast-enhancement (OR: 1.60, 95%CI 1.04-2.46; p=.031), intratumoral calcifications (OR: 1.91, 95%CI 1.17-3.10; p=.009), an irregular shape (OR: 2.07, 95%CI 1.32-3.26; p=.002) as well as tumor (OR: 1.01 per ccm, 95%CI 1.00-1.02; p=.001) and edema volumes (OR: 1.01 per ccm, 95%CI 1.00-1.01; p.001) were correlated with seizures. Semiology was not related to any of the analyzed variables (p.05, each). No associations were found between seizures and histological subtype of 832 grade I meningiomas (p=.391). In multivariate analyses, only non-skull base tumor location (OR: 3.12, 95%CI 1.74-5.59; p.001) and a rising peritumoral edema volume (OR: 1.01 per ccm, 95%CI 1.00-1.01; p.001) were identified as independent predictors for preoperative seizures.Several mostly radiological variables were identified as risk factors for epilepsy. However, multivariate analyses confirmed only peritumoral edema and non-skull base tumor location as independent predictors for preoperative seizures. None of the variables predicts semiology.

This paper combines long-term state-of-the-art climate projections and indices to provide detailed insights into the future climate of Suriname to facilitate comprehensive information of areas and sectors at high climate risk for political decision-making. The study analyses Suriname’s historical climate (1990–2014) and provides climate projections for three time horizons (2020–2044, 2045–2069, 2070–2094) and two emissions scenarios (intermediate/SSP2-4.5 and severe/SSP5-8.5). Coupled Model Intercomparison Project (CMIP6) modeling is used to analyze changes in sea level, temperature, precipitation, relative humidity, and winds. In addition, risk impact chains were produced for the country’s four most important socio-economic sectors: agriculture and fisheries, forestry, water, and infrastructure. Results show the temperature is expected to increase for all regions and timeframes, reaching warming up to 6 °C in the southern region in the long-term future (2070–2094). Projections point towards a reduction in precipitation in the southwest and coastal regions and a rise in mean sea level. Regarding risk, Paramaribo and Wanica face the highest climate risk. Coronie and Nickerie face the least climate risk. These regions remain the most and least vulnerable in both the SSP2-4.5 and SSP5-8.5 scenarios, but overall values of their risk indices increase substantially over time.