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6. Corrigendum

Author

Skuli, Nicolas, Majmundar, Amar J., Krock, Bryan L., Mesquita, Rickson C., Mathew, Lijoy K., Quinn, Zachary L., Runge, Anja, Liu, Liping, Kim, Meeri N., Liang, Jiaming, Schenkel, Steven, Yodh, Arjun G., Keith, Brian, and Simon, M. Celeste

Subjects
Health care industry
Abstract

Original citation: J Clin Invest. 2012;122(4):1427-1443. https://doi.org/10.1172/JCI57322. Citation for this corrigendum: J Clin Invest. 2024;134(8):e180863. https://doi.org/10.1172/JCI180863. The authors recently became aware that the image presented in Figure 4A for the [...]

Published
2024
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7. Predictive modeling of on‐time graduation in computing engineering programs: A case study from Northern Chile.

Author

Quelopana, Aldo, Keith, Brian, and Pizarro, Ricardo

Abstract

In the ever‐evolving landscape of 21st‐century education, this research seeks to understand the challenges of on‐time graduation for students in two related computing majors. In particular, we focus on the Universidad Católica del Norte computing engineering programs in Chile, specifically the "Computing and Informatics Civil Engineering" (ICCI) and "Computing and Informatics Execution Engineering" (IECI) programs. We developed a machine‐learning‐based model using random forests to predict delays in submissions of the final report of graduation projects, the key step in the graduation pipeline of the analyzed students. We had access to a data set comprised of 209 students in the period from 2013 to 2017, out of these students, only 111 completed all their graduation requirements. Thus, we focused on this subset of students for the analysis. Our analyses of results indicate that individual advisors minimally contribute to predicting timely or late submissions, emphasizing the need for a holistic approach. In contrast, the specific major, graduation modality, and time in the program play crucial roles, with GPA emerging as the most influential factor (24.06%). Notably, the "Professional Work" modality exhibits a moderate positive correlation with late submissions, contextualized by students' employment commitments. The study's predictive model offers actionable insights for educators and administrators, identifying at‐risk students and advocating for personalized support strategies. This research contributes to the ongoing dialogue on enhancing educational outcomes by integrating data‐driven approaches tailored to diverse student profiles. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Figure S7 from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah M., primary, Coffey, Nathan J., primary, Carens, Madeleine, primary, Mesaros, Clementina, primary, Xu, Jimmy P., primary, Xue, Yizheng, primary, Davis, Leah, primary, Demczyszyn, Sara, primary, Vogt, Austin, primary, Olia, Adam, primary, Finan, Jennifer M., primary, Godfrey, Jason, primary, Schultz, David C., primary, Blair, Ian A., primary, Keith, Brian, primary, Marmorstein, Ronen, primary, Skuli, Nicolas, primary, and Simon, M. Celeste, primary

Published
2024
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9. Data from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah M., primary, Coffey, Nathan J., primary, Carens, Madeleine, primary, Mesaros, Clementina, primary, Xu, Jimmy P., primary, Xue, Yizheng, primary, Davis, Leah, primary, Demczyszyn, Sara, primary, Vogt, Austin, primary, Olia, Adam, primary, Finan, Jennifer M., primary, Godfrey, Jason, primary, Schultz, David C., primary, Blair, Ian A., primary, Keith, Brian, primary, Marmorstein, Ronen, primary, Skuli, Nicolas, primary, and Simon, M. Celeste, primary

Published
2024
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10. Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

Author

Skuli, Nicolas, primary, Majmundar, Amar J., additional, Krock, Bryan L., additional, Mesquita, Rickson C., additional, Mathew, Lijoy K., additional, Quinn, Zachary L., additional, Runge, Anja, additional, Liu, Liping, additional, Kim, Meeri N., additional, Liang, Jiaming, additional, Schenkel, Steven, additional, Yodh, Arjun G., additional, Keith, Brian, additional, and Simon, M. Celeste, additional

Published
2024
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11. Association between grass, tree and weed pollen and asthma health outcomes in Adelaide, South Australia: a time series regression analysis

Author

Monika Nitschke, Nicola Spurrier, Keith Brian Gordon Dear, Kamalesh Venugopal, Katrina Margaret Rose Lyne, Hubertus Paul Anton Jersmann, and David Leslie Simon

Subjects
Medicine
Abstract

Objectives We aim to establish daily risk estimates of the relationships between grass, tree and weed pollen and asthma health outcomes.Design Time series regression analysis of exposure and health outcomes using interaction by month to determine risk estimates all year round.Setting Metropolitan Adelaide, South Australia.Participants Health outcomes for asthma are based on 15 years of hospital admissions, 13 years emergency presentations and ambulance callouts. In adults (≥18 years), there were 10 381 hospitalisations, 26 098 emergency department (ED) presentations and 11 799 ambulance callouts and in children (0–17 years), 22 114, 39 813 and 3774, respectively.Outcome measures The cumulative effect of 7 day lags was calculated as the sum of the coefficients and reported as incidence rate ratio (IRR) related to an increase in 10 grains of pollen/m3.Results In relation to grass pollen, children and adults were disparate in their timing of health effects. Asthma outcomes in children were positively related to grass pollen in May, and for adults in October. Positive associations with weed pollen in children was seen from February to May across all health outcomes. For adults, weed pollen-related health outcomes were restricted to February. Adults were not affected by tree pollen, while children’s asthma morbidity was associated with tree pollen in August and September. In children, IRRs ranged from 1.14 (95% CI 1.06 to 1.21) for ED presentations for tree pollen in August to 1.98 (95% CI 1.06 to 3.72) for weed pollen in February. In adults, IRRs ranged from 1.28 (95% CI 1.01 to 1.62) for weed pollen in February to 1.31 (95% CI 1.08 to 1.57) for grass pollen in October.Conclusion Monthly risk assessment indicated that most pollen-related asthma health outcomes in children occur in the colder part of the year, while adults are affected in the warm season. The findings indicate a need for year-round pollen monitoring and related health campaigns to provide effective public health prevention.

Published
2022
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12. The scientific landscape of phytoremediation of tailings: a bibliometric and scientometric analysis.

Author

Keith, Brian F., Lam, Elizabeth J., Montofré, Ítalo L., Zetola, Vicente, and Bech, Jaume

Subjects
*BIBLIOMETRICS, *PHYTOREMEDIATION, *MINE waste, *ENVIRONMENTAL sciences, *QUANTITATIVE research, *HYPERACCUMULATOR plants
Abstract

AbstractThis article seeks to evaluate the scientific landscape of the phytoremediation of mine tailings through a series of bibliometric and scientometric techniques. Phytoremediation has emerged as a sustainable approach to remediate metal-contaminated mine waste areas. A scientometric analysis of 913 publications indexed in Web of Science from 1999 to 2023 was conducted using CiteSpace. The results reveal an expanding, interdisciplinary field with environmental sciences as the core category. Keyword analysis of 561 nodes and 2,825 links shows a focus on plant-metal interactions, microbial partnerships, bioavailability, and field validation. Co-citation analysis of 1,032 nodes and 2,944 links identifies seminal works on native species, plant-microbe interactions, and amendments. Temporal mapping of 15 co-citation clusters indicates a progression from early risk assessments and native plant inquiries to integrated biological systems, economic feasibility, and sustainability considerations. Recent trends emphasize multidimensional factors influencing adoption, such as plant-soil-microbe interactions, organic amendments, and field-scale performance evaluation. The findings demonstrate an intensifying translation of phytoremediation from scientific novelty to engineering practice. This quantitative and qualitative analysis of research trends aids in understanding the development of phytoremediation for mine tailings. The results provide valuable insights for researchers and practitioners in this evolving field. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah M., additional, Coffey, Nathan J., additional, Carens, Madeleine, additional, Mesaros, Clementina, additional, Xu, Jimmy P., additional, Xue, Yizheng, additional, Davis, Leah, additional, Demczyszyn, Sara, additional, Vogt, Austin, additional, Olia, Adam, additional, Finan, Jennifer M., additional, Godfrey, Jason, additional, Schultz, David C., additional, Blair, Ian A., additional, Keith, Brian, additional, Marmorstein, Ronen, additional, Skuli, Nicolas, additional, and Simon, M. Celeste, additional

Published
2024
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15. Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

Author

Li, Fuming, primary, Liu, Pingyu, additional, Mi, Wen, additional, Li, Liucheng, additional, Anderson, Nicole M., additional, Lesner, Nicholas P., additional, Burrows, Michelle, additional, Plesset, Jacqueline, additional, Majer, Ariana, additional, Wang, Guanlin, additional, Li, Jinyang, additional, Zhu, Lingzhi, additional, Keith, Brian, additional, and Simon, M. Celeste, additional

Published
2024
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18. Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

Author

Alexander, Katherine A, primary, Yu, Ruofan, additional, Skuli, Nicolas, additional, Coffey, Nathan J, additional, Nguyen, Son, additional, Faunce, Christine, additional, Huang, Hua, additional, Dardani, Ian, additional, Good, Austin L, additional, Lim, Joan, additional, Li, Catherin, additional, Biddle, Nicholas, additional, Joyce, Eric F, additional, Raj, Arjun, additional, Lee, Daniel, additional, Keith, Brian, additional, Simon, M Celeste, additional, and Berger, Shelley L, additional

Published
2023
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19. Abstract B008: Activation of the bile acid pathway promotes tumorigenesis in clear cell renal cell carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah, additional, Carens, Madeleine, additional, Mesaros, Clementina, additional, Xu, Jimmy, additional, Coffey, Nate, additional, Davis, Leah, additional, Vogt, Austin, additional, Olia, Adam, additional, Finan, Jennifer, additional, Godfrey, Jason, additional, Blair, Ian, additional, Keith, Brian, additional, Marmorstein, Ronen, additional, Skuli, Nicolas, additional, and Simon, Celeste, additional

Published
2023
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20. Abstract B003: Increasing branched-chain amino acid metabolism reduces clear cell renal cell carcinoma growth

Author

Coffey, Nathan J., primary, Riscal, Romain, additional, Skuli, Nicolas, additional, Lesner, Nicholas P., additional, Noji, Michael, additional, Jiang, Christine, additional, Kim, Laura C., additional, Han, Xu, additional, Blair, Megan C., additional, Keith, Brian, additional, Arany, Zoltan, additional, and Simon, M. Celeste, additional

Published
2023
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25. Table S3 from Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma

Author

Riscal, Romain, primary, Bull, Caroline J., primary, Mesaros, Clementina, primary, Finan, Jennifer M., primary, Carens, Madeleine, primary, Ho, Elaine S., primary, Xu, Jimmy P., primary, Godfrey, Jason, primary, Brennan, Paul, primary, Johansson, Mattias, primary, Purdue, Mark P., primary, Chanock, Stephen J., primary, Mariosa, Daniela, primary, Timpson, Nicholas J., primary, Vincent, Emma E., primary, Keith, Brian, primary, Blair, Ian A., primary, Skuli, Nicolas, primary, and Simon, M. Celeste, primary

Published
2023
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26. Figure S6 from Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma

Author

Riscal, Romain, primary, Bull, Caroline J., primary, Mesaros, Clementina, primary, Finan, Jennifer M., primary, Carens, Madeleine, primary, Ho, Elaine S., primary, Xu, Jimmy P., primary, Godfrey, Jason, primary, Brennan, Paul, primary, Johansson, Mattias, primary, Purdue, Mark P., primary, Chanock, Stephen J., primary, Mariosa, Daniela, primary, Timpson, Nicholas J., primary, Vincent, Emma E., primary, Keith, Brian, primary, Blair, Ian A., primary, Skuli, Nicolas, primary, and Simon, M. Celeste, primary

Published
2023
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30. Data from Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma

Author

Riscal, Romain, primary, Bull, Caroline J., primary, Mesaros, Clementina, primary, Finan, Jennifer M., primary, Carens, Madeleine, primary, Ho, Elaine S., primary, Xu, Jimmy P., primary, Godfrey, Jason, primary, Brennan, Paul, primary, Johansson, Mattias, primary, Purdue, Mark P., primary, Chanock, Stephen J., primary, Mariosa, Daniela, primary, Timpson, Nicholas J., primary, Vincent, Emma E., primary, Keith, Brian, primary, Blair, Ian A., primary, Skuli, Nicolas, primary, and Simon, M. Celeste, primary

Published
2023
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38. Supplementary Procedures and Figure Legends from Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

Author

Licciulli, Silvia, primary, Avila, Jacqueline L., primary, Hanlon, Linda, primary, Troutman, Scott, primary, Cesaroni, Matteo, primary, Kota, Smitha, primary, Keith, Brian, primary, Simon, M. Celeste, primary, Puré, Ellen, primary, Radtke, Fred, primary, Capobianco, Anthony J., primary, and Kissil, Joseph L., primary

Published
2023
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43. Eliciting Music Performance Anxiety of Vocal and Piano Students Through the Use of Virtual Reality

Author

Pace, Keith Brian and Pace, Keith Brian

Abstract

Despite the growth of virtual reality technologies, there is a lack of understanding of implementing these technologies within the collegiate classroom. This case study provides a mixed-method insight into a virtual reality (VR) asset deployed in a music performance environment. The study examined the effectiveness of a virtual reality environment as measured by the physiological response and user feedback. Ten voice and four piano college students participated in the study. Each participant performed musical works within an authentic practice room and the virtual concert hall via a Virtual Reality (VR) headset. Data was collected across four criteria. Participants’ heart rates were recorded before and after the performances. A State-Trait Anxiety Inventory test was presented to participants before and after the performances. Each performance was recorded and then blindly evaluated by two licensed music adjudicators. After the performances, participants completed a self-evaluation. Results indicated that virtual concert hall sessions caused a change in some categories of physiological, performance, and anxiety compared to an authentic practice room. No statistical difference was recorded in heart rate for vocalists between both environments. This project serves as a proof of concept that VR technologies can effectively elicit change in music performance anxiety. Furthermore, the study could encourage further research on mitigating music performance anxiety through virtual environment exposure.

Published
2022

45. Bridging the Gap between Spontaneous Behavior- and Stereotype-based Impressions

Author

Jacqueline Chen, Kimberly A Quinn, and Keith Brian Maddox

Abstract

This chapter explores the largely parallel progressions of person memory and stereotyping research in social cognition, with particular focus on spontaneous inferences drawn from descriptions of behavior or social group membership. We consider the potential benefits of several potential empirical intersections for theory and for a more open and inclusive psychological science.

Published
2021

50. Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment

Author

Han, Xu, Burrows, Michelle, Kim, Laura C., Xu, Jimmy P., Vostrejs, Will, Van Le, Tran Ngoc, Poltorack, Carson, Jiang, Yanqing, Cukierman, Edna, Stanger, Ben Z., Reiss, Kim A., Shaffer, Sydney M., Mesaros, Clementina, Keith, Brian, and Simon, M. Celeste

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with abundant cancer-associated fibroblasts (CAFs) creating hallmark desmoplasia that limits oxygen and nutrient delivery. This study explores the importance of lipid homeostasis under stress. Exogenous unsaturated lipids, rather than de novosynthesis, sustain PDAC cell viability by relieving endoplasmic reticulum (ER) stress under nutrient scarcity. Furthermore, CAFs are less hypoxic than adjacent malignant cells in vivo, nominating them as a potential source of unsaturated lipids. CAF conditioned medium promotes PDAC cell survival upon nutrient and oxygen deprivation, an effect reversed by delipidation. Lysophosphatidylcholines (LPCs) are particularly enriched in CAF conditioned medium and preferentially taken up by PDAC cells, where they are converted to phosphatidylcholine (PC) to sustain membrane integrity. Blocking LPC to PC conversion inhibits PDAC cell survival and increases ER stress. These findings reveal a critical lipid “cross-feeding” mechanism that promotes PDAC cell survival, offering a potential metabolic target for treatment.

Published
2024
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