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Background/Objectives: Films in the mouth offer a promising alternative drug delivery system for oral administration, with several advantages over traditional oral formulations. Furthermore, their non-invasive nature and easy administration make them conducive to increasing patient compliance. The use of active agents in these films can further improve their drug delivery properties, making them an even more useful drug delivery system. Methods: In this research, carrageenan was used as a polymer, while glycerine was added as a plasticizer, furthermore, lidocaine hydrochloride and diclofenac sodium were used as the active agents. The prepared films were characterized by analytical techniques. Results: The results showed that glycerine reduced the mucoadhesivity and breaking hardness of the films and increasing the temperature made the films brittle. These results are also confirmed by the statistical analysis. Based on the FTIR results, glycerine can be used in films without structural changes. Conclusions: Based on the findings, films prepared from a solution with a concentration of 1.5% carrageenan and 1.5% glycerine at 70 °C are suitable as a drug delivery system for use on the buccal mucosa when combined with active agents. Carrageenan was successfully used as a carrier for two different types of active agents. [ABSTRACT FROM AUTHOR]

Sporobolus cryptandrus is a C4 perennial bunchgrass native to extensive areas of North America. As a non-native species, it has been reported from several continents, and it has been described as a transformer species in sand steppes of Central and Eastern Europe. However, its spreading ability across the landscape and within habitats has not been quantified, and factors determining its success have not yet been assessed. In this study, we focused on the largest stronghold of S. cryptandrus invasion in Hungary, where the species was first recorded in 2016, and investigated its present distribution in the landscape by mapping along dirt roads. In a separate local study in a heavily infested sand dune site of 2 km2, we assessed the infestation level and factors affecting the species' establishment. Our landscape-scale mapping found that in April 2023, the distribution of S. cryptandrus encompassed a largely contiguous 600 km2, with documented presence from 282 1-km2 mapping units. The species occurred more than 5 m away from roads in 71 mapping units, mostly in the centre of its distribution area. Sporobolus cryptandrus presence was negatively related to soil organic matter content and positively related to sand content. At the local scale, we found the species in 39% of vegetation plots in a sand dune site originally covered by Pannonic sand steppes, a priority habitat in the EU Habitats Directive. Sporobolus cryptandrus presence at this site was negatively related to the total cover of resident grassland but, surprisingly, was unrelated to the distance from roads. Collectively, these results suggest that primary spread occurs mostly along roads; these roadside populations likely serve as sources for establishment in neighbouring grasslands, but subsequent mass invasion becomes independent from roads. Together with the species' broad macroclimatic tolerance in North America and reported mass invasion events in Ukraine and Russia, our results suggest that S. cryptandrus likely poses a broad-scale threat to Eurasian dry grasslands, in particular on coarse-textured sandy soils with low vegetation cover. [ABSTRACT FROM AUTHOR]

Aim: We evaluated stands of the invasive grass, Sporobolus cryptandrus in its native North American range and its non-native European range, where it is a recent invader. Our aim was to reveal how the species’ increasing abundance affects functional diversity and the ecosystem service-provisioning capacities of plant communities in both ranges. Location: Sand grasslands in the Kiskunság, Hungary and in Montana, USA. Methods: All vascular plant species and their relative abundances were recorded in a stratified random manner in 1 m × 1 m plots in each range, using the following cover categories of Sporobolus as strata: 1%–25%, 26%–50%, 50%–75%, and 75%–100%. The functional characteristics of the plant communities in the two continents were compared. We performed comparisons of the communities both with and without including Sporobolus. Results: Increasing Sporobolus cover resulted in a lower functional diversity and species richness, reduced average specific leaf area and increased the height of whole plant communities in both ranges but these effects were significantly stronger in the non-native stands. Sporobolus also negatively affected the cover of insect-pollinated plant species and the proportion of native perennials, switching the rest of the community from perennial-dominated to annual-dominated. In plant communities without Sporobolus, increasing Sporobolus cover led to a higher specific leaf area and seed mass in both ranges, but average height was decreasing along the Sporobolus abundance gradient in the native range, whereas it was increasing in the non-native range. Conclusions: The spread of Sporobolus, away from its native range, leads to the impoverishment of host communities and compromises the biomass and floral resourceprovisioning capacity of the vegetation to higher trophic levels. Tackling the spread of this new invader should therefore be a priority task. [ABSTRACT FROM AUTHOR]

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