Search

Your search keyword '"Kirchner, Henriette"' showing total 20 results
Start Over Author "Kirchner, Henriette" Publication Year Range Last 3 years
Sorry, I don't understand your search. ×
20 results on '"Kirchner, Henriette"'

5. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity.

Author

Krause, Christin, Britsemmer, Jan H., Bernecker, Miriam, Molenaar, Anna, Taege, Natalie, Lopez-Alcantara, Nuria, GeiÃ?ler, Cathleen, Kaehler, Meike, Iben, Katharina, Judycka, Anna, Wagner, Jonas, Wolter, Stefan, Mann, Oliver, Pfluger, Paul, Cascorbi, Ingolf, Lehnert, Hendrik, Stemmer, Kerstin, Schriever, Sonja C., and Kirchner, Henriette

Published
2024
Full Text
View/download PDF

6. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

Author

Krause, Christin, primary, Britsemmer, Jan H., additional, Bernecker, Miriam, additional, Molenaar, Anna, additional, Taege, Natalie, additional, Geißler, Cathleen, additional, Kaehler, Meike, additional, Iben, Katharina, additional, Judycka, Anna, additional, Wagner, Jonas, additional, Wolter, Stefan, additional, Mann, Oliver, additional, Pfluger, Paul T., additional, Cascorbi, Ingolf, additional, Lehnert, Hendrik, additional, Stemmer, Kerstin, additional, Schriever, Sonja C., additional, and Kirchner, Henriette, additional

Published
2023
Full Text
View/download PDF

7. Resistance to thyroid hormone induced tachycardia in RTHα syndrome

Author

Dore, Riccardo, primary, Watson, Laura, additional, Hollidge, Stefanie, additional, Krause, Christin, additional, Sentis, Sarah Christine, additional, Oelkrug, Rebecca, additional, Geißler, Cathleen, additional, Johann, Kornelia, additional, Pedaran, Mehdi, additional, Lyons, Greta, additional, Lopez-Alcantara, Nuria, additional, Resch, Julia, additional, Sayk, Friedhelm, additional, Iwen, Karl Alexander, additional, Franke, Andre, additional, Boysen, Teide Jens, additional, Dalley, Jeffrey W., additional, Lorenz, Kristina, additional, Moran, Carla, additional, Rennie, Kirsten L., additional, Arner, Anders, additional, Kirchner, Henriette, additional, Chatterjee, Krishna, additional, and Mittag, Jens, additional

Published
2023
Full Text
View/download PDF

8. Resistance to thyroid hormone induced tachycardia in RTHα syndrome

Author

Dore, Riccardo, Watson, Laura, Hollidge, Stefanie, Krause, Christin, Sentis, Sarah Christine, Oelkrug, Rebecca, Geißler, Cathleen, Johann, Kornelia, Pedaran, Mehdi, Lyons, Greta, Lopez-Alcantara, Nuria, Resch, Julia, Sayk, Friedhelm, Iwen, Karl Alexander, Franke, Andre, Boysen, Teide Jens, Dalley, Jeffrey W, Lorenz, Kristina, Moran, Carla, Rennie, Kirsten L, Arner, Anders, Kirchner, Henriette, Chatterjee, Krishna, Mittag, Jens, Dore, Riccardo [0000-0001-5988-9885], Johann, Kornelia [0000-0002-5089-7237], Franke, Andre [0000-0003-1530-5811], Dalley, Jeffrey W [0000-0002-2282-3660], Chatterjee, Krishna [0000-0002-2654-8854], Mittag, Jens [0000-0001-7778-5158], and Apollo - University of Cambridge Repository

Subjects
Thyroid Hormone Resistance Syndrome, Male, Mice, Thyroid Hormones, Thyroxine, Tachycardia, Mutation, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Animals, Thyroid Hormone Receptors alpha
Abstract

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persistent bradycardia is caused by an intrinsic cardiac defect and not due to altered autonomic control. Transcriptomic analyses show preserved, thyroid hormone (T3)-dependent upregulation of pacemaker channels (Hcn2, Hcn4), but irreversibly reduced expression of several ion channel genes controlling heart rate. Exposure of TRα1 mutant male mice to higher maternal T3 concentrations in utero, restores altered expression and DNA methylation of ion channels, including Ryr2. Our findings indicate that target genes other than Hcn2 and Hcn4 mediate T3-induced tachycardia and suggest that treatment of RTHα patients with thyroxine in high dosage without concomitant tachycardia, is possible.

Published
2023

9. Fatty Acid Induced Hypermethylation in the Slc2a4 Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity

Author

Britsemmer, Jan H., primary, Krause, Christin, additional, Taege, Natalie, additional, Geißler, Cathleen, additional, Lopez-Alcantara, Nuria, additional, Schmidtke, Linda, additional, Naujack, Alison-Michelle, additional, Wagner, Jonas, additional, Wolter, Stefan, additional, Mann, Oliver, additional, and Kirchner, Henriette, additional

Published
2023
Full Text
View/download PDF

11. Deiodinase type I (DIO1) regulation in non-alcoholic fatty liver disease (NAFLD)

Author

Lopez, Alcantara Nuria, primary, Geissler, Cathleen, additional, Naujack, Alison-Michelle, additional, Chen, Yingfu, additional, Taege, Natalie, additional, H., Britsemmer Jan, additional, Vinicius, Monteiro De Assis Leonardo, additional, Oster, Henrik, additional, Spranger, Joachim, additional, Katrin, Wirth Eva, additional, Nogueiras, Ruben, additional, Kirchner, Henriette, additional, and Mittag, Jens, additional

Published
2022
Full Text
View/download PDF

12. Deiodinase Type I regulation in fatty liver disease

Author

Lopez, Alcantara Nuria, primary, Geiszler, Cathleen, additional, Naujack, Alison-Michelle, additional, Chen, Yingfu, additional, Taege, Natalie, additional, Britsemmer, Jan H., additional, Vinicius, Monteiro De Assis Leonardo, additional, Oster, Henrik, additional, Spranger, Joachim, additional, Wirth, Eva, additional, Nogueiras, Ruben, additional, Kirchner, Henriette, additional, and Mittag, Jens, additional

Published
2022
Full Text
View/download PDF

16. Transcriptional Alterations in X-Linked Dystonia–Parkinsonism Caused by the SVA Retrotransposon

Author

Pozojevic, Jelena, primary, Algodon, Shela Marie, additional, Cruz, Joseph Neos, additional, Trinh, Joanne, additional, Brüggemann, Norbert, additional, Laß, Joshua, additional, Grütz, Karen, additional, Schaake, Susen, additional, Tse, Ronnie, additional, Yumiceba, Veronica, additional, Kruse, Nathalie, additional, Schulz, Kristin, additional, Sreenivasan, Varun K. A., additional, Rosales, Raymond L., additional, Jamora, Roland Dominic G., additional, Diesta, Cid Czarina E., additional, Matschke, Jakob, additional, Glatzel, Markus, additional, Seibler, Philip, additional, Händler, Kristian, additional, Rakovic, Aleksandar, additional, Kirchner, Henriette, additional, Spielmann, Malte, additional, Kaiser, Frank J., additional, Klein, Christine, additional, and Westenberger, Ana, additional

Published
2022
Full Text
View/download PDF

17. Meeting Report on “10th Anniversary Symposium on Inflammatory Skin Disease”

Author

Emtenani, Shirin, Baines, John F., Bieber, Katja, Gaffal, Evelyn, Goletz, Stephanie, Hernández, Gema, Hirose, Misa, Hoffmann, Markus, Joly, Pascal, Kirchner, Henriette, Köhl, Jörg, Murthy, Sripriya, Patzelt, Sabrina, Petersen, Frank, Pigors, Manuela, Riemekasten, Gabriela, Schmidt-Jiménez, Leon, Sezin, Tanya, Spielmann, Malte, Thaçi, Diamant, van Beek, Nina, Waschke, Jens, Ludwig, Ralf J., and Schmidt, Enno

Abstract

The Lübeck Institute of Experimental Dermatology celebrated its 10thAnniversary Symposium on Inflammatory Skin Diseases at the University of Lübeck, Germany, on October 17–18, 2024. This event brought together international key opinion leaders, faculty members, researchers, and clinicians to foster insightful discussions on the diagnosis, pathomechanisms, and treatment of autoimmune skin diseases, with a particular focus on pemphigus, pemphigoid diseases, and systemic sclerosis.

Published
2025
Full Text
View/download PDF

19. Die Genexpressionsprofile von Lebergewebe, subkutanem und viszeralem Fettgewebe korrelieren mit der Krankheitsschwere der metabolischen Fettlebererkrankung bei stark adipösen Patienten.

Author

Jegodzinski, Lina, Castven, Darko, Becker, Diana, Affonso, Juliana Marques, de Benito, Alvaro Mallagaray, Rudolph, Lorena, Rout, Ashok Kumar, Laudes, Matthias, Günther, Rainer, Schreiber, Stefan, Meyhöfer, Svenja, Sayk, Friedhelm, Kirchner, Henriette, Becker, Thomas, Beckmann, Jan Henrik, Günther, Ulrich L., von Schönfels, Witigo, and Marquardt, Jens U.

Published
2024
Full Text
View/download PDF

20. Epigenetic regulation of thyroid hormone action in human metabolic dysfunction-associated steatohepatitis.

Author

Naujack AM, Krause C, Britsemmer JH, Taege N, Mittag J, and Kirchner H

Subjects
Humans, Hep G2 Cells, Male, Female, Middle Aged, Liver metabolism, Liver pathology, Fatty Liver genetics, Fatty Liver metabolism, Fatty Liver pathology, Adult, Epigenesis, Genetic, MicroRNAs genetics, MicroRNAs metabolism, DNA Methylation, Thyroid Hormones metabolism, Thyroid Hormones genetics, Thyroid Hormone Receptors beta genetics, Thyroid Hormone Receptors beta metabolism, Iodide Peroxidase genetics, Iodide Peroxidase metabolism
Abstract

Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by inflammation, fibrosis, and accumulation of fatty acids in the liver. MASH disease progression has been associated with reduced thyroid hormone (TH) signaling in the liver, including reduced expression of deiodinase type I (DIO1) and TH receptor beta (THRB). However, the underlying mechanisms mediating these effects remain elusive. Here, we hypothesized that epigenetic mechanisms may be involved in modulating hepatic TH action., Methods: Liver samples from patients with and without MASH were analyzed by qRT-PCR and correlated with clinical parameters. Luciferase reporter assays and overexpression of miRNA in HepG2 cells were used to validate the functional binding of miRNA to predicted targets. DNA methylation was analyzed by bisulfite pyrosequencing., Results: miR-34a-5p was upregulated in MASH patients and correlated positively with the clinical parameters of MASH. Using in silico and in vitro analysis, we demonstrate that miR-34a-5p is capable of targeting several modulators of local hepatic TH action, as evidenced by the functional binding of miR-34a-5p to the seed sequence in the THRB and DIO1 genes. Consequently, overexpression of miR-34a-5p in HepG2 cells reduced the expression of THRA, THRB, DIO1, and SLC10A1, thus potentially mediating an acquired hepatic resistance to TH in MASH. As an additional regulatory mechanism, DNA methylation of THRB intron 1 was increased in MASH and negatively correlated with THRB expression., Conclusion: miR-34a-5p constitutes a possible epigenetic master regulator of hepatic TH action, which together with THRB-specific DNA methylation could explain a possible developing TH resistance in the liver during MASH progression on the molecular level.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results