137 results on '"Klaus, C."'
Search Results
2. Germany's Security Failure: Bumbling Chancellor Scholz puts the West at risk
- Author
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Engelen, Klaus C.
- Subjects
Security management ,Banking, finance and accounting industries - Abstract
'At first it meant a 'historical shift' that happened to Germany, now the term 'Zeitenwende' is widely used to describe the country's much-needed foreign and security policy rethink,' says Benjamin [...]
- Published
- 2024
3. Cystic endometrial hyperplasia-pyometra syndrome impairs the preantral follicle reserve in domestic bitches (Canis familiaris)
- Author
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Camozzi, Mylene G.M., Saturnino, Klaus C., Machado, Mônica R.F., Gastal, Gustavo D.A., Moreira, Cecília N., and Alves, Benner G.
- Published
- 2023
- Full Text
- View/download PDF
4. Heat Pump Fiasco: How the Greens fell from grace
- Author
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Engelen, Klaus C.
- Subjects
Cabinet officers -- Political aspects -- Political activity ,Banking, finance and accounting industries - Abstract
Berlin's focus has shifted. German Chancellor Olaf Scholz's 'tank battle' and the insufficient German military support for Ukraine's defense against the Russian invaders are no longer the major issues. Germany's [...]
- Published
- 2023
5. Deutschland Debacle: The court's fiscal boot is on the neck of the ruling coalition
- Author
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Engelen, Klaus C.
- Subjects
Political parties ,Opposition (Political science) -- Political aspects ,Coalition governments -- Political aspects ,Cabinet officers -- Political aspects -- Political activity ,Banking, finance and accounting industries ,Free Democratic Party -- Political activity -- Political aspects - Abstract
Germany's traffic-light coalition of Social Democrats, Greens, and Liberals is unable to escape crisis mode. The coalition's top leaders, Chancellor Olaf Scholz of the Social Democrats, Vice Chancellor and economy [...]
- Published
- 2023
6. Reply to: Assessment of 3D MINFLUX data for quantitative structural biology in cells
- Author
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Gwosch, Klaus C., Balzarotti, Francisco, Pape, Jasmin K., Hoess, Philipp, Ellenberg, Jan, Ries, Jonas, Matti, Ulf, Schmidt, Roman, Sahl, Steffen J., and Hell, Stefan W.
- Published
- 2023
- Full Text
- View/download PDF
7. Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry
- Author
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Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G.-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K.A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Ding, Wern Yew, Kotalczyk, Agnieszka, Boriani, Giuseppe, Marin, Francisco, Blomström-Lundqvist, Carina, Potpara, Tatjana S., Fauchier, Laurent, and Lip, Gregory.Y.H.
- Published
- 2022
- Full Text
- View/download PDF
8. Dragging Down Europe: Germany in the hot seat
- Author
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Engelen, Klaus C.
- Subjects
Foreign investments ,Economic growth ,Banking, finance and accounting industries ,International Monetary Fund - Abstract
The key message from the International Monetary Fund annual meeting in October 2022 was that Germany would fall into recession in 2023 with the worst economic growth among the major [...]
- Published
- 2023
9. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry
- Author
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Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M.R., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Lane, D., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Vitolo, Marco, Malavasi, Vincenzo L., Proietti, Marco, Diemberger, Igor, Fauchier, Laurent, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana S., Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo Pietro, Lane, Deirdre A., Lip, Gregory Y.H., and Boriani, Giuseppe
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- 2022
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10. Did Germany Inadvertently Encourage Putin's War?
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Engelen, Klaus C.
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Russian Invasion of Ukraine, 2022- -- Military aspects ,Soldiers -- Military aspects ,Foreign ministers -- Military aspects ,Banking, finance and accounting industries - Abstract
When Vladimir Putin twice in two days addressed his citizens about his intended offensive actions in Ukraine, for Germans the horrible writing was on the wall. In the early hours [...]
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- 2022
11. Lifetime economic potential of mobile stroke units in acute stroke care: A model-based analysis of the drivers of cost-effectiveness.
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Rink, Johann S, Froelich, Matthias F, Nour, May, Saver, Jeffrey L, Szabo, Kristina, Hoyer, Carolin, Fassbender, Klaus C, Schoenberg, Stefan O, and Tollens, Fabian
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MEDICAL economics ,HEMORRHAGIC stroke ,QUALITY-adjusted life years ,ISCHEMIC stroke ,GROSS domestic product ,STROKE units - Abstract
Background and purpose: To simulate patient-level costs, analyze the economic potential of telemedicine-based mobile stroke units for acute prehospital stroke care, and identify major determinants of cost-effectiveness, based on two recent prospective trials from the United States and Germany. Methods: A Markov decision model was developed to simulate lifetime costs and outcomes of mobile stroke unit. The model compares diagnostic and therapeutic pathways of ischemic stroke, hemorrhagic stroke, and stroke mimic patients by conventional care or by mobile stroke units. The treatment outcomes were derived from the B_PROUD and the BEST-mobile stroke unit trials and further input parameters were derived from recent literature. Uncertainty was addressed by deterministic and probabilistic sensitivity analyses. A lifetime horizon based on the US healthcare system was adopted to evaluate different cost thresholds for mobile stroke unit and the resulting cost-effectiveness. Willingness-to-pay thresholds were set at 1x and 3x gross domestic product per capita, as recommended by the World Health Organization. Results: In the base case scenario, mobile stroke unit care yielded an incremental gain of 0.591 quality-adjusted life years per dispatch. Mobile stroke unit was highly cost-effective up to a maximum average cost of 43,067 US dollars per patient. Sensitivity analyses revealed that MSU cost-effectiveness is mainly affected by reduction of long-term disability costs. Also, among other parameters, the rate of stroke mimics patients diagnosed by MSU plays an important role. Conclusion: This study demonstrated that mobile stroke unit can possibly be operated on an excellent level of cost-effectiveness in urban areas in North America with number of stroke mimic patients and long-term stroke survivor costs as major determinants of lifetime cost-effectiveness. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Challenges in Prehospital Diagnosis of Acute Stroke in Women: A Case-Based Reflection.
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Wells, Brittany, Nasreldein, Ahmed, Hall, Joseph R., Bachhuber, Monika, Khedr, Eman M., Abd-Allah, Foad, Fassbender, Klaus C., van Wijck, Frederike, and Walter, Silke
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- 2024
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13. Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry
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Romiti, Giulio Francesco, Proietti, Marco, Vitolo, Marco, Bonini, Niccolò, Fawzy, Ameenathul Mazaya, Ding, Wern Yew, Fauchier, Laurent, Marin, Francisco, Nabauer, Michael, Dan, Gheorghe Andrei, Potpara, Tatjana S., Boriani, Giuseppe, Lip, Gregory Y. H., Tavazzi, L., Maggioni, A. P., Kalarus, Z., Ferrari, R., Shantsila, A., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E. N., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M. R., Crijns, H., Erküner, Atar, D., Lenarczyk, R., Oliveira, M. Martins, Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Joensen, A. Marni, Gammelmark, A., Rasmussen, L. Hvilsted, Dinesen, P., Venø, S. Krogh, Sorensen, B., Korsgaard, A., Andersen, K., Hellum, C. 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L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Popescu, M. Ioachim, Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Polovina, M., Vujisic-Tesic, B., Nedeljkovic, M., Zlatar, M., Asanin, M., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Ortega, M. Gil, Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Kurklu, S. Tan, Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M. 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Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O’Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Romiti G.F., Proietti M., Vitolo M., Bonini N., Fawzy A.M., Ding W.Y., Fauchier L., Marin F., Nabauer M., Dan G.A., Potpara T.S., Boriani G., Lip G.Y.H., Tavazzi L., Maggioni A.P., Kalarus Z., Ferrari R., Shantsila A., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E.N., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M.R., Crijns H., Erkuner O., Atar D., Lenarczyk R., Oliveira M.M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., el Husseini Z., Raepers M., Leroy J., Haushan P., Jourdan A., Lepiece C., Desteghe L., Vijgen J., Koopman P., Van Genechten G., Heidbuchel H., Boussy T., De Coninck M., Van Eeckhoutte H., Bouckaert N., Friart A., Boreux J., Arend C., Evrard P., Stefan L., Hoffer E., Herzet J., Massoz M., Celentano C., Sprynger M., Pierard L., Melon P., Van Hauwaert B., Kuppens C., Faes D., Van Lier D., Van Dorpe A., Gerardy A., Deceuninck O., Xhaet O., Dormal F., Ballant E., Blommaert D., Yakova D., Hristov M., Yncheva T., Stancheva N., Tisheva S., Tokmakova M., Nikolov F., Gencheva D., Kunev B., Stoyanov M., Marchov D., Gelev V., Traykov V., Kisheva A., Tsvyatkov H., Shtereva R., Bakalska-Georgieva S., Slavcheva S., Yotov Y., Kubickova M., Joensen A.M., Gammelmark A., Rasmussen L.H., Dinesen P., Veno S.K., Sorensen B., Korsgaard A., Andersen K., Hellum C.F., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., Le Moal V., Leclercq C., Beitar T., Martel I., Schmid A., Sadki N., Romeyer-Bouchard C., Da Costa A., Arnault I., Boyer M., Piat C., Lozance N., Nastevska S., Doneva A., Fortomaroska Milevska B., Sheshoski B., Petroska K., Taneska N., Bakrecheski N., Lazarovska K., Jovevska S., Ristovski V., Antovski A., Lazarova E., Kotlar I., Taleski J., Kedev S., Zlatanovik N., Jordanova S., Bajraktarova Proseva T., Doncovska S., Maisuradze D., Esakia A., Sagirashvili E., Lartsuliani K., Natelashvili N., Gumberidze N., Gvenetadze R., Gotonelia N., Kuridze N., Papiashvili G., Menabde I., Gloggler S., Napp A., Lebherz C., Romero H., Schmitz K., Berger M., Zink M., Koster S., Sachse J., Vonderhagen E., Soiron G., Mischke K., Reith R., Schneider M., Rieker W., Boscher D., Taschareck A., Beer A., Oster D., Ritter O., Adamczewski J., Walter S., Frommhold A., Luckner E., Richter J., Schellner M., Landgraf S., Bartholome S., Naumann R., Schoeler J., Westermeier D., William F., Wilhelm K., Maerkl M., Oekinghaus R., Denart M., Kriete M., Tebbe U., Scheibner T., Gruber M., Gerlach A., Beckendorf C., Anneken L., Arnold M., Lengerer S., Bal Z., Uecker C., Fortsch H., Fechner S., Mages V., Martens E., Methe H., Schmidt T., Schaeffer B., Hoffmann B., Moser J., Heitmann K., Willems S., Klaus C., Lange I., Durak M., Esen E., Mibach F., Mibach H., Utech A., Gabelmann M., Stumm R., Landle V., Gartner C., Goerg C., Kaul N., Messer S., Burkhardt D., Sander C., Orthen R., Kaes S., Baumer A., Dodos F., Barth A., Schaeffer G., Gaertner J., Winkler J., Fahrig A., Aring J., Wenzel I., Steiner S., Kliesch A., Kratz E., Winter K., Schneider P., Haag A., Mutscher I., Bosch R., Taggeselle J., Meixner S., Schnabel A., Shamalla A., Hotz H., Korinth A., Rheinert C., Mehltretter G., Schon B., Schon N., Starflinger A., Englmann E., Baytok G., Laschinger T., Ritscher G., Gerth A., Dechering D., Eckardt L., Kuhlmann M., Proskynitopoulos N., Brunn J., Foth K., Axthelm C., Hohensee H., Eberhard K., Turbanisch S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V.L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Burg M., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., Van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Popescu M.I., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Polovina M., Vujisic-Tesic B., Nedeljkovic M., Zlatar M., Asanin M., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Ortega M.G., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I.E., Yilmaz K., Ozin B., Kurklu S.T., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A.K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U.O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M.B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Senoo K., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Cardiology, Pulmonary Medicine, General Practice, ACS - Heart failure & arrhythmias, Medical Oncology, Erasmus School of Health Policy & Management, Radiotherapy, Department of Technology and Operations Management, Virology, Erasmus School of Social and Behavioural Sciences, Child and Adolescent Psychiatry / Psychology, Internal Medicine, Tax Law, Epidemiology, Neurosciences, Rheumatology, Erasmus School of Economics, Department of Business-Society Management, Pediatrics, Erasmus MC other, Orthopedics and Sports Medicine, Intensive Care, Department of Marketing Management, Clinical Genetics, Surgery, Econometrics, Research & Education, Radiology & Nuclear Medicine, Neurosurgery, Psychiatry, Department of Psychology, Education and Child Studies, Plastic and Reconstructive Surgery and Hand Surgery, Dermatology, Public Health, Gastroenterology & Hepatology, Erasmus School of Law, and Sociology
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Registrie ,Atrial Fibrillation/drug therapy ,Integrated management ,Risk Factor ,Atrial fibrillation ,Clinical complexity ,Outcomes ,Anticoagulants ,Humans ,Registries ,Risk Factors ,Atrial Fibrillation ,Stroke ,Anticoagulant ,General Medicine ,Anticoagulants/therapeutic use ,Stroke/complications ,Outcome ,Human - Abstract
Background Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients.
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- 2022
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14. Suppl. Tables 1-3 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Mohme, Malte, primary, Schliffke, Simon, primary, Maire, Cecile L., primary, Rünger, Alessandra, primary, Glau, Laura, primary, Mende, Klaus C., primary, Matschke, Jakob, primary, Gehbauer, Christina, primary, Akyüz, Nuray, primary, Zapf, Svenja, primary, Holz, Mareike, primary, Schaper, Miriam, primary, Martens, Tobias, primary, Schmidt, Nils O., primary, Peine, Sven, primary, Westphal, Manfred, primary, Binder, Mascha, primary, Tolosa, Eva, primary, and Lamszus, Katrin, primary
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15. Suppl. Fig. 1 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Mohme, Malte, primary, Schliffke, Simon, primary, Maire, Cecile L., primary, Rünger, Alessandra, primary, Glau, Laura, primary, Mende, Klaus C., primary, Matschke, Jakob, primary, Gehbauer, Christina, primary, Akyüz, Nuray, primary, Zapf, Svenja, primary, Holz, Mareike, primary, Schaper, Miriam, primary, Martens, Tobias, primary, Schmidt, Nils O., primary, Peine, Sven, primary, Westphal, Manfred, primary, Binder, Mascha, primary, Tolosa, Eva, primary, and Lamszus, Katrin, primary
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16. Suppl. Fig. 2 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Mohme, Malte, primary, Schliffke, Simon, primary, Maire, Cecile L., primary, Rünger, Alessandra, primary, Glau, Laura, primary, Mende, Klaus C., primary, Matschke, Jakob, primary, Gehbauer, Christina, primary, Akyüz, Nuray, primary, Zapf, Svenja, primary, Holz, Mareike, primary, Schaper, Miriam, primary, Martens, Tobias, primary, Schmidt, Nils O., primary, Peine, Sven, primary, Westphal, Manfred, primary, Binder, Mascha, primary, Tolosa, Eva, primary, and Lamszus, Katrin, primary
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17. Suppl. Fig. 3 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Mohme, Malte, primary, Schliffke, Simon, primary, Maire, Cecile L., primary, Rünger, Alessandra, primary, Glau, Laura, primary, Mende, Klaus C., primary, Matschke, Jakob, primary, Gehbauer, Christina, primary, Akyüz, Nuray, primary, Zapf, Svenja, primary, Holz, Mareike, primary, Schaper, Miriam, primary, Martens, Tobias, primary, Schmidt, Nils O., primary, Peine, Sven, primary, Westphal, Manfred, primary, Binder, Mascha, primary, Tolosa, Eva, primary, and Lamszus, Katrin, primary
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18. Suppl. Fig. 4 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Mohme, Malte, primary, Schliffke, Simon, primary, Maire, Cecile L., primary, Rünger, Alessandra, primary, Glau, Laura, primary, Mende, Klaus C., primary, Matschke, Jakob, primary, Gehbauer, Christina, primary, Akyüz, Nuray, primary, Zapf, Svenja, primary, Holz, Mareike, primary, Schaper, Miriam, primary, Martens, Tobias, primary, Schmidt, Nils O., primary, Peine, Sven, primary, Westphal, Manfred, primary, Binder, Mascha, primary, Tolosa, Eva, primary, and Lamszus, Katrin, primary
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19. Outbreak of follicular conjunctivitis associated with the diagnosis of anaplasmosis in a sheep herd
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Paula M. Oliveira, Dirceu G. S. Ramos, Klaus C. Saturnino, and Andréia V. C. Amaral
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General Veterinary - Published
- 2022
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20. Data from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Purpose: Immunotherapeutic treatment strategies for glioblastoma (GBM) are under investigation in clinical trials. However, our understanding of the immune phenotype of GBM-infiltrating T cells (tumor-infiltrating lymphocytes; TILs) and changes during disease progression is limited. Deeper insight is urgently needed to therapeutically overcome tumor-induced immune exhaustion.Experimental Design: We used flow cytometry and cytokine assays to profile TILs and peripheral blood lymphocytes (PBLs) from patients with GBM, comparing newly diagnosed or recurrent GBM to long-term survivors (LTS) and healthy donors. TCR sequencing was performed on paired samples of newly diagnosed and recurrent GBM.Results: We identified a clear immune signature of exhaustion and clonal restriction in the TILs of patients with GBM. Exhaustion of CD8+ TILs was defined by an increased prevalence of PD-1+, CD39+, Tim-3+, CD45RO+, HLA-DR+ marker expression, and exhibition of an effector-/transitional memory differentiation phenotype, whereas KLRG1 and CD57 were underrepresented. Immune signatures were similar in primary and recurrent tumors; however, restricted TCR repertoire clonality and a more activated memory phenotype were observed in TILs from recurrent tumors. Moreover, a reduced cytokine response to PHA stimulation in the blood compartment indicates a dysfunctional peripheral T-cell response in patients with GBM. LTS displayed a distinct profile, with abundant naïve and less exhausted CD8+ T cells.Conclusions: TILs and PBLs exhibit contrasting immune profiles, with a distinct exhaustion signature present in TILs. While the exhaustion profiles of primary and recurrent GBM are comparable, TCR sequencing demonstrated a contracted repertoire in recurrent GBM, concomitant with an increased frequency of activated memory T cells in recurrent tumors. Clin Cancer Res; 24(17); 4187–200. ©2018 AACR.See related commentary by Jackson and Lim, p. 4059
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21. Suppl. Fig. 2 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Flow-cytometry gating strategy for T-cell memory/activation and ectoenzymatic exhaustion markers.
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22. Suppl. Fig. 4 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Supplemental data of next-generation T-cell receptor sequencing.
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23. Supplemental Legends from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Supplementary Figure and Table Legends
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24. Suppl. Fig. 3 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Additional cytokines determined by multiplex flow-cytometry after PHA stimulation of PBL.
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25. Suppl. Tables 1-3 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Supplemental Table 1. Patient characteristics for flow-cytometry analysis. IDH=isocitrate dehydrogenase, MGMT=O6-Methylguanin-DNA-Methyltransferase. Supplemental Table 2. Matched-paired GBM patient samples for TCR repertoire sequencing analysis. T=radiotherapy, CT=chemotherapy with temozolomide Supplemental Table 3. Antibodies used to polychromatic flow-cytometry analysis of T-cells
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26. Suppl. Fig. 1 from Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
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Katrin Lamszus, Eva Tolosa, Mascha Binder, Manfred Westphal, Sven Peine, Nils O. Schmidt, Tobias Martens, Miriam Schaper, Mareike Holz, Svenja Zapf, Nuray Akyüz, Christina Gehbauer, Jakob Matschke, Klaus C. Mende, Laura Glau, Alessandra Rünger, Cecile L. Maire, Simon Schliffke, and Malte Mohme
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Flow-cytometry gating strategy for T-cell differentiation and exhaustion markers.
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27. Impact of renal impairment on atrial fibrillation
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Ding W. Y., Potpara T. S., Blomstrom-Lundqvist C., Boriani G., Marin F., Fauchier L., Lip G. Y. H., Tavazzi L., Maggioni A. P., Dan G. -A., Potpara T., Nabauer M., Kalarus Z., Goda A., Mairesse G., Shalganov T., Antoniades L., Taborsky M., Riahi S., Muda P., Garcia Bolao I., Piot O., Etsadashvili K., Simantirakis E., Haim M., Azhari A., Najafian J., Santini M., Mirrakhimov E., Kulzida K., Erglis A., Poposka L., Burg M., Crijns H., Erkuner O., Atar D., Lenarczyk R., Martins Oliveira M., Shah D., Serdechnaya E., Diker E., Lane D., Zera E., Ekmekciu U., Paparisto V., Tase M., Gjergo H., Dragoti J., Ciutea M., Ahadi N., Husseini Z. 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Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I. E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A. K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U. O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M. B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., 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Hvilsted Rasmussen L., Dinesen P., Krogh Veno S., Sorensen B., Korsgaard A., Andersen K., Fragtrup Hellum C., Svenningsen A., Nyvad O., Wiggers P., May O., Aarup A., Graversen B., Jensen L., Andersen M., Svejgaard M., Vester S., Hansen S., Lynggaard V., Ciudad M., Vettus R., Maestre A., Castano S., Cheggour S., Poulard J., Mouquet V., Leparree S., Bouet J., Taieb J., Doucy A., Duquenne H., Furber A., Dupuis J., Rautureau J., Font M., Damiano P., Lacrimini M., Abalea J., Boismal S., Menez T., Mansourati J., Range G., Gorka H., Laure C., Vassaliere C., Elbaz N., Lellouche N., Djouadi K., Roubille F., Dietz D., Davy J., Granier M., Winum P., Leperchois-Jacquey C., Kassim H., Marijon E., Le Heuzey J., Fedida J., Maupain C., Himbert C., Gandjbakhch E., Hidden-Lucet F., Duthoit G., Badenco N., Chastre T., Waintraub X., Oudihat M., Lacoste J., Stephan C., Bader H., Delarche N., Giry L., Arnaud D., Lopez C., Boury F., Brunello I., Lefevre M., Mingam R., Haissaguerre M., Le Bidan M., Pavin D., 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S., Hassler N., Koestler A., Stenzel G., Kschiwan D., Schwefer M., Neiner S., Hettwer S., Haeussler-Schuchardt M., Degenhardt R., Sennhenn S., Brendel M., Stoehr A., Widjaja W., Loehndorf S., Logemann A., Hoskamp J., Grundt J., Block M., Ulrych R., Reithmeier A., Panagopoulos V., Martignani C., Bernucci D., Fantecchi E., Diemberger I., Ziacchi M., Biffi M., Cimaglia P., Frisoni J., Giannini I., Boni S., Fumagalli S., Pupo S., Di Chiara A., Mirone P., Pesce F., Zoccali C., Malavasi V.L., Mussagaliyeva A., Ahyt B., Salihova Z., Koshum-Bayeva K., Kerimkulova A., Bairamukova A., Lurina B., Zuzans R., Jegere S., Mintale I., Kupics K., Jubele K., Kalejs O., Vanhear K., Cachia M., Abela E., Warwicker S., Tabone T., Xuereb R., Asanovic D., Drakalovic D., Vukmirovic M., Pavlovic N., Music L., Bulatovic N., Boskovic A., Uiterwaal H., Bijsterveld N., De Groot J., Neefs J., van den Berg N., Piersma F., Wilde A., Hagens V., Van Es J., van Opstal J., Van Rennes B., Verheij H., Breukers W., Tjeerdsma G., Nijmeijer R., Wegink D., Binnema R., Said S., Philippens S., van Doorn W., Szili-Torok T., Bhagwandien R., Janse P., Muskens A., van Eck M., Gevers R., van der Ven N., Duygun A., Rahel B., Meeder J., Vold A., Holst Hansen C., Engset I., Dyduch-Fejklowicz B., Koba E., Cichocka M., Sokal A., Kubicius A., Pruchniewicz E., Kowalik-Sztylc A., Czapla W., Mroz I., Kozlowski M., Pawlowski T., Tendera M., Winiarska-Filipek A., Fidyk A., Slowikowski A., Haberka M., Lachor-Broda M., Biedron M., Gasior Z., Kolodziej M., Janion M., Gorczyca-Michta I., Wozakowska-Kaplon B., Stasiak M., Jakubowski P., Ciurus T., Drozdz J., Simiera M., Zajac P., Wcislo T., Zycinski P., Kasprzak J., Olejnik A., Harc-Dyl E., Miarka J., Pasieka M., Zieminska-Luc M., Bujak W., Sliwinski A., Grech A., Morka J., Petrykowska K., Prasal M., Hordynski G., Feusette P., Lipski P., Wester A., Streb W., Romanek J., Wozniak P., Chlebus M., Szafarz P., Stanik W., Zakrzewski M., Kazmierczak J., Przybylska A., Skorek E., Blaszczyk H., Stepien M., Szabowski S., Krysiak W., Szymanska M., Karasinski J., Blicharz J., Skura M., Halas K., Michalczyk L., Orski Z., Krzyzanowski K., Skrobowski A., Zielinski L., Tomaszewska-Kiecana M., Dluzniewski M., Kiliszek M., Peller M., Budnik M., Balsam P., Opolski G., Tyminska A., Ozieranski K., Wancerz A., Borowiec A., Majos E., Dabrowski R., Szwed H., Musialik-Lydka A., Leopold-Jadczyk A., Jedrzejczyk-Patej E., Koziel M., Mazurek M., Krzemien-Wolska K., Starosta P., Nowalany-Kozielska E., Orzechowska A., Szpot M., Staszel M., Almeida S., Pereira H., Brandao Alves L., Miranda R., Ribeiro L., Costa F., Morgado F., Carmo P., Galvao Santos P., Bernardo R., Adragao P., Ferreira da Silva G., Peres M., Alves M., Leal M., Cordeiro A., Magalhaes P., Fontes P., Leao S., Delgado A., Costa A., Marmelo B., Rodrigues B., Moreira D., Santos J., Santos L., Terchet A., Darabantiu D., Mercea S., Turcin Halka V., Pop Moldovan A., Gabor A., Doka B., Catanescu G., Rus H., Oboroceanu L., Bobescu E., Popescu R., Dan A., Buzea A., Daha I., Dan G., Neuhoff I., Baluta M., Ploesteanu R., Dumitrache N., Vintila M., Daraban A., Japie C., Badila E., Tewelde H., Hostiuc M., Frunza S., Tintea E., Bartos D., Ciobanu A., Popescu I., Toma N., Gherghinescu C., Cretu D., Patrascu N., Stoicescu C., Udroiu C., Bicescu G., Vintila V., Vinereanu D., Cinteza M., Rimbas R., Grecu M., Cozma A., Boros F., Ille M., Tica O., Tor R., Corina A., Jeewooth A., Maria B., Georgiana C., Natalia C., Alin D., Dinu-Andrei D., Livia M., Daniela R., Larisa R., Umaar S., Tamara T., Ioachim Popescu M., Nistor D., Sus I., Coborosanu O., Alina-Ramona N., Dan R., Petrescu L., Ionescu G., Vacarescu C., Goanta E., Mangea M., Ionac A., Mornos C., Cozma D., Pescariu S., Solodovnicova E., Soldatova I., Shutova J., Tjuleneva L., Zubova T., Uskov V., Obukhov D., Rusanova G., Isakova N., Odinsova S., Arhipova T., Kazakevich E., Zavyalova O., Novikova T., Riabaia I., Zhigalov S., Drozdova E., Luchkina I., Monogarova Y., Hegya D., Rodionova L., Nevzorova V., Lusanova O., Arandjelovic A., Toncev D., Vukmirovic L., Radisavljevic M., Milanov M., Sekularac N., Zdravkovic M., Hinic S., Dimkovic S., Acimovic T., Saric J., Radovanovic S., Kocijancic A., Obrenovic-Kircanski B., Kalimanovska Ostric D., Simic D., Jovanovic I., Petrovic I., Polovina M., Vukicevic M., Tomasevic M., Mujovic N., Radivojevic N., Petrovic O., Aleksandric S., Kovacevic V., Mijatovic Z., Ivanovic B., Tesic M., Ristic A., Vujisic-Tesic B., Nedeljkovic M., Karadzic A., Uscumlic A., Prodanovic M., Zlatar M., Asanin M., Bisenic B., Vasic V., Popovic Z., Djikic D., Sipic M., Peric V., Dejanovic B., Milosevic N., Backovic S., Stevanovic A., Andric A., Pencic B., Pavlovic-Kleut M., Celic V., Pavlovic M., Petrovic M., Vuleta M., Petrovic N., Simovic S., Savovic Z., Milanov S., Davidovic G., Iric-Cupic V., Djordjevic D., Damjanovic M., Zdravkovic S., Topic V., Stanojevic D., Randjelovic M., Jankovic-Tomasevic R., Atanaskovic V., Antic S., Simonovic D., Stojanovic M., Stojanovic S., Mitic V., Ilic V., Petrovic D., Deljanin Ilic M., Ilic S., Stoickov V., Markovic S., Mijatovic A., Tanasic D., Radakovic G., Peranovic J., Panic-Jelic N., Vujadinovic O., Pajic P., Bekic S., Kovacevic S., Garcia Fernandez A., Perez Cabeza A., Anguita M., Tercedor Sanchez L., Mau E., Loayssa J., Ayarra M., Carpintero M., Roldan Rabadan I., Gil Ortega M., Tello Montoliu A., Orenes Pinero E., Manzano Fernandez S., Romero Aniorte A., Veliz Martinez A., Quintana Giner M., Ballesteros G., Palacio M., Alcalde O., Garcia-Bolao I., Bertomeu Gonzalez V., Otero-Ravina F., Garcia Seara J., Gonzalez Juanatey J., Dayal N., Maziarski P., Gentil-Baron P., Koc M., Onrat E., Dural I.E., Yilmaz K., Ozin B., Tan Kurklu S., Atmaca Y., Canpolat U., Tokgozoglu L., Dolu A.K., Demirtas B., Sahin D., Ozcan Celebi O., Gagirci G., Turk U.O., Ari H., Polat N., Toprak N., Sucu M., Akin Serdar O., Taha Alper A., Kepez A., Yuksel Y., Uzunselvi A., Yuksel S., Sahin M., Kayapinar O., Ozcan T., Kaya H., Yilmaz M.B., Kutlu M., Demir M., Gibbs C., Kaminskiene S., Bryce M., Skinner A., Belcher G., Hunt J., Stancombe L., Holbrook B., Peters C., Tettersell S., Shantsila A., Senoo K., Proietti M., Russell K., Domingos P., Hussain S., Partridge J., Haynes R., Bahadur S., Brown R., McMahon S., McDonald J., Balachandran K., Singh R., Garg S., Desai H., Davies K., Goddard W., Galasko G., Rahman I., Chua Y., Payne O., Preston S., Brennan O., Pedley L., Whiteside C., Dickinson C., Brown J., Jones K., Benham L., Brady R., Buchanan L., Ashton A., Crowther H., Fairlamb H., Thornthwaite S., Relph C., McSkeane A., Poultney U., Kelsall N., Rice P., Wilson T., Wrigley M., Kaba R., Patel T., Young E., Law J., Runnett C., Thomas H., McKie H., Fuller J., Pick S., Sharp A., Hunt A., Thorpe K., Hardman C., Cusack E., Adams L., Hough M., Keenan S., Bowring A., Watts J., Zaman J., Goffin K., Nutt H., Beerachee Y., Featherstone J., Mills C., Pearson J., Stephenson L., Grant S., Wilson A., Hawksworth C., Alam I., Robinson M., Ryan S., Egdell R., Gibson E., Holland M., Leonard D., Mishra B., Ahmad S., Randall H., Hill J., Reid L., George M., McKinley S., Brockway L., Milligan W., Sobolewska J., Muir J., Tuckis L., Winstanley L., Jacob P., Kaye S., Morby L., Jan A., Sewell T., Boos C., Wadams B., Cope C., Jefferey P., Andrews N., Getty A., Suttling A., Turner C., Hudson K., Austin R., Howe S., Iqbal R., Gandhi N., Brophy K., Mirza P., Willard E., Collins S., Ndlovu N., Subkovas E., Karthikeyan V., Waggett L., Wood A., Bolger A., Stockport J., Evans L., Harman E., Starling J., Williams L., Saul V., Sinha M., Bell L., Tudgay S., Kemp S., Frost L., Ingram T., Loughlin A., Adams C., Adams M., Hurford F., Owen C., Miller C., Donaldson D., Tivenan H., Button H., Nasser A., Jhagra O., Stidolph B., Brown C., Livingstone C., Duffy M., Madgwick P., Roberts P., Greenwood E., Fletcher L., Beveridge M., Earles S., McKenzie D., Beacock D., Dayer M., Seddon M., Greenwell D., Luxton F., Venn F., Mills H., Rewbury J., James K., Roberts K., Tonks L., Felmeden D., Taggu W., Summerhayes A., Hughes D., Sutton J., Felmeden L., Khan M., Walker E., Norris L., O'Donohoe L., Mozid A., Dymond H., Lloyd-Jones H., Saunders G., Simmons D., Coles D., Cotterill D., Beech S., Kidd S., Wrigley B., Petkar S., Smallwood A., Jones R., Radford E., Milgate S., Metherell S., Cottam V., Buckley C., Broadley A., Wood D., Allison J., Rennie K., Balian L., Howard L., Pippard L., Board S., Pitt-Kerby T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, and Radiology and nuclear medicine
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Male ,Medicin och hälsovetenskap ,Clinical Biochemistry ,Hemorrhage ,Medical and Health Sciences ,Biochemistry ,Brain Ischemia ,Risk Factors ,Hemorrhage/chemically induced ,death ,Humans ,Acute Coronary Syndrome/complications ,atrial fibrillation ,Renal Insufficiency ,Registries ,Acute Coronary Syndrome ,Renal Insufficiency/chemically induced ,Anticoagulants ,General Medicine ,thromboembolism ,kidney failure ,Stroke ,Anticoagulants/therapeutic use ,major bleeding ,outcome ,Female ,Atrial Fibrillation/complications ,chronic kidney disease ,Stroke/complications - Abstract
Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p 2 decrease), that was most notable in patients with eGFR 2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m 2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF.
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- 2022
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28. Pepperberg plot: Modeling flash response saturation in retinal rods of mouse
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Caruso, G, Klaus, C, Hamm, He, Gurevich, Vv, Bisegna, P, Andreucci, D, Dibenedetto, E, and Makino, Cl
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visual transduction ,Cellular and Molecular Neuroscience ,cyclic GMP ,GRK ,membrane guanylate cyclase ,G protein ,Settore ICAR/08 ,CNG channel ,PDE ,RGS9 ,Molecular Biology - Abstract
Retinal rods evolved to be able to detect single photons. Despite their exquisite sensitivity, rods operate over many log units of light intensity. Several processes inside photoreceptor cells make this incredible light adaptation possible. Here, we added to our previously developed, fully space resolved biophysical model of rod phototransduction, some of the mechanisms that play significant roles in shaping the rod response under high illumination levels: the function of RGS9 in shutting off G protein transducin, and calcium dependences of the phosphorylation rates of activated rhodopsin, of the binding of cGMP to the light-regulated ion channel, and of two membrane guanylate cyclase activities. A well stirred version of this model captured the responses to bright, saturating flashes in WT and mutant mouse rods and was used to explain “Pepperberg plots,” that graph the time during which the response is saturated against the natural logarithm of flash strength for bright flashes. At the lower end of the range, saturation time increases linearly with the natural logarithm of flash strength. The slope of the relation (τD) is dictated by the time constant of the rate-limiting (slowest) step in the shutoff of the phototransduction cascade, which is the hydrolysis of GTP by transducin. We characterized mathematically the X-intercept (Φo) which is the number of photoisomerizations that just saturates the rod response. It has been observed that for flash strengths exceeding a few thousand photoisomerizations, the curves depart from linearity. Modeling showed that the “upward bend” for very bright flash intensities could be explained by the dynamics of RGS9 complex and further predicted that there would be a plateau at flash strengths giving rise to more than ~107 photoisomerizations due to activation of all available PDE. The model accurately described alterations in saturation behavior of mutant murine rods resulting from transgenic perturbations of the cascade targeting membrane guanylate cyclase activity, and expression levels of GRK, RGS9, and PDE. Experimental results from rods expressing a mutant light-regulated channel purported to lack calmodulin regulation deviated from model predictions, suggesting that there were other factors at play.
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- 2023
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29. Active Instability Suppression Using Vortex-Droplet Interaction
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Yu, Ken H., primary, Wilson, K. J., additional, and Schadow, Klaus C., additional
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- 2023
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30. The efficiency of probiotic-based adsorbent in reducing the intoxication in Piarcatus mesopotamicus: metabolic performance and histology of the liver for evaluating good health
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Henrique M. Ziemniczak, Antonio Cesar Godoy, Jarred Hugh Oxford, Welinton V. Silva, Jean C. S. Melo, Klaus C. Saturnino, Jeferson R. Gandra, Dacley H. Neu, Ulisses Padua Pereira, and Claucia A. Honorato
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In this study, we evaluated the effect of aflatoxin B1 (AFB1) in pacus (Piaractus mesopotam- icus) that were fed diets containing 0.0; 25.0; 50.0; 100.0; 200.0, and 400.0 µg kg−1 of AFB1 for 10 days. Furthermore, also was evaluated the effect of an adsorbent (0.2%) supplemented in fish diets containing 0.0, 25.0, and 400.0 µg kg−1 of AFB1. At the end of each experiment, fish were fasted for 24 h, and the survival rate was measured. Six specimens from each treatment were randomly selected for assays of tissue metabolic indicators in the liver: superoxide dismutase, catalase, alanine aminotransferase, aspar- tate aminotransferase, and albumin and six, for histopathological analysis. Hepatic metabolism showed lesions in fish fed with doses higher than 25.0 µg kg−1 of AFB1. The histopathological results revealed necrosis of the liver. The addition of 0.2% adsorbent promoted the restoration of liver functions in fish fed with diets containing 25.0 µg kg−1 AFB1. The histopathological results demonstrated hepatic tissue with a healthy architecture. In conclusion, AFB1 at a concertation of 25.0 µg kg−1 negatively affects the liver, but the addition of a probiotic-based adsorbent (PBA) in fish diet containing 25.0 µg kg−1 AFB1 cancels the toxic effects of AFB1. Therefore, the use of PBAs in fish diets are recommended.
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- 2022
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31. The efficiency of probiotic-based adsorbent in reducing the intoxication in Piarcatus mesopotamicus: metabolic performance and histology of the liver for evaluating good health
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Ziemniczak, Henrique M., primary, Godoy, Antonio Cesar, additional, Oxford, Jarred Hugh, additional, Silva, Welinton V., additional, Melo, Jean C. S., additional, Saturnino, Klaus C., additional, Gandra, Jeferson R., additional, Neu, Dacley H., additional, Pereira, Ulisses Padua, additional, and Honorato, Claucia A., additional
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- 2022
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32. Reply to: Assessment of 3D MINFLUX data for quantitative structural biology in cells
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Gwosch, Klaus C., primary, Balzarotti, Francisco, additional, Pape, Jasmin K., additional, Hoess, Philipp, additional, Ellenberg, Jan, additional, Ries, Jonas, additional, Matti, Ulf, additional, Schmidt, Roman, additional, Sahl, Steffen J., additional, and Hell, Stefan W., additional
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- 2022
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33. Lifetime economic potential of mobile stroke units in acute stroke care: A model-based analysis of the drivers of cost-effectiveness
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Rink, Johann S, primary, Froelich, Matthias F, additional, Nour, May, additional, Saver, Jeffrey L, additional, Szabo, Kristina, additional, Hoyer, Carolin, additional, Fassbender, Klaus C, additional, Schoenberg, Stefan O, additional, and Tollens, Fabian, additional
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- 2022
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34. Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry
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Ding, Wern Yew, primary, Kotalczyk, Agnieszka, additional, Boriani, Giuseppe, additional, Marin, Francisco, additional, Blomström-Lundqvist, Carina, additional, Potpara, Tatjana S., additional, Fauchier, Laurent, additional, Lip, Gregory.Y.H., additional, Boriani, G., additional, Lip, G.Y.H., additional, Tavazzi, L., additional, Maggioni, A.P., additional, Dan, G.-A., additional, Potpara, T., additional, Nabauer, M., additional, Marin, F., additional, Kalarus, Z., additional, Goda, A., additional, Mairesse, G., additional, Shalganov, T., additional, Antoniades, L., additional, Taborsky, M., additional, Riahi, S., additional, Muda, P., additional, García Bolao, I., additional, Piot, O., additional, Etsadashvili, K., additional, Simantirakis, E., additional, Haim, M., additional, Azhari, A., additional, Najafian, J., additional, Santini, M., additional, Mirrakhimov, E., additional, Kulzida, K.A., additional, Erglis, A., additional, Poposka, L., additional, Burg, M., additional, Crijns, H., additional, Erküner, Ö., additional, Atar, D., additional, Lenarczyk, R., additional, Martins Oliveira, M., additional, Shah, D., additional, Serdechnaya, E., additional, Diker, E., additional, Lane, D., additional, Zëra, E., additional, Ekmekçiu, U., additional, Paparisto, V., additional, Tase, M., additional, Gjergo, H., additional, Dragoti, J., additional, Ciutea, M., additional, Ahadi, N., additional, el Husseini, Z., additional, Raepers, M., additional, Leroy, J., additional, Haushan, P., additional, Jourdan, A., additional, Lepiece, C., additional, Desteghe, L., additional, Vijgen, J., additional, Koopman, P., additional, Van Genechten, G., additional, Heidbuchel, H., additional, Boussy, T., additional, De Coninck, M., additional, Van Eeckhoutte, H., additional, Bouckaert, N., additional, Friart, A., additional, Boreux, J., additional, Arend, C., additional, Evrard, P., additional, Stefan, L., additional, Hoffer, E., additional, Herzet, J., additional, Massoz, M., additional, Celentano, C., additional, Sprynger, M., additional, Pierard, L., additional, Melon, P., additional, Van Hauwaert, B., additional, Kuppens, C., additional, Faes, D., additional, Van Lier, D., additional, Van Dorpe, A., additional, Gerardy, A., additional, Deceuninck, O., additional, Xhaet, O., additional, Dormal, F., additional, Ballant, E., additional, Blommaert, D., additional, Yakova, D., additional, Hristov, M., additional, Yncheva, T., additional, Stancheva, N., additional, Tisheva, S., additional, Tokmakova, M., additional, Nikolov, F., additional, Gencheva, D., additional, Kunev, B., additional, Stoyanov, M., additional, Marchov, D., additional, Gelev, V., additional, Traykov, V., additional, Kisheva, A., additional, Tsvyatkov, H., additional, Shtereva, R., additional, Bakalska-Georgieva, S., additional, Slavcheva, S., additional, Yotov, Y., additional, Kubíčková, M., additional, Marni Joensen, A., additional, Gammelmark, A., additional, Hvilsted Rasmussen, L., additional, Dinesen, P., additional, Krogh Venø, S., additional, Sorensen, B., additional, Korsgaard, A., additional, Andersen, K., additional, Fragtrup Hellum, C., additional, Svenningsen, A., additional, Nyvad, O., additional, Wiggers, P., additional, May, O., additional, Aarup, A., additional, Graversen, B., additional, Jensen, L., additional, Andersen, M., additional, Svejgaard, M., additional, Vester, S., additional, Hansen, S., additional, Lynggaard, V., additional, Ciudad, M., additional, Vettus, R., additional, Maestre, A., additional, Castaño, S., additional, Cheggour, S., additional, Poulard, J., additional, Mouquet, V., additional, Leparrée, S., additional, Bouet, J., additional, Taieb, J., additional, Doucy, A., additional, Duquenne, H., additional, Furber, A., additional, Dupuis, J., additional, Rautureau, J., additional, Font, M., additional, Damiano, P., additional, Lacrimini, M., additional, Abalea, J., additional, Boismal, S., additional, Menez, T., additional, Mansourati, J., additional, Range, G., additional, Gorka, H., additional, Laure, C., additional, Vassalière, C., additional, Elbaz, N., additional, Lellouche, N., additional, Djouadi, K., additional, Roubille, F., additional, Dietz, D., additional, Davy, J., additional, Granier, M., additional, Winum, P., additional, Leperchois-Jacquey, C., additional, Kassim, H., additional, Marijon, E., additional, Le Heuzey, J., additional, Fedida, J., additional, Maupain, C., additional, Himbert, C., additional, Gandjbakhch, E., additional, Hidden-Lucet, F., additional, Duthoit, G., additional, Badenco, N., additional, Chastre, T., additional, Waintraub, X., additional, Oudihat, M., additional, Lacoste, J., additional, Stephan, C., additional, Bader, H., additional, Delarche, N., additional, Giry, L., additional, Arnaud, D., additional, Lopez, C., additional, Boury, F., additional, Brunello, I., additional, Lefèvre, M., additional, Mingam, R., additional, Haissaguerre, M., additional, Le Bidan, M., additional, Pavin, D., additional, Le Moal, V., additional, Leclercq, C., additional, Beitar, T., additional, Martel, I., additional, Schmid, A., additional, Sadki, N., additional, Romeyer-Bouchard, C., additional, Da Costa, A., additional, Arnault, I., additional, Boyer, M., additional, Piat, C., additional, Lozance, N., additional, Nastevska, S., additional, Doneva, A., additional, Fortomaroska Milevska, B., additional, Sheshoski, B., additional, Petroska, K., additional, Taneska, N., additional, Bakrecheski, N., additional, Lazarovska, K., additional, Jovevska, S., additional, Ristovski, V., additional, Antovski, A., additional, Lazarova, E., additional, Kotlar, I., additional, Taleski, J., additional, Kedev, S., additional, Zlatanovik, N., additional, Jordanova, S., additional, Bajraktarova Proseva, T., additional, Doncovska, S., additional, Maisuradze, D., additional, Esakia, A., additional, Sagirashvili, E., additional, Lartsuliani, K., additional, Natelashvili, N., additional, Gumberidze, N., additional, Gvenetadze, R., additional, Gotonelia, N., additional, Kuridze, N., additional, Papiashvili, G., additional, Menabde, I., additional, Glöggler, S., additional, Napp, A., additional, Lebherz, C., additional, Romero, H., additional, Schmitz, K., additional, Berger, M., additional, Zink, M., additional, Köster, S., additional, Sachse, J., additional, Vonderhagen, E., additional, Soiron, G., additional, Mischke, K., additional, Reith, R., additional, Schneider, M., additional, Rieker, W., additional, Boscher, D., additional, Taschareck, A., additional, Beer, A., additional, Oster, D., additional, Ritter, O., additional, Adamczewski, J., additional, Walter, S., additional, Frommhold, A., additional, Luckner, E., additional, Richter, J., additional, Schellner, M., additional, Landgraf, S., additional, Bartholome, S., additional, Naumann, R., additional, Schoeler, J., additional, Westermeier, D., additional, William, F., additional, Wilhelm, K., additional, Maerkl, M., additional, Oekinghaus, R., additional, Denart, M., additional, Kriete, M., additional, Tebbe, U., additional, Scheibner, T., additional, Gruber, M., additional, Gerlach, A., additional, Beckendorf, C., additional, Anneken, L., additional, Arnold, M., additional, Lengerer, S., additional, Bal, Z., additional, Uecker, C., additional, Förtsch, H., additional, Fechner, S., additional, Mages, V., additional, Martens, E., additional, Methe, H., additional, Schmidt, T., additional, Schaeffer, B., additional, Hoffmann, B., additional, Moser, J., additional, Heitmann, K., additional, Willems, S., additional, Klaus, C., additional, Lange, I., additional, Durak, M., additional, Esen, E., additional, Mibach, F., additional, Mibach, H., additional, Utech, A., additional, Gabelmann, M., additional, Stumm, R., additional, Ländle, V., additional, Gartner, C., additional, Goerg, C., additional, Kaul, N., additional, Messer, S., additional, Burkhardt, D., additional, Sander, C., additional, Orthen, R., additional, Kaes, S., additional, Baumer, A., additional, Dodos, F., additional, Barth, A., additional, Schaeffer, G., additional, Gaertner, J., additional, Winkler, J., additional, Fahrig, A., additional, Aring, J., additional, Wenzel, I., additional, Steiner, S., additional, Kliesch, A., additional, Kratz, E., additional, Winter, K., additional, Schneider, P., additional, Haag, A., additional, Mutscher, I., additional, Bosch, R., additional, Taggeselle, J., additional, Meixner, S., additional, Schnabel, A., additional, Shamalla, A., additional, Hötz, H., additional, Korinth, A., additional, Rheinert, C., additional, Mehltretter, G., additional, Schön, B., additional, Schön, N., additional, Starflinger, A., additional, Englmann, E., additional, Baytok, G., additional, Laschinger, T., additional, Ritscher, G., additional, Gerth, A., additional, Dechering, D., additional, Eckardt, L., additional, Kuhlmann, M., additional, Proskynitopoulos, N., additional, Brunn, J., additional, Foth, K., additional, Axthelm, C., additional, Hohensee, H., additional, Eberhard, K., additional, Turbanisch, S., additional, Hassler, N., additional, Koestler, A., additional, Stenzel, G., additional, Kschiwan, D., additional, Schwefer, M., additional, Neiner, S., additional, Hettwer, S., additional, Haeussler-Schuchardt, M., additional, Degenhardt, R., additional, Sennhenn, S., additional, Brendel, M., additional, Stoehr, A., additional, Widjaja, W., additional, Loehndorf, S., additional, Logemann, A., additional, Hoskamp, J., additional, Grundt, J., additional, Block, M., additional, Ulrych, R., additional, Reithmeier, A., additional, Panagopoulos, V., additional, Martignani, C., additional, Bernucci, D., additional, Fantecchi, E., additional, Diemberger, I., additional, Ziacchi, M., additional, Biffi, M., additional, Cimaglia, P., additional, Frisoni, J., additional, Giannini, I., additional, Boni, S., additional, Fumagalli, S., additional, Pupo, S., additional, Di Chiara, A., 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Kazakevich, E., additional, Zavyalova, O., additional, Novikova, T., additional, Riabaia, I., additional, Zhigalov, S., additional, Drozdova, E., additional, Luchkina, I., additional, Monogarova, Y., additional, Hegya, D., additional, Rodionova, L., additional, Nevzorova, V., additional, Lusanova, O., additional, Arandjelovic, A., additional, Toncev, D., additional, Vukmirovic, L., additional, Radisavljevic, M., additional, Milanov, M., additional, Sekularac, N., additional, Zdravkovic, M., additional, Hinic, S., additional, Dimkovic, S., additional, Acimovic, T., additional, Saric, J., additional, Radovanovic, S., additional, Kocijancic, A., additional, Obrenovic-Kircanski, B., additional, Kalimanovska Ostric, D., additional, Simic, D., additional, Jovanovic, I., additional, Petrovic, I., additional, Polovina, M., additional, Vukicevic, M., additional, Tomasevic, M., additional, Mujovic, N., additional, Radivojevic, N., additional, Petrovic, O., additional, Aleksandric, S., 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Topic, V., additional, Stanojevic, D., additional, Randjelovic, M., additional, Jankovic-Tomasevic, R., additional, Atanaskovic, V., additional, Antic, S., additional, Simonovic, D., additional, Stojanovic, M., additional, Stojanovic, S., additional, Mitic, V., additional, Ilic, V., additional, Petrovic, D., additional, Deljanin Ilic, M., additional, Ilic, S., additional, Stoickov, V., additional, Markovic, S., additional, Mijatovic, A., additional, Tanasic, D., additional, Radakovic, G., additional, Peranovic, J., additional, Panic-Jelic, N., additional, Vujadinovic, O., additional, Pajic, P., additional, Bekic, S., additional, Kovacevic, S., additional, García Fernandez, A., additional, Perez Cabeza, A., additional, Anguita, M., additional, Tercedor Sanchez, L., additional, Mau, E., additional, Loayssa, J., additional, Ayarra, M., additional, Carpintero, M., additional, Roldán Rabadan, I., additional, Gil Ortega, M., additional, Tello Montoliu, A., additional, Orenes Piñero, E., additional, Manzano Fernández, S., additional, Marín, F., additional, Romero Aniorte, A., additional, Veliz Martínez, A., additional, Quintana Giner, M., additional, Ballesteros, G., additional, Palacio, M., additional, Alcalde, O., additional, García-Bolao, I., additional, Bertomeu Gonzalez, V., additional, Otero-Raviña, F., additional, García Seara, J., additional, Gonzalez Juanatey, J., additional, Dayal, N., additional, Maziarski, P., additional, Gentil-Baron, P., additional, Koç, M., additional, Onrat, E., additional, Dural, I.E., additional, Yilmaz, K., additional, Özin, B., additional, Tan Kurklu, S., additional, Atmaca, Y., additional, Canpolat, U., additional, Tokgozoglu, L., additional, Dolu, A.K., additional, Demirtas, B., additional, Sahin, D., additional, Ozcan Celebi, O., additional, Gagirci, G., additional, Turk, U.O., additional, Ari, H., additional, Polat, N., additional, Toprak, N., additional, Sucu, M., additional, Akin Serdar, O., additional, Taha Alper, A., additional, Kepez, A., additional, Yuksel, Y., additional, Uzunselvi, A., additional, Yuksel, S., additional, Sahin, M., additional, Kayapinar, O., additional, Ozcan, T., additional, Kaya, H., additional, Yilmaz, M.B., additional, Kutlu, M., additional, Demir, M., additional, Gibbs, C., additional, Kaminskiene, S., additional, Bryce, M., additional, Skinner, A., additional, Belcher, G., additional, Hunt, J., additional, Stancombe, L., additional, Holbrook, B., additional, Peters, C., additional, Tettersell, S., additional, Shantsila, A., additional, Senoo, K., additional, Proietti, M., additional, Russell, K., additional, Domingos, P., additional, Hussain, S., additional, Partridge, J., additional, Haynes, R., additional, Bahadur, S., additional, Brown, R., additional, McMahon, S., additional, McDonald, J., additional, Balachandran, K., additional, Singh, R., additional, Garg, S., additional, Desai, H., additional, Davies, K., additional, Goddard, W., additional, Galasko, G., additional, Rahman, I., additional, Chua, Y., additional, Payne, O., additional, Preston, S., additional, Brennan, O., additional, Pedley, L., additional, Whiteside, C., additional, Dickinson, C., additional, Brown, J., additional, Jones, K., additional, Benham, L., additional, Brady, R., additional, Buchanan, L., additional, Ashton, A., additional, Crowther, H., additional, Fairlamb, H., additional, Thornthwaite, S., additional, Relph, C., additional, McSkeane, A., additional, Poultney, U., additional, Kelsall, N., additional, Rice, P., additional, Wilson, T., additional, Wrigley, M., additional, Kaba, R., additional, Patel, T., additional, Young, E., additional, Law, J., additional, Runnett, C., additional, Thomas, H., additional, McKie, H., additional, Fuller, J., additional, Pick, S., additional, Sharp, A., additional, Hunt, A., additional, Thorpe, K., additional, Hardman, C., additional, Cusack, E., additional, Adams, L., additional, Hough, M., additional, Keenan, S., additional, Bowring, A., additional, Watts, J., additional, Zaman, J., additional, Goffin, K., additional, Nutt, H., additional, Beerachee, Y., additional, Featherstone, J., additional, Mills, C., additional, Pearson, J., additional, Stephenson, L., additional, Grant, S., additional, Wilson, A., additional, Hawksworth, C., additional, Alam, I., additional, Robinson, M., additional, Ryan, S., additional, Egdell, R., additional, Gibson, E., additional, Holland, M., additional, Leonard, D., additional, Mishra, B., additional, Ahmad, S., additional, Randall, H., additional, Hill, J., additional, Reid, L., additional, George, M., additional, McKinley, S., additional, Brockway, L., additional, Milligan, W., additional, Sobolewska, J., additional, Muir, J., additional, Tuckis, L., additional, Winstanley, L., additional, Jacob, P., additional, Kaye, S., additional, Morby, L., additional, Jan, A., additional, Sewell, T., additional, Boos, C., additional, Wadams, B., additional, Cope, C., additional, Jefferey, P., additional, Andrews, N., additional, Getty, A., additional, Suttling, A., additional, Turner, C., additional, Hudson, K., additional, Austin, R., additional, Howe, S., additional, Iqbal, R., additional, Gandhi, N., additional, Brophy, K., additional, Mirza, P., additional, Willard, E., additional, Collins, S., additional, Ndlovu, N., additional, Subkovas, E., additional, Karthikeyan, V., additional, Waggett, L., additional, Wood, A., additional, Bolger, A., additional, Stockport, J., additional, Evans, L., additional, Harman, E., additional, Starling, J., additional, Williams, L., additional, Saul, V., additional, Sinha, M., additional, Bell, L., additional, Tudgay, S., additional, Kemp, S., additional, Frost, L., additional, Ingram, T., additional, Loughlin, A., additional, Adams, C., additional, Adams, M., additional, Hurford, F., additional, Owen, C., additional, Miller, C., additional, Donaldson, D., additional, Tivenan, H., additional, Button, H., additional, Nasser, A., additional, Jhagra, O., additional, Stidolph, B., additional, Brown, C., additional, Livingstone, C., additional, Duffy, M., additional, Madgwick, P., additional, Roberts, P., additional, Greenwood, E., additional, Fletcher, L., additional, Beveridge, M., additional, Earles, S., additional, McKenzie, D., additional, Beacock, D., additional, Dayer, M., additional, Seddon, M., additional, Greenwell, D., additional, Luxton, F., additional, Venn, F., additional, Mills, H., additional, Rewbury, J., additional, James, K., additional, Roberts, K., additional, Tonks, L., additional, Felmeden, D., additional, Taggu, W., additional, Summerhayes, A., additional, Hughes, D., additional, Sutton, J., additional, Felmeden, L., additional, Khan, M., additional, Walker, E., additional, Norris, L., additional, O'Donohoe, L., additional, Mozid, A., additional, Dymond, H., additional, Lloyd-Jones, H., additional, Saunders, G., additional, Simmons, D., additional, Coles, D., additional, Cotterill, D., additional, Beech, S., additional, Kidd, S., additional, Wrigley, B., additional, Petkar, S., additional, Smallwood, A., additional, Jones, R., additional, Radford, E., additional, Milgate, S., additional, Metherell, S., additional, Cottam, V., additional, Buckley, C., additional, Broadley, A., additional, Wood, D., additional, Allison, J., additional, Rennie, K., additional, Balian, L., additional, Howard, L., additional, Pippard, L., additional, Board, S., additional, and Pitt-Kerby, T., additional
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35. Epidemiology and impact of frailty in patients with atrial fibrillation in Europe
- Author
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Proietti, Marco, Romiti, Giulio Francesco, Vitolo, Marco, Harrison, Stephanie L., Lane, Deirdre A., Fauchier, Laurent, Marin, Francisco, Näbauer, Michael, Potpara, Tatjana S., Dan, Gheorghe-Andrei, Maggioni, Aldo P., Cesari, Matteo, Boriani, Giuseppe, Lip, Gregory Y. H., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Goda, A., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Shalganov, T., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Riahi, S., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Muda, P., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Piot, O., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Fauchier, L., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Poposka, L., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Etsadashvili, K., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Boriani, G., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Mirrakhimov, E., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Erglis, A., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Erküner, Philippens, S., van Doorn, W., Crijns, H., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Atar, D., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Zieminska-Łuć, M., Bujak, W., Sliwinski, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordynski, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Wozniak, P., Chlebus, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kazmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stepien, M., Szabowski, S., Krysiak, W., Szymanska, M., Karasinski, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyzanowski, K., Skrobowski, A., Zielinski, L., Tomaszewska-Kiecana, M., Dłuzniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tyminska, A., Ozieranski, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Lenarczyk, R., Mazurek, M., Kalarus, Z., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Odinsova, S., Arhipova, T., Kazakevich, E., Serdechnaya, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Polovina, M., Potpara, T., Vujisic-Tesic, B., Nedeljkovic, M., Zlatar, M., Asanin, M., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Shah, D., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Diker, E., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Lane, D., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., Lip, G. Y. H., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O’Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Laboratory Medicine, Cardiology, and ACS - Heart failure & arrhythmias
- Subjects
Oral ,Male ,Aging ,Administration, Oral ,frailty ,Frailty/chemically induced ,outcomes ,Europe/epidemiology ,older people ,Risk Factors ,atrial fibrillation ,chronicity ,epidemiology ,oral anticoagulant therapy ,Aged ,Anticoagulants ,Europe ,Female ,Humans ,Quality of Life ,Registries ,Atrial Fibrillation ,Frailty ,Stroke ,Atrial Fibrillation/diagnosis ,General Medicine ,Administration ,Geriatrics and Gerontology ,Anticoagulants/adverse effects ,Stroke/complications - Abstract
Background Frailty is a medical syndrome characterised by reduced physiological reserve and increased vulnerability to stressors. Data regarding the relationship between frailty and atrial fibrillation (AF) are still inconsistent. Objectives We aim to perform a comprehensive evaluation of frailty in a large European cohort of AF patients. Methods A 40-item frailty index (FI) was built according to the accumulation of deficits model in the AF patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry. Association of baseline characteristics, clinical management, quality of life, healthcare resources use and risk of outcomes with frailty was examined. Results Among 10,177 patients [mean age (standard deviation) 69.0 (11.4) years, 4,103 (40.3%) females], 6,066 (59.6%) were pre-frail and 2,172 (21.3%) were frail, whereas only 1,939 (19.1%) were considered robust. Baseline thromboembolic and bleeding risks were independently associated with increasing FI. Frail patients with AF were less likely to be treated with oral anticoagulants (OACs) (odds ratio 0.70, 95% confidence interval 0.55–0.89), especially with non-vitamin K antagonist OACs and managed with a rhythm control strategy, compared with robust patients. Increasing frailty was associated with a higher risk for all outcomes examined, with a non-linear exponential relationship. The use of OAC was associated with a lower risk of outcomes, except in patients with very/extremely high frailty. Conclusions In this large cohort of AF patients, there was a high burden of frailty, influencing clinical management and risk of adverse outcomes. The clinical benefit of OAC is maintained in patients with high frailty, but not in very high/extremely frail ones.
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- 2022
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36. Assessment of 3D MINFLUX data for quantitative structural biology in cells revisited
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Klaus C. Gwosch, Francisco Balzarotti, Jasmin K. Pape, Philipp Hoess, Jan Ellenberg, Jonas Ries, Ulf Matti, Roman Schmidt, Steffen J. Sahl, and Stefan W. Hell
- Abstract
Prakash and Curd provide a re-analysis1 of individual datasets taken from our report2 demonstrating MINFLUX 3D imaging in cells. Their evaluation confirms the unique localization precision provided by MINFLUX2,3 featuring a standard deviation of σ = 1-3 nm. We appreciate their confirmation and also welcome the opportunity to clarify their remaining points. The hitherto almost unconceivable 3D localization precision attained by MINFLUX is likely to hold the key to an all-optical dynamical structural biology.
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- 2022
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37. Clinical utility and prognostic implications of the novel 4S-AF scheme to characterize and evaluate patients with atrial fibrillation:a report from ESC-EHRA EORP-AF Long-Term General Registry
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Ding, Wern Yew, Proietti, Marco, Boriani, Giuseppe, Fauchier, Laurent, Blomström-Lundqvist, Carina, Marin, Francisco, Potpara, Tatjana S., Lip, Gregory Y. H., Boriani, G., Lip, G. Y. H., Tavazzi, L., Maggioni, A. P., Dan, G. A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K. A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., van Genechten, G., Heidbuchel, H., Boussy, T., de Coninck, M., van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., van Hauwaert, B., Kuppens, C., Faes, D., van Lier, D., van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., le Bidan, M., Pavin, D., le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V. L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., de Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., van Es, J., van Opstal, J., van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-ŁUć, M., Bujak, W., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stȩpień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, C. F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Mijatovic, S. A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I. E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A. K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U. O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Ozcan, O. T., Kaya, H., Yilmaz, M. B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Pulmonary medicine, Rehabilitation medicine, Internal medicine, Radiology and nuclear medicine, Laboratory Medicine, Cardiology, and ACS - Heart failure & arrhythmias
- Subjects
Characterization ,Bleeding ,4S-AF ,Atrial fibrillation ,Classification ,EORP-AF registry ,Mortality ,Prognostic implications ,Stroke ,Thromboembolism ,Validation ,Anticoagulants ,Hemorrhage ,Humans ,Prognosis ,Registries ,Risk Factors ,Atrial Fibrillation ,Brain Ischemia ,Ischemic Stroke ,Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Aims The 4S-AF classification scheme comprises of four domains: stroke risk (St), symptoms (Sy), severity of atrial fibrillation (AF) burden (Sb), and substrate (Su). We sought to examine the implementation of the 4S-AF scheme in the EORP-AF General Long-Term Registry and compare outcomes in AF patients according to the 4S-AF-led decision-making process. Methods and results Atrial fibrillation patients from 250 centres across 27 European countries were included. A 4S-AF score was calculated as the sum of each domain with a maximum score of 9. Of 6321 patients, 8.4% had low (St), 47.5% EHRA I (Sy), 40.5% newly diagnosed or paroxysmal AF (Sb), and 5.1% no cardiovascular risk factors or left atrial enlargement (Su). Median follow-up was 24 months. Using multivariable Cox regression analysis, independent predictors of all-cause mortality were (St) [adjusted hazard ratio (aHR) 8.21, 95% confidence interval (CI): 2.60–25.9], (Sb) (aHR 1.21, 95% CI: 1.08–1.35), and (Su) (aHR 1.27, 95% CI: 1.14–1.41). For CV mortality and any thromboembolic event, only (Su) (aHR 1.73, 95% CI: 1.45–2.06) and (Sy) (aHR 1.29, 95% CI: 1.00–1.66) were statistically significant, respectively. None of the domains were independently linked to ischaemic stroke or major bleeding. Higher 4S-AF score was related to a significant increase in all-cause mortality, CV mortality, any thromboembolic event, and ischaemic stroke but not major bleeding. Treatment of all 4S-AF domains was associated with an independent decrease in all-cause mortality (aHR 0.71, 95% CI: 0.55–0.92). For each 4S-AF domain left untreated, the risk of all-cause mortality increased substantially (aHR 1.35, 95% CI: 1.16–1.56). Conclusion Implementation of the novel 4S-AF scheme is feasible, and treatment decisions based on this scheme improve mortality rates in AF.
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- 2022
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38. Assessment of 3D MINFLUX data for quantitative structural biology in cells revisited
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Gwosch, Klaus C., primary, Balzarotti, Francisco, additional, Pape, Jasmin K., additional, Hoess, Philipp, additional, Ellenberg, Jan, additional, Ries, Jonas, additional, Matti, Ulf, additional, Schmidt, Roman, additional, Sahl, Steffen J., additional, and Hell, Stefan W., additional
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- 2022
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39. Outbreak of follicular conjunctivitis associated with the diagnosis of anaplasmosis in a sheep herd
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Oliveira, Paula M., primary, Ramos, Dirceu G. S., additional, Saturnino, Klaus C., additional, and Amaral, Andréia V. C., additional
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- 2022
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40. Lifetime economic potential of mobile stroke units in acute stroke care: A model-based analysis of the drivers of cost-effectiveness
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Johann S Rink, Matthias F Froelich, May Nour, Jeffrey L Saver, Kristina Szabo, Carolin Hoyer, Klaus C Fassbender, Stefan O Schoenberg, and Fabian Tollens
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Health Informatics - Abstract
Background and purpose To simulate patient-level costs, analyze the economic potential of telemedicine-based mobile stroke units for acute prehospital stroke care, and identify major determinants of cost-effectiveness, based on two recent prospective trials from the United States and Germany. Methods A Markov decision model was developed to simulate lifetime costs and outcomes of mobile stroke unit. The model compares diagnostic and therapeutic pathways of ischemic stroke, hemorrhagic stroke, and stroke mimic patients by conventional care or by mobile stroke units. The treatment outcomes were derived from the B_PROUD and the BEST-mobile stroke unit trials and further input parameters were derived from recent literature. Uncertainty was addressed by deterministic and probabilistic sensitivity analyses. A lifetime horizon based on the US healthcare system was adopted to evaluate different cost thresholds for mobile stroke unit and the resulting cost-effectiveness. Willingness-to-pay thresholds were set at 1x and 3x gross domestic product per capita, as recommended by the World Health Organization. Results In the base case scenario, mobile stroke unit care yielded an incremental gain of 0.591 quality-adjusted life years per dispatch. Mobile stroke unit was highly cost-effective up to a maximum average cost of 43,067 US dollars per patient. Sensitivity analyses revealed that MSU cost-effectiveness is mainly affected by reduction of long-term disability costs. Also, among other parameters, the rate of stroke mimics patients diagnosed by MSU plays an important role. Conclusion This study demonstrated that mobile stroke unit can possibly be operated on an excellent level of cost-effectiveness in urban areas in North America with number of stroke mimic patients and long-term stroke survivor costs as major determinants of lifetime cost-effectiveness.
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- 2022
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41. Diaphyseal Fractures of the Third Metacarpal and Third Metatarsal Bones
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Lischer, C., primary and Klaus, C., additional
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- 2022
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42. Handbuch Assistiertes und Automatisiertes Fahren : Grundlagen, Komponenten und Systeme für assistiertes und automatisiertes Fahren
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Hermann Winner, Klaus C J Dietmayer, Lutz Eckstein, Meike Jipp, Markus Maurer, Christoph Stiller, Hermann Winner, Klaus C J Dietmayer, Lutz Eckstein, Meike Jipp, Markus Maurer, and Christoph Stiller
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- Automotive engineering, Engines
- Abstract
In diesem Grundlagenwerk werden Systeme, die Fahrzeugführung unterstützen oder ganz übernehmen in Aufbau und Funktion ausführlich erklärt. Darüber hinaus enthält es eine Übersicht der Rahmenbedingungen für die Entwicklung solcher Systeme sowie Erläuterungen der angewandten Entwicklungs- und Testwerkzeuge. Die Beschreibung umfasst die heute bekannten Assistenzsysteme einschließlich des Ausblicks auf deren zukünftigen Entwicklungen. Speziell wird den vielfältigen Aspekten der Automatisierung des Fahrens Rechnung getragen, denn mit der Übertragung der Fahraufgabe an eine Maschine leiten sich viele neue Herausforderungen ab. Im Handbuch werden Funktionsprinzipien und Ausführungsformen die dazu erforderlichen Komponenten und Architekturen für die maschinelle Wahrnehmung, der Planung und der Aktorik erläutert. Der nutzergerechten Gestaltung der Mensch-Maschine-Schnittstellen von Assistenz- und Automatisierungssystemen wird ebenso Rechnung getragen wie die Diskussion zu den Herausforderungen für die Einführung des hochautomatisierten Fahrens ab Level 3. Besonderheiten von Systemen zum assistierten und automatisierten Fahrens bei Nutzfahrzeugen und Motorrädern runden den umfassenden Ansatz ab.
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- 2024
43. Phase 1 trial of KT‐333, a STAT3 degrader, in patients with relapsed or refractory lymphomas, large granular lymphocytic leukemia and solid tumors.
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Smith, S., Olszewski, A., Starodub, A. N., Stevens, D. A., Feldman, T., Porcu, P., Epstein‐Peterson, Z., Huen, A., Pinter‐Brown, L., Mattour, A., Perea, R., Gollerkeri, A., Dey, J., Klaus, C., Agarwal, S., Gollob, J., and Shastri, A.
- Subjects
LYMPHOCYTIC leukemia ,STAT proteins ,LYMPHOMAS ,CUTANEOUS T-cell lymphoma ,HODGKIN'S disease ,TUMORS - Abstract
It is projected that higher doses of KT-333 will achieve the predicted degradation profile in tumors that may translate into clinical benefit in patients with STAT3-dependent T cell malignancies. B Background: b KT-333 is a first-in-class, potent, highly selective, heterobifunctional small molecule degrader of the signal transducer and activator of transcription 3 (STAT3) protein. Phase 1 trial of KT-333, a STAT3 degrader, in patients with relapsed or refractory lymphomas, large granular lymphocytic leukemia and solid tumors. [Extracted from the article]
- Published
- 2023
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44. Bestimmung der Glukoseaufnahme in Mikrogliasubtypen bei Neurodegeneration
- Author
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Wagner, S., Bartos, L. M., Zenatti, V., Prtvar, D., Fixemer, S., Klaus, C., Herms, J., Paeger, L., Prestel, M., Tahirovic, S., and Brendel, M.
- Published
- 2024
- Full Text
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45. Regionale Desynchronisation der Mikrogliaaktivität korreliert mit kognitivem Abbau bei Alzheimer-Krankheit
- Author
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Zatcepin, A., Gnörich, J., Rauchmann, B., Bartos, L. M., Wagner, S., Franzmeier, N., Xiang, X., Shi, Y., Grosch, M., Wind-Mark, K., Beyer, L., Klaus, C., Biechele, G., Finze, A., Eckenweber, F., Lindner, S., Bartenstein, P., Albert, N. L., Ziegler, S. I., and Brendel, M.
- Published
- 2024
- Full Text
- View/download PDF
46. Multizentrischer Ansatz bei der β-Amyloid-µPET-Bildgebung: Machbarkeit und Grenzen in einem Kopf-an-Kopf-Vergleich mit drei Scannern
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Gnörich, J., Koehler, M., Wind, K., Klaus, C., Zatcepin, A., Monasor, L., Beyer, L., Eckenweber, F., Scheifele, M., Gildehaus, F., Ungern-Sternberg, B., Barthel, H., Haass, C., Bartenstein, P., Herms, J., Tahirovic, S., Ziegler, S., and Brendel, M.
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- 2024
- Full Text
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47. Unterstützung von Fahrfunktionen durch die digitale Karte
- Author
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Homeier, Roland, Jentsch, Roland, Jülge, Katharina, Lippelt, Benjamin, Pöchmüller, Werner, Winner, Hermann, editor, Dietmayer, Klaus C J, editor, Eckstein, Lutz, editor, Jipp, Meike, editor, Maurer, Markus, editor, and Stiller, Christoph, editor
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- 2024
- Full Text
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48. Fahrerassistenzsysteme im Nutzfahrzeug
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Ballarin, Christian, Reisgys, Felix Manuel, Scherhaufer, Ingo, Tresp, Christoph, Winner, Hermann, editor, Dietmayer, Klaus C J, editor, Eckstein, Lutz, editor, Jipp, Meike, editor, Maurer, Markus, editor, and Stiller, Christoph, editor
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- 2024
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49. Motorrad-Fahrassistenzsysteme
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Pleß, Raphael, Georgi, Andreas, Lichtenthäler, Jonas, Matschl, Gerald, Will, Sebastian, Winner, Hermann, editor, Dietmayer, Klaus C J, editor, Eckstein, Lutz, editor, Jipp, Meike, editor, Maurer, Markus, editor, and Stiller, Christoph, editor
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- 2024
- Full Text
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50. Längsregelung
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Winner, Hermann, Desens, Jens, Winner, Hermann, editor, Dietmayer, Klaus C J, editor, Eckstein, Lutz, editor, Jipp, Meike, editor, Maurer, Markus, editor, and Stiller, Christoph, editor
- Published
- 2024
- Full Text
- View/download PDF
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