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2. Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

Author

Nagaraj, Gayathri, Vinayak, Shaveta, Khaki, Ali Raza, Sun, Tianyi, Kuderer, Nicole M, Aboulafia, David M, Acoba, Jared D, Awosika, Joy, Bakouny, Ziad, Balmaceda, Nicole B, Bao, Ting, Bashir, Babar, Berg, Stephanie, Bilen, Mehmet A, Bindal, Poorva, Blau, Sibel, Bodin, Brianne E, Borno, Hala T, Castellano, Cecilia, Choi, Horyun, Deeken, John, Desai, Aakash, Edwin, Natasha, Feldman, Lawrence E, Flora, Daniel B, Friese, Christopher R, Galsky, Matthew D, Gonzalez, Cyndi J, Grivas, Petros, Gupta, Shilpa, Haynam, Marcy, Heilman, Hannah, Hershman, Dawn L, Hwang, Clara, Jani, Chinmay, Jhawar, Sachin R, Joshi, Monika, Kaklamani, Virginia, Klein, Elizabeth J, Knox, Natalie, Koshkin, Vadim S, Kulkarni, Amit A, Kwon, Daniel H, Labaki, Chris, Lammers, Philip E, Lathrop, Kate I, Lewis, Mark A, Li, Xuanyi, de Lima Lopes, Gilbert, Lyman, Gary H, Makower, Della F, Mansoor, Abdul-Hai, Markham, Merry-Jennifer, Mashru, Sandeep H, McKay, Rana R, Messing, Ian, Mico, Vasil, Nadkarni, Rajani, Namburi, Swathi, Nguyen, Ryan H, Nonato, Taylor Kristian, O'Connor, Tracey Lynn, Panagiotou, Orestis A, Park, Kyu, Patel, Jaymin M, Patel, Kanishka GopikaBimal, Peppercorn, Jeffrey, Polimera, Hyma, Puc, Matthew, Rao, Yuan James, Razavi, Pedram, Reid, Sonya A, Riess, Jonathan W, Rivera, Donna R, Robson, Mark, Rose, Suzanne J, Russ, Atlantis D, Schapira, Lidia, Shah, Pankil K, Shanahan, M Kelly, Shapiro, Lauren C, Smits, Melissa, Stover, Daniel G, Streckfuss, Mitrianna, Tachiki, Lisa, Thompson, Michael A, Tolaney, Sara M, Weissmann, Lisa B, Wilson, Grace, Wotman, Michael T, Wulff-Burchfield, Elizabeth M, Mishra, Sanjay, French, Benjamin, Warner, Jeremy L, Lustberg, Maryam B, Accordino, Melissa K, and Shah, Dimpy P

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Coronaviruses, Infectious Diseases, Women's Health, Clinical Research, Cancer, Breast Cancer, Lung, Emerging Infectious Diseases, Good Health and Well Being, United States, Humans, Female, Middle Aged, COVID-19, SARS-CoV-2, Cohort Studies, Breast Neoplasms, Retrospective Studies, COVID-19 and Cancer Consortium, breast cancer, epidemiology, global health, human, oncology, pandemic, racial inequities, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundLimited information is available for patients with breast cancer (BC) and coronavirus disease 2019 (COVID-19), especially among underrepresented racial/ethnic populations.MethodsThis is a COVID-19 and Cancer Consortium (CCC19) registry-based retrospective cohort study of females with active or history of BC and laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection diagnosed between March 2020 and June 2021 in the US. Primary outcome was COVID-19 severity measured on a five-level ordinal scale, including none of the following complications, hospitalization, intensive care unit admission, mechanical ventilation, and all-cause mortality. Multivariable ordinal logistic regression model identified characteristics associated with COVID-19 severity.Results1383 female patient records with BC and COVID-19 were included in the analysis, the median age was 61 years, and median follow-up was 90 days. Multivariable analysis revealed higher odds of COVID-19 severity for older age (aOR per decade, 1.48 [95% CI, 1.32-1.67]); Black patients (aOR 1.74; 95 CI 1.24-2.45), Asian Americans and Pacific Islander patients (aOR 3.40; 95 CI 1.70-6.79) and Other (aOR 2.97; 95 CI 1.71-5.17) racial/ethnic groups; worse ECOG performance status (ECOG PS ≥2: aOR, 7.78 [95% CI, 4.83-12.5]); pre-existing cardiovascular (aOR, 2.26 [95% CI, 1.63-3.15])/pulmonary comorbidities (aOR, 1.65 [95% CI, 1.20-2.29]); diabetes mellitus (aOR, 2.25 [95% CI, 1.66-3.04]); and active and progressing cancer (aOR, 12.5 [95% CI, 6.89-22.6]). Hispanic ethnicity, timing, and type of anti-cancer therapy modalities were not significantly associated with worse COVID-19 outcomes. The total all-cause mortality and hospitalization rate for the entire cohort was 9% and 37%, respectively however, it varied according to the BC disease status.ConclusionsUsing one of the largest registries on cancer and COVID-19, we identified patient and BC-related factors associated with worse COVID-19 outcomes. After adjusting for baseline characteristics, underrepresented racial/ethnic patients experienced worse outcomes compared to non-Hispanic White patients.FundingThis study was partly supported by National Cancer Institute grant number P30 CA068485 to Tianyi Sun, Sanjay Mishra, Benjamin French, Jeremy L Warner; P30-CA046592 to Christopher R Friese; P30 CA023100 for Rana R McKay; P30-CA054174 for Pankil K Shah and Dimpy P Shah; KL2 TR002646 for Pankil Shah and the American Cancer Society and Hope Foundation for Cancer Research (MRSG-16-152-01-CCE) and P30-CA054174 for Dimpy P Shah. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS/NIH). The funding sources had no role in the writing of the manuscript or the decision to submit it for publication.Clinical trial numberCCC19 registry is registered on ClinicalTrials.gov, NCT04354701.

Published
2023

3. The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network

Author

Leppig, Kathleen A., Kulchak Rahm, Alanna, Appelbaum, Paul, Aufox, Sharon, Bland, Harris T., Buchanan, Adam, Christensen, Kurt D., Chung, Wendy K., Clayton, Ellen Wright, Crosslin, David, Denny, Josh, DeVange, Shannon, Gordon, Adam, Green, Robert C., Hakonarson, Hakon, Harr, Margaret H., Henrikson, Nora, Hoell, Christin, Holm, Ingrid A., Kullo, Iftikhar J., Jarvik, Gail P., Lammers, Philip E., Larson, Eric B., Lindor, Noralane M., Marasa, Maddalena, Myers, Melanie F., Perez, Emma, Peterson, Josh F., Pratap, Siddharth, Prows, Cynthia A., Ralston, James D., Rasouly, Hila Milo, Roden, Dan M., Sharp, Richard R., Singh, Rajbir, Shaibi, Gabriel, Smith, Maureen E., Sturm, Amy, Thiese, Heidi A., Van Driest, Sara L., Williams, Janet, Williams, Marc S., Wynn, Julia, Blout Zawatsky, Carrie L., and Wiesner, Georgia L.

Published
2022
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4. Pulmonale Hypertonie bei Erwachsenen mit angeborenen Herzfehlern im Lichte der 2022-ESC-PAH-Leitlinien

Author

Kaemmerer, Harald, additional, Diller, Gerhard Paul, additional, Achenbach, Stephan, additional, Dähnert, Ingo, additional, Eichstaedt, Christina A., additional, Eicken, Andreas, additional, Freiberger, Annika, additional, Freilinger, Sebastian, additional, Geiger, Ralf, additional, Gorenflo, Matthias, additional, Grünig, Ekkehard, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer-Suleiman, Ann-Sophie, additional, Kozlik-Feldmann, Rainer, additional, Lammers, Astrid E., additional, Nagdyman, Nicole, additional, Michel, Sebastian, additional, Schmidt, Kai Helge, additional, Uebing, Anselm, additional, von Scheidt, Fabian, additional, and Apitz, Christian, additional

Published
2024
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6. Author response: Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study

Author

Nagaraj, Gayathri, primary, Vinayak, Shaveta, additional, Khaki, Ali Raza, additional, Sun, Tianyi, additional, Kuderer, Nicole M, additional, Aboulafia, David M, additional, Acoba, Jared D, additional, Awosika, Joy, additional, Bakouny, Ziad, additional, Balmaceda, Nicole B, additional, Bao, Ting, additional, Bashir, Babar, additional, Berg, Stephanie, additional, Bilen, Mehmet A, additional, Bindal, Poorva, additional, Blau, Sibel, additional, Bodin, Brianne E, additional, Borno, Hala T, additional, Castellano, Cecilia, additional, Choi, Horyun, additional, Deeken, John, additional, Desai, Aakash, additional, Edwin, Natasha, additional, Feldman, Lawrence E, additional, Flora, Daniel B, additional, Friese, Christopher R, additional, Galsky, Matthew D, additional, Gonzalez, Cyndi J, additional, Grivas, Petros, additional, Gupta, Shilpa, additional, Haynam, Marcy, additional, Heilman, Hannah, additional, Hershman, Dawn L, additional, Hwang, Clara, additional, Jani, Chinmay, additional, Jhawar, Sachin R, additional, Joshi, Monika, additional, Kaklamani, Virginia, additional, Klein, Elizabeth J, additional, Knox, Natalie, additional, Koshkin, Vadim S, additional, Kulkarni, Amit A, additional, Kwon, Daniel H, additional, Labaki, Chris, additional, Lammers, Philip E, additional, Lathrop, Kate I, additional, Lewis, Mark A, additional, Li, Xuanyi, additional, Lopes, Gilbert de Lima, additional, Lyman, Gary H, additional, Makower, Della F, additional, Mansoor, Abdul-Hai, additional, Markham, Merry-Jennifer, additional, Mashru, Sandeep H, additional, McKay, Rana R, additional, Messing, Ian, additional, Mico, Vasil, additional, Nadkarni, Rajani, additional, Namburi, Swathi, additional, Nguyen, Ryan H, additional, Nonato, Taylor Kristian, additional, O'Connor, Tracey Lynn, additional, Panagiotou, Orestis A, additional, Park, Kyu, additional, Patel, Jaymin M, additional, Patel, Kanishka GopikaBimal, additional, Peppercorn, Jeffrey, additional, Polimera, Hyma, additional, Puc, Matthew, additional, Rao, Yuan James, additional, Razavi, Pedram, additional, Reid, Sonya A, additional, Riess, Jonathan W, additional, Rivera, Donna R, additional, Robson, Mark, additional, Rose, Suzanne J, additional, Russ, Atlantis D, additional, Schapira, Lidia, additional, Shah, Pankil K, additional, Shanahan, M Kelly, additional, Shapiro, Lauren C, additional, Smits, Melissa, additional, Stover, Daniel G, additional, Streckfuss, Mitrianna, additional, Tachiki, Lisa, additional, Thompson, Michael A, additional, Tolaney, Sara M, additional, Weissmann, Lisa B, additional, Wilson, Grace, additional, Wotman, Michael T, additional, Wulff-Burchfield, Elizabeth M, additional, Mishra, Sanjay, additional, French, Benjamin, additional, Warner, Jeremy L, additional, Lustberg, Maryam B, additional, Accordino, Melissa K, additional, and Shah, Dimpy P, additional

Published
2023
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7. Supplementary data from Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Author

Boutaud, Olivier, primary, Sosa, I. Romina, primary, Amin, Taneem, primary, Oram, Denise, primary, Adler, David, primary, Hwang, Hyun S., primary, Crews, Brenda C., primary, Milne, Ginger, primary, Harris, Bradford K., primary, Hoeksema, Megan, primary, Knollmann, Bjorn C., primary, Lammers, Philip E., primary, Marnett, Lawrence J., primary, Massion, Pierre P., primary, and Oates, John A., primary

Published
2023
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8. Data from Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Author

Boutaud, Olivier, primary, Sosa, I. Romina, primary, Amin, Taneem, primary, Oram, Denise, primary, Adler, David, primary, Hwang, Hyun S., primary, Crews, Brenda C., primary, Milne, Ginger, primary, Harris, Bradford K., primary, Hoeksema, Megan, primary, Knollmann, Bjorn C., primary, Lammers, Philip E., primary, Marnett, Lawrence J., primary, Massion, Pierre P., primary, and Oates, John A., primary

Published
2023
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9. Supplementary Figures from Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Author

Boutaud, Olivier, primary, Sosa, I. Romina, primary, Amin, Taneem, primary, Oram, Denise, primary, Adler, David, primary, Hwang, Hyun S., primary, Crews, Brenda C., primary, Milne, Ginger, primary, Harris, Bradford K., primary, Hoeksema, Megan, primary, Knollmann, Bjorn C., primary, Lammers, Philip E., primary, Marnett, Lawrence J., primary, Massion, Pierre P., primary, and Oates, John A., primary

Published
2023
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11. Clinical Characteristics, Racial Inequities, and Outcomes in Patients with Breast Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Cohort Study

Author

Nagaraj, Gayathri, primary, Vinayak, Shaveta, additional, Khaki, Ali Raza, additional, Sun, Tianyi, additional, Kuderer, Nicole M., additional, Aboulafia, David M., additional, Acoba, Jared D., additional, Awosika, Joy, additional, Bakouny, Ziad, additional, Balmaceda, Nicole B., additional, Bao, Ting, additional, Bashir, Babar, additional, Berg, Stephanie, additional, Bilen, Mehmet A., additional, Bindal, Poorva, additional, Blau, Sibel, additional, Bodin, Brianne E., additional, Borno, Hala T., additional, Castellano, Cecilia, additional, Choi, Horyun, additional, Deeken, John, additional, Desai, Aakash, additional, Edwin, Natasha, additional, Feldman, Lawrence E., additional, Flora, Daniel B., additional, Friese, Christopher R., additional, Galsky, Matthew D., additional, Gonzalez, Cyndi J., additional, Grivas, Petros, additional, Gupta, Shilpa, additional, Haynam, Marcy, additional, Heilman, Hannah, additional, Hershman, Dawn L., additional, Hwang, Clara, additional, Jani, Chinmay, additional, Jhawar, Sachin R., additional, Joshi, Monika, additional, Kaklamani, Virginia, additional, Klein, Elizabeth J., additional, Knox, Natalie, additional, Koshkin, Vadim S., additional, Kulkarni, Amit A., additional, Kwon, Daniel H., additional, Labaki, Chris, additional, Lammers, Philip E., additional, Lathrop, Kate I., additional, Lewis, Mark A., additional, Li, Xuanyi, additional, de Lima Lopes, Gilberto, additional, Lyman, Gary H., additional, Makower, Della F., additional, Mansoor, Abdul-Hai, additional, Markham, Merry-Jennifer, additional, Mashru, Sandeep H., additional, McKay, Rana R., additional, Messing, Ian, additional, Mico, Vasil, additional, Nadkarni, Rajani, additional, Namburi, Swathi, additional, Nguyen, Ryan H., additional, Nonato, Taylor Kristian, additional, O’Connor, Tracey Lynn, additional, Panagiotou, Orestis A., additional, Park, Kyu, additional, Patel, Jaymin M., additional, Patel, Kanishka GopikaBimal, additional, Peppercorn, Jeffrey, additional, Polimera, Hyma, additional, Puc, Matthew, additional, Rao, Yuan James, additional, Razavi, Pedram, additional, Reid, Sonya A., additional, Riess, Jonathan W., additional, Rivera, Donna R., additional, Robson, Mark, additional, Rose, Suzanne J., additional, Russ, Atlantis D., additional, Schapira, Lidia, additional, Shah, Pankil K., additional, Shanahan, M. Kelly, additional, Shapiro, Lauren C., additional, Smits, Melissa, additional, Stover, Daniel G., additional, Streckfuss, Mitrianna, additional, Tachiki, Lisa, additional, Thompson, Michael A., additional, Tolaney, Sara M., additional, Weissmann, Lisa B., additional, Wilson, Grace, additional, Wotman, Michael T., additional, Wulff-Burchfield, Elizabeth M., additional, Mishra, Sanjay, additional, French, Benjamin, additional, Warner, Jeremy L., additional, Lustberg, Maryam B., additional, Accordino, Melissa K., additional, and Shah, Dimpy P., additional

Published
2023
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13. The Reckoning: The Return of Genomic Results to 1444 Participants Across the eMERGE3 Network

Author

Leppig, Kathleen A., primary, Rahm, Alanna Kulchak, additional, Appelbaum, Paul, additional, Aufox, Sharon, additional, Bland, Sarah T., additional, Buchanan, Adam, additional, Christensen, Kurt D., additional, Chung, Wendy K., additional, Clayton, Ellen Wright, additional, Crosslin, David, additional, Denny, Josh, additional, DeVange, Shannon, additional, Gordon, Adam, additional, Green, Robert C., additional, Hakonarson, Hakon, additional, Harr, Margaret H., additional, Henrikson, Nora, additional, Hoell, Christin, additional, Holm, Ingrid A., additional, Kullo, Iftikhar J., additional, Jarvik, Gail P., additional, Lammers, Philip E., additional, Larson, Eric B., additional, Lindor, Noralane M., additional, Marasa, Maddalena, additional, Myers, Melanie F., additional, Perez, Emma, additional, Peterson, Josh F., additional, Pratap, Siddharth, additional, Prows, Cynthia A., additional, Ralston, James D., additional, Rasouly, Hila Milo, additional, Roden, Dan M., additional, Sharp, Richard R., additional, Singh, Rajbir, additional, Shaibi, Gabriel, additional, Smith, Maureen E., additional, Sturm, Amy, additional, Thiese, Heidi A., additional, Van Driest, Sara L., additional, Williams, Janet, additional, Williams, Marc S., additional, Wynn, Julia, additional, Blout Zawatsky, Carrie L., additional, and Wiesner, Georgia L., additional

Published
2022
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14. A framework of deep learning networks provides expert-level accuracy for the detection and prognostication of pulmonary arterial hypertension

Author

Diller, Gerhard-Paul, primary, Benesch Vidal, Maria Luisa, additional, Kempny, Aleksander, additional, Kubota, Kana, additional, Li, Wei, additional, Dimopoulos, Konstantinos, additional, Arvanitaki, Alexandra, additional, Lammers, Astrid E, additional, Wort, Stephen J, additional, Baumgartner, Helmut, additional, Orwat, Stefan, additional, and Gatzoulis, Michael A, additional

Published
2022
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17. framework of deep learning networks provides expert-level accuracy for the detection and prognostication of pulmonary arterial hypertension.

Author

Diller, Gerhard-Paul, Vidal, Maria Luisa Benesch, Kempny, Aleksander, Kubota, Kana, Li, Wei, Dimopoulos, Konstantinos, Arvanitaki, Alexandra, Lammers, Astrid E, Wort, Stephen J, Baumgartner, Helmut, Orwat, Stefan, and Gatzoulis, Michael A

Subjects
DEEP learning, STATISTICS, MULTIVARIATE analysis, TETRALOGY of Fallot, CONCEPTUAL structures, ATRIAL septal defects, ARTIFICIAL neural networks, PROPORTIONAL hazards models
Abstract

Aims To test the hypothesis that deep learning (DL) networks reliably detect pulmonary arterial hypertension (PAH) and provide prognostic information. Methods and results Consecutive patients with PAH, right ventricular (RV) dilation (without PAH), and normal controls were included. An ensemble of deep convolutional networks incorporating echocardiographic views and estimated RV systolic pressure (RVSP) was trained to detect (invasively confirmed) PAH. In addition, DL-networks were trained to segment cardiac chambers and extracted geometric information throughout the cardiac cycle. The ability of DL parameters to predict all-cause mortality was assessed using Cox-proportional hazard analyses. Overall, 450 PAH patients, 308 patients with RV dilatation (201 with tetralogy of Fallot and 107 with atrial septal defects) and 67 normal controls were included. The DL algorithm achieved an accuracy and sensitivity of detecting PAH on a per patient basis of 97.6 and 100%, respectively. On univariable analysis, automatically determined right atrial area, RV area, RV fractional area change, RV inflow diameter and left ventricular eccentricity index (P < 0.001 for all) were significantly related to mortality. On multivariable analysis DL-based RV fractional area change (P < 0.001) and right atrial area (P = 0.003) emerged as independent predictors of outcome. Statistically, DL parameters were non-inferior to measures obtained manually by expert echocardiographers in predicting prognosis. Conclusion The study highlights the utility of DL algorithms in detecting PAH on routine echocardiograms irrespective of RV dilatation. The algorithms outperform conventional echocardiographic evaluation and provide prognostic information at expert-level. Therefore, DL methods may allow for improved screening and optimized management of PAH. [ABSTRACT FROM AUTHOR]

Published
2022
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