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3. Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis.

Author

Liu, Cong, Schönke, Milena, Zhou, Enchen, Li, Zhuang, Kooijman, Sander, Boon, Mariëtte, Larsson, Mikael, Wallenius, Kristina, Dekker, Niek, Barlind, Louise, Peng, Xiao-Rong, Wang, Yanan, and Rensen, Patrick

Subjects
Adipose-liver axis, Atherosclerotic cardiovascular disease, Brown adipose tissue, Dyslipidaemia, Lipoprotein metabolism, Adipose Tissue, Brown, Adipose Tissue, White, Adiposity, Animals, Anticholesteremic Agents, Apolipoprotein E3, Atherosclerosis, Biomarkers, Cholesterol, Disease Models, Animal, Energy Metabolism, Fibroblast Growth Factors, Hypercholesterolemia, Lipid Metabolism, Lipoproteins, VLDL, Liver, Mice, Transgenic, Plaque, Atherosclerotic, Recombinant Proteins, Triglycerides
Abstract

AIMS: Fibroblast growth factor (FGF) 21, a key regulator of energy metabolism, is currently evaluated in humans for treatment of type 2 diabetes and non-alcoholic steatohepatitis. However, the effects of FGF21 on cardiovascular benefit, particularly on lipoprotein metabolism in relation to atherogenesis, remain elusive. METHODS AND RESULTS: Here, the role of FGF21 in lipoprotein metabolism in relation to atherosclerosis development was investigated by pharmacological administration of a half-life extended recombinant FGF21 protein to hypercholesterolaemic APOE*3-Leiden.CETP mice, a well-established model mimicking atherosclerosis initiation and development in humans. FGF21 reduced plasma total cholesterol, explained by a reduction in non-HDL-cholesterol. Mechanistically, FGF21 promoted brown adipose tissue (BAT) activation and white adipose tissue (WAT) browning, thereby enhancing the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT and into browned WAT, consequently accelerating the clearance of the cholesterol-enriched remnants by the liver. In addition, FGF21 reduced body fat, ameliorated glucose tolerance and markedly reduced hepatic steatosis, related to up-regulated hepatic expression of genes involved in fatty acid oxidation and increased hepatic VLDL-triglyceride secretion. Ultimately, FGF21 largely decreased atherosclerotic lesion area, which was mainly explained by the reduction in non-HDL-cholesterol as shown by linear regression analysis, decreased lesion severity, and increased atherosclerotic plaque stability index. CONCLUSION: FGF21 improves hypercholesterolaemia by accelerating triglyceride-rich lipoprotein turnover as a result of activating BAT and browning of WAT, thereby reducing atherosclerotic lesion severity and increasing atherosclerotic lesion stability index. We have thus provided additional support for the clinical use of FGF21 in the treatment of atherosclerotic cardiovascular disease.

Published
2022

6. Porojen talviruokinta ja sen vaikutukset porojen käyttäytymiseen, poronhoitokäytäntöihin ja ympäristöön

Author

Skarin, Anna, primary, Turunen, Minna, additional, Eilertsen, Svein Morten, additional, Rautiainen, Heidi, additional, Horstkotte, Tim, additional, Baal, Ole Nils Aslak, additional, Blind, Leif-Anders, additional, Emanuelsson, Ove, additional, Hallergren, Ove, additional, Kaddik, Anna-Marja, additional, Labba, Lars-Tomas, additional, Larsson, Helén, additional, Larsson, Mikael, additional, Lifjell, Tom, additional, Lundgren, Johan, additional, Majuri, Karoliina, additional, Mustonen, Janne, additional, Oskal, Helge, additional, Paulsen, Majken, additional, Post, Laura, additional, Rasmus, Sirpa, additional, Risvoll, Camilla, additional, Tømmervik, Hans, additional, Utsi, Nils-Johan, additional, Nejne Vannar, Elisabeth, additional, and Åhman, Birgitta, additional

Published
2024
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11. Book Reviews

Author

Berglund, Carl Johan, primary, Bergström, Ulf, additional, Damgaard, Finn, additional, Eidevall, Göran, additional, Elgvin, Torleif, additional, Eriksson, LarsOlov, additional, Forsling, Josef, additional, Hägerland, Tobias, additional, Imberg, Johannes, additional, Johnson, Bo, additional, Larsson, Mikael, additional, Norin, Stig, additional, Nylund, Jan H., additional, Nyström, Jennifer, additional, Roitto, Rikard, additional, Stenström, Hanna, additional, Sturesson, Maria, additional, Sundkvist, Mikael, additional, Tiemeyer, Lena-Sofia, additional, Wassén, Cecilia, additional, Wessbrandt, Martin, additional, and Ålöw, Tobias, additional

Published
2023
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12. Book Reviews

Author

Alm, Lars-Göran, primary, Berglund, Bim, additional, Börjesson, David, additional, Eidevall, Göran, additional, Ekenberg, Anders, additional, Elgvin, Torleif, additional, Eriksson, LarsOlov, additional, Fornberg, Tord, additional, Green, Stefan, additional, Holmstrand, Jonas, additional, Hägerland, Tobias, additional, Larsson, Mikael, additional, Leander, Hans, additional, Månsson, Tobias, additional, Nyström, Jennifer, additional, Norin, Stig, additional, Olsson, Birger, additional, Ottosson, Magnus, additional, Runesson, Anders, additional, Scheuer, Blaženka, additional, Starr, James, additional, Stenström, Hanna, additional, Svensson, Samuel, additional, Svärd, David, additional, Sånglöf, Mathias, additional, Tiemeyer, Lena-Sofia, additional, and Wessbrandt, Martin, additional

Published
2023
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13. Book Reviews

Author

Klein, Anja, primary, Ljungberg, Bo Krister, additional, Berglund, Carl Johan, additional, Wassén, Cecilia, additional, Power, Cian, additional, Retsö, Jan, additional, Kuhlin, Joel, additional, Forsling, Josef, additional, Eriksson, LarsOlov, additional, Halle, Magnus, additional, Wessbrandt, Martin, additional, Larsson, Mikael, additional, Tellbe, Mikael, additional, Linjamaa, Paul, additional, Green, Stefan, additional, Norin, Stig, additional, Ålöw, Tobias, additional, and Löfstedt, Torsten, additional

Published
2023
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14. Recensioner

Author

Berglund, Carl Johan, primary, Eurell, John-Christian, additional, Evertsson, Magnus, additional, Forsling, Josef, additional, Green, Stefan, additional, Hagel, Lukas, additional, Hermansson, Per-Olof, additional, Holst, Søren, additional, Kuhlin, Joel, additional, Larsson, Mikael, additional, Leckström, Johannes, additional, Ljungberg, Bo Krister, additional, Pleijel, Richard, additional, Sabir, Adam, additional, Skarström Hinojosa, Kamilla, additional, Starr, James, additional, Svensson, Ludvig, additional, Tellbe, Mikael, additional, Thörn, Lennart, additional, Tiemeyer, Lena-Sofia, additional, Tillberg, Karin, additional, Wassén, Cecilia, additional, Wessbrandt, Martin, additional, Willgren, David, additional, and Ålöw, Tobias, additional

Published
2023
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18. Citrated cellulose nanocrystals from post-consumer cotton textiles

Author

Ruiz-Caldas, Maria-Ximena, primary, Apostolopoulou-Kalkavoura, Varvara, additional, Hellström, Anna-Karin, additional, Hildenbrand, Jutta, additional, Larsson, Mikael, additional, Jaworski, Aleksander, additional, Samec, Joseph S. M., additional, Lahtinen, Panu, additional, Tammelin, Tekla, additional, and Mathew, Aji P., additional

Published
2023
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26. Vocational education, vocational teaching & professional identity : A triad of complexity, values & challenges

Author

Larsson, Mikael

Subjects
Vocational education, Pedagogy, Vocational teachers, Pedagogik, Anställningsbarhet, Vocational identity, kritiskt tänkande, yrkesutbildning, yrkesidentitet, yrkeslärare
Abstract

The school and the workplace often characterize two diverse cultures in terms of what is treasured as important skills and values. The role of vocational teachers is to ensure that the students are surrounded by both these cultures. Because the way vocational education and vocational teaching is valued in the courses enclosed to the area of construction and painting field, the students miss a lot of knowledge to become an conscious citizen. However, because of significant differences between the school and the workplace, this positions a professional challenge and a potential for value conflicts. This reflects in the way teachers value such things as critical thinking and the way characters for employment tend to be organiseed in the education. Some values change with the help from schooling to become an educated teacher, some do not. Because years of practice in one profession tends to give a person a strong identity, and this identity follows them, until they take a constructive side too see things from additional side, with the knowledge from those around them.

Published
2022

27. The king's spice cabinet–Plant remains from Gribshunden, a 15th century royal shipwreck in the Baltic Sea.

Author

Larsson, Mikael and Foley, Brendan

Subjects
*SPICES, *SHIPWRECKS, *NOBILITY (Social class), *ARISTOCRACY (Social class), *SOCIAL context, *MIDDLE Ages, *EXPLOSIONS
Abstract

Maritime archaeological investigations of the wreck of the medieval warship Gribshunden (1495), flagship of King Hans of Denmark and Norway, have revealed diverse artifacts including exotic spices imported from far distant origins: saffron, ginger, clove, peppercorns, and almond. The special circumstances of the vessel's last voyage add unique context to the assemblage. Gribshunden and an accompanying squadron conveyed the king, courtiers, noblemen, and soldiers from Copenhagen to a political summit in Kalmar, Sweden. At that conference, Hans expected the Swedish Council to elect him king of Sweden, and thereby fulfill his ambition to reunify the Nordic region under a single crown. To achieve this, Hans assembled in his fleet and particularly aboard his flagship the people and elite cultural signifiers that would convince the Swedish delegation to accept his rule. Along the way, the ships anchored near Ronneby, Blekinge. Written sources record that an explosion and fire caused Gribshunden to sink off Stora Ekön (Great Oak Island). Exotic spices were status markers among the aristocracy in Scandinavia and around the Baltic Sea during the Middle Ages (1050–1550 CE). Until the Gribshunden finds, these extravagances have rarely or never been represented archaeologically. Evidence of their use and consumption in medieval Scandinavia has been limited to sparse written references. We present here the botanical remains from the Gribshunden shipwreck and compare them to previous archaeobotanical finds from the medieval Baltic region. These opulent status symbols traveled with a medieval king en route to a major historical event. The combination of textual and archaeological evidence allows a novel analytical view of the social environment in which these luxurious foods were consumed. [ABSTRACT FROM AUTHOR]

Published
2023
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