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Your search keyword '"Le Teuff, Gwénaël"' showing total 15 results
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15 results on '"Le Teuff, Gwénaël"'

1. Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis

Author

Le Teuff, Gwénaël, Cozic, Nathalie, Boyer, Jean-Christophe, Boige, Valérie, Diasio, Robert B., Taieb, Julien, Meulendijks, Didier, Palles, Claire, Schwab, Matthias, Deenen, Maarten, Largiadèr, Carlo R., Marinaki, Anthony, Jennings, Barbara A., Wettergren, Yvonne, Di Paolo, Antonello, Gross, Eva, Budai, Barna, Ackland, Stephen P., van Kuilenburg, André B. P., McLeod, Howard L., Milano, Gérard, Thomas, Fabienne, Loriot, Marie-Anne, Kerr, David, Schellens, Jan H. M., Laurent-Puig, Pierre, Shi, Qian, Pignon, Jean-Pierre, and Etienne-Grimaldi, Marie-Christine

Published
2024
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4. Response to first line platinum-based chemotherapy in mismatch repair deficient (MMRd)/ microsatellite instability high (MSI-high) endometrial carcinoma

Author

Colomba, Emeline, Alexandre, Jérôme, Le Teuff, Gwénaël, Genestie, Catherine, Coupez, Dahna, Coquard, Isabelle Ray, Brachet, Pierre Emmanuel, de Percin, Sixtine, Sajous, Christophe, Fabbro, Michel, Delanoy, Nicolas, Joly, Florence, Frenel, Jean Sebastien, Pautier, Patricia, and Leary, Alexandra

Published
2023
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5. Personalized Chemotherapy on the Basis of Tumor Marker Decline in Poor-Prognosis Germ-Cell Tumors: Updated Analysis of the GETUG-13 Phase III Trial.

Author

Fizazi, Karim, Le Teuff, Gwénaël, Fléchon, Aude, Pagliaro, Lance, Mardiak, Josef, Geoffrois, Lionnel, Laguerre, Brigitte, Chevreau, Christine, Delva, Remy, Rolland, Frederic, Theodore, Christine, Roubaud, Guilhem, Gravis, Gwenaëlle, Eymard, Jean-Christophe, Cancel, Mathilde, Juzyna, Beata, Reckova, Maria, Naoun, Natacha, Logothetis, Christopher, and Culine, Stephane

Published
2024
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7. A framework to characterise the reproducibility of meta‐analysis results with its application to direct oral anticoagulants in the acute treatment of venous thromboembolism.

Author

Chapelle, Céline, Le Teuff, Gwénaël, Zufferey, Paul Jacques, Laporte, Silvy, and Ollier, Edouard

Subjects
*ORAL medication, *THROMBOEMBOLISM, *COMPRESSION bandages, *STATISTICAL software, *STATISTICAL correlation, *META-analysis, *STATISTICS
Abstract

The number of meta‐analyses of aggregate data has dramatically increased due to the facility of obtaining data from publications and the development of free, easy‐to‐use, and specialised statistical software. Even when meta‐analyses include the same studies, their results may vary owing to different methodological choices. Assessment of the replication of meta‐analysis provides an example of the variation of effect 'naturally' observed between multiple research projects. Reproducibility of results has mostly been reported using graphical descriptive representations. A quantitative analysis of such results would enable (i) breakdown of the total observed variability with quantification of the variability generated by the replication process and (ii) identification of which variables account for this variability, such as methodological quality or the statistical analysis procedures used. These variables might explain systematic mean differences between results and dispersion of the results. To quantitatively characterise the reproducibility of meta‐analysis results, a bivariate linear mixed‐effects model was developed to simulate both mean results and their corresponding uncertainty. Results were assigned to several replication groups, those assessing the same studies, outcomes, treatment indication and comparisons classified in the same replication group. A nested random effect structure was used to break down the total variability within each replication group and between these groups to enable calculation of an intragroup correlation coefficient and quantification of reproducibility. Determinants of variability were investigated by modelling both mean and variance parameters using covariates. The proposed model was applied to the example of meta‐analyses evaluating direct oral anticoagulants in the acute treatment of venous thromboembolism. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Data from Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Author

Goubet, Anne-Gaëlle, primary, Lordello, Leonardo, primary, Alves Costa Silva, Carolina, primary, Peguillet, Isabelle, primary, Gazzano, Marianne, primary, Mbogning-Fonkou, Maxime Descartes, primary, Thelemaque, Cassandra, primary, Lebacle, Cédric, primary, Thibault, Constance, primary, Audenet, François, primary, Pignot, Géraldine, primary, Gravis, Gwenaelle, primary, Helissey, Carole, primary, Campedel, Luca, primary, Roupret, Morgan, primary, Xylinas, Evanguelos, primary, Ouzaid, Idir, primary, Dubuisson, Agathe, primary, Mazzenga, Marine, primary, Flament, Caroline, primary, Ly, Pierre, primary, Marty, Virginie, primary, Signolle, Nicolas, primary, Sauvat, Allan, primary, Sbarrato, Thomas, primary, Filahi, Mounia, primary, Davin, Caroline, primary, Haddad, Gabriel, primary, Bou Khalil, Jacques, primary, Bleriot, Camille, primary, Danlos, François-Xavier, primary, Dunsmore, Garett, primary, Mulder, Kevin, primary, Silvin, Aymeric, primary, Raoult, Thibault, primary, Archambaud, Baptiste, primary, Belhechmi, Shaima, primary, Gomperts Boneca, Ivo, primary, Cayet, Nadège, primary, Moya-Nilges, Maryse, primary, Mallet, Adeline, primary, Daillere, Romain, primary, Rouleau, Etienne, primary, Radulescu, Camelia, primary, Allory, Yves, primary, Fieschi, Jacques, primary, Rouanne, Mathieu, primary, Ginhoux, Florent, primary, Le Teuff, Gwénaël, primary, Derosa, Lisa, primary, Marabelle, Aurélien, primary, Van Dorp, Jeroen, primary, Van Dijk, Nick, primary, Van Der Heijden, Michiel S., primary, Besse, Benjamin, primary, Andre, Fabrice, primary, Merad, Miriam, primary, Kroemer, Guido, primary, Scoazec, Jean-Yves, primary, Zitvogel, Laurence, primary, and Loriot, Yohann, primary

Published
2023
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9. Supplementary Figure from Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Author

Goubet, Anne-Gaëlle, primary, Lordello, Leonardo, primary, Alves Costa Silva, Carolina, primary, Peguillet, Isabelle, primary, Gazzano, Marianne, primary, Mbogning-Fonkou, Maxime Descartes, primary, Thelemaque, Cassandra, primary, Lebacle, Cédric, primary, Thibault, Constance, primary, Audenet, François, primary, Pignot, Géraldine, primary, Gravis, Gwenaelle, primary, Helissey, Carole, primary, Campedel, Luca, primary, Roupret, Morgan, primary, Xylinas, Evanguelos, primary, Ouzaid, Idir, primary, Dubuisson, Agathe, primary, Mazzenga, Marine, primary, Flament, Caroline, primary, Ly, Pierre, primary, Marty, Virginie, primary, Signolle, Nicolas, primary, Sauvat, Allan, primary, Sbarrato, Thomas, primary, Filahi, Mounia, primary, Davin, Caroline, primary, Haddad, Gabriel, primary, Bou Khalil, Jacques, primary, Bleriot, Camille, primary, Danlos, François-Xavier, primary, Dunsmore, Garett, primary, Mulder, Kevin, primary, Silvin, Aymeric, primary, Raoult, Thibault, primary, Archambaud, Baptiste, primary, Belhechmi, Shaima, primary, Gomperts Boneca, Ivo, primary, Cayet, Nadège, primary, Moya-Nilges, Maryse, primary, Mallet, Adeline, primary, Daillere, Romain, primary, Rouleau, Etienne, primary, Radulescu, Camelia, primary, Allory, Yves, primary, Fieschi, Jacques, primary, Rouanne, Mathieu, primary, Ginhoux, Florent, primary, Le Teuff, Gwénaël, primary, Derosa, Lisa, primary, Marabelle, Aurélien, primary, Van Dorp, Jeroen, primary, Van Dijk, Nick, primary, Van Der Heijden, Michiel S., primary, Besse, Benjamin, primary, Andre, Fabrice, primary, Merad, Miriam, primary, Kroemer, Guido, primary, Scoazec, Jean-Yves, primary, Zitvogel, Laurence, primary, and Loriot, Yohann, primary

Published
2023
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10. Supplementary Figure Legends from TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)

Author

Werbrouck, Coralie, primary, Evangelista, Cláudia C.S., primary, Lobón-Iglesias, María-Jesús, primary, Barret, Emilie, primary, Le Teuff, Gwénaël, primary, Merlevede, Jane, primary, Brusini, Romain, primary, Kergrohen, Thomas, primary, Mondini, Michele, primary, Bolle, Stéphanie, primary, Varlet, Pascale, primary, Beccaria, Kevin, primary, Boddaert, Nathalie, primary, Puget, Stéphanie, primary, Grill, Jacques, primary, Debily, Marie-Anne, primary, and Castel, David, primary

Published
2023
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11. Supplementary Figures from TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)

Author

Werbrouck, Coralie, primary, Evangelista, Cláudia C.S., primary, Lobón-Iglesias, María-Jesús, primary, Barret, Emilie, primary, Le Teuff, Gwénaël, primary, Merlevede, Jane, primary, Brusini, Romain, primary, Kergrohen, Thomas, primary, Mondini, Michele, primary, Bolle, Stéphanie, primary, Varlet, Pascale, primary, Beccaria, Kevin, primary, Boddaert, Nathalie, primary, Puget, Stéphanie, primary, Grill, Jacques, primary, Debily, Marie-Anne, primary, and Castel, David, primary

Published
2023
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12. Supplementary Tables from TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)

Author

Werbrouck, Coralie, primary, Evangelista, Cláudia C.S., primary, Lobón-Iglesias, María-Jesús, primary, Barret, Emilie, primary, Le Teuff, Gwénaël, primary, Merlevede, Jane, primary, Brusini, Romain, primary, Kergrohen, Thomas, primary, Mondini, Michele, primary, Bolle, Stéphanie, primary, Varlet, Pascale, primary, Beccaria, Kevin, primary, Boddaert, Nathalie, primary, Puget, Stéphanie, primary, Grill, Jacques, primary, Debily, Marie-Anne, primary, and Castel, David, primary

Published
2023
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13. Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine

Author

Belhechmi, Shaima, Le Teuff, Gwénaël, De Bin, Riccardo, Rotolo, Federico, and Michiels, Stefan

Subjects
Structural Biology, Applied Mathematics, Molecular Biology, Biochemistry, Computer Science Applications
Abstract

Background The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its main effects are also in the model. However, this constraint is not guaranteed in the standard penalized statistical approaches. We aimed to find a compromise for high-dimensional data between the need for sparse model selection and the need for the hierarchical constraint. Results To favor the property of the hierarchical interaction constraint, we proposed to create groups composed of the biomarker main effect and its interaction with treatment and to perform the bi-level selection on these groups. We proposed two weighting approaches (Single Wald (SW) and likelihood ratio test (LRT)) for the adaptive lasso method. The selection performance of these two approaches is compared to alternative lasso extensions (adaptive lasso with ridge-based weights, composite Minimax Concave Penalty, group exponential lasso and Sparse Group Lasso) through a simulation study. A RCT (NSABP B-31) randomizing 1574 patients (431 events) with early breast cancer aiming to evaluate the effect of adjuvant trastuzumab on distant-recurrence free survival with expression data from 462 genes measured in the tumour will serve for illustration. The simulation study illustrates that the adaptive lasso LRT and SW, and the group exponential lasso favored the hierarchical interaction constraint. Overall, in the alternative scenarios, they had the best balance of false discovery and false negative rates for the main effects of the selected interactions. For NSABP B-31, 12 gene-treatment interactions were identified more than 20% by the different methods. Among them, the adaptive lasso (SW) approach offered the best trade-off between a high number of selected gene-treatment interactions and a high proportion of selection of both the gene-treatment interaction and its main effect. Conclusions Adaptive lasso with Single Wald and likelihood ratio test weighting and the group exponential lasso approaches outperformed their competitors in favoring the hierarchical constraint of the biomarker-treatment interaction. However, the performance of the methods tends to decrease in the presence of prognostic biomarkers.

Published
2022
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14. Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Author

Goubet, Anne-Gaëlle, primary, Lordello, Leonardo, additional, Alves Costa Silva, Carolina, additional, Peguillet, Isabelle, additional, Gazzano, Marianne, additional, Mbogning-Fonkou, Maxime Descartes, additional, Thelemaque, Cassandra, additional, Lebacle, Cédric, additional, Thibault, Constance, additional, Audenet, François, additional, Pignot, Géraldine, additional, Gravis, Gwenaelle, additional, Helissey, Carole, additional, Campedel, Luca, additional, Roupret, Morgan, additional, Xylinas, Evanguelos, additional, Ouzaid, Idir, additional, Dubuisson, Agathe, additional, Mazzenga, Marine, additional, Flament, Caroline, additional, Ly, Pierre, additional, Marty, Virginie, additional, Signolle, Nicolas, additional, Sauvat, Allan, additional, Sbarrato, Thomas, additional, Filahi, Mounia, additional, Davin, Caroline, additional, Haddad, Gabriel, additional, Bou Khalil, Jacques, additional, Bleriot, Camille, additional, Danlos, François-Xavier, additional, Dunsmore, Garett, additional, Mulder, Kevin, additional, Silvin, Aymeric, additional, Raoult, Thibault, additional, Archambaud, Baptiste, additional, Belhechmi, Shaima, additional, Gomperts Boneca, Ivo, additional, Cayet, Nadège, additional, Moya-Nilges, Maryse, additional, Mallet, Adeline, additional, Daillere, Romain, additional, Rouleau, Etienne, additional, Radulescu, Camelia, additional, Allory, Yves, additional, Fieschi, Jacques, additional, Rouanne, Mathieu, additional, Ginhoux, Florent, additional, Le Teuff, Gwénaël, additional, Derosa, Lisa, additional, Marabelle, Aurélien, additional, Van Dorp, Jeroen, additional, Van Dijk, Nick, additional, Van Der Heijden, Michiel S., additional, Besse, Benjamin, additional, Andre, Fabrice, additional, Merad, Miriam, additional, Kroemer, Guido, additional, Scoazec, Jean-Yves, additional, Zitvogel, Laurence, additional, and Loriot, Yohann, additional

Published
2022
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15. Weight and skeletal muscle loss with cabozantinib in metastatic renal cell carcinoma

Author

Colomba, Emeline, primary, Alves Costa Silva, Carolina, additional, Le Teuff, Gwénaël, additional, Elmawieh, Jamie, additional, Afonso, Daniel, additional, Benchimol‐Zouari, Axelle, additional, Guida, Annalisa, additional, Derosa, Lisa, additional, Flippot, Ronan, additional, Raynard, Bruno, additional, Escudier, Bernard, additional, Bidault, François, additional, and Albiges, Laurence, additional

Published
2022
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