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Your search keyword '"Lee, Jin S."' showing total 4 results
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4 results on '"Lee, Jin S."'

1. Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response

Author

Jackson, Hannah K., primary, Long, Heather M., additional, Yam‐Puc, Juan Carlos, additional, Palmulli, Roberta, additional, Haigh, Tracey A., additional, Gerber, Pehuén Pereyra, additional, Lee, Jin S., additional, Matheson, Nicholas J., additional, Young, Lesley, additional, Trowsdale, John, additional, Lo, Mathew, additional, Taylor, Graham S., additional, Thaventhiran, James E., additional, and Edgar, James R., additional

Published
2024
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2. Tetherin antagonism by SARS‐CoV‐2 ORF3a and spike protein enhances virus release

Author

Stewart, Hazel, primary, Palmulli, Roberta, additional, Johansen, Kristoffer H, additional, McGovern, Naomi, additional, Shehata, Ola M, additional, Carnell, George W, additional, Jackson, Hannah K, additional, Lee, Jin S, additional, Brown, Jonathan C, additional, Burgoyne, Thomas, additional, Heeney, Jonathan L, additional, Okkenhaug, Klaus, additional, Firth, Andrew E, additional, Peden, Andrew A, additional, and Edgar, James R, additional

Published
2023
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3. Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

Author

Scagliotti, Giorgio Vittorio, primary, Parikh, Purvish, additional, von Pawel, Joachim, additional, Biesma, Bonne, additional, Vansteenkiste, Johan, additional, Manegold, Christian, additional, Serwatowski, Piotr, additional, Gatzemeier, Ulrich, additional, Digumarti, Raghunadharao, additional, Zukin, Mauro, additional, Lee, Jin S., additional, Mellemgaard, Anders, additional, Park, Keunchil, additional, Patil, Shehkar, additional, Rolski, Janusz, additional, Goksel, Tuncay, additional, de Marinis, Filippo, additional, Simms, Lorinda, additional, Sugarman, Katherine P., additional, and Gandara, David, additional

Published
2023
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4. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic.

Author

Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, and Edgar JR

Abstract

The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae . Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral particles, linking viruses to the surface of infected cells and inhibiting their release. We demonstrated that SARS-CoV-2 infection causes tetherin downregulation, and that tetherin depletion from cells enhances SARS-CoV-2 viral titres. We investigated the potential viral proteins involved in abrogating tetherin function and found that SARS-CoV-2 ORF3a reduces tetherin localisation within biosynthetic organelles via reduced retrograde recycling and increases tetherin localisation to late endocytic organelles. By removing tetherin from the Coronavirus budding compartments, ORF3a enhances virus release. We also found expression of Spike protein caused a reduction in cellular tetherin levels. Our results confirm that tetherin acts as a host restriction factor for SARS-CoV-2 and highlight the multiple distinct mechanisms by which SARS-CoV-2 subverts tetherin function., Competing Interests: Competing interests: no competing interests.

Published
2022
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