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Your search keyword '"Lee, S.M."' showing total 48 results
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48 results on '"Lee, S.M."'

4. Alpha backgrounds in NaI(Tl) crystals of COSINE-100

Author

Adhikari, G., Carlin, N., Cavalcante, D.F.F.S., Cho, J.Y., Choi, J.J., Choi, S., Ezeribe, A.C., França, L.E., Ha, C., Hahn, I.S., Hollick, S.J., Jeon, E.J., Joo, H.W., Kang, W.G., Kauer, M., Kim, B.H., Kim, H.J., Kim, J., Kim, K.W., Kim, S.H., Kim, S.K., Kim, S.W., Kim, W.K., Kim, Y.D., Kim, Y.H., Ko, Y.J., Lee, D.H., Lee, E.K., Lee, H., Lee, H.S., Lee, H.Y., Lee, I.S., Lee, J., Lee, J.Y., Lee, M.H., Lee, S.H., Lee, S.M., Lee, Y.J., Leonard, D.S., Luan, N.T., Manzato, B.B., Maruyama, R.H., Neal, R.J., Nikkel, J.A., Olsen, S.L., Park, B.J., Park, H.K., Park, H.S., Park, J.C., Park, K.S., Park, S.D., Pitta, R.L.C., Prihtiadi, H., Ra, S.J., Rott, C., Scarff, A., Shin, K.A., Son, M.K., Spooner, N.J.C., Truc, L.T., Yang, L., and Yu, G.H.

Published
2024
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19. Photobiomodulation of Gingival Cells Challenged with Viable Oral Microbes.

Author

Tanum, J., Kim, H.E., Lee, S.M., Kim, A., Korostoff, J., and Hwang, G.

Subjects
PEPTIDE antibiotics, GINGIVA, PHOTOBIOMODULATION therapy, REACTIVE oxygen species, NEAR infrared radiation, CELL survival, ANTIMICROBIAL peptides, ORAL microbiology
Abstract

The oral cavity, a unique ecosystem harboring diverse microorganisms, maintains health through a balanced microflora. Disruption may lead to disease, emphasizing the protective role of gingival epithelial cells (GECs) in preventing harm from pathogenic oral microbes. Shifting GECs' response from proinflammatory to antimicrobial could be a novel strategy for periodontitis. Photobiomodulation therapy (PBMT), a nonpharmacologic host modulatory approach, is considered an alternative to drugs. While the host cell response induced by a single type of pathogen-associated molecular patterns (PAMPs) was widely studied, this model does not address the cellular response to intact microbes that exhibit multiple PAMPs that might modulate the response. Inspired by this, we developed an in vitro model that simulates direct interactions between host cells and intact pathogens and evaluated the effect of PBMT on the response of human gingival keratinocytes (HGKs) to challenge viable oral microbes at both the cellular and molecular levels. Our data demonstrated that LED pretreatment on microbially challenged HGKs with specific continuous wavelengths (red: 615 nm; near-infrared: 880 nm) induced the production of various antimicrobial peptides, enhanced cell viability and proliferation, promoted reactive oxygen species scavenging, and down-modulated proinflammatory activity. The data also suggest a potential explanation regarding the superior efficacy of near-infrared light treatment compared with red light in enhancing antimicrobial activity and reducing cellular inflammation of HGKs. Taken together, the findings suggest that PBMT enhances the overall barrier function of gingival epithelium while minimizing inflammation-mediated breakdown of the underlying structures. [ABSTRACT FROM AUTHOR]

Published
2024
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20. EP11.02-06 Atezolizumab vs Single-Agent Chemo in NSCLC Patients Ineligible for a 1L Platinum Regimen: Asian Subgroup Analysis of IPSOS

Author

Lee, S.M., primary, Han, B., additional, Peters, S., additional, Le, A.T., additional, Huang, D., additional, Wu, G., additional, Cao, L., additional, Pham, C.P., additional, Zhao, J., additional, Wang, K., additional, Yang, N., additional, Zhong, H., additional, Hu, Y., additional, Morris, S., additional, Lam, V., additional, Graupner, V., additional, Gitlitz, B., additional, Hoglander, E., additional, and Schulz, C., additional

Published
2023
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21. Improving Cancer Care by Incorporating the Patient's Voice in Symptom Management (IMPROVE): A Multicenter-Prospective Pilot Study

Author

Voong, K.R., primary, Shokek, O.B., additional, Hill, C., additional, Hu, C., additional, Hales, R.K., additional, Greco, S.C., additional, Meyer, J.J., additional, Wright, J.L., additional, Lowe, K., additional, McNutt, T.R., additional, Narang, A., additional, PhD, C. Snyder, additional, and Lee, S.M., additional

Published
2023
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28. The evolution of lung cancer and impact of subclonal selection in TRACERx

Author

Frankell, A.M., Dietzen, M., Al Bakir, M., Lim, E.L., Karasaki, T., Ward, S., Veeriah, S., Colliver, E., Huebner, A., Bunkum, A., Hill, M.S., Grigoriadis, K., Moore, D.A., Black, J.R.M., Liu, W.K., Thol, K., Pich, O., Watkins, T.B.K., Naceur-Lombardelli, C., Cook, D.E., Salgado, R., Wilson, G.A., Bailey, C., Angelova, M., Bentham, R., Martínez-Ruiz, C., Abbosh, C., Nicholson, A.G., Le Quesne, J., Biswas, D., Rosenthal, R., Puttick, C., Hessey, S., Lee, C., Prymas, P., Toncheva, A., Smith, J., Xing, W., Nicod, J., Price, G., Kerr, K.M., Naidu, B., Middleton, G., Blyth, K.G., Fennell, D.A., Forster, M.D., Lee, S.M., Falzon, M., Hewish, M., Shackcloth, M.J., Lim, E., Benafif, S., Russell, P., Boleti, E., Krebs, M.G., Lester, J.F., Papadatos-Pastos, D., Ahmad, T., Thakrar, R.M., Lawrence, D., Navani, N., Janes, S.M., Dive, C., Blackhall, F.H, Summers, Y., Cave, J., Marafioti, T., Herrero, J., Quezada, S.A., Peggs, K.S., Schwarz, R.F., Van Loo, P., Miedema, D.M., Birkbak, N.J., Hiley, C.T., Hackshaw, A., Zaccaria, S., Jamal-Hanjani, M., McGranahan, N., and Swanton, C.

Subjects
Cancer Research
Abstract

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource.

Published
2023

33. LBA11 IPSOS: Results from a phase III study of first-line (1L) atezolizumab (atezo) vs single-agent chemotherapy (chemo) in patients (pts) with NSCLC not eligible for a platinum-containing regimen

Author

Lee, S.M., primary, Schulz, C., additional, Prabhash, K., additional, Han, B., additional, Szczesna, A., additional, Cortinovis, D.L., additional, Rittmeyer, A., additional, Baz, D. Vicente, additional, Califano, R., additional, Anh, L. Tuan, additional, Liu, G., additional, Cappuzzo, F., additional, Contreras, J.G. Reyes, additional, Reck, M., additional, Hu, Y., additional, Morris, S., additional, Hoeglander, E.K., additional, Connors, M., additional, Vollan, H.K.M., additional, and Peters, S., additional

Published
2022
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39. Accuracy Validation of Cough Counting AI Algorithm Using a Smartphone App in Patients with Asthma Exacerbation

Author

Lee, S.M., primary, Kim, B.-K., additional, Kim, M.-H., additional, Kim, S.-H., additional, Song, C., additional, Kwon, J.-W., additional, Shim, J.-S., additional, Kang, S.-Y., additional, Yang, M.-S., additional, Lee, S.-P., additional, Park, H.-K., additional, Ahn, K.M., additional, Park, H.-W., additional, Lee, A., additional, and Kim, J.-H., additional

Published
2022
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42. The environmental monitoring system at the COSINE-100 experiment

Author

Kim, H., additional, Adhikari, G., additional, Barbosa de Souza, E., additional, Carlin, N., additional, Choi, J.J., additional, Choi, S., additional, Djamal, M., additional, Ezeribe, A.C., additional, França, L.E., additional, Ha, C., additional, Hahn, I.S., additional, Jeon, E.J., additional, Jo, J.H., additional, Joo, H.W., additional, Kang, W.G., additional, Kauer, M., additional, Kim, H.J., additional, Kim, K.W., additional, Kim, S.H., additional, Kim, S.K., additional, Kim, W.K., additional, Kim, Y.D., additional, Kim, Y.H., additional, Ko, Y.J., additional, Lee, E.K., additional, Lee, H., additional, Lee, H.S., additional, Lee, H.Y., additional, Lee, I.S., additional, Lee, J., additional, Lee, J.Y., additional, Lee, M.H., additional, Lee, S.H., additional, Lee, S.M., additional, Leonard, D.S., additional, Manzato, B.B., additional, Maruyama, R.H., additional, Neal, R.J., additional, Olsen, S.L., additional, Park, B.J., additional, Park, H.K., additional, Park, H.S., additional, Park, K.S., additional, Pitta, R.L.C., additional, Prihtiadi, H., additional, Ra, S.J., additional, Rott, C., additional, Shin, K.A., additional, Scarff, A., additional, Spooner, N.J.C., additional, Thompson, W.G., additional, Yang, L., additional, and Yu, G.H., additional

Published
2022
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43. Long-term Outcomes of Liver Transplantation versus Resection for Hepatocellular Carcinoma: A Single-Center Experience

Author

Wang, S.Z., primary, Lee, S.M., additional, Lee, S.D., additional, Anderson, M., additional, Hatfield, B., additional, Khan, A., additional, Lee, H., additional, Matherly, S., additional, Bhati, C., additional, Sharma, A., additional, Bruno, D., additional, Kumaran, V., additional, Cotterell, A., additional, and Levy, M., additional

Published
2022
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44. Use of Angiotensin Converting Enzyme Inhibitors and Risk of Late Bladder Toxicity Following Radiotherapy for Prostate Cancer

Author

Kerns, S.L., primary, Morlang, A., additional, Lee, S.M., additional, Hall, W.A., additional, Peterson, D., additional, Marples, B., additional, Zhang, H., additional, Bylund, K.C., additional, Rosenzweig, D., additional, de Ruyck, K., additional, Rosenstein, B.S., additional, CaamaNo, A.Gomez, additional, Vega, A., additional, Parker, C., additional, West, C.M.L., additional, Janelsins, M., additional, Chen, Y., additional, Messing, E., additional, and Morrow, G., additional

Published
2021
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46. FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland.

Author

Lee, S.M., Lee, S.W., Kang, M., Choi, J.K., Park, K., Byun, J.S., and Kim, D.Y.

Subjects
AQUAPORINS, SALIVARY glands, FORKHEAD transcription factors, PROTEIN expression, SJOGREN'S syndrome
Abstract

Forkhead box O1 (FoxO1) is a multifunctional initiator, mediator, and repressor of autoimmune diseases in an organ- or disease-specific manner. However, the role of FoxO1 in the salivary gland has not yet been elucidated. In this study, we discovered that FoxO1 and aquaporin 5 (AQP5) are both significantly downregulated in the patients with primary Sjögren syndrome, an autoimmune disease accompanying salivary gland dysfunction. Pharmacologic or genetic perturbation of FoxO1 in the rat salivary gland acinar cell line, SMG-C6, induced a significant downregulation of AQP5 expression, as observed in clinical specimens. There was a strong correlation between FoxO1 and AQP5 expression because FoxO1 is a direct regulator of AQP5 expression in salivary gland acinar cells through its interaction with the promoter region of AQP5. Serial injection of a FoxO1 inhibitor into mice induced a reduction of AQP5 expression in submandibular glands and, consequently, hyposalivation, which is one of the major clinical symptoms of primary Sjögren syndrome. However, there was no sign of inflammation or cell damage in the submandibular glands harvested from mice treated with the FoxO1 inhibitor. In conclusion, our findings indicate that FoxO1 in salivary gland tissue acts as a direct regulator of AQP5 expression. Thus, downregulation of FoxO1 observed in primary Sjögren syndrome is a putative mechanism for hyposalivation without the involvement of previously reported soluble factors in primary Sjögren syndrome patient sera. [ABSTRACT FROM AUTHOR]

Published
2021
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