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267 results on '"Leemans, C. René"'

2. Parapharyngeal Space Tumour Excision

Author

Rijken, Johannes A., Palme, Carsten E., Leemans, C. René, Lumley, J. S. P., Series Editor, Howe, James R., Series Editor, Simo, Ricard, editor, Pracy, Paul, editor, and Fernandes, Rui, editor

Published
2024
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4. Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Author

Zeng, Peter YF, Cecchini, Matthew J, Barrett, John W, Shammas-Toma, Matthew, De Cecco, Loris, Serafini, Mara S, Cavalieri, Stefano, Licitra, Lisa, Hoebers, Frank, Brakenhoff, Ruud H, Leemans, C René, Scheckenbach, Kathrin, Poli, Tito, Wang, Xiaowei, Liu, Xinyi, Laxague, Francisco, Prisman, Eitan, Poh, Catherine, Bose, Pinaki, Dort, Joseph C, Shaikh, Mushfiq H, Ryan, Sarah EB, Dawson, Alice, Khan, Mohammed I, Howlett, Christopher J, Stecho, William, Plantinga, Paul, da Silva, Sabrina Daniela, Hier, Michael, Khan, Halema, MacNeil, Danielle, Mendez, Adrian, Yoo, John, Fung, Kevin, Lang, Pencilla, Winquist, Eric, Palma, David A, Ziai, Hedyeh, Amelio, Antonio L, Li, Shawn S-C, Boutros, Paul C, Mymryk, Joe S, and Nichols, Anthony C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Prevention, Infectious Diseases, Precision Medicine, Radiation Oncology, Digestive Diseases, Sexually Transmitted Infections, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Humans, Papillomavirus Infections, Retrospective Studies, Neoplasm Recurrence, Local, Oropharyngeal Neoplasms, Squamous Cell Carcinoma of Head and Neck, Prognosis, Biomarkers, Human Papillomavirus Viruses, Head and Neck Neoplasms, Papillomaviridae, Head and neck squamous cell carcinoma, Transcriptomics, Cancer immunology, HPV, De-escalation, Clinical Sciences, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundThere is significant interest in treatment de-escalation for human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15-30% of patients recur after primary treatment, reflecting a need for improved risk-stratification tools. We sought to develop a molecular test to risk stratify HPV+ OPSCC patients.MethodsWe created an immune score (UWO3) associated with survival outcomes in six independent cohorts comprising 906 patients, including blinded retrospective and prospective external validations. Two aggressive radiation de-escalation cohorts were used to assess the ability of UWO3 to identify patients who recur. Multivariate Cox models were used to assess the associations between the UWO3 immune class and outcomes.FindingsA three-gene immune score classified patients into three immune classes (immune rich, mixed, or immune desert) and was strongly associated with disease-free survival in six datasets, including large retrospective and prospective datasets. Pooled analysis demonstrated that the immune rich group had superior disease-free survival compared to the immune desert (HR = 9.0, 95% CI: 3.2-25.5, P = 3.6 × 10-5) and mixed (HR = 6.4, 95% CI: 2.2-18.7, P = 0.006) groups after adjusting for age, sex, smoking status, and AJCC8 clinical stage. Finally, UWO3 was able to identify patients from two small treatment de-escalation cohorts who remain disease-free after aggressive de-escalation to 30 Gy radiation.InterpretationWith additional prospective validation, the UWO3 score could enable biomarker-driven clinical decision-making for patients with HPV+ OPSCC based on robust outcome prediction across six independent cohorts. Prospective de-escalation and intensification clinical trials are currently being planned.FundingCIHR, European Union, and the NIH.

Published
2022

12. The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

Author

Verdonck-de Leeuw, Irma M., Korsten, Laura H.A., van Nieuwenhuizen, Annette, Baatenburg de Jong, Rob J., Brakenhoff, Ruud H., Buffart, Laurien M., Lamers, Femke, Langendijk, Johannes A., Leemans, C. René, Smit, Jan H., Sprangers, Mirjam A., Takes, Robert P., Terhaard, Chris H. J., Lissenberg-Witte, Birgit I., and Jansen, Femke

Published
2023
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18. Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

Author

Jansen, Femke, Brakenhoff, Ruud H., Baatenburg de Jong, Rob J., Langendijk, Johannes A., Leemans, C. René, Takes, Robert P., Terhaard, Chris H. J., Smit, Jan H., and Verdonck-de Leeuw, Irma M.

Published
2022
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31. Mental healthcare utilization among head and neck cancer patients: A longitudinal cohort study.

Author

Jansen, Femke, Lissenberg‐Witte, Birgit I., Hardillo, Jose A., Takes, Robert P., de Bree, Remco, Lamers, Femke, Langendijk, Johannes A., Leemans, C. René, and Verdonck‐de Leeuw, Irma M.

Subjects
HEAD & neck cancer, MENTAL health services, MEDICAL care use, SOCIAL anxiety, CANCER patients, GENERALIZED estimating equations, SENSATION seeking, COHORT analysis
Abstract

Objective: To investigate utilization of mental healthcare among head and neck cancer (HNC) patients from diagnosis to 2 years after treatment, in relation to psychological symptoms, mental disorders, need for mental healthcare, and sociodemographic, clinical and personal factors. Methods: Netherlands Quality of life and Biomedical Cohort study data as measured before treatment, at 3 and 6 months, and at 1 and 2 years after treatment was used (n = 610). Data on mental healthcare utilization (iMCQ), psychological symptoms (Hospital Anxiety and Depression Scale, Cancer Worry Scale), mental disorders (CIDI interview), need for mental healthcare (Supportive Care Needs Survey Short‐Form 34, either as continuous outcome indicating the level of need or dichotomized into unmet need (yes/no)) and several sociodemographic, clinical and personal factors were collected. Factors associated with mental healthcare utilization were investigated using generalized estimating equations (p < 0.05). Results: Of all HNC patients, 5%–9% used mental healthcare per timepoint. This was 4%–14% in patients with mild‐severe psychological symptoms, 4%–17% in patients with severe psychological symptoms, 15%–35% in patients with a mental disorder and 5%–16% in patients with an unmet need for mental healthcare. Among all patients, higher symptoms of anxiety, a higher need for mental healthcare, lower age, higher disease stage, lower self‐efficacy and higher social support seeking were significantly associated with mental healthcare utilization. Conclusion: Mental health care utilization among HNC patients is limited, and is related to psychological symptoms, need for mental healthcare, and sociodemographic, clinical and personal factors. [ABSTRACT FROM AUTHOR]

Published
2024
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32. MRI-based radiomic prognostic signature for locally advanced oral cavity squamous cell carcinoma:development, testing and comparison with genomic prognostic signatures

Author

Corti, Anna, De Cecco, Loris, Cavalieri, Stefano, Lenoci, Deborah, Pistore, Federico, Calareso, Giuseppina, Mattavelli, Davide, de Graaf, Pim, Leemans, C René, Brakenhoff, Ruud H, Ravanelli, Marco, Poli, Tito, Licitra, Lisa, Corino, Valentina, and Mainardi, Luca

Abstract

BACKGROUND: . At present, the prognostic prediction in advanced oral cavity squamous cell carcinoma (OCSCC) is based on the tumor-node-metastasis (TNM) staging system, and the most used imaging modality in these patients is magnetic resonance image (MRI). With the aim to improve the prediction, we developed an MRI-based radiomic signature as a prognostic marker for overall survival (OS) in OCSCC patients and compared it with published gene expression signatures for prognosis of OS in head and neck cancer patients, replicated herein on our OCSCC dataset.METHODS: For each patient, 1072 radiomic features were extracted from T1 and T2-weighted MRI (T1w and T2w). Features selection was performed, and an optimal set of five of them was used to fit a Cox proportional hazard regression model for OS. The radiomic signature was developed on a multi-centric locally advanced OCSCC retrospective dataset (n = 123) and validated on a prospective cohort (n = 108).RESULTS: The performance of the signature was evaluated in terms of C-index (0.68 (IQR 0.66-0.70)), hazard ratio (HR 2.64 (95% CI 1.62-4.31)), and high/low risk group stratification (log-rank p CONCLUSIONS: Overall, the present study suggests that MRI signatures, containing non-invasive and cost-effective remarkable information, could be exploited as prognostic tools.

Published
2023

33. Critical Issues in Head and Neck Oncology

Author

Vermorken, Jan B., Budach, Volker, Leemans, C. René, Machiels, Jean-Pascal, Nicolai, Piero, and O'Sullivan, Brian

Subjects
Head and Neck Cancer, Predictive markers, Non-orophayngeal head and neck cancer, Induction chemotherapy, Radiation Oncology, Surgical Oncology, Liquid biopsies, Precision medicine, HNSCC, Nasopharynx cancer, Immunotherapy, Personalized Medicine, thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology, thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKS Medical imaging::MKSH Medical imaging: radiology
Abstract

This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Published
2023
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42. Legends to supplementary figures from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics

Author

Martens-de Kemp, Sanne R., primary, Brink, Arjen, primary, van der Meulen, Ida H., primary, de Menezes, Renée X., primary, te Beest, Dennis E., primary, Leemans, C. René, primary, van Beusechem, Victor W., primary, Braakhuis, Boudewijn J.M., primary, and Brakenhoff, Ruud H., primary

Published
2023
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47. Data from Drug Sensitivity Prediction Models Reveal a Link between DNA Repair Defects and Poor Prognosis in HNSCC

Author

Essers, Paul B.M., primary, van der Heijden, Martijn, primary, Verhagen, Caroline V.M., primary, Ploeg, Emily M., primary, de Roest, Reinout H., primary, Leemans, C. René, primary, Brakenhoff, Ruud H., primary, van den Brekel, Michiel W.M., primary, Bartelink, Harry, primary, Verheij, Marcel, primary, and Vens, Conchita, primary

Published
2023
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48. Supplementary Data from Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas

Author

Schaaij-Visser, Tieneke B.M., primary, Graveland, A. Peggy, primary, Gauci, Sharon, primary, Braakhuis, Boudewijn J.M., primary, Buijze, Marijke, primary, Heck, Albert J.R., primary, Kuik, Dirk J., primary, Bloemena, Elisabeth, primary, Leemans, C. René, primary, Slijper, Monique, primary, and Brakenhoff, Ruud H., primary

Published
2023
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