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Your search keyword '"Lefèvre, Philippe"' showing total 40 results
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40 results on '"Lefèvre, Philippe"'

20. Multicenter Performance Evaluation of the Revogene® GBS DS Real-Time PCR Assay for Group B Streptococcus Detection During Labor.

Author

d'Otreppe, Stéphanie, Lefèvre, Philippe, Meex, Cécile, Devey, Anaïs, Sacheli, Rosalie, Gerard, Martin, and Melin, Pierrette

Subjects
*STREPTOCOCCUS agalactiae, *LABOR (Obstetrics), *WOMEN'S hospitals, *BIRTHING centers
Abstract

Purpose: This study aimed to evaluate the performance and ease of use of the Revogene® GBS DS PCR assay for the intrapartum detection of Group B Streptococcus (GBS) colonization, as compared with intrapartum culture and antenatal culture-based screening. Methods: Between April and August 2019, 398 women who gave birth in one of the three maternities participating in this study agreed to the collection of a vaginal swab when they arrived in the labor ward. The samples were immediately sent to the adjacent laboratory where they were discharged into the buffer provided with the Revogene® GBS DS assay. Part of the buffer was used to perform the Revogene® GBS DS test, and part of the same buffer was used for GBS culture. Results: The Revogene® GBS DS assay provided a valid result in less than 70 min for 356 (89%) women. The sensitivity of the test was 85.7% (66.4–95.3%). The specificity of the test was 99.1% (97.3–99.8%). The positive predictive value was 88.9% (69.7–97.1%). The negative predictive value was 98.9% (96.9–99.6%). Conclusion: The easy-to-use Revogene® GBS DS assay provides a valuable tool for the detection of GBS colonization at the beginning of labor. The sensitivity and turn-around time are adequate. The high number of invalid results needs to be addressed before the Revogene® GBS DS test can be expected to replace the current screening-based approach. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Transcranial focused ultrasonic stimulation to modulate cortical activity in humans : development and application

Author

Lambert, Julien, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - Faculté de pharmacie et des sciences biomédicales, Mouraux, André, Craeye, Christophe, Missal, Marcus, Lefèvre, Philippe, Zenon, Alexandre, Andrès, Michael, Yoo, Seung-Schik, and Bourguignon, Mathieu

Subjects
Neuromodulation, Transcranial focused ultrasound stimulation, Somatosensory, Noninvasive brain stimulation
Abstract

The aim of my project was to develop and apply focused ultrasound stimulation (FUS) to study the human brain. Recently, TFUS was proposed as an advantageous alternative technique for non-invasive modulation of human brain activity. Compared to transcranial magnetic stimulation and transcranial direct current stimulation, the two most-used techniques for neuromodulation, TFUS is more focal and allow to target deeper brain structures with a reduced effect on surrounding cortical tissue. I first determined the sonication parameters to use according to international safety guidelines. Then, I used the prototype I designed to characterize the effects of TFUS sonication over the primary somatosensory cortex using somatosensory-evoked potentials elicited by transcutaneous electrical stimulation of the median nerve (MN). We report the successful modulation of early SEPs potentials (N20 and P27) for TFUS applied 200ms before the delivery of MN stimulation. (BIFA - Sciences biomédicales et pharmaceutiques) -- UCL, 2023

Published
2023

40. Multicenter Performance Evaluation of the Revogene ® GBS DS Real-Time PCR Assay for Group B Streptococcus Detection During Labor.

Author

d'Otreppe S, Lefèvre P, Meex C, Devey A, Sacheli R, Gerard M, and Melin P

Subjects
Pregnancy, Female, Humans, Male, Real-Time Polymerase Chain Reaction, Prenatal Diagnosis methods, Predictive Value of Tests, Streptococcus agalactiae genetics, Sensitivity and Specificity, Pregnancy Complications, Infectious diagnosis, Streptococcal Infections diagnosis
Abstract

Purpose: This study aimed to evaluate the performance and ease of use of the Revogene ® GBS DS PCR assay for the intrapartum detection of Group B Streptococcus (GBS) colonization, as compared with intrapartum culture and antenatal culture-based screening., Methods: Between April and August 2019, 398 women who gave birth in one of the three maternities participating in this study agreed to the collection of a vaginal swab when they arrived in the labor ward. The samples were immediately sent to the adjacent laboratory where they were discharged into the buffer provided with the Revogene ® GBS DS assay. Part of the buffer was used to perform the Revogene ® GBS DS test, and part of the same buffer was used for GBS culture., Results: The Revogene ® GBS DS assay provided a valid result in less than 70 min for 356 (89%) women. The sensitivity of the test was 85.7% (66.4-95.3%). The specificity of the test was 99.1% (97.3-99.8%). The positive predictive value was 88.9% (69.7-97.1%). The negative predictive value was 98.9% (96.9-99.6%)., Conclusion: The easy-to-use Revogene ® GBS DS assay provides a valuable tool for the detection of GBS colonization at the beginning of labor. The sensitivity and turn-around time are adequate. The high number of invalid results needs to be addressed before the Revogene ® GBS DS test can be expected to replace the current screening-based approach., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Published
2023
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