Search

Your search keyword '"Lewis, Peter L"' showing total 19 results
Start Over Author "Lewis, Peter L" Publication Year Range Last 3 years
19 results on '"Lewis, Peter L"'

4. Barriers and enablers to the implementation and sustainability of short‐stay arthroplasty programs for elective primary total hip and knee replacement: A systematic review with qualitative evidence synthesis

Author

Berkovic, Danielle, primary, Vallance, Patrick, additional, Harris, Ian A., additional, Naylor, Justine M., additional, Lewis, Peter L., additional, de Steiger, Richard, additional, Buchbinder, Rachelle, additional, Ademi, Zanfina, additional, and Ackerman, Ilana N., additional

Published
2024
Full Text
View/download PDF

12. Dual mobility versus conventional total hip arthroplasty in femoral neck fractures (DISTINCT): protocol for a registry-nested, open-label, cluster-randomised crossover trial

Author

Farey, John E, primary, Hooper, Tamara, additional, Alland, Tania, additional, Naylor, Justine M, additional, Kelly, Thu-Lan, additional, Lorimer, Michelle, additional, Lewin, Adriane M, additional, Rogers, Margaret, additional, Law, Chi Kin, additional, Close, Jacqueline, additional, Graves, Steven E, additional, de Steiger, Richard S, additional, Lewis, Peter L, additional, Adie, Sam, additional, and Harris, Ian A, additional

Published
2022
Full Text
View/download PDF

18. Dual mobility versus conventional total hip arthroplasty in femoral neck fractures (DISTINCT): protocol for a registry-nested, open-label, cluster-randomised crossover trial

Author

John E Farey, Tamara Hooper, Tania Alland, Justine M Naylor, Thu-Lan Kelly, Michelle Lorimer, Adriane M Lewin, Margaret Rogers, Chi Kin Law, Jacqueline Close, Steven E Graves, Richard S de Steiger, Peter L Lewis, Sam Adie, Ian A Harris, Farey, John E, Hooper, Tamara, Alland, Tania, Naylor, Justine M, Kelly, Thu-Lan, Lorimer, Michelle, Lewin, Adriane M, Rogers, Margaret, Law, Chi Kin, Close, Jacqueline, Graves, Steven E, de Steiger, Richard S, Lewis, Peter L, Adie, Sam, and Harris, Ian A

Subjects
Adult, Reoperation, Cross-Over Studies, hip, Hip Fractures, geriatric medicine, Arthroplasty, Replacement, Hip, anaesthesia in orthopaedics, Australia, General Medicine, Middle Aged, adult orthopaedics, Prosthesis Design, Femoral Neck Fractures, Prosthesis Failure, trauma management, Humans, Hip Prosthesis, Registries, Randomized Controlled Trials as Topic
Abstract

IntroductionHip fractures treated with total hip arthroplasty (THA) are at high risk of prosthesis instability, and dislocation is the most common indication for revision surgery. This study aims to determine whether dual mobility THA implants reduce the risk of dislocation compared with conventional THA in patients with hip fracture suitable to be treated with THA.Methods and analysisThis is a cluster-randomised, crossover, open-label trial nested within the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). The clusters will comprise hospitals that perform at least 12 THAs for hip fracture per annum. All adults age ≥50 years who meet the Australian and New Zealand Hip Fracture Registry guidelines for THA will be included. The intervention will be dual mobility THA and the comparator will be conventional THA. Each hospital will be allocated to two consecutive periods, one of dual mobility THA and the other of conventional THA in random order, aiming for an average of 16 patients eligible for the primary analysis per group (32 total per site), allowing different recruitment totals between sites. Data will be collected through the AOANJRR and linked with patient-level discharge data acquired through government agencies. The primary outcome is dislocation within 1 year. Secondary outcomes include revision surgery for dislocation and all-cause, complications and mortality at 1, 2 and 5 years. If dual mobility THA is found to be superior, a cost-effectiveness analysis will be conducted. The study will aim to recruit 1536 patients from at least 48 hospitals over 3 years.Ethics and disseminationEthics approval has been granted (Sydney Local Health District - Royal Prince Alfred Hospital Zone (approval X20-0162 and 2020/ETH00680) and site-specific approvals). Participant recruitment is via an opt-out consent process as both treatments are considered accepted, standard practice. The trial is endorsed by the Australia and New Zealand Musculoskeletal Clinical Trials Network.Trial registration numberACTRN12621000069853.

Published
2022

19. Effect of Aspirin vs Enoxaparin on 90-Day Mortality in Patients Undergoing Hip or Knee Arthroplasty: A Secondary Analysis of the CRISTAL Cluster Randomized Trial.

Author

Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, Adie S, Cashman K, Ackerman IN, Bastiras D, Brighton R, Burns AWR, Chong BH, Clavisi O, Cripps M, Dekkers M, de Steiger R, Dixon M, Ellis A, Griffith EC, Hale D, Hansen A, Harris A, Hau R, Horsley M, James D, Khorshid O, Kuo L, Lewis PL, Lieu D, Lorimer M, MacDessi SJ, McCombe P, McDougall C, Mulford J, Naylor JM, Page RS, Radovanovic J, Solomon M, Sorial R, Summersell P, Tran P, Walter WL, Webb S, Wilson C, Wysocki D, and Harris IA

Subjects
Adult, Humans, Female, Adolescent, Aged, Male, Enoxaparin therapeutic use, Enoxaparin adverse effects, Aspirin therapeutic use, Venous Thromboembolism drug therapy, Arthroplasty, Replacement, Knee adverse effects, Arthroplasty, Replacement, Hip adverse effects
Abstract

Importance: Ischemic heart disease remains the leading cause of mortality following hip and knee arthroplasty. Due to its antiplatelet and cardioprotective properties, aspirin has been proposed as an agent that could reduce mortality when used as venous thromboembolism (VTE) prophylaxis following these procedures., Objective: To compare aspirin with enoxaparin in reducing 90-day mortality for patients undergoing hip or knee arthroplasty procedures., Design, Setting, and Participants: This study was a planned secondary analysis of the CRISTAL cluster randomized, crossover, registry-nested trial performed across 31 participating hospitals in Australia between April 20, 2019, and December 18, 2020. The aim of the CRISTAL trial was to determine whether aspirin was noninferior to enoxaparin in preventing symptomatic VTE following hip or knee arthroplasty. The primary study restricted the analysis to patients undergoing total hip or knee arthroplasty for a diagnosis of osteoarthritis only. This study includes all adult patients (aged ≥18 years) undergoing any hip or knee arthroplasty procedure at participating sites during the course of the trial. Data were analyzed from June 1 to September 6, 2021., Interventions: Hospitals were randomized to administer all patients oral aspirin (100 mg daily) or subcutaneous enoxaparin (40 mg daily) for 35 days after hip arthroplasty and 14 days after knee arthroplasty procedures., Main Outcomes and Measures: The primary outcome was mortality within 90 days. The between-group difference in mortality was estimated using cluster summary methods., Results: A total of 23 458 patients from 31 hospitals were included, with 14 156 patients allocated to aspirin (median [IQR] age, 69 [62-77] years; 7984 [56.4%] female) and 9302 patients allocated to enoxaparin (median [IQR] age, 70 [62-77] years; 5277 [56.7%] female). The mortality rate within 90 days of surgery was 1.67% in the aspirin group and 1.53% in the enoxaparin group (estimated difference, 0.04%; 95% CI, -0.05%-0.42%). For the subgroup of 21 148 patients with a nonfracture diagnosis, the mortality rate was 0.49% in the aspirin group and 0.41% in the enoxaparin group (estimated difference, 0.05%; 95% CI, -0.67% to 0.76%)., Conclusions and Relevance: In this secondary analysis of a cluster randomized trial comparing aspirin with enoxaparin following hip or knee arthroplasty, there was no significant between-group difference in mortality within 90 days when either drug was used for VTE prophylaxis., Trial Registration: http://anzctr.org.au Identifier: ACTRN12618001879257.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results