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2. Atmospheric retrievals suggest the presence of a secondary atmosphere and possible sulfur species on L 98-59 d from JWST NIRSpec G395H transmission spectroscopy

Author

Banerjee, Agnibha, Barstow, Joanna K., Gressier, Amélie, Espinoza, Néstor, Sing, David K., Allen, Natalie H., Birkmann, Stephan M., Challener, Ryan C., Crouzet, Nicolas, Haswell, Carole A., Lewis, Nikole K., Lewis, Stephen R., and Yang, Jingxuan

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

L 98-59 d is a Super-Earth planet orbiting an M-type star. We performed retrievals on the transmission spectrum of L 98-59 d obtained using NIRSpec G395H during a single transit, from JWST Cycle 1 GTO 1224. The wavelength range of this spectrum allows us to detect the presence of several atmospheric species. We found that the spectrum is consistent with a high mean molecular weight atmosphere. The atmospheric spectrum indicates the possible presence of the sulfur-bearing species H$_2$S and SO$_2$, which could hint at active volcanism on this planet if verified by future observations. We also tested for signs of stellar contamination in the spectrum, and found signs of unocculted faculae on the star. The tentative signs of an atmosphere on L 98-59 d presented in this work from just one transit bodes well for possible molecular detections in the future, particularly as it is one of the best targets among small exoplanets for atmospheric characterization using JWST., Comment: Accepted for publication to ApJL

Published
2024
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3. Spinal cord injury in high-risk complex adult spinal deformity surgery: review of incidence and outcomes from the Scoli-RISK-1 study.

Author

Jiang, Fan, Joshi, Hetshree, Badhiwala, Jetan, Wilson, Jamie, Lenke, Lawrence, Shaffrey, Christopher, Cheung, Kenneth, Carreon, Leah, Dekutoski, Mark, Schwab, Frank, Boachie-Adjei, Oheneba, Kebaish, Khaled, Ames, Christopher, Berven, Sigurd, Qiu, Yong, Matsuyama, Yukihiro, Dahl, Benny, Mehdian, Hossein, Pellisé, Ferran, Lewis, Stephen, and Fehlings, Michael

Subjects
Humans, Spinal Cord Injuries, Male, Female, Middle Aged, Adult, Incidence, Postoperative Complications, Aged, Treatment Outcome, Cohort Studies, Prospective Studies
Abstract

STUDY DESIGN: Clinical case series. OBJECTIVE: To describe the cause, treatment and outcome of 6 cases of perioperative spinal cord injury (SCI) in high-risk adult deformity surgery. SETTING: Adult spinal deformity patients were enrolled in the multi-center Scoli-RISK-1 cohort study. METHODS: A total of 272 patients who underwent complex adult deformity surgery were enrolled in the prospective, multi-center Scoli-RISK-1 cohort study. Clinical follow up data were available up to a maximum of 2 years after index surgery. Cases of perioperative SCI were identified and an extensive case review was performed. RESULTS: Six individuals with SCI were identified from the Scoli-RISK-1 database (2.2%). Two cases occurred intraoperatively and four cases occurred postoperatively. The first case was an incomplete SCI due to a direct intraoperative insult and was treated postoperatively with Riluzole. The second SCI case was caused by a compression injury due to overcorrection of the deformity. Three cases of incomplete SCI occurred; one case of postoperative hematoma, one case of proximal junctional kyphosis (PJK) and one case of adjacent segment disc herniation. All cases of post-operative incomplete SCI were managed with revision decompression and resulted in excellent clinical recovery. One case of incomplete SCI resulted from infection and PJK. The patients treatment was complicated by a delay in revision and the patient suffered persistent neurological deficits up to six weeks following the onset of SCI. CONCLUSION: Despite the low incidence in high-risk adult deformity surgeries, perioperative SCI can result in devastating consequences. Thus, appropriate postoperative care, follow up and timely management of SCI are essential.

Published
2024

5. Intraoperative fluid management in adult spinal deformity surgery: variation analysis and association with outcomes

Author

Cetik, Riza M., Gum, Jeffrey L., Lafage, Renaud, Smith, Justin S., Bess, Shay, Mullin, Jeffrey P., Kelly, Michael P., Diebo, Bassel G., Buell, Thomas J., Scheer, Justin K., Line, Breton G., Lafage, Virginie, Klineberg, Eric O., Kim, Han Jo, Passias, Peter G., Kebaish, Khaled M., Eastlack, Robert K., Daniels, Alan H., Soroceanu, Alex, Mundis, Gregory M., Hostin, Richard A., Protopsaltis, Themistocles S., Hamilton, D. Kojo, Hart, Robert A., Gupta, Munish C., Lewis, Stephen J., Schwab, Frank J., Lenke, Lawrence G., Shaffrey, Christopher I., Ames, Christopher P., and Burton, Douglas C.

Published
2024
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6. Contemporary utilization of three-column osteotomy techniques in a prospective complex spinal deformity multicenter database: implications on full-body alignment and perioperative course

Author

Williamson, Tyler K., Mir, Jamshaid M., Smith, Justin S., Lafage, Virginie, Lafage, Renaud, Line, Breton, Diebo, Bassel G., Daniels, Alan H., Gum, Jeffrey L., Hamilton, D. Kojo, Scheer, Justin K., Eastlack, Robert, Demetriades, Andreas K., Kebaish, Khaled M., Lewis, Stephen, Lenke, Lawrence G., Hostin Jr, Richard A., Gupta, Munish C., Kim, Han Jo, Ames, Christopher P., Burton, Douglas C., Shaffrey, Christopher I., Klineberg, Eric O., Bess, Shay, and Passias, Peter G.

Published
2024
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9. Activity and sports resumption after long segment fusions to the pelvis for adult spinal deformity: survey results of AO Spine members.

Author

Theologis, Alekos, Cummins, Daniel, Kato, So, Lewis, Stephen, Shaffrey, Christopher, Lenke, Lawrence, and Berven, Sigurd

Subjects
AO Spine, Adult spinal deformity, Pelvic fixation, Return to sports, Survey
Abstract

PURPOSE: To assess recommendations for when adult spinal deformity (ASD) patients may return to athletic activities after surgery. METHODS: A web-based survey was administered to members of AO Spine. The survey consisted of surgeon demographic information and questions asking when a patient undergoing a long thoracolumbar fusion (> 5 levels) with pelvic fixation for ASD would be allowed to resume unrestricted range of motion (ROM), non-contact sports, and contact sports postoperatively. Ordinal logistic regression was used to determine predictors for time to resume each activity. RESULTS: One hundred twenty four members responses were included for analysis. The majority of respondents would allow unrestricted ROM within 3 months postop ( 3 months: 19%]. For when to return to non-contact sports, the most common responses were 2-3 months (26.6%), 3-4 months (26.6%), and 6-12 months (18.5%). For when to return to contact sports, the majority advised > 4 months postop [> 4 months: 4-6 months (19.2%), 6-12 months (28.0%),  > 12 months (28.8%) versus

Published
2023

10. Effect of Centrifugal Force on Transmission Spectroscopy of Exoplanet Atmospheres

Author

Banerjee, Agnibha, Barstow, Joanna K., Haswell, Carole A., and Lewis, Stephen R.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Transmission spectroscopy is one of the most successful methods of learning about exoplanet atmospheres. The process of retrievals using transmission spectroscopy consists of creating numerous forward models and comparing them to observations to solve the inverse problem of constraining the atmospheric properties of exoplanets. We explore the impact of one simplifying assumption commonly employed by forward models of transiting exoplanets: namely that the planet can be treated as an isolated, non-rotating spherical body. The centrifugal acceleration due to a planet's rotation opposes the gravitational pull on a planet's atmosphere and increases its scale height. Conventional forward models used for retrievals generally do not include this effect. We find that atmospheric retrievals produce significantly different results for close-in planets with low gravity when this assumption is removed, e.g., differences between true and retrieved values of gas abundances greater than 1$\sigma$ for a simulated planet analogous to WASP-19 b. We recommend that the correction to the atmospheric scale height due to this effect be taken into account for the analysis of high precision transmission spectra of exoplanets in the future, most immediately JWST Cycle 1 targets WASP-19 b and WASP-121 b., Comment: 5 pages, 4 figures, accepted for publication in MNRAS Letters

Published
2023
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18. Patient-Reported Outcomes After Complex Adult Spinal Deformity Surgery: 5-Year Results of the Scoli-Risk-1 Study

Author

Zuckerman, Scott L, Cerpa, Meghan, Lenke, Lawrence G, Shaffrey, Christopher I, Carreon, Leah Y, Cheung, Kenneth MC, Kelly, Michael P, Fehlings, Michael G, Ames, Christopher P, Boachie-Adjei, Oheneba, Dekutoski, Mark B, Kabeaish, Khaled M, Lewis, Stephen J, Matsuyama, Yukihiro, Pellisé, Ferran, Qiu, Yong, Schwab, Frank J, Smith, Justin S, and Group, AO Spine Knowledge Forum Deformity and SRS Scoli-RISK-1 Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Brain Disorders, Good Health and Well Being, adult spinal deformity, patient reported outcomes, deformity, spinal deformity surgery, adult idiopathic scoliosis, AO Spine Knowledge Forum Deformity and SRS Scoli-RISK-1 Study Group, Clinical sciences
Abstract

Study designProspective cohort.ObjectiveTo prospectively evaluate PROs up to 5-years after complex ASD surgery.MethodsThe Scoli-RISK-1 study enrolled 272 ASD patients undergoing surgery from 15 centers. Inclusion criteria was Cobb angle of >80°, corrective osteotomy for congenital or revision deformity, and/or 3-column osteotomy. The following PROs were measured prospectively at intervals up to 5-years postoperative: ODI, SF36-PCS/MCS, SRS-22, NRS back/leg. Among patients with 5-year follow-up, comparisons were made from both baseline and 2-years postoperative to 5-years postoperative. PROs were analyzed using mixed models for repeated measures.ResultsSeventy-seven patients (28.3%) had 5-year follow-up data. Comparing baseline to 5-year data among these 77 patients, significant improvement was seen in all PROs: ODI (45.2 vs. 29.3, P < 0.001), SF36-PCS (31.5 vs. 38.8, P < 0.001), SF36-MCS (44.9 vs. 49.1, P = 0.009), SRS-22-total (2.78 vs. 3.61, P < 0.001), NRS-back pain (5.70 vs. 2.95, P < 0.001) and NRS leg pain (3.64 vs. 2.62, P = 0.017). In the 2 to 5-year follow-up period, no significant changes were seen in any PROs. The percentage of patients achieving MCID from baseline to 5-years were: ODI (62.0%) and the SRS-22r domains of function (70.4%), pain (63.0%), mental health (37.5%), self-image (60.3%), and total (60.3%). Surprisingly, mean values (P > 0.05) and proportion achieving MCID did not differ significantly in patients with major surgery-related complications compared to those without.ConclusionsAfter complex ASD surgery, significant improvement in PROs were seen at 5-years postoperative in ODI, SF36-PCS/MCS, SRS-22r, and NRS-back/leg pain. No significant changes in PROs occurred during the 2 to 5-year postoperative period. Those with major surgery-related complications had similar PROs and proportion of patients achieving MCID as those without these complications.

Published
2022

20. Restoring L4-S1 Lordosis Shape in Severe Sagittal Deformity: Impact of Correction Techniques on Alignment and Complication Profile

Author

Singh, Manjot, Balmaceno-Criss, Mariah, Daher, Mohammad, Lafage, Renaud, Hamilton, D. Kojo, Smith, Justin S., Eastlack, Robert K., Fessler, Richard G., Gum, Jeffrey L., Gupta, Munish C., Hostin, Richard, Kebaish, Khaled M., Klineberg, Eric O., Lewis, Stephen J., Line, Breton G., Nunley, Pierce D., Mundis, Gregory M., Passias, Peter G., Protopsaltis, Themistocles S., Buell, Thomas, Ames, Christopher P., Mullin, Jeffrey P., Soroceanu, Alex, Scheer, Justin K., Lenke, Lawrence G., Bess, Shay, Shaffrey, Christopher I., Schwab, Frank J., Lafage, Virginie, Burton, Douglas C., Diebo, Bassel G., and Daniels, Alan H.

Published
2024
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22. Impact of Hip and Knee Osteoarthritis on Full Body Sagittal Alignment and Compensation for Sagittal Spinal Deformity

Author

Balmaceno-Criss, Mariah, Lafage, Renaud, Alsoof, Daniel, Daher, Mohammad, Hamilton, David Kojo, Smith, Justin S., Eastlack, Robert K., Fessler, Richard G., Gum, Jeffrey L., Gupta, Munish C., Hostin, Richard, Kebaish, Khaled M., Klineberg, Eric O., Lewis, Stephen J., Line, Breton G., Nunley, Pierce D., Mundis, Gregory M., Passias, Peter G., Protopsaltis, Themistocles S., Buell, Thomas, Scheer, Justin K., Mullin, Jeffrey P., Soroceanu, Alex, Ames, Christopher P., Lenke, Lawrence G., Bess, Shay, Shaffrey, Christopher I., Schwab, Frank J., Lafage, Virginie, Burton, Douglas C., Diebo, Bassel G., and Daniels, Alan H.

Published
2024
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23. Educational Stakeholders' Attitudes and Knowledge about Nonsuicidal Self-Injury among University Students: A Cross-National Study

Author

Hamza, Chloe A., Robinson, Kealagh, Hasking, Penny A., Heath, Nancy L., Lewis, Stephen P., Lloyd-Richardson, Elizabeth, Whitlock, Janis, and Wilson, Marc S.

Abstract

Objective: Nonsuicidal self-injury (NSSI) is a commonly occurring, yet historically poorly understood, mental health concern among post-secondary students. The present study sought to identify the current knowledge needs of university stakeholders to inform training efforts around effective NSSI response and student support on university campuses. Participants: Participants were 1,762 university students, staff, and student-staff (77% female) from seven universities in Canada, the USA, New Zealand, and Australia. Methods: Methods: Participants completed an online survey about their attitudes and knowledge of both general mental health and NSSI. Results: University stakeholders reported significantly greater stigma toward NSSI than mental illness in general. Student-staff reported greater perceived knowledge and comfort, and demonstrated greater knowledge of NSSI, than students and staff. Conclusions: Findings underscore the need for additional training and resources to reduce stigma and increase knowledge about NSSI on university campuses internationally.

Published
2023
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24. Early Aboriginal pottery production and offshore island occupation on Jiigurru (Lizard Island group), Great Barrier Reef, Australia

Author

Ulm, Sean, McNiven, Ian J., Summerhayes, Glenn R., Wu, Pei-hua, Bunbury, Magdalena M.E., Petchey, Fiona, Hua, Quan, Skelly, Robert, Lambrides, Ariana B.J., Rowe, Cassandra, Lowe, Kelsey M., Reepmeyer, Christian H., Maclaurin, Cailey, Woo, Katherine G.P., Harris, Matthew, Morgan, Sarah B., Turner-Kose, Kayla L., Slater, Sarah A., Connelly, Joshua D., Kneppers, Michael C., Szabó, Katherine, Fairbairn, Andrew, Haberle, Simon G., Hopf, Felicitas, Bultitude, Robert, Ash, Jeremy, Lewis, Stephen E., Beaman, Robin J., Leon, Javier Xavier, McDowell, Matthew C., Potter, Martin, Connelly, Benjamin, Little, Chris, Jackson, Scott, McCarthy, John, Nothdurft, Luke D., Zhao, Jian-xin, Bird, Michael I., Felgate, Matthew W., and Cobus, Brian

Published
2024
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25. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton VJ, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Kennedy, Nicholas A, Goodhand, James R, Lin, Simeng, Chanchlani, Neil, Nice, Rachel, McDonald, Timothy J, Bewshea, Claire, Al-Nuaimi, Yusur, Richards, Ellen, Haigh, Richard, Greenish, Huw, Heath, Harry, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul JR, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, JR Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Hamilton, Benjamin, Thomas, Amanda, Smith, Rebecca, Roberts, Christopher, Bishara, Maria, and Lees, Charlie W

Published
2024
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35. Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Author

Aitken, Madison, Ameis, Stephanie H., Andrade, Brendan F., Battaglia, Marco, Boileau, Isabelle, Cleverley, Kristin, Courtney, Darren B., Diaconescu, Andreea O., Dickie, Erin W., Felsky, Daniel, Foussias, George, Goldstein, Benjamin I., Gonçalves, Vanessa, Hamilton, Hayley, Griffiths, John D., Haltigan, John D., Hawke, Lisa D., Hill, Sean, Husain, Muhammad Omair, Jani, Melanie, Kidd, Sean A., Kozloff, Nicole, Kurdyak, Paul, Lai, Meng-Chuan, Lewis, Stephen P., Levitan, Robert D., Lin, Hsiang-Yuan, Lunsky, Yona, Mohan, Akshay, Nikolova, Yuliya S., Osman, Sam, Pascoe, Shannon, Polillo, Alexia, Putterman, Connie, Rotenberg, Martin, Quilty, Lena C., Sivakumar, Harijah, Szatmari, Peter, Tempelaar, Wanda, Vasdev, Neil, Wang, Wei, Wheeler, Anne L., van der Miesen, Anna I.R., Vieira, Erica L., Voineskos, Aristotle N., Husain, Muhammad O., Rubin-Kahana, Dafna S., Iftikhar, Myera, MacIntosh, Bradley J., Vieira, Erica, Ahmadzadeh, Ghazaleh, Heyland, Lindsay, Ogunsanya, Feyi, Oliver, Lindsay D., Zhu, Cherrie, Wong, Jimmy K.Y., Charlton, Colleen, Truong, Jennifer, Yu, Lujia, and Kelly, Rachel

Published
2024
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36. Cognition and Educational Achievement in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Author

Aitken, Madison, Ameis, Stephanie H., Andrade, Brendan F., Battaglia, Marco, Boileau, Isabelle, Cleverley, Kristin, Courtney, Darren B., Diaconescu, Andreea O., Dickie, Erin W., Felsky, Daniel, Foussias, George, Goldstein, Benjamin I., Gonçalves, Vanessa, Griffiths, John D., Haltigan, John D., Hamilton, Hayley, Hawke, Lisa D., Hill, Sean, Husain, Muhammad Omair, Jani, Melanie, Kidd, Sean A., Kozloff, Nicole, Kurdyak, Paul, Lai, Meng-Chuan, Lewis, Stephen P., Levitan, Robert D., Lin, Hsiang-Yuan, Lunsky, Yona, Mohan, Akshay, Nikolova, Yuliya S., Osman, Sam, Pascoe, Shannon, Polillo, Alexia, Putterman, Connie, Rotenberg, Martin, Rubin-Kahana, Dafna Sara, Quilty, Lena C., Sivakumar, Harijah, Szatmari, Peter, Tempelaar, Wanda, Vasdev, Neil, Wang, Wei, Wheeler, Anne L., van der Miesen, Anna I.R., Vieira, Erica L., Voineskos, Aristotle N., Chen, Sheng, Wong, Jimmy K.Y., Lau, Chloe, Sedrak, Andrew B., and Kelly, Rachel

Published
2024
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37. The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality

Author

Aitken, Madison, Ameis, Stephanie H., Andrade, Brendan F., Battaglia, Marco, Boileau, Isabelle, Cleverley, Kristin, Courtney, Darren B., Diaconescu, Andreea O., Dickie, Erin W., Felsky, Daniel, Foussias, George, Goldstein, Benjamin I., Gonçalves, Vanessa, Griffiths, John D., Haltigan, John D., Hamilton, Hayley, Hawke, Lisa D., Hill, Sean, Husain, Muhammad Omair, Jani, Melanie, Kidd, Sean A., Kozloff, Nicole, Kurdyak, Paul, Lai, Meng-Chuan, Lewis, Stephen P., Levitan, Robert D., Lin, Hsiang-Yuan, Lunsky, Yona, Mohan, Akshay, Nikolova, Yuliya S., Osman, Sam, Pascoe, Shannon, Polillo, Alexia, Putterman, Connie, Rotenberg, Martin, Rubin-Kahana, Dafna Sara, Quilty, Lena C., Sivakumar, Harijah, Szatmari, Peter, Tempelaar, Wanda, Vasdev, Neil, Wang, Wei, Wheeler, Anne L., van der Miesen, Anna I.R., Vieira, Erica L., Voineskos, Aristotle N., Mahleka, Don, Frayne, Margot, Wong, Jimmy K.Y., Kelly, Rachel, Kidd, Sean, and Ahmadzadasl, Masoud

Published
2024
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