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Background: As physical signals, mechanical cues regulate the neural cells in the brain. The mechanosensitive channels (MSCs) perceive the mechanical cues and transduce them by permeating specific ions or molecules across the plasma membrane, and finally trigger a series of intracellular bioelectrical and biochemical signals. Emerging evidence supports that wide‐distributed, high‐expressed MSCs like Piezo1 play important roles in several neurophysiological processes and neurological disorders. Aim s : To systematically conclude the functions of MSCs in the brain and provide a novel mechanobiological perspective for brain diseases. Method: We summarized the mechanical cues and MSCs detected in the brain and the research progress on the functional roles of MSCs in physiological conditions. We then concluded the pathological activation and downstream pathways triggered by MSCs in two categories of brain diseases, neurodegenerative diseases and place‐occupying damages. Finally, we outlined the methods for manipulating MSCs and discussed their medical potential with some crucial outstanding issues. Results: The MSCs present underlying common mechanisms in different brain diseases by acting as the "transportation hubs" to transduce the distinct signal patterns: the upstream mechanical cues and the downstream intracellular pathways. Manipulating the MSCs is feasible to alter the complicated downstream processes, providing them promising targets for clinical treatment. Conclusions: Recent research on MSCs provides a novel insight into brain diseases. The common mechanisms mediated by MSCs inspire a wide range of therapeutic potentials targeted on MSCs in different brain diseases. [ABSTRACT FROM AUTHOR]

Objective: The aim was to research ACTL6A's role in oral squamous cell carcinoma (OSCC). Methods: OSCC and normal samples were obtained from patients and public databases. GSEA was performed. CIBERSORT was utilized to analyze immune landscape. Kaplan–Meier survival analysis and multivariate Cox regression analysis were conducted. After knocking down ACTL6A, we performed MTT assay, transwell assays, and flow cytometry to detect the impact of knockdown. Results: ACTL6A expressed higher in OSCC samples than normal samples. The CNV and mutation rate of TP53 was higher in ACTL6A high‐expression group. TFs E2F7 and TP63 and miRNA hsa‐mir‐381 were significantly related to ACTL6A. ACTL6A could influence immune microenvironment of OSCC. Knockdown of ACTL6A inhibited OSCC cells' proliferation, migration, and invasion. ACTL6A was able to predict OSCC prognosis independently. Conclusion: ACTL6A expressed higher in OSCC than normal samples and it could be used as an independent prognostic marker in OSCC patients. [ABSTRACT FROM AUTHOR]

Structural optimization is essential to improve the performance of mixing equipment. An efficient optimization strategy based on computational fluid dynamics, machine learning, and the multi‐objective genetic algorithm was proposed to predict and optimize the performance of the stirred tank. Single‐factor analysis was performed to study the effects of structural parameters on power consumption and mixing time, which were reduced by 16.0% and 1.4%, respectively, in the optimized stirred vessel. To further optimize the stirred tank geometries and maximize the integrated performance, XGB coupled NSGA‐ІІ were utilized to minimize the power consumption and mixing time. The optimal design parameters from the Pareto front were identified by two well‐known decision‐making methods (LINMAP and TOPSIS), which decreased power consumption and mixing time by 12.3% and 13.4% compared to the stirred tank with the baseline structure. This research further confirmed the accuracy and reliability of the machine learning‐based optimization method. [ABSTRACT FROM AUTHOR]

In this paper the single-use protective clothing for medical use was sterilized by γ-ray irradiation. Compared with the non-irradiated control, the apparent morphology of PP melt-blown fiber and amboss had no fracture. According to the national standard of GB/T 19082-2009, the mechanical properties, resistance to synthetic blood penetration, resistance to water penetration and filtering efficiency were measured. The results showed that the post-irradiation effects did not decrease the resistance to synthetic blood penetration or water penetration. Moreover, the filtering efficiency remained higher than 99.8%. On the other hand, the mechanical properties were reduced significantly due to the degradation of poly chain of PP induced by γ-ray irradiation. It has been assured that the important properties of single-use protective clothing for medical use are still above the quality level after γ-ray irradiation sterilization process. which can supply reference for the produce single-use protection of clothing of medical purpose at high quality.

Electro‐chemically reducing CO2 in a highly acidic medium is promising for addressing the issue of carbonate accumulation. However, the hydrogen evolution reaction (HER) typically dominates the acidic CO2 reduction. Herein, we construct an efficient electro‐catalyst for CO formation based on a core‐shell structure, where nitrogen‐doped Ni nanoparticles coexist with nitrogen‐coordinated Ni single atoms. The optimal catalyst demonstrates a significantly improved CO faradaic efficiency (FE) of 96.7 % in the acidic electrolyte (pH=1) at an industrial‐scale current density of 500 mA cm−2. Notably, the optimal catalyst maintains a high FE of CO exceeding 90 % (current density=500 mA cm−2) in the electrolyte with a wide pH range from 0.67 to 14. In‐situ spectroscopic characterization and density functional theory calculations show that the local electron density of Ni‐N‐C sites is enhanced by N‐doped Ni particles, which facilitates the formation of *COOH intermediate and the adsorption of *CO. This study demonstrates the potential of a hybrid metal/Ni‐N‐C interface in boosting acidic CO2 electro‐reduction. [ABSTRACT FROM AUTHOR]