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Sea ice formation over open water exerts critical control on polar atmosphere‐ocean‐ice interactions, but is only crudely represented in sea ice models. In this study, a collection depth parameterization of new ice for flux polynya models is modified by including the sea ice concentration and ice growth rate as additional factors. We evaluated it in a climate model BCC‐CSM2‐MR and found that it improves simulation of Antarctic sea ice concentration and thickness in most of Indian and Atlantic sectors. Disagreement between the observed Antarctic sea ice expansion during 1981–2014 and the modeled decline still exists but is mitigated when the modified scheme is implemented. Further analysis indicates that these improvements are associated with the overcoming of premature closure of open water, which enhances the response of ocean to surface wind intensification during 1981–2014, and consequently slowdowns the sea surface temperature increase and the resulting Antarctic sea ice reduction. Plain Language Summary: Open water ice formation critically modulates sea ice variations and the associated polar atmosphere‐ocean interaction, but is not well represented in sea ice models. In this study, a modified collection depth parameterization of new ice based on an existing scheme is presented after including sea ice concentration and ice growth rate as additional factors. We evaluated this modified scheme in BCC‐CSM2‐MR and found that it can improve the simulation of mean Antarctic sea ice thickness and concentration in winter as well as Antarctic sea ice expansion from 1981 to 2014. Further analysis implies that these improvements can be attributed to the overcoming of the premature closure of open water areas in model simulations. Key Points: A modified collection thickness parameterization of new ice suitable for large‐scale climate simulations is presentedIt improves the simulation of Antarctic sea ice thickness and concentration, as well as Antarctic sea ice expansion during 1981–2014The improved simulations can be attributed to the overcoming of the premature closure of open water areas where new ice forms [ABSTRACT FROM AUTHOR]

Understanding the immediate impacts of air pollution is crucial, especially as non-health outcomes like player productivity are covert. This paper focuses on investigating the causal relationship between air pollution and player productivity, which is theoretically established by the health consequences of air pollution and the Grossman health production function. The dataset used comprises over 20,000 observations from 1,440 matches in the Chinese Football Association Super League from 2014 to 2019. The IV estimation results show that a 1% increase in air pollution results in a reduction of 0.101% in the number of passes, which is five times larger than the OLS estimation. Heterogeneity results suggest that possessing an advantage (physical fitness, technical skills, or playing at home) contributes to mitigating the adverse effects of air pollution. This study underscores the critical role of clean air in enabling football players to achieve high productivity in the game. [ABSTRACT FROM AUTHOR]

Rabies is a lethal disease caused by the rabies virus (RABV), which causes acute neurological infections in mammals, including human beings. We previously reported that an mRNA vaccine (LVRNA001) encoding the rabies virus's glycoprotein induced strong protective immune responses to rabies in mice and dogs. Here, we further evaluate the safety of LVRNA001. First, we performed a confirmative efficacy study in dogs, which showed that LVRNA001 fully protected the animals from the virus, both pre- and post-infection. Moreover, using pre- and post-exposure prophylaxis murine models, we showed that LVRNA001, built from the CTN-1 strain, was able to protect against various representative RABV strains from the China I–VII clades. To evaluate the safety of the vaccine, chronic and reproductive toxicity studies were performed with cynomolgus macaques and rats, respectively. In a repeated-dose chronic toxicity study, vaccinated monkeys displayed no significant alterations in body weight, temperature, or hematological and biochemical markers. Lymphocyte subset measurement and histopathological examination showed that no toxicity was associated with the vaccine. The immunogenicity study in cynomolgus macaques demonstrated that LVRNA001 promoted the generation of neutralizing antibodies and Th1-biased immune response. Evaluation of reproductive toxicity in rats revealed that administration of LVRNA001 had no significant effects on fertility, maternal performance, reproductive processes, and postnatal outcomes. In conclusion, LVRNA001 can provide efficient protection against rabies virus infection in dogs and mice, and toxicity studies showed no significant vaccine-related adverse effects, suggesting that LVRNA001 is a promising and safe vaccine candidate for rabies prophylaxis and therapy. [ABSTRACT FROM AUTHOR]

Whispering gallery mode (WGM) resonators have high-quality factors and can be used in high-sensitivity sensors due to the narrow line width that allows for the detection of small external changes. In this paper, a force-sensing system based on a high-Q asymmetric V-shaped CaF2 resonator is proposed. Based on the dispersion coupling mechanism, the deformation of the resonator is achieved by loading force, and the resonant frequency is changed to determine the measurement. By adjusting the structural parameters of the asymmetric V-shaped resonator, the deformation of the resonator under force loading is improved. The experimental results show that the sensitivity of the V-shaped tip is 18.84 V/N, which determines the force-sensing resolution of 8.49 μN. This work provides a solution for force-sensing measurements based on a WGM resonator. [ABSTRACT FROM AUTHOR]

The potential of PulY103A (a moderate amylopullulanase originating from Bacillus megaterium) for resistant starch production under moderate conditions (40 °C; a pH of 6.5) was investigated. PulY103A was much more suitable for pea resistant starch production with a high growth rate of 3.63. The pea resistant starch (PSpa) produced with PulY103A had lower levels of swelling power and solubility and a better level of thermostability than native pea starch (PSn) and autoclaved PS (PSa). The starch crystallinity pattern was B + V, which indicated that the PSpa belonged to RS types III + V. In addition, PSpa was used for breadmaking. The results showed that the bread quality was not significantly influenced compared to the control group when the content of PSpa was under 10% (p > 0.05). The bread supplemented with 10% PSpa had a significantly increased TDF content compared to that of the control (p < 0.05). Moreover, the in vitro mineral bioavailability of the bread sample was influenced gently compared to other dietary fibers, and the bread sample changed from a high-glycemic-index (GI) food to a medium-GI food corresponding to white bread at the same concentration of PSpa. These results indicated that PSpa is a good candidate for the production of dietary foods. [ABSTRACT FROM AUTHOR]

Cervical perivascular sympathectomy (CPVS) can improve communication disorders in children with cerebral palsy (CP); however, there are no research reports on the factors affecting surgical efficacy. This study aimed to establish a nomogram for poor prognosis after CPVS. We collected data from 313 CP patients who underwent CPVS at the Neurosurgery Cerebral Palsy Center of the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to January 2023. Among them, 70% (n = 216) formed the training cohort and 30% (n = 97) the validation cohort. The general data and laboratory examination data of both groups were analyzed. In training cohort, 82 (37.96%) showed improved postoperative communication function. Logistic analysis identified motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity as the prognostic factors. Using these four factors, a prediction model was constructed with an area under the curve (AUC) of 0.807 (95% confidence interval [CI], 0.743–0.870), indicating its ability to predict adverse outcomes after CPVS. The validation cohort results showed an AUC of 0.76 (95% CI, 0.650–0.869). The consistency curve and Hosmer–Lemeshow test (χ2 = 10.988 and p = 0.202, respectively) demonstrated good consistency between the model-predicted incidence and the actual incidence of poor prognosis. Motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity are independent risk factors associated with the prognosis of communication disorders after CPVS. The combined prediction model has a good clinical prediction effect and has promising potential to be used for early prediction of prognosis of CPVS. [ABSTRACT FROM AUTHOR]

In recent years, the task of maritime emergency rescue has increased, while the cost of time for traditional methods of search and rescue is pretty long with poor effect subject to the constraints of the complex circumstances around the sea, the effective conditions, and the support capability. This paper applies deep learning and proposes a YOLOv5s‐SwinDS algorithm for target detection in distress at sea. Firstly, the backbone network of the YOLOv5s algorithm is replaced by swin transformer, and a multi‐level feature fusion module is introduced to enhance the feature expression ability for maritime targets. Secondly, deformable convolutional networks v2 (DCNv2) is used instead of traditional convolution to improve the recognition capability for irregular targets when the neck network features are output. Finally, the CIoU loss function is replaced with SIoU to reduce the redundant box effectively while accelerating the convergence and regression of the predicted box. Experimenting on the publicly dataset SeaDronesSee, the Precision$Precision$, Recall$Recall$, mAP0.5$mAP_{0.5}$ and mAP0.5−0.95$mAP_{0.5-0.95}$ of YOLOv5s‐SwinDS model are 87.9%, 75.8%, 79.1% and 42.9%, respectively, which get higher results than the original YOLOv5s model, the YOLOv7 series of models, and the YOLOv8 series of models. The experiments verifies that the algorithm has good performance in detecting maritime distress targets. [ABSTRACT FROM AUTHOR]