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The Lower Mekong River is one of the significant rivers nurturing people on the Southeast Asian mainland. Its tributaries include the Mun River (NE Thailand), which often experiences extreme water events. In this study, the streamflow change in the year 2115 was simulated by relying on the Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) experiment and the Model for Interdisciplinary Research on Climate, version 5 (MIROC5) climate model for average global warming of 1.5 °C (Plus1.5) and 2.0 °C (Plus2.0) above pre-industrial levels and compared with the base year in 2015 for the Mun River Basin. The Soil–Water Assessment Tool (SWAT) was used for the streamflow simulation. The results showed an increasing air temperature against lowering rainfall and relative humidity (except for the post-monsoon months), suggesting overall rain suppression in response to the warming climate. The median projected annual streamflow to the Mekong River in 2115 decreased for both ‘Plus1.5’ (−32.5%, median) and ‘Plus2.0’ (−23.1%, median). However, increasing annual streamflow could be found only in the middle part. Seasonal streamflow changes revealed a different spatiotemporal response to climate change resulting in inconsistent streamflow changes across the basin. The adaptive measures for the middle part should be focused on flooding control, whereas the upper and the lower parts should be against drought. HIGHLIGHTS IPCC AR6 HAPPI predicts overall rain suppression in response to the warming climate across the Mun River Basin.; The projected streamflow to the Mekong River in 2115 declines for both warming scenarios.; Positive annual streamflow anomalies could be found in the middle part.; In this middle part, we found higher dry-season streamflow and less wet-season streamflow.; Upper and lower parts tend to be drought-prone.;

In the pursuit of highly efficient perovskite solar cells, spiro‐OMeTAD has demonstrated recorded power conversion efficiencies (PCEs), however, the stability issue remains one of the bottlenecks constraining its commercial development. In this study, we successfully synthesize a novel self‐polymerized spiro‐type interfacial molecule, termed v‐spiro. The linearly arranged molecule exhibits stronger intermolecular interactions and higher intrinsic hole mobility compared to spiro‐OMeTAD. Importantly, the vinyl groups in v‐spiro enable in situ polymerization, forming a polymeric protective layer on the perovskite film surface, which proves highly effective in suppressing moisture degradation and ion migration. Utilizing these advantages, poly‐v‐spiro‐based device achieves an outstanding efficiency of 24.54 %, with an enhanced open‐circuit voltage of 1.173 V and a fill factor of 81.11 %, owing to the reduced defect density, energy level alignment and efficient interfacial hole extraction. Furthermore, the operational stability of unencapsulated devices is significantly enhanced, maintaining initial efficiencies above 90 % even after 2000 hours under approximately 60 % humidity or 1250 hours under continuous AM 1.5G sunlight exposure. This work presents a comprehensive approach to achieving both high efficiency and long‐term stability in PSCs through innovative interfacial design. [ABSTRACT FROM AUTHOR]

Reconciling optimal cooling effects with color regulation in functional textiles, while preserving infrared characteristics, remains a formidable technological challenge. Here, a novel dynamically hierarchical metafabric is reported that integrates temperature-adaptive thermochromic and moisture-wicking functionalities into a passive radiative cooling system, which effectively achieves energy-efficient personal thermal management. The objective was achieved by employing a hierarchically organized metafabric, which utilized the techniques of electrospinning and facile spray coating. Specifically, the metafabric is composed of polyamide 6/silicon dioxide/thermochromic chameleon microcapsules/hygroscopic agent layers. The metafabric demonstrates excellent selective infrared emissivity (0.95 in the 8–13 μm wavelength range) and moisture permeability through large-scale electrospinning and hierarchical design, while simultaneously maintaining superior mechanical strength. Specifically, the incorporation of thermochromic microcapsules facilitates reversible color alteration and self-adaptive modulation of solar energy (ΔRlum = 52.64%), which significantly expands the potential applications for energy-saving thermoregulation. The resulting metafabric exhibits exceptional outdoor thermoregulation capabilities, demonstrating a cooling effect of 7.9 °C compared to commercial cotton in an outdoor environment under solar intensity of approximately 40 mW cm−2. This study presents promising potential for the development of advanced personal thermal management systems with exceptional thermoregulatory capabilities, which could have significant implications in various fields such as wearable technology and medical devices. [ABSTRACT FROM AUTHOR]

Compared with inverted 3D perovskite solar cell (PSCs), inverted quasi-2D PSCs have advantages in device stability, but the device efficiency is still lagging behind. Constructing polymer hole-transporting materials (HTMs) with passivation functions to improve the buried interface and crystallization properties of perovskite films is one of the effective strategies to improve the performance of inverted quasi-2D PSCs. Herein, two novel side-chain functionalized polymer HTMs containing methylthio-based passivation groups are designed, named PVCz-SMeTPA and PVCz-SMeDAD, for inverted quasi-2D PSCs. Benefited from the non-conjugated flexible backbone bearing functionalized side-chain groups, the polymer HTMs exhibit excellent film-forming properties, well-matched energy levels and improved charge mobility, which facilitates the charge extraction and transport between HTM and quasi-2D perovskite layer. More importantly, by introducing methylthio units, the polymer HTMs can enhance the contact and interactions with quasi-2D perovskite, and further passivating the buried interface defects and assisting the deposition of high-quality perovskite. Due to the suppressed interfacial non-radiative recombination, the inverted quasi-2D PSCs using PVCz-SMeTPA and PVCz-SMeDAD achieve impressive power conversion efficiency (PCE) of 21.41% and 20.63% with open-circuit voltage of 1.23 and 1.22 V, respectively. Furthermore, the PVCz-SMeTPA based inverted quasi-2D PSCs also exhibits negligible hysteresis and considerably improved thermal and long-term stability. [ABSTRACT FROM AUTHOR]

This essay traces the development of Isaiah Berlin's conception of history from the 1930s to the 1960s, extrapolating the ways in which he responded to and dismantled the monist and determinist claims by logical positivists and scientific rationalists, which were alleged to repudiate unrealised possibilities and men's voluntary power in history. Berlin's elaboration of such notions as 'concepts and categories' as governing principles dictating the intellectual features of a given society not only lays a conceptual foundation for intellectual history, but also underscores historicity as a dimension of paramount importance to the study of mankind. Making use of Berlin's correspondence with the American philosopher Morton White, this essay examines their abortive project on the philosophy of history. Apathetic about any analytic anatomy of historical knowledge, Berlin was much more interested in exploring the emergence of historical understanding as a distinctive type of knowledge demarcated from other—in particular scientific—forms of knowledge in European history of ideas. Berlin's ideas of history thus make a case for the history of ideas as an intellectual practice, whereas his history of ideas delineates the development of a particular idea of history. [ABSTRACT FROM AUTHOR]

Organic-inorganic hybrid ternary copper halides offer a broader spectrum of structural possibilities for finely tuning their optoelectronic properties. Herein, we demonstrate for the first time the potential of [N(C 2 H 5 ) 4 ] 2 [Cu 2 Br 4 ], a zero-dimensional hybrid copper halide [(TEA) 2 Cu 2 Br 4 ], for ultraviolet (UV) photodetection. A self-powered, visible-blind UV photodetector based on a (TEA) 2 Cu 2 Br 4 /GaN heterojunction architecture is developed, exhibiting a high responsivity, a high detectivity, and fast response speeds. The device demonstrates exceptional stability against environmental oxygen/moisture, heat, and UV light illumination, surpassing the stability of reported copper-based UV photodetectors. Our work highlights the significant potential of (TEA) 2 Cu 2 Br 4 as a lead-free, stable, and efficient material for next-generation UV photodetection technology.

In the pursuit of highly efficient perovskite solar cells, spiro-OMeTAD has demonstrated recorded power conversion efficiencies (PCEs), however, the stability issue remains one of the bottlenecks constraining its commercial development. In this study, we successfully synthesize a novel self-polymerized spiro-type interfacial molecule, termed v-spiro. The linearly arranged molecule exhibits stronger intermolecular interactions and higher intrinsic hole mobility compared to spiro-OMeTAD. Importantly, the vinyl groups in v-spiro enable in situ polymerization, forming a polymeric protective layer on the perovskite film surface, which proves highly effective in suppressing moisture degradation and ion migration. Utilizing these advantages, poly-v-spiro-based device achieves an outstanding efficiency of 24.54 %, with an enhanced open-circuit voltage of 1.173 V and a fill factor of 81.11 %, owing to the reduced defect density, energy level alignment and efficient interfacial hole extraction. Furthermore, the operational stability of unencapsulated devices is significantly enhanced, maintaining initial efficiencies above 90 % even after 2000 hours under approximately 60 % humidity or 1250 hours under continuous AM 1.5G sunlight exposure. This work presents a comprehensive approach to achieving both high efficiency and long-term stability in PSCs through innovative interfacial design., (© 2024 Wiley-VCH GmbH.)

Introduction: The role and prognostic value of POLA2 in liver cancer were comprehensively analyzed through TCGA, GEO, and ICGC databases, and the role of POLA2 in liver cancer cells and the regulatory mechanism involved were further verified through cell experiments. Hepatocellular carcinoma (HCC) is the most prevalent malignancy with high morbidity and mortality. Consequently, it is critical to identify robust and reliable predictive biomarkers and therapeutic targets for HCC patients. POLA2 is involved in the regulation of various tumors, but the specific role of POLA2 in HCC has not been reported. The regulatory role and prognostic value of POLA2 in HCC were determined by bioinformatics techniques and cell experiments., Methods: The specific role and prognostic value of POLA2 in HCC were comprehensively analyzed by combining the expression data of POLA2 in TCGA, GEO, and ICGC databases and clinical data. In clinical samples, the expression of POLA2 in liver cancer was verified by QPCR. Further, the regulatory role of POLA2 in HCC was explored through cell experiments such as CCK-8, clonal formation experiment, EDU cell proliferation experiment, and flow cytometry. In terms of mechanism exploration, western blot was used to verify the specific regulatory mechanism that POLA2 participated in. Finally, the relationship between POLA2 and immune invasion of HCC was analyzed by using the TIMER database., Results: A POLA2 expression and prognosis analysis of HCC patients was conducted using the TCGA, GEO, and ICGC databases. We hypothesized that POLA2 might be one of the key factors contributing to the HCC progression. According to a combined analysis of TCGA, ICGC, and GEO databases, POLA2 was highly expressed in HCC. This was further confirmed in clinical samples using the qPCR. POLA2 knockdown was also performed in vitro on HCC cell lines to study the changes in their biological behavior. We confirmed that POLA2 was associated with HCC proliferation by CCK-8, Colony Formation, and EDU assay. We verified the POLA2's involvement in cell cycle regulation using flow techniques. The relationship between POLA2 and PI3K/AKT/mTOR pathway was explored using Western Blotting experiments regarding its mechanism. Further analysis revealed that the POLA2 expression was significantly associated with HCC immune infiltration., Conclusion: Our study demonstrated POLA2's importance in HCC development and progression and its potential role as a biomarker for disease progression on multiple levels. POLA2 has an important role in regulating the cell cycle and cell proliferation. By interfering with the cell cycle and proliferation, HCC cell growth is inhibited. Furthermore, POLA2 expression was significantly associated with immune infiltration. POLA2 may play a role in HCC immunotherapy based on its correlation with several immune cell types' genetic markers. The findings of this study are expected to lead to new anticancer strategies for HCC., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Ternary copper halides have become promising materials for UV photodetection due to their stability and eco-friendliness. However, the uncontrollable crystallization induces high-concentration defects in these films, inherently limiting further improvement in device performance. Herein, we reveal the antisolvent-assisted crystallization kinetics mechanism of CsCu 2 I 3 during the film-forming process. The nucleation rate is manipulated by adjusting precursor supersaturation using different antisolvents, resulting in decreased density and preferential orientation of the nuclei within the wet film. Subsequent annealing leads to a homogeneous and low-defect CsCu 2 I 3 film with 40-μm-scale spherulites. A resulting visible-blind ultraviolet photodetector exhibits a responsivity of 8.73 A W -1 , a specific detectivity of 5.28 × 10 12 jones, and a response speed of 1.12 ms. The unencapsulated photodetector shows negligible degradation of responsivity in ambient air (∼70% humidity) for one month. Moreover, the flexible device with a responsivity of 420.2 mA W -1 and a detectivity of 1.18 × 10 12 jones also shows excellent bending stability.

Although the power conversion efficiency values of perovskite solar cells continue to be refreshed, it is still far from the theoretical Shockley-Queisser limit. Two major issues need to be addressed, including disorder crystallization of perovskite and unbalanced interface charge extraction, which limit further improvements in device efficiency. Herein, we develop a thermally polymerized additive as the polymer template in the perovskite film, which can form monolithic perovskite grain and a unique "Mortise-Tenon" structure after spin-coating hole-transport layer. Importantly, the suppressed non-radiative recombination and balanced interface charge extraction benefit from high-quality perovskite crystals and Mortise-Tenon structure, resulting in enhanced open-circuit voltage and fill-factor of the device. The PSCs achieve certified efficiency of 24.55% and maintain >95% initial efficiency over 1100 h in accordance with the ISOS-L-2 protocol, as well as excellent endurance according to the ISOS-D-3 accelerated aging test., (© 2023. The Author(s).)

Background: Hepatocellular Carcinoma (HCC) is one of the fastest-growing malignancies globally. The impact of surgical treatment is limited, and molecular targeted therapy has not yielded a consistent efficacy. This warrants for identification of novel molecular targets. The Anti- Silencing Function of 1B histone chaperone (ASF1B) was previously studied in numerous cancers. However, the understanding of its role in HCC is limited., Methods: The TIMER database was used to analyze the ASF1B expression in pan-cancer and paracarcinoma tissues. ASF1B expression in HCC was confirmed using the HCCDB database, Quantitative real-time PCR (q-PCR), and Western Blot (WB) assays. The relationship between clinicopathological parameters and ASF1B expression was analyzed using UALCAN, whereas the prognostic value of ASF1B was evaluated using the GEPIA database. Linkedomics and cBioPortal databases were used to validate the ASF1B co-expression associated with immune infiltration by the TIMER database. Moreover, cell proliferation after ASF1B-knockdown was determined through CCK8 and clone formation assays., Results: ASF1B was highly expressed in HCC tissues, and the expression levels were linked to tumor grade, race, and disease stage. Univariate and multivariate Cox models showed that ASF1B is an independent prognostic factor in HCC. CCK8 and clone formation assays demonstrated that ASF1B promotes cell proliferation. Gene co-expression analysis in Linkedomics demonstrated that HJURP, KIF2C, KIF4A, KIF18B, and KIFC1 expressions were closely associated with ASF1B and immune infiltrate cells., Conclusion: This study shows that ASF1B promotes the proliferation of HCC. Besides, ASF1B could be a potential prognostic biomarker for HCC patients., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Ternary copper halides with a formula of CsCu 2 X 3 (X = Cl, Br, I) have been considered as prospective materials for ultraviolet (UV) photodetectors, due to their suitable band gaps, environmental stability, eco-friendliness, and low cost. However, the crystal orientation of one-dimensional (1D) CsCu 2 X 3 perovskites significantly affects the exciton/carrier transport in the films and thus the photodetector performance. Here, we tune the crystal orientation and exciton/charge transport of 1D CsCu 2 I 3 perovskite films by using antisolvents during the film formation process. Compared to the randomly oriented film treated by ethyl acetate, the CsCu 2 I 3 film using toluene as antisolvent exhibits preferential (221)-oriented growth, which induces enhanced vertical exciton diffusion/charge transport and suppressed nonradiative recombination. On the basis of this strategy, we demonstrate a self-powered, stable, and visible-blind UV photodetector with significantly enhanced response speed and detectivity. Our work clarifies that tuning the crystal orientation of 1D CsCu 2 X 3 perovskites is the key to achieve efficient exciton diffusion/charge transport and thus high-performance lead-free perovskite optoelectronic devices.