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Lymphoma-associated hemophagocytic syndrome (LAHS) is a rare and life-threatening clinical syndrome with rapidly deteriorating health and high mortality. We retrospectively analyzed clinical features and prognostic factors from 117 patients diagnosed with LAHS. The cumulative incidence rate of LAHS was 4.0% (117/2906). Patients were classified into B-cell LAHS (B-LAHS, n = 22) and T/natural killer (NK)-cell LAHS (T/NK-LAHS, n = 95) groups. Patients with T/NK-LAHS were younger and had lower neutrophil counts and fibrinogen values, higher LDH and transaminase levels, and were more likely to develop hemophagocytic syndrome (HPS) during the clinical course than those with B-LAHS. The median survival time for the entire cohort was 57 days, and for the T/NK-LAHS and B-LAHS groups, it was 52 and 154 days, respectively, after the diagnosis of LAHS. Patients with B-LAHS had superior 1-year OS (p = 0.003, 36.4% versus 14.5%) compared with those with T/NK-LAHS. Prognostic factor analysis revealed that elevated LDH levels (LDH > 1000 IU/L) (p = 0.004), T/NK-cell lineage (p

Abstract Background Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel, clinically applicable prognostic index for adult patients with sporadic BL. Methods We surveyed retrospectively 336 adult patients with newly diagnosed sporadic BL at 8 Chinese medical centers and divided into training cohort (n = 229) and validation cohort (n = 107). The pretreatment inflammatory biomarkers were calculated for optimal cut-off value. The association between serum biomarkers and overall survival (OS) was analyzed by Kaplan–Meier curves and Cox proportional models. The risk stratification was defined based on normal LDH level, Ann Arbor stage of I and completely resected abdominal lesion or single extra-abdominal mass

Nasal-type, extranodal nature killer (NK)/T-cell lymphoma-associated hemophagocytic syndrome (NK/T-LAHS) is a rare and life-threatening disease, requiring investigation of risk stratification. We conducted a retrospective study and proposed nomograms to predict NK/T-LAHS. The discriminative ability and calibration of the nomograms for prediction were tested using C statistics and calibration plots. We analyzed 533 patients with extranodal NK/T-cell lymphoma (ENKTL), out of which 71 were diagnosed with hemophagocytic syndrome (HPS), with a cumulative incidence of 13.3%. Significant difference for 2-year survival was found between patients with and without HPS (14.7% vs. 77.5%). Analyses showed that Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥2, B symptoms, and bone marrow (BM) invasion were significantly associated with NK/T-LAHS. We used these data as the basis to establish a nomogram of risk index for ENKTL (RINK). In 335 patients with available data for Epstein-Barr virus DNA (EBV-DNA), we found high viral copies (≥4,450 copies/ml) were correlated with NK/T-LAHS. When these data were added to RINK, we developed another nomogram that included EBV-DNA data (RINK-E). The nomograms displayed good accuracy in predicting NK/T-LAHS with a C-statistics of 0.919 for RINK and a C-statistics of 0.946 for RINK-E, respectively. The calibration chart also showed an excellent consistency between the predicted and observed probabilities. The proposed nomograms provided individualized risk estimate of HPS in patients with ENKTL.

The Xikuangshan antimony (Sb) deposit is the largest Sb deposit in the world; however, the metal source and cycling and a holistic understanding of the deposit genesis remain equivocal. Sulfur isotope signatures offer a means of fingerprinting different sources in a hydrothermal deposit, although one must be careful to rule out subsequent isotope fractionation during fluid ascent, mixing, and ore precipitation. Here, we investigated the sulfur isotope composition of stibnite occurring at depth in the Xikuangshan deposit to distinguish the isotopic signals from the source and the superimposed imprint from near-surface-derived sulfur mixing or isotopic fractionation. All stibnites from the deep orebodies displayed limited δ34S variation from +6.8‰ to +8.4‰, despite their widely varying depths. These results provide direct evidence that δ34S values measured in deep orebodies are representative of the isotopic composition of initial fluids. The most likely factor controlling the variation of the sulfur isotopes in shallow stibnites (+3.5‰ to +16.3‰) is a series of hydrothermal processes, including Rayleigh fractionation during ore precipitation, fluid boiling induced by pressure release, and/or local input of pyrite from wall rocks via fluid-rock interaction. Accordingly, we conclude that the Neoproterozoic basement served as the metal source. We propose a holistic genetic model wherein we envisage that Sb and S were leached from the basement rocks, and the ore-bearing fluids ascended along a deep fault and eventually precipitated beneath the Devonian shale cap. Thus, sulfur isotopic systematics represent a powerful repository for interrogating the metal source and cycling in the hydrothermal ore system. [ABSTRACT FROM AUTHOR]