18 results on '"Lindberg, Amanda"'
Search Results
2. Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer
- Author
-
Backman, Max, Strell, Carina, Lindberg, Amanda, Mattsson, Johanna S.M., Elfving, Hedvig, Brunnström, Hans, O'Reilly, Aine, Bosic, Martina, Gulyas, Miklos, Isaksson, Johan, Botling, Johan, Kärre, Klas, Jirström, Karin, Lamberg, Kristina, Pontén, Fredrik, Leandersson, Karin, Mezheyeuski, Artur, and Micke, Patrick
- Published
- 2023
- Full Text
- View/download PDF
3. Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial
- Author
-
Schiza, Aglaia, Thurfjell, Viktoria, Stenmark Tullberg, Axel, Olofsson, Helena, Lindberg, Amanda, Holmberg, Erik, Bremer, Troy, Micke, Patrick, Karlsson, Per, Wärnberg, Fredrik, and Strell, Carina
- Published
- 2022
- Full Text
- View/download PDF
4. Loss of chromosome Y in regulatory T cells
- Author
-
Mattisson, Jonas, primary, Halvardson, Jonatan, additional, Davies, Hanna, additional, Bruhn-Olszewska, Bożena, additional, Olszewski, Paweł, additional, Danielsson, Marcus, additional, Bjurling, Josefin, additional, Lindberg, Amanda, additional, Zaghlool, Ammar, additional, Rychlicka-Buniowska, Edyta, additional, Dumanski, Jan P., additional, and Forsberg, Lars A., additional
- Published
- 2024
- Full Text
- View/download PDF
5. Dödligt partnervåld i svensk media : En kvalitativ innehållsanalys om framställning av kvinnliga och manliga förövare i Aftonbladet och Expressen
- Author
-
Lindberg, Amanda, Ollesdotter, Sofia, Lindberg, Amanda, and Ollesdotter, Sofia
- Abstract
Denna studie syftar till att analysera hur kvällspressen framställer manliga och kvinnliga förövare av dödligt partnervåld och se om det finns några likheter och skillnader i konstruktionen mellan könen. Analysen utgår från den genusteoretiska ansatsen normativ femininitet och maskulinitet samt medieteorin om nyhetsvärden. Det empiriska materialet hämtades ur de två mest rikstäckande kvällstidningarna Aftonbladet och Expressen och gäller de mest omskrivna fallen av dödligt partnervåld mellan åren 2017–2022, två fall med kvinnliga förövare och två med manliga. Genom en kvalitativ innehållsanalys framträdde tre teman; ”Skuld, driv & ursäkter”, ”Våld & kontroll”, och ”Kvinnliga kontraster & Manlig dubbelhet”. Det empiriska materialet visar hur artiklarna reproducerar samhällets normativa föreställningar om genus även när det gäller något så avvikande som dödligt partnervåld. Detta görs dock på olika sätt gällande de manliga och kvinnliga förövarna då männen framställs som avvikande från den normativa maskuliniteten medan kvinnorna avviker från hela det feminina spektret. Samtliga förövare anses chockerande och sensationella vilket gör dem nyhetsvärdiga men framställningen av förövarna skiljer sig beroende på kön vilket delvis tycks vara påverkat av föreställningar om genus. Det återfinns flera nyhetsvärden i materialet, trots att även de till viss del skiljer sig åt mellan de kvinnliga och de manliga förövarna. Gällande de kvinnliga förövarna höjs nyhetsvärdet av att förövaren är en kvinna och gällande de manliga förövarna höjs nyhetsvärdet av fallens grova våldshandlingar och det längre händelseförloppet.
- Published
- 2024
6. Ett ledarlöst slavarbete : Arbetstagarnas upplevelse av den algoritmiska arbetsledningen i gig-ekonomin
- Author
-
Dahlberg, Ellinor, Lindberg, Amanda, Dahlberg, Ellinor, and Lindberg, Amanda
- Abstract
Studiens syfte är att öka förståelsen om arbetstagarnas upplevelser avalgoritmisk arbetsledning inom gig-ekonomin, samt identifiera vilkaformer av motstånd arbetstagare utvecklar. Studien ämnar att lyfta framarbetstagarnas röster i en trygg och anonym miljö. Studien identifierade ineffektivitet för arbetstagarna. Trots attalgoritmer ofta framhålls som effektiva innebär det nödvändigtvis inteatt de upplevs effektiva ur arbetstagarnas perspektiv. Algoritmerna ärutformade för att maximera effektiviteten för plattformarna ochkunden, snarare än för arbetstagarna. Det är intressant hur effektivitetdefinieras och upplevs av olika parter inom gig-ekonomin. Därav böreffektiviteten optimeras för alla parter på plattformarna.Studien identifierade kollektivt motstånd bland arbetstagarna. Dettamotstånd är ett avsteg från tidigare forskning och indikerar attarbetsvillkoren har försämrats till den grad att arbetstagarna känner ettbehov av att sträva efter förändring., The purpose of this study is to increase the understanding ofemployee´s experiences of algorithmic management in thegig-economy, as well as identifying what forms of resistanceemployees develop. The study aims to highlight the employees´voicesin a safe and anonymous environment. The study identified inefficiencies for workers. Despite the factthat algorithms are often highlighted as efficient, this doesnot necessarily mean that they are perceived to be efficient fromthe workers' perspective. The algorithms are designed to maximizeefficiency for the platforms and the customer, rather than for theworkers. It is interesting how efficiency is defined and experienced bydifferent parties within the gig economy. Hence, efficiency should beoptimized for all parties on the platforms.The study identified collective resistance among the workers. Thisresistance is a departure from previous research and indicates that theworking conditions have deteriorated to the point where workers feelthe need to push for change.
- Published
- 2024
7. Loss of chromosome Y in regulatory T cells
- Author
-
Mattisson, Jonas, Halvardson, Jonatan, Davies, Hanna, Bruhn-Olszewska, Bozena, Olszewski, Paweł, Danielsson, Marcus, Bjurling, Josefin, Lindberg, Amanda, Zaghlool, Ammar, Rychlicka-Buniowska, Edyta, Dumanski, Jan P., Forsberg, Lars A., Mattisson, Jonas, Halvardson, Jonatan, Davies, Hanna, Bruhn-Olszewska, Bozena, Olszewski, Paweł, Danielsson, Marcus, Bjurling, Josefin, Lindberg, Amanda, Zaghlool, Ammar, Rychlicka-Buniowska, Edyta, Dumanski, Jan P., and Forsberg, Lars A.
- Abstract
Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer. It has been suggested that the association between LOY and disease risk depends on what type of leukocyte is affected with Y loss, with prostate cancer patients showing higher levels of LOY in CD4 + T lymphocytes. In previous studies, Y loss has however been observed at relatively low levels in this cell type. This motivated us to investigate whether specific subsets of CD4 + T lymphocytes are particularly affected by LOY. Publicly available, T lymphocyte enriched, single-cell RNA sequencing datasets from patients with liver, lung or colorectal cancer were used to study how LOY affects different subtypes of T lymphocyte. To validate the observations from the public data, we also generated a single-cell RNA sequencing dataset comprised of 23 PBMC samples and 32 CD4 + T lymphocytes enriched samples. Results Regulatory T cells had significantly more LOY than any other studied T lymphocytes subtype. Furthermore, LOY in regulatory T cells increased the ratio of regulatory T cells compared with other T lymphocyte subtypes, indicating an effect of Y loss on lymphocyte differentiation. This was supported by developmental trajectory analysis of CD4 + T lymphocytes culminating in the regulatory T cells cluster most heavily affected by LOY. Finally, we identify dysregulation of 465 genes in regulatory T cells with Y loss, many involved in the immunosuppressive functions and development of regulatory T cells. Conclusions Here, we show that regulatory T cells are particularly affected by Y loss, resulting in an increased fraction of regulatory T cells and dysregulated immune functions. Considering that regulatory T cells plays a critical role in the process of immunosuppression; this enrichment for regulatory T cells with LOY might contribute to, De två första författarna delar förstaförfattarskapet
- Published
- 2024
- Full Text
- View/download PDF
8. Loss of chromosome Y in regulatory T cells
- Author
-
Mattisson, Jonas, primary, Halvardson, Jonatan, additional, Davies, Hanna, additional, Bruhn-Olszewska, Bożena, additional, Olszewski, Paweł, additional, Danielsson, Marcus, additional, Bjurling, Josefin, additional, Lindberg, Amanda, additional, Zaghlool, Ammar, additional, Rychlicka-Buniowska, Edyta, additional, Dumanski, Jan P., additional, and Forsberg, Lars A., additional
- Published
- 2023
- Full Text
- View/download PDF
9. An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
- Author
-
Mezheyeuski, Artur, primary, Backman, Max, additional, Mattsson, Johanna, additional, Martín-Bernabé, Alfonso, additional, Larsson, Chatarina, additional, Hrynchyk, Ina, additional, Hammarström, Klara, additional, Ström, Simon, additional, Ekström, Joakim, additional, Mauchanski, Siarhei, additional, Khelashvili, Salome, additional, Lindberg, Amanda, additional, Agnarsdóttir, Margrét, additional, Edqvist, Per-Henrik, additional, Huvila, Jutta, additional, Segersten, Ulrika, additional, Malmström, Per-Uno, additional, Botling, Johan, additional, Nodin, Björn, additional, Hedner, Charlotta, additional, Borg, David, additional, Brändstedt, Jenny, additional, Sartor, Hanna, additional, Leandersson, Karin, additional, Glimelius, Bengt, additional, Portyanko, Anna, additional, Ponten, Fredrik, additional, Jirström, Karin, additional, Micke, Patrick, additional, and Sjöblom, Tobias, additional
- Published
- 2023
- Full Text
- View/download PDF
10. An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
- Author
-
Mezheyeuski, Artur, Backman, Max, Mattsson, Johanna Sofia Margareta, Martin-Bernabe, Alfonso, Larsson, Chatarina, Hrynchyk, Ina, Hammarström, Klara, Ström, Simon, Ekström, Joakim, Mauchanski, Siarhei, Khelashvili, Salome, Lindberg, Amanda, Agnarsdóttir, Margrét, Edqvist, Per-Henrik D, Huvila, Jutta, Segersten, Ulrika, Malmström, Per-Uno, Botling, Johan, Nodin, Bjoern, Hedner, Charlotta, Borg, David, Brandstedt, Jenny, Sartor, Hanna, Leandersson, Karin, Glimelius, Bengt, Portyanko, Anna, Pontén, Fredrik, Jirstrom, Karin, Micke, Patrick, Sjöblom, Tobias, Mezheyeuski, Artur, Backman, Max, Mattsson, Johanna Sofia Margareta, Martin-Bernabe, Alfonso, Larsson, Chatarina, Hrynchyk, Ina, Hammarström, Klara, Ström, Simon, Ekström, Joakim, Mauchanski, Siarhei, Khelashvili, Salome, Lindberg, Amanda, Agnarsdóttir, Margrét, Edqvist, Per-Henrik D, Huvila, Jutta, Segersten, Ulrika, Malmström, Per-Uno, Botling, Johan, Nodin, Bjoern, Hedner, Charlotta, Borg, David, Brandstedt, Jenny, Sartor, Hanna, Leandersson, Karin, Glimelius, Bengt, Portyanko, Anna, Pontén, Fredrik, Jirstrom, Karin, Micke, Patrick, and Sjöblom, Tobias
- Abstract
Background: Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression. Methods: Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data sets were used for functional analysis and validation of prognostic and predictive associations. Findings: By combining the prognostic information of anti-tumoural CD8+ lymphocytes and tumour supportive CD68+CD163+ macrophages in colorectal cancer we generated a signature of immune activation (SIA). The prognostic impact of SIA was independent of conventional parameters and comparable with the state-of-art immune score. The SIA was also associated with patient survival in oesophageal adenocarcinoma, bladder cancer, lung adenocarcinoma and melanoma, but not in endometrial, ovarian and squamous cell lung carcinoma. We identified CD68+CD163+ macrophages as the major producers of complement C1q, which could serve as a surrogate marker of this macrophage subset. Consequently, the RNA-based version of SIA (ratio of CD8A to C1QA) was predictive for survival in independent RNAseq data sets from these six cancer types. Finally, the CD8A/C1QA mRNA ratio was also predictive for the response to checkpoint inhibitor therapy. Interpretation: Our findings extend current concepts to procure prognostic information from the tumour immune microenvironment and provide an immune activation signature with high clinical potential in common human cancer types.
- Published
- 2023
- Full Text
- View/download PDF
11. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
- Author
-
Moro, Carlos Fernandez, Geyer, Natalie, Harrizi, Sara, Hamidi, Yousra, Söderqvist, Sara, Kuznyecov, Danyil, Tidholm Qvist, Evelina, Salmonson Schaad, Media, Hermann, Laura, Lindberg, Amanda, Heuchel, Rainer L., Martin-Bernabe, Alfonso, Dhanjal, Soniya, Navis, Anna C., Villard, Christina, del Valle, Andrea C., Bozoky, Lorand, Sparrelid, Ernesto, Dirix, Luc, Strell, Carina, Östman, Arne, Schmierer, Bernhard, Vermeulen, Peter B., Engstrand, Jennie, Bozoky, Bela, Gerling, Marco, Moro, Carlos Fernandez, Geyer, Natalie, Harrizi, Sara, Hamidi, Yousra, Söderqvist, Sara, Kuznyecov, Danyil, Tidholm Qvist, Evelina, Salmonson Schaad, Media, Hermann, Laura, Lindberg, Amanda, Heuchel, Rainer L., Martin-Bernabe, Alfonso, Dhanjal, Soniya, Navis, Anna C., Villard, Christina, del Valle, Andrea C., Bozoky, Lorand, Sparrelid, Ernesto, Dirix, Luc, Strell, Carina, Östman, Arne, Schmierer, Bernhard, Vermeulen, Peter B., Engstrand, Jennie, Bozoky, Bela, and Gerling, Marco
- Abstract
A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFR(high) stroma at the liver edge to FAP(high) stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.
- Published
- 2023
- Full Text
- View/download PDF
12. Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis
- Author
-
Johansson, Josefin, Frykholm, Carina, Ericson, Katharina, Kazamia, Kalliopi, Lindberg, Amanda, Mulaiese, Nancy, Falck, Geir, Gustafsson, Per-Erik, Lidéus, Sarah, Gudmundsson, Sanna, Ameur, Adam, Bondeson, Marie-Louise, Wilbe, Maria, Johansson, Josefin, Frykholm, Carina, Ericson, Katharina, Kazamia, Kalliopi, Lindberg, Amanda, Mulaiese, Nancy, Falck, Geir, Gustafsson, Per-Erik, Lidéus, Sarah, Gudmundsson, Sanna, Ameur, Adam, Bondeson, Marie-Louise, and Wilbe, Maria
- Abstract
The Nexilin F-Actin Binding Protein (Nexilin) encoded by NEXN is a cardiac Z-disc protein important for cardiac function and development in humans, zebrafish, and mice. Heterozygote variants in the human NEXN gene have been reported to cause dilated and hypertrophic cardiomyopathy. Homozygous variants in NEXN cause a lethal form of human fetal cardiomyopathy, only described in two patients before. In a Swedish, four-generation, non-consanguineous family comprising 42 individuals, one female had three consecutive pregnancies with intrauterine fetal deaths caused by a lethal form of dilated cardiomyopathy. Whole-exome sequencing and variant analysis revealed that the affected fetuses were homozygous for a NEXN variant (NM_144573:c.1302del;p.(Ile435Serfs*3)). Moreover, autopsy and histology staining declared that they presented with cardiomegaly and endocardial fibroelastosis. Immunohistochemistry staining for Nexilin in the affected fetuses revealed reduced antibody staining and loss of striation in the heart, supporting loss of Nexilin function. Clinical examination of seven heterozygote carriers confirmed dilated cardiomyopathy (two individuals), other cardiac findings (three individuals), or no cardiac deviations (two individuals), indicating incomplete penetrance or age-dependent expression of dilated cardiomyopathy. RNA sequencing spanning the variant in cDNA blood of heterozygote individuals revealed nonsense-mediated mRNA decay of the mutated transcripts. In the current study, we present the first natural course of the recessively inherited lethal form of human fetal cardiomyopathy caused by loss of Nexilin function. The affected family had uneventful pregnancies until week 23-24, followed by fetal death at week 24-30, characterized by cardiomegaly and endocardial fibroelastosis.
- Published
- 2022
- Full Text
- View/download PDF
13. Miljökontroversers effekt på företags Environmental Pillar Score och CSR-strategier : En studie av 309 företag inom industrisektorn
- Author
-
Henriksson Lindberg, Amanda, Lundqvist, Sara, Henriksson Lindberg, Amanda, and Lundqvist, Sara
- Abstract
Titel: Miljökontroversers effekt på Environmental Pillar Score och CSR-strategier – enstudie på 309 företag inom industrisektorn. Nivå: Examensarbete på grundnivå (kandidatexamen) i ämnet företagsekonomi Författare: Sara Lundqvist och Amanda Henriksson Lindberg Handledare: Jan Svanberg Datum: januari 2022 Syfte: Syftet med studien var att undersöka om det fanns ett kausalt samband mellanmiljökontroverser och Environmental Pillar Score i industrisektorn. Tidigare forskninghar kommit fram till att det finns anledning att ifrågasätta tillförlitligheten i ESGbedömningar, till exempel har det framkommit att kontroverser haft en negativ påverkanpå ESG-betyget. Det betyder att hållbarhetsriskerna som ska beaktas i ESG-betyget interäknas med på ett korrekt sätt. Detta påverkar i sin tur investerare som baserar sinainvesteringsbeslut på felaktig information. Studien fokuserar på miljödimensionen avESG-betyget och avgränsas till industrisektorn. Metod: Data inhämtades för 309 publika bolag för åren 2016–2020 från databasenRefinitiv Eikon. Datamaterialet analyserades sedan med hjälp av tre logistiskaregressionsanalyser samt en multipel regressionsanalys. Resultat och slutsats: Studiens resultat visar ett positivt kausalt samband mellan CSRrapport och miljökontroverser, mellan MLS och miljökontroverser fann studien ettnegativt kausalt samband och för CSR sustainability committee och miljökontroverserkunde inget kausalt samband bekräftas. Slutsatsen av de tre analyserna blir att det finnsbåde en positiv och negativ effekt av miljökontroverser på CSR-prestationer för företaginom industrisektorn. Utöver det visade studiens resultat ett signifikant kausalt negativtsamband mellan miljökontroverser och Environmental Pillar Score. Utifrån resultatendras slutsatsen att miljökontroverser medför viss negativ förändring på EnvironmentalPillar Score, samt att tidigare miljökontroverser på kort sikt har både en positiv och ennegativ effekt på företags CSR-prestation. Studiens bidrag: Syft, Title: The effect of environmental controversy on Environmental Pillar Score and CSRstrategies - a study of 309 companies in the industrial sector. Level: Student thesis, final assignment for bachelor’s degree in business administration Authors: Sara Lundqvist and Amanda Henriksson Lindberg Supervisor: Jan Svanberg Date: January 2022 Aim: The purpose of the study was to investigate whether there was a causal correlationbetween environmental controversy and the Environmental Pillar Score in the industrialsector. Previous research indicated that the reliability of ESG assessments can bequestioned. For example, it has emerged that controversy has had a negative impact onthe ESG rating. This means the sustainability risks to be considered in the ESG rating arenot considered correctly. This affects investors who base their investment decisions onincorrect information. The study focuses on the environmental dimension of the ESGrating and is limited to the industrial sector. Method: Data were collected for 309 public companies for the years 2016–2020 fromthe Refinitiv Eikon database. The data material was analyzed using three logisticregression analyzes and a multiple regression analysis. Result and conclusions: The results of the study show a positive causal relationshipbetween CSR report and environmental controversies, between MLS and environmentalcontroversies the study found a negative causal relationship and for CSR sustainabilitycommittee and environmental controversies no causal relationship could be confirmed.The conclusion of the three analysis is that there is both a positive and negative effect ofenvironmental controversies on CSR performance for companies in the industrial sector.In addition, the results of the study showed a significant causal negative associationbetween environmental controversy and the Environmental Pillar Score. Based on theresults, it is concluded that environmental controversies lead to some negative change inthe Environmental Pillar S
- Published
- 2022
14. Fastighetsmäklarens syn på förhandling : En diskursanalys om hur fastighetsmäklare beskriver och ser på förhandling utefter Big Fives personlighetsdrag
- Author
-
Lindberg, Amanda, Lundstedt, Ellen, Lindberg, Amanda, and Lundstedt, Ellen
- Abstract
Titel: Fastighetsmäklarens syn på förhandling Nivå: Examensarbete på grundnivå(kandidatexamen) i ämnet företagsekonomi Författare: Amanda Lindberg och Ellen Lundstedt Handledare: Lars-Johan Åge Datum: 2022 - maj Syfte: Syftet med studien är att studera hur olika fastighetsmäklare, utefter deras personlighetsdrag, ser och uttrycker sig om sina förhandlingar. Metod: Studien har genomförts via en diskursanalys. Sex fastighetsmäklare har intervjuats med hjälp av frågor kopplade till förhandling. Intervjusvaren har sedan analyserats genom en utformad femstegsmodell anpassad för diskursanalyser. Utöver intervjun har varje mäklare genomfört en personlighetstest. Resultat och slutsats: Studien visar vad som anses viktigt för respektive fastighetsmäklare i en förhandling samt vilka ord mäklarna tenderar att använda. Det framställs att mäklare med höga nivåer av neuroticism talar mycket om ståndpunkter medan mäklare med höga nivåer av extraversion talar om social förmåga, samarbete och relationer. De med höga drag av agreeableness talar i stället om relationer, förtroende och behovsanalys. Mäklare med höga nivåer av openness to experience håller med om att behovsanalys är viktigt i en förhandling medan mäklare med personlighetsdraget conscientiousness fokuserar på mål och förberedelse. Examensarbetets bidrag: Studien bidrar till en ökad förståelse för hur fastighetsmäklare, utefter Big Fives personlighetstyper, talar om förhandling. Studien öppnar möjligheter till fastighetsmäklarbranschen och kan bidra till utveckling hos mäklare och mäklarstudenter. Förslag till vidare forskning: Ett förslag till vidare forskning är att differentiera fastighetsmäklarna från stad och kontor. Därefter studera om fastighetsmäklarens syn på förhandling beror på annat än deras personlighetsdrag. Nyckelord: Big Five, förhandling, diskursanalys, fastighetsmäklare.
- Published
- 2022
15. Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis
- Author
-
Johansson, Josefin, primary, Frykholm, Carina, additional, Ericson, Katharina, additional, Kazamia, Kalliopi, additional, Lindberg, Amanda, additional, Mulaiese, Nancy, additional, Falck, Geir, additional, Gustafsson, Per‐Erik, additional, Lidéus, Sarah, additional, Gudmundsson, Sanna, additional, Ameur, Adam, additional, Bondeson, Marie‐Louise, additional, and Wilbe, Maria, additional
- Published
- 2022
- Full Text
- View/download PDF
16. An Immune Score Reflecting Pro-and Anti-Tumoral Balance of Tumor Microenvironment Has Major Prognostic Impact and Predicts Immunotherapy Response in Solid Cancers
- Author
-
Mezheyeuski, Artur, primary, Backman, Max, additional, Mattsson, Johanna, additional, Martín-Bernabé, Alfonso, additional, Larsson, Chatarina, additional, Hrynchyk, Ina, additional, Hammarström, Klara, additional, Ström, Simon, additional, Ekström, Joakim, additional, Mauchanski, Siarhei, additional, Khelashvili, Salome, additional, Lindberg, Amanda, additional, Agnarsdóttir, Margrét, additional, Edqvist, Per-Henrik, additional, Huvila, Jutta, additional, Segersten, Ulrika, additional, Malmström, Per-Uno, additional, Botling, Johan, additional, Nodin, Björn, additional, Hedner, Charlotta, additional, Borg, David, additional, Brändstedt, Jenny, additional, Sartor, Hanna, additional, Leandersson, Karin, additional, Glimelius, Bengt, additional, Portyanko, Anna, additional, Ponten, Fredrik, additional, Jirström, Karin, additional, Micke, Patrick, additional, and Sjöblom, Tobias, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Spatial Immunophenotyping of the Tumor Microenvironment in Non-Small Cell Lung Cancer
- Author
-
Backman, Max, primary, Strell, Carina, additional, Lindberg, Amanda, additional, Mattsson, Johanna, additional, Elfving, Hedvig, additional, Brunström, Hans, additional, O'Reilly, Aine, additional, Bosic, Martina, additional, Gulyas, Miklos, additional, Isaksson, Johan, additional, Botling, Johan, additional, Kärre, Klas, additional, Jirström, Karin, additional, Lamberg, Kristina, additional, Ponten, Fredrik, additional, Leandersson, Karin, additional, Mezheyeuski, Artur, additional, and Micke, Patrick, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer.
- Author
-
Backman, Max, La Fleur, Linnéa, Kurppa, Pinja, Djureinovic, Dijana, Elfving, Hedvig, Brunnström, Hans, Mattsson, Johanna Sofia Margareta, Lindberg, Amanda, Pontén, Victor, Eltahir, Mohamed, Mangsbo, Sara, Gulyas, Miklos, Isaksson, Johan, Jirström, Karin, Kärre, Klas, Leandersson, Karin, Mezheyeuski, Artur, Pontén, Fredrik, Strell, Carina, and Lindskog, Cecilia
- Subjects
NON-small-cell lung carcinoma ,KILLER cells ,PLASMA cells ,GENETIC mutation ,GENETIC load - Abstract
Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of immune cell infiltration in non‐small cell lung cancer (NSCLC) in relation to its molecular and clinicopathologic characteristics. Lymphocytes (CD3+, CD4+, CD8+, CD20+, FOXP3+, CD45RO+), macrophages (CD163+), plasma cells (CD138+), NK cells (NKp46+), PD1+, and PD‐L1+ were annotated on a tissue microarray including 357 NSCLC cases. Somatic mutations were analyzed by targeted sequencing for 82 genes and a tumor mutational load score was estimated. Transcriptomic immune patterns were established in 197 patients based on RNA sequencing data. The immune cell infiltration was variable and showed only poor association with specific mutations. The previously defined immune phenotypic patterns, desert, inflamed, and immune excluded, comprised 30, 13, and 57% of cases, respectively. Notably, mRNA immune activation and high estimated tumor mutational load were unique only for the inflamed pattern. However, in the unsupervised cluster analysis, including all immune cell markers, these conceptual patterns were only weakly reproduced. Instead, four immune classes were identified: (1) high immune cell infiltration, (2) high immune cell infiltration with abundance of CD20+ B cells, (3) low immune cell infiltration, and (4) a phenotype with an imprint of plasma cells and NK cells. This latter class was linked to better survival despite exhibiting low expression of immune response‐related genes (e.g. CXCL9, GZMB, INFG, CTLA4). This compartment‐specific immune cell analysis in the context of the molecular and clinical background of NSCLC reveals two previously unrecognized immune classes. A refined immune classification, including traits of the humoral and innate immune response, is important to define the immunogenic potency of NSCLC in the era of immunotherapy. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.