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The paper develops an analytical method to design the plane arrangement of stabilising piles under spatial lateral load of 3D colluvial landslides with multilayer sliding masses. Firstly, an approach based on the geological map and binary Lagrange Interpolation method was presented to establish 3D landslide calculation models. The improved 3D limit equilibrium method was then proposed to calculate the stability coefficient and spatial distributed lateral load of landslide with multilayer sliding masses. And main sliding direction of 3D multilayer landslide can be determined by the developed principle of minimum potential energy. Moreover, through assuming the piles and soil as elastic transversely isotropic continuum medium, analytical approach was employed to accurately calculate the stress distribution of soil between adjacent piles; and the maximum pile spacing can be calculated. Finally, the reasonable arrangement of stabilising piles can be determined based on Monte-Carlo method and cost of all piles. The finite difference method was employed to validate the theoretical results through the case study of Bazimen landslide. And it is found that the proposed method for the design of piles' arrangement is economically beneficial compared with the traditional method on the premise of ensuring safety. [ABSTRACT FROM AUTHOR]