Search

Your search keyword '"Lorena Lôbo Figueiredo-Pontes"' showing total 3 results
Start Over Author "Lorena Lôbo Figueiredo-Pontes" Publication Year Range Last 3 years
3 results on '"Lorena Lôbo Figueiredo-Pontes"'

1. Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model

Author

Antônio Bruno Alves-Silva, Bruna Alves Fenerich, Natasha Peixoto Fonseca, Jaqueline Cristina Fernandes, Juan Luiz Coelho-Silva, Diego Antonio Pereira-Martins, Thiago Mantello Bianco, Priscila Santos Scheucher, Eduardo Magalhães Rego, Fernando Chahud, João Agostinho Machado-Neto, Lorena Lôbo Figueiredo-Pontes, and Fabiola Traina

Subjects
Pharmacology, Oncology, Pharmacology (medical)
Published
2022
Full Text
View/download PDF

2. Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2

Author

Jaqueline Cristina, Fernandes, Bruna Alves, Fenerich, Antônio Bruno, Alves-Silva, Natasha Peixoto, Fonseca, Juan Luiz, Coelho-Silva, Priscila Santos, Scheucher, Eduardo Magalhães, Rego, Lorena Lôbo, Figueiredo-Pontes, João Agostinho, Machado-Neto, and Fabiola, Traina

Subjects
Mice, Myeloproliferative Disorders, Mutation, Animals, Antineoplastic Agents, Apoptosis, Janus Kinase 2, Cell Proliferation, Receptor, IGF Type 1, Signal Transduction
Abstract

Myeloproliferative neoplasms (MPN) belong to a group of clonal diseases of hematopoietic stem cells characterized by aberrant proliferation of mature myeloid lineages. The constitutive activation of the JAK2/STAT signaling pathway is now well established to play a central role in MPN pathogenesis; however, accumulating evidence now indicates that the IGF1R-mediated signaling pathway contributes to the maintenance of the malignant phenotype. Studies using inhibitors of IGF1-mediated signaling have reported cytotoxic effects in cellular and murine models of MPN, but no consensus has been reached regarding the potency and efficacy of inhibitors of the IGF1R-related pathway in this context. In the present study, we compared the potency and efficacy of three inhibitors of IGF1R-related pathways in a JAK2

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results