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5. Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

Author

Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Katz, Jeffrey N, Nevitt, Michael C, Lynch, John A, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Kwoh, C Kent, Hoffmann, Steve, and Kraus, Virginia B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biomedical Imaging, Pain Research, Arthritis, Aging, Chronic Pain, Clinical Research, Musculoskeletal, Biomarkers, Cartilage, Articular, Disease Progression, Humans, Knee Joint, Magnetic Resonance Imaging, National Institutes of Health (U.S.), Osteoarthritis, Knee, Synovitis, United States, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science
Abstract

ObjectiveTo determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression.MethodsThe present study was a nested case-control trial from the Foundation of the National Institutes of Health OA Biomarkers Consortium that assessed study participants with a Kellgren/Lawrence grade of 1-3 who had complete biomarker data available (n = 539 to 550). Cases were participants' knees that had radiographic and pain progression between 24 and 48 months compared to baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) that had a P value of

Published
2022

8. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop

Author

Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, and Watt, Fiona E.

Published
2024
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11. The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis: Design and rationale

Author

Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., and Hunter, David J.

Published
2024
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20. Understanding Stakeholders’ Perspectives to Increase COVID‐19 Vaccine and Booster Uptake Among Black Individuals With Rheumatic Conditions

Author

Ezeh, Nnenna, Sirek, Greta, Ulysse, Sciaska N., Williams, Jessica N., Chandler, Mia T., Ojikutu, Bisola O., York, Michael, Crespo‐Bosque, Monica, Jean‐Jacques, Muriel, Roberson, Tonya, Mancera‐Cuevas, Karen, Milaeger, Holly, Losina, Elena, Dhand, Amar, Son, Mary Beth, Ramsey‐Goldman, Rosalind, and Feldman, Candace H.

Published
2023
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23. Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates.

Author

Kinsley, Sarah E., Song, Shuang, Losina, Elena, and Talbot, Simon G.

Abstract

Background: Candidate selection for upper extremity transplantation remains an inherently subjective process. This work evaluated the effect that psychosocial factors have on outcomes, both to standardize evaluation of potential candidates and in optimizing these factors prior to transplantation. Our goal was to measure and quantify the risk that various psychosocial factors have on transplant outcomes. Methods: Given that we do not have sufficient post-transplant patients to examine specific factors, we chose to have experts in the field evaluate hypothetical patients based on their experience. We used a Generalized Estimating Equation to estimate and compare surgical candidacy scores using patient scenario vignettes based on the presence or absence of permutations of the following: (1) depression; (2) participation in occupational therapy (OT); (3) expectation of post-transplant function; (4) punctuality; and (5) family support were given to experts in the field. Results: This work suggests there is a decrease in predicted success with increasing numbers of negative factors with participation in OT and realistic expectations of outcomes being most important. An increase in the summarizing risk score from 0 to 1.7 was associated with a decrease in the outcome surgical candidacy score from 8.6 to 5.3, meaning candidates with 2 risk factors would often observe a large drop in surgical candidacy score. Conclusions: Focusing on optimizing psychosocial variables in transplant candidates may help improve hand transplant success. [ABSTRACT FROM AUTHOR]

Published
2025
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24. Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity.

Author

Messier, Stephen P., Monroe, Megan G., Callahan, Leigh F., Mihalko, Shannon L., Beavers, Daniel P., Queen, Kate, Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., DeVita, Paul, Hunter, David J., and Quandt, Sara A.

Subjects
KNEE osteoarthritis, CONTROL (Psychology), WEIGHT loss, ATTENTION control, OLDER people
Abstract

Objective: The study objective was to determine whether the clinical response of older adults with knee osteoarthritis and overweight or obesity to 18 months of diet and exercise (D + E) or attention control (C) interventions differed between participants from rural versus urban communities. Methods: Participants were 823 older adults (mean age, 64.6 years; 77% women) with knee osteoarthritis and overweight or obesity who resided in rural (n = 410) and urban (n = 413) counties in North Carolina. All were enrolled in the Weight Loss and Exercise for Communities with Arthritis in North Carolina clinical trial that randomly assigned participants to either 18 months of D + E or C interventions. General linear models were used to examine differences in clinical outcomes between rural and urban groups after adjusting for covariates. Results: The rural group had significant differences (P < 0.05) at baseline in clinical outcomes, education, comorbidities, medication use, and income compared with the urban dwellers. After adjusting for baseline differences, the group (rural or urban) by treatment (D + E or C) interactions for Western Ontario McMasters Universities Osteoarthritis Index (WOMAC) pain (rural: D + E – C = −0.63, 95% confidence interval [CI] −1.31 to 0.06; urban: D + E − C= −0.29, 95% CI −0.99 to 0.41; P = 0.50) and WOMAC function (rural: D + E − C = −4.60, 95% CI −6.89 to −2.31; urban: D + E − C = −1.38, 95% CI −3.73 to 0.94; P = 0.054) indicated that the groups responded similarly to the interventions. Conclusion: Among participants with knee osteoarthritis and overweight or obesity, D + E compared to C led to similar pain outcomes in rural and urban dwellers that favored D + E. The possibility that there may be greater differential efficacy in functional outcomes among rural participants needs further study. [ABSTRACT FROM AUTHOR]

Published
2025
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27. Association Between Baseline Meniscal Symptoms and Outcomes of Operative and Nonoperative Treatment of Meniscal Tear in Patients With Osteoarthritis

Author

MacFarlane, Lindsey A., Yang, Heidi, Collins, Jamie E., Brophy, Robert H., Cole, Brian J., Spindler, Kurt P., Guermazi, Ali, Jones, Morgan H., Mandl, Lisa A., Martin, Scott, Marx, Robert G., Levy, Bruce A., Stuart, Michael, Safran‐Norton, Clare, Wright, John, Wright, Rick W., Losina, Elena, and Katz, Jeffrey N.

Published
2022
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31. The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis:Design and rationale

Author

Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J., Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., and Hunter, David J.

Abstract

Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ​≥ ​30 ​kg/m2) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA.Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

Published
2024

32. Toward designing human intervention studies to prevent osteoarthritis after knee injury:A report from an interdisciplinary OARSI 2023 workshop

Author

Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, Watt, Fiona E., Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, and Watt, Fiona E.

Abstract

Objective: The global impact of osteoarthritis is growing. Currently no disease modifying osteoarthritis drugs/therapies exist, increasing the need for preventative strategies. Knee injuries have a high prevalence, distinct onset, and strong independent association with post-traumatic osteoarthritis (PTOA). Numerous groups are embarking upon research that will culminate in clinical trials to assess the effect of interventions to prevent knee PTOA despite challenges and lack of consensus about trial design in this population. Our objectives were to improve awareness of knee PTOA prevention trial design and discuss state-of-the art methods to address the unique opportunities and challenges of these studies. Design: An international interdisciplinary group developed a workshop, hosted at the 2023 Osteoarthritis Research Society International Congress. Here we summarize the workshop content and outputs, with the goal of moving the field of PTOA prevention trial design forward. Results: Workshop highlights included discussions about target population (considering risk, homogeneity, and possibility of modifying osteoarthritis outcome); target treatment (considering delivery, timing, feasibility and effectiveness); comparators (usual care, placebo), and primary symptomatic outcomes considering surrogates and the importance of knee function and symptoms other than pain to this population. Conclusions: Opportunities to test multimodal PTOA prevention interventions across preclinical models and clinical trials exist. As improving symptomatic outcomes aligns with patient and regulator priorities, co-primary symptomatic (single or aggregate/multidimensional outcome considering function and symptoms beyond pain) and structural/physiological outcomes may be appropriate for these trials. To ensure PTOA prevention trials are relevant and acceptable to all stakeholders, future research should address critical knowledge gaps and challenges.

Published
2024

33. Projected Life Expectancy Gains From Improvements in HIV Care in Black and White Men Who Have Sex With Men

Author

Rich, Katherine M., primary, Pandya, Ankur, additional, Chiosi, John J., additional, Reddy, Krishna P., additional, Shebl, Fatma M., additional, Ciaranello, Andrea L., additional, Neilan, Anne M., additional, Pinkney, Jodian A., additional, Losina, Elena, additional, Freedberg, Kenneth A., additional, Ahonkhai, Aima A., additional, and Hyle, Emily P., additional

Published
2023
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34. Clinical, Health‐Related Quality of Life, and Gait Differences Among Obesity Classes in Adults with Knee Osteoarthritis

Author

Messier, Stephen P., primary, Gill, Malia E., additional, Mihalko, Shannon L., additional, Beavers, Daniel P., additional, Queen, Kate, additional, Miller, Gary D., additional, Losina, Elena, additional, Katz, Jeffrey N., additional, Loeser, Richard F., additional, DeVita, Paul, additional, Hunter, David J., additional, Quandt, Sara A., additional, Lyles, Mary F., additional, Hudson, David, additional, and Callahan, Leigh F., additional

Published
2023
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35. Radiographic Changes Five Years After Treatment of Meniscal Tear and Osteoarthritic Changes

Author

Katz, Jeffrey N., primary, Collins, Jamie E., additional, Brophy, Robert H., additional, Cole, Brian J., additional, Cox, Charles L., additional, Guermazi, Ali, additional, Jones, Morgan H., additional, Levy, Bruce A., additional, MacFarlane, Lindsey A., additional, Mandl, Lisa A., additional, Marx, Robert G., additional, Selzer, Faith, additional, Spindler, Kurt P., additional, Wright, Rick W., additional, Losina, Elena, additional, and Chang, Yuchiao, additional

Published
2023
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38. Cost‐Effectivenessof Community‐BasedDiet and Exercise for Patients with Knee Osteoarthritis and Obesity or Overweight

Author

Kopp, Paul T., Yang, Catherine, Yang, Heidi, Katz, Jeffrey N., Paltiel, A. David, Hunter, David J., Callahan, Leigh F., Mihalko, Shannon L., Newman, Jovita J., DeVita, Paul, Loeser, Richard F., Miller, Gary D., Messier, Stephen P., and Losina, Elena

Abstract

Obesity exacerbates pain and functional limitation in persons with knee osteoarthritis (OA). In the Weight Loss and Exercise for Communities with Arthritis in North Carolina (WE‐CAN) study, a community‐based diet and exercise (D + E) intervention led to an additional 6 kg weight loss and 20% greater pain relief in persons with knee OA and body mass index (BMI) >27 kg/m2relative to a group‐based health education (HE) intervention. We sought to determine the incremental cost‐effectiveness of the usual care (UC), UC + HE, and UC + (D + E) programs, comparing each strategy with the “next‐best” strategy ranked by increasing lifetime cost. We used the Osteoarthritis Policy Model to project long‐term clinical and economic benefits of the WE‐CAN interventions. We considered three strategies: UC, UC + HE, and UC + (D + E). We derived cohort characteristics, weight, and pain reduction from the WE‐CAN trial. Our outcomes included quality‐adjusted life years (QALYs), cost, and incremental cost‐effectiveness ratios (ICERs). In a cohort with mean age 65 years, BMI 37 kg/m2, and Western Ontario and McMaster Universities Osteoarthritis Index pain score 38 (scale 0–100, 100 = worst), UC leads to 9.36 QALYs/person, compared with 9.44 QALYs for UC + HE and 9.49 QALYS for UC + (D + E). The corresponding lifetime costs are $147,102, $148,139, and $151,478. From the societal perspective, UC + HE leads to an ICER of $12,700/QALY; adding D + E to UC leads to an ICER of $61,700/QALY. The community‐based D + E program for persons with knee OA and BMI >27kg/m2could be cost‐effective for willingness‐to‐pay thresholds greater than $62,000/QALY. These findings suggest that incorporation of community‐based D + E programs into OA care may be beneficial for public health.

Published
2024
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40. Clinical, Health‐RelatedQuality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

Author

Messier, Stephen P., Gill, Malia E., Mihalko, Shannon L., Beavers, Daniel P., Queen, Kate, Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., DeVita, Paul, Hunter, David J., Quandt, Sara A., Lyles, Mary F., Hudson, David, and Callahan, Leigh F.

Abstract

The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. This cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0–34.9; class II, BMI 35.0–39.9; class III BMI ≥40.0). Patients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0–20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0–2.1; P< 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6–1.7; P= 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference −6.2; 95% CI −7.8 to −4.7; P< 0.0001) and class II (mean 31.0 vs 35.0; difference −3.9; 95% CI −5.6 to −2.2; P< 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6–4.0; P< 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6–3.2; P< 0.0001) obesity groups. Among adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity.

Published
2024
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42. Evaluating Osteoarthritis Management Programs: Outcome Domain Recommendations from the OARSI Joint Effort Initiative

Author

Allen, Kelli D., primary, Huffman, Katie, additional, Cleveland, Rebecca J., additional, van der Esch, Martin, additional, Abbott, J. Haxby, additional, Abbott, Allan, additional, Bennell, Kim, additional, Bowden, Jocelyn L., additional, Eyles, Jillian, additional, Healey, Emma L., additional, Holden, Melanie A, additional, Jayakumar, Prakash, additional, Koenig, Karl, additional, Lo, Grace, additional, Losina, Elena, additional, Miller, Katie, additional, Østerås, Nina, additional, Pratt, Carin, additional, Quicke, Jonathan G, additional, Sharma, Saurab, additional, Skou, Søren T, additional, Woolf, Anthony, additional, Yu, Shirley P., additional, Hinman, Rana S., additional, and Tveter, Anne Therese, additional

Published
2023
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44. sj-docx-4-han-10.1177_15589447231184895 – Supplemental material for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates

Author

Kinsley, Sarah E., Song, Shuang, Losina, Elena, and Talbot, Simon G.

Subjects
Medicine, Orthopaedics, Sports Medicine
Abstract

Supplemental material, sj-docx-4-han-10.1177_15589447231184895 for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates by Sarah E. Kinsley, Shuang Song, Elena Losina and Simon G. Talbot in HAND

Published
2023
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45. sj-docx-2-han-10.1177_15589447231184895 – Supplemental material for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates

Author

Kinsley, Sarah E., Song, Shuang, Losina, Elena, and Talbot, Simon G.

Subjects
Medicine, Orthopaedics, Sports Medicine
Abstract

Supplemental material, sj-docx-2-han-10.1177_15589447231184895 for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates by Sarah E. Kinsley, Shuang Song, Elena Losina and Simon G. Talbot in HAND

Published
2023
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46. sj-docx-1-han-10.1177_15589447231184895 – Supplemental material for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates

Author

Kinsley, Sarah E., Song, Shuang, Losina, Elena, and Talbot, Simon G.

Subjects
Medicine, Orthopaedics, Sports Medicine
Abstract

Supplemental material, sj-docx-1-han-10.1177_15589447231184895 for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates by Sarah E. Kinsley, Shuang Song, Elena Losina and Simon G. Talbot in HAND

Published
2023
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47. sj-docx-3-han-10.1177_15589447231184895 – Supplemental material for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates

Author

Kinsley, Sarah E., Song, Shuang, Losina, Elena, and Talbot, Simon G.

Subjects
Medicine, Orthopaedics, Sports Medicine
Abstract

Supplemental material, sj-docx-3-han-10.1177_15589447231184895 for Psychosocial Risk Stratification in Upper Extremity Transplantation Candidates by Sarah E. Kinsley, Shuang Song, Elena Losina and Simon G. Talbot in HAND

Published
2023
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49. Effect of Diet and Exercise on Knee Pain in Patients With Osteoarthritis and Overweight or Obesity

Author

Messier, Stephen P., primary, Beavers, Daniel P., additional, Queen, Kate, additional, Mihalko, Shannon L., additional, Miller, Gary D., additional, Losina, Elena, additional, Katz, Jeffrey N., additional, Loeser, Richard F., additional, DeVita, Paul, additional, Hunter, David J., additional, Newman, Jovita J., additional, Quandt, Sara A., additional, Lyles, Mary F., additional, Jordan, Joanne M., additional, and Callahan, Leigh F., additional

Published
2022
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