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A novel citrate anion-intercalated Mg/Al layered double hydroxide (CA-LDH) is synthesized via a one-step hydrothermal process. The synthesized CA-LDH is a hollow flower-like microsphere composed of thin nanoflakes (10 nm in thickness). After calcination, the formed Mg/Al layered double oxide (CA-LDO) hollow microspheres possess a high specific surface area of 247.8 m2 g−1 and a high pore volume of 0.97 cm3 g−1, which endow them with excellent adsorption ability towards Congo red (CR). The maximum adsorption capacity of CR onto CA-LDO can reach up to 1883 mg g−1. The significantly improved adsorption capacity of CA-LDO can be attributed to its unique structures of hierarchical hollow microspheres, in which the hierarchical porous shell layer provides enough adsorption sites to anchor the dye molecules, and the hollow core can preserve the absorbed dye. This study provides a promising novel adsorbent which can be used for efficient water remediation. [ABSTRACT FROM AUTHOR]

Background: Observational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However, the causal relationship between peripheral blood immune cells and PSC remains insufficiently understood., Methods: A bidirectional two-sample Mendelian randomization (MR) analysis was implemented to determine the causal effect between PBC and 731 immune cells. All datasets were extracted from a publicly available genetic database. The standard inverse variance weighted (IVW) method was selected as the main method for the causality analysis. Cochran's Q statistics and MR-Egger intercept were performed to evaluate heterogeneity and pleiotropy., Results: In forward MR analysis, the expression ratios of CD11c on CD62L+ myeloid DC (OR = 1.136, 95% CI = 1.032-1.250, p = 0.009) and CD62L-myeloid DC AC (OR = 1.267, 95% CI = 1.086-1.477, p = 0.003) were correlated with a higher risk of PSC. Each one standard deviation increase of CD28 on resting regulatory T cells (Treg) (OR = 0.724, 95% CI = 0.630-0.833, p < 0.001) and CD3 on secreting Treg (OR = 0.893, 95% CI = 0.823-0.969, p = 0.007) negatively associated with the risk of PSC. In reverse MR analysis, PSC was identified with a genetic causal effect on EM CD8+ T cell AC, CD8+ T cell AC, CD28- CD127- CD25++ CD8+ T cell AC, CD28- CD25++ CD8+ T cell AC, CD28- CD8+ T cell/CD8+ T cell, CD28- CD8+ T cell AC, and CD45 RA- CD28- CD8+ T cell AC., Conclusion: Our study indicated the evidence of causal effects between PSC and immune cells, which may provide a potential foundation for future diagnosis and treatment of PSC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wu, Xie, Cai, Liu, Lv, Yang, He, Yin, Lan and Wu.)

A novel citrate anion-intercalated Mg/Al layered double hydroxide (CA-LDH) is synthesized via a one-step hydrothermal process. The synthesized CA-LDH is a hollow flower-like microsphere composed of thin nanoflakes (10 nm in thickness). After calcination, the formed Mg/Al layered double oxide (CA-LDO) hollow microspheres possess a high specific surface area of 247.8 m 2 g -1 and a high pore volume of 0.97 cm 3 g -1 , which endow them with excellent adsorption ability towards Congo red (CR). The maximum adsorption capacity of CR onto CA-LDO can reach up to 1883 mg g -1 . The significantly improved adsorption capacity of CA-LDO can be attributed to its unique structures of hierarchical hollow microspheres, in which the hierarchical porous shell layer provides enough adsorption sites to anchor the dye molecules, and the hollow core can preserve the absorbed dye. This study provides a promising novel adsorbent which can be used for efficient water remediation.