8 results on '"M., Aliotta"'
Search Results
2. Advances in radiative capture studies at LUNA with a segmented BGO detector
- Author
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J Skowronski, R M Gesuè, A Boeltzig, G F Ciani, D Piatti, D Rapagnani, M Aliotta, C Ananna, F Barile, D Bemmerer, A Best, C Broggini, C G Bruno, A Caciolli, M Campostrini, F Cavanna, P Colombetti, A Compagnucci, P Corvisiero, L Csedreki, T Davinson, R Depalo, A Di Leva, Z Elekes, F Ferraro, A Formicola, Zs Fülöp, G Gervino, A Guglielmetti, C Gustavino, Gy Gyürky, G Imbriani, M Junker, M Lugaro, P Marigo, E Masha, R Menegazzo, V Paticchio, R Perrino, P Prati, V Rigato, L Schiavulli, R S Sidhu, O Straniero, T Szücs, and S Zavatarelli
- Subjects
Nuclear and High Energy Physics ,gamma-ray total absorption spectroscopy ,radiation shielding and background reduction ,nuclear astrophysics experiment ,activation measurement ,segmented bismuth germanium oxide (BGO) detector ,Settore FIS/04 - Fisica Nucleare e Subnucleare - Abstract
Studies of charged-particle reactions for low-energy nuclear astrophysics require high sensitivity, which can be achieved by means of detection setups with high efficiency and low backgrounds, to obtain precise measurements in the energy region of interest for stellar scenarios. High-efficiency total absorption spectroscopy is an established and powerful tool for studying radiative capture reactions, particularly if combined with the cosmic background reduction by several orders of magnitude obtained at the Laboratory for Underground Nuclear Astrophysics (LUNA). We present recent improvements in the detection setup with the Bismuth Germanium Oxide (BGO) detector at LUNA, aiming to reduce high-energy backgrounds and increase the summing detection efficiency. The new design results in enhanced sensitivity of the BGO setup, as we demonstrate and discuss in the context of the first direct measurement of the 65 keV resonance (E x = 5672 keV) of the 17O(p,γ)18F reaction. Moreover, we show two applications of the BGO detector, which exploit its segmentation. In the case of complex γ-ray cascades, e.g. the de-excitation of E x = 5672 keV in 18F, the BGO segmentation allows to identify and suppress the beam-induced background signals that mimic the sum peak of interest. We demonstrate another new application for such a detector in form of in situ activation measurements of a reaction with β + unstable product nuclei, e.g. the 14N(p,γ)15O reaction.
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- 2023
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3. Storage, Accumulation and Deceleration of Secondary Beams for Nuclear Astrophysics
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J. Glorius, Yu. A. Litvinov, M. Aliotta, F. Amjad, B. Brückner, C.G. Bruno, R. Chen, T. Davinson, S.F. Dellmann, T. Dickel, I. Dillmann, P. Erbacher, O. Forstner, H. Geissel, C.J. Griffin, R. Grisenti, A. Gumberidze, E. Haettner, R. Hess, P.-M. Hillenbrand, C. Hornung, R. Joseph, B. Jurado, E. Kazanseva, R. Knöbel, D. Kostyleva, C. Kozhuharov, N. Kuzminchuk, C. Langer, G. Leckenby, C. Lederer-Woods, M. Lestinsky, S. Litvinov, B. Löher, B. Lorenz, E. Lorenz, J. Marsh, E. Menz, T. Morgenroth, I. Mukha, N. Petridis, U. Popp, A. Psaltis, S. Purushothaman, R. Reifarth, E. Rocco, P. Roy, M.S. Sanjari, C. Scheidenberger, M. Sguazzin, R.S. Sidhu, U. Spillmann, M. Steck, T. Stöhlker, J.A. Swartz, Y.K. Tanaka, H. Törnqvist, L. Varga, D. Vescovi, H. Weick, M. Weigand, P.J. Woods, T. Yamaguchi, and J. Zhao
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Storage rings ,Nuclear and High Energy Physics ,Rare ion beans ,Physics - Instrumentation and Detectors ,In-flight production ,FOS: Physical sciences ,Nuclear reaction ,Instrumentation and Detectors (physics.ins-det) ,Nuclear Experiment (nucl-ex) ,Nuclear Experiment ,Instrumentation - Abstract
Low-energy investigations on rare ion beams are often limited by the available intensity and purity of the ion species in focus. Here, we present the first application of a technique that combines in-flight production at relativistic energies with subsequent secondary beam storage, accumulation and finally deceleration to the energy of interest. Using the FRS and ESR facilities at GSI, this scheme was pioneered to provide a secondary beam of $^{118}$Te$^{52+}$ for the measurement of nuclear proton-capture at energies of 6 and 7 MeV/u. The technique provided stored beam intensities of about $10^6$ ions at high purity and brilliance, representing a major step towards low-energy nuclear physics studies using rare ion beams.
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- 2023
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4. Direct measurements of the $$^{12}$$C+$$^{12}$$C reactions cross-sections towards astrophysical energies
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L. Morales-Gallegos, M. Aliotta, L. Gialanella, A. Best, C. G. Bruno, R. Buompane, T. Davinson, M. De Cesare, A. Di Leva, A. D’Onofrio, J. G. Duarte, L. R. Gasques, G. Imbriani, G. Porzio, D. Rapagnani, M. Romoli, F. Terrasi, Morales-Gallegos, L., Aliotta, M., Gialanella, L., Best, A., Bruno, C. G., Buompane, R., Davinson, T., De Cesare, M., Di Leva, A., D'Onofrio, A., Duarte, J. G., Gasques, L. R., Imbriani, G., Porzio, G., Rapagnani, D., Romoli, M., and Terrasi, F.
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Nuclear and High Energy Physics ,Experimental Nuclear Astrophysics Carbon burning in stars ,ASTROFÍSICA - Abstract
Carbon fusion reactions $$^{12}$$ 12 C($$^{12}$$ 12 C,p)$$^{23}$$ 23 Na and $$^{12}$$ 12 C($$^{12}$$ 12 C,$$\alpha $$ α )$$^{20}$$ 20 Ne play a key role in the evolution of massive stars and in explosive scenarios such as type-Ia supernovae and super-bursts in binary stars. A direct determination of their cross sections is extremely challenging and discrepancies exist between different data sets in the literature. Here we report the results of a direct measurement performed at the CIRCE Tandem Accelerator Laboratory in Caserta (Italy), using $$\varDelta E-E$$ Δ E - E detectors for unambiguous charge identification. Cross sections were measured in the energy range $$E_{\mathrm{c.m.}} =2.51{-}4.36$$ E c . m . = 2.51 - 4.36 MeV with energy steps between 10 and 25 keV in the centre of mass. To our knowledge these represent the finest energy steps to date. Results are presented in the form of partial and summed astrophysical $${\tilde{S}}$$ S ~ -factors for individual proton- and $$\alpha $$ α -particle channels. Branching ratios of individual proton- and $$\alpha $$ α -particle groups were found to vary significantly with energy. Angular distributions, albeit limited to three angles, were also found to be non-isotropic, which could be a potential explanation for the discrepancies observed among different data sets. Further efforts are ongoing to extend measurements to lower energies.
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- 2022
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5. Proton capture on stored radioactive 118Te ions
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S. F. Dellmann, J. Glorius, Y. A. Litvinov, R. Reifarth, K. Al-Khasawneh, M. Aliotta, L. Bott, B. Brückner, C. Bruno, R. J. Chen, T. Davinson, T. Dickel, I Dillmann, D. Dmytriev, P. Erbacher, D. Freire-Fernández, O. Forstner, H. Geissel, K. Göbel, C. J. Griffin, R. Grisenti, A. Gumberidze, E. Haettner, S. Hagmann, M. Heil, R. Heß, P.-M. Hillenbrand, R. Joseph, B. Jurado, C. Kozhuharov, I. Kulikov, B. Löher, C. Langer, G. Leckenby, C. Lederer-Woods, M. Lestinsky, S. Litvinov, B. A. Lorenz, E. Lorenz, J. Marsh, E. Menz, T. Morgenroth, N. Petridis, J. Pibernat, U. Popp, A. Psaltis, S. Sanjari, C. Scheidenberger, M. Sguazzin, R. S. Sidhu, U. Spillmann, M. Steck, T. Stöhlker, A. Surzhykov, J. A. Swartz, H. Törnqvist, L. Varga, D. Vescovi, H. Weick, M. Weigand, P. Woods, Y. Xing, and T. Yamaguchi
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General Medicine - Abstract
Experimental determination of the cross sections of proton capture on radioactive nuclei is extremely difficult. Therefore, it is of substantial interest for the understanding of the production of the p-nuclei. For the first time, a direct measurement of proton-capture cross sections on stored, radioactive ions became possible in an energy range of interest for nuclear astrophysics. The experiment was performed at the Experimental Storage Ring (ESR) at GSI by making use of a sensitive method to measure (p,γ) and (p,n) reactions in inverse kinematics. These reaction channels are of high relevance for the nucleosyn-thesis processes in supernovae, which are among the most violent explosions in the universe and are not yet well understood. The cross section of the 118Te(p,γ) reaction has been measured at energies of 6 MeV/u and 7 MeV/u. The heavy ions interacted with a hydrogen gas jet target. The radiative recombination process of the fully stripped 118Te ions and electrons from the hydrogen target was used as a luminosity monitor. An overview of the experimental method and preliminary results from the ongoing analysis will be presented.
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- 2023
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6. First Direct Measurement of the 64.5 keV Resonance Strength in the ^{17}O(p,γ)^{18}F Reaction.
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Gesuè RM, Ciani GF, Piatti D, Boeltzig A, Rapagnani D, Aliotta M, Ananna C, Barbieri L, Barile F, Bemmerer D, Best A, Broggini C, Bruno CG, Caciolli A, Campostrini M, Casaburo F, Cavanna F, Colombetti P, Compagnucci A, Corvisiero P, Csedreki L, Davinson T, De Gregorio GM, Dell'Aquila D, Depalo R, Di Leva A, Elekes Z, Ferraro F, Formicola A, Fülöp Z, Gervino G, Guglielmetti A, Gustavino C, Gyürky G, Imbriani G, Junker M, Lugaro M, Marigo P, Marsh J, Masha E, Menegazzo R, Mercogliano D, Paticchio V, Perrino R, Prati P, Rigato V, Robb D, Schiavulli L, Sidhu RS, Skowronski J, Straniero O, Szücs T, and Zavatarelli S
- Abstract
The CNO cycle is one of the most important nuclear energy sources in stars. At temperatures of hydrostatic H-burning (20 MK
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- 2024
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7. Proton-Capture Rates on Carbon Isotopes and Their Impact on the Astrophysical ^{12}C/^{13}C Ratio.
- Author
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Skowronski J, Boeltzig A, Ciani GF, Csedreki L, Piatti D, Aliotta M, Ananna C, Barile F, Bemmerer D, Best A, Broggini C, Bruno CG, Caciolli A, Campostrini M, Cavanna F, Colombetti P, Compagnucci A, Corvisiero P, Davinson T, Depalo R, Di Leva A, Elekes Z, Ferraro F, Formicola A, Fülöp Z, Gervino G, Gesuè RM, Guglielmetti A, Gustavino C, Gyürky G, Imbriani G, Junker M, Lugaro M, Marigo P, Masha E, Menegazzo R, Paticchio V, Perrino R, Prati P, Rapagnani D, Rigato V, Schiavulli L, Sidhu RS, Straniero O, Szücs T, and Zavatarelli S
- Abstract
The ^{12}C/^{13}C ratio is a significant indicator of nucleosynthesis and mixing processes during hydrogen burning in stars. Its value mainly depends on the relative rates of the ^{12}C(p,γ)^{13}N and ^{13}C(p,γ)^{14}N reactions. Both reactions have been studied at the Laboratory for Underground Nuclear Astrophysics (LUNA) in Italy down to the lowest energies to date (E_{c.m.}=60 keV) reaching for the first time the high energy tail of hydrogen burning in the shell of giant stars. Our cross sections, obtained with both prompt γ-ray detection and activation measurements, are the most precise to date with overall systematic uncertainties of 7%-8%. Compared with most of the literature, our results are systematically lower, by 25% for the ^{12}C(p,γ)^{13}N reaction and by 30% for ^{13}C(p,γ)^{14}N. We provide the most precise value up to now of 3.6±0.4 in the 20-140 MK range for the lowest possible ^{12}C/^{13}C ratio that can be produced during H burning in giant stars.
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- 2023
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8. Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.
- Author
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Travelli C, Colombo G, Aliotta M, Fagiani F, Fava N, De Sanctis R, Grolla AA, Garcia JGN, Clemente N, Portararo P, Costanza M, Condorelli F, Colombo MP, Sangaletti S, and Genazzani AA
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- Humans, Female, Mice, Animals, Nicotinamide Phosphoribosyltransferase metabolism, Immune Evasion, Cytokines metabolism, Prognosis, Breast Neoplasms
- Abstract
Background: Nicotinamide phosphoribosyltransferase (NAMPT) is a key intracellular enzyme that participates in nicotinamide adenine dinucleotide (NAD) homeostasis as well as a released cytokine (eNAMPT) that is elevated in inflammatory conditions and in cancer. In patients with breast cancer, circulating eNAMPT is elevated and its plasma levels correlate with prognosis and staging. In light of this, we investigated the contribution of eNAMPT in triple negative mammary carcinoma progression by investigating the effect of its neutralization via a specific neutralizing monoclonal antibody (C269)., Methods: We used female BALB/c mice injected with 4T1 clone 5 cells and female C57BL6 injected with EO771 cells, evaluating tumoral size, spleen weight and number of metastases. We injected two times a week the anti-eNAMPT neutralizing antibody and we sacrificed the mice after 28 days. Harvested tumors were analyzed by histopathology, flow cytometry, western blot, immunohistochemistry, immunofluorescence and RNA sequencing to define tumor characteristics (isolating tumor infiltrating lymphocytes and tumoral cells) and to investigate the molecular mechanisms behind the observed phenotype. Moreover, we dissected the functional relationship between T cells and tumoral cells using three-dimensional (3D) co-cultures., Results: The neutralization of eNAMPT with C269 led to decreased tumor size and reduced number of lung metastases. RNA sequencing and functional assays showed that eNAMPT controlled T-cell response via the programmed death-ligand 1/programmed cell death protein 1 (PD-L1/PD-1) axis and its neutralization led to a restoration of antitumoral immune responses. In particular, eNAMPT neutralization was able to activate CD8
+ IFNγ+ GrzB+ T cells, reducing the immunosuppressive phenotype of T regulatory cells., Conclusions: These studies indicate for the first time eNAMPT as a novel immunotherapeutic target for triple negative breast cancer., Competing Interests: Competing interests: No, there are no competing interests., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2023
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