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Italy is frequently hit and damaged by landslides, resulting in substantial and widespread disruptions. In particular, slope failures have a high impact on the population, communication infrastructure, and economic and productive sectors. The hazard posed by landslides requires adequate responses for landslide risk mitigation, with special attention to the risk to the population. In 2006 the Italian Department of Civil Protection, an office of the Prime Minister, commissioned the Research Institute for Geo-Hydrological Protection (Istituto di Ricerca per la Protezione Idrogeologica), a research institute of the Italian National Research Council, to carry out operational forecasting of rainfall-induced landslides. Collecting landslide information in a catalogue is a preliminary action toward landslide forecasting. The use of spatially and temporally inaccurate landslide catalogues results in uncertain and unreliable operational landslide forecasting. Consequently, accurate catalogues are needed to reduce the uncertainties, which are to some extent unavoidable. To this end, over the last 15 years many researchers have been involved in compiling a catalogue called ITALICA (ITAlian rainfall-induced LandslIdes CAtalogue), which currently lists 6312 records with information on rainfall-induced landslides that occurred over the Italian territory between January 1996 and December 2021. Overall, more than one-third of the catalogue has very high geographic accuracy (less than 1 km2) and hourly temporal resolution. In contrast, less than 2 % of the catalogue has low and very low geographical accuracy and daily temporal resolution. This makes ITALICA the largest catalogue of rainfall-induced landslides accurately located in space and time available in Italy. Without this high level of accuracy, the precipitation responsible for the initiation of landslides cannot be reliably reconstructed, thus making the prediction of landslide occurrence ineffective. ITALICA can be accessed at https://doi.org/10.5281/zenodo.8009366 (Brunetti et al., 2023). ITALICA's information on rainfall-induced landslides in Italy places a special emphasis on their spatial and temporal locations, making the catalogue especially suitable for defining the rainfall conditions capable of triggering future landslides in the Italian territory. This information is fundamental for decision-making in landslide risk management.

Aims: The last released European guidelines on the management of heart failure (HF) recommend in patients with chronic HF with reduced ejection fraction (HFrEF) a pharmacological approach based on four fundamental drugs to be rapidly implemented and then uptitrated to modify disease progression. The aim of the Optimization of Therapy in the Italian Management of Heart Failure (OPTIMA-HF) registry is to collect data on chronic HF outpatients in different settings of care. In the present analysis, we report the first analysis of the OPTIMA-HF registry, focusing on the real-life use of guideline-directed medical therapy in patients affected by HFrEF., Methods: OPTIMA-HF is an observational, cross-sectional, multicentre, real-life Italian registry conducted in two different clinical settings: HF outpatients' clinics of Italian hospitals and community HF outpatients' services. The study comprises a T0 phase-retrospective data collection, in which data of consecutive HF outpatients seen between January and October 2022 were collected; an educational activity phase; and a T1 phase-prospective data collection, in which data of consecutive HF outpatients seen between September 2023 and November 2023 were collected. In the present analysis, we describe the T0 phase focusing on HFrEF drug prescription rates, types, doses, combination therapy, the presence of contraindications and reasons of non-optimized treatment., Results: Twenty-nine centres enrolled 2110 HF patients, of which 1390 (65.9%) had HFrEF [69.5 ± 11.9 years, 76.2% males, 4.1 years since HF diagnosis, median ejection fraction (EF) 33%]. Among HFrEF patients, 89.1% were on treatment with renin-angiotensin-aldosterone system inhibitor (RAASi)/angiotensin receptor neprilysin inhibitor (ARNI) (72% ARNI and 17.1% RAASi), 95.1% with beta-blockers, 75.8% with mineralocorticoid receptor antagonists (MRA) and 63.2% with sodium/glucose cotransporter 2 inhibitors (SGLT2i). Despite high prescription rates, a non-negligible number of patients with no contraindications were not treated with each specific drug. Patients taking all four drug classes, as recommended by guidelines, were mere 46.9%. Regarding doses, a still low number of patients on RAASi/ARNI and beta-blockers were treated with a dose ≥50% of the target doses recommended by the European guidelines., Conclusions: The OPTIMA-HF registry reported that HFrEF fundamental drugs are prescribed in most Italian patients; however, <50% of patients receive optimal combination therapy, and still not a satisfying number of patients receive target doses. Strategies to improve implementation of guideline-directed medical therapy are needed to improve HF prognosis., (© 2025 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Dust grains absorb half of the radiation emitted by stars throughout the history of the universe, re-emitting this energy at infrared wavelengths 1-3 . Polycyclic aromatic hydrocarbons (PAHs) are large organic molecules that trace millimetre-size dust grains and regulate the cooling of interstellar gas within galaxies 4,5 . Observations of PAH features in very distant galaxies have been difficult owing to the limited sensitivity and wavelength coverage of previous infrared telescopes 6,7 . Here we present James Webb Space Telescope observations that detect the 3.3 μm PAH feature in a galaxy observed less than 1.5 billion years after the Big Bang. The high equivalent width of the PAH feature indicates that star formation, rather than black hole accretion, dominates infrared emission throughout the galaxy. The light from PAH molecules, hot dust and large dust grains and stars are spatially distinct from one another, leading to order-of-magnitude variations in PAH equivalent width and ratio of PAH to total infrared luminosity across the galaxy. The spatial variations we observe suggest either a physical offset between PAHs and large dust grains or wide variations in the local ultraviolet radiation field. Our observations demonstrate that differences in emission from PAH molecules and large dust grains are a complex result of localized processes within early galaxies., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)