1. Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
- Author
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Anton Filipchuk, Joanna Schwenkgrub, Alain Destexhe, Brice Bathellier, Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Funding was provided by the European Community, Future and Emerging Technologies program—Human Brain Project (no. H2020-945539 to A.D.), Paris-Saclay University ‘Initiatives de Recherches Stratégiques’—NeuroSaclay and Icode (to B.B. and A.D.), Agence Nationale pour la Recherche (no. 12-PDOC-0006 to B.B., PARADOX to A.D.), Région Ile de France—DIM Cerveau Pensée—MULTISENSE (to B.B.), Fondation pour l’Audition (nos. FPA IDA02 and APA 2016-03 to B.B.), and the European Research Council (no. CoG 770841 DEEPEN to B.B.). B.B. thanks the Fondation pour l’Audition for their support to the Institut de l’Audition., ANR-12-PDOC-0006,SENSEMAKER,Traitement cortical multisensoriel et émergence de percepts supra-modaux(2012), ANR-17-CE16-0024,PARADOX,Le sommeil paradoxical décodé(2017), European Project: 945539,H2020,H2020-SGA-FETFLAG-HBP-2019,HBP SGA3(2020), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), PERIGNON, Alain, Retour Post-Doctorant - Traitement cortical multisensoriel et émergence de percepts supra-modaux - - SENSEMAKER2012 - ANR-12-PDOC-0006 - PDOC - VALID, Le sommeil paradoxical décodé - - PARADOX2017 - ANR-17-CE16-0024 - AAPG2017 - VALID, and Human Brain Project Specific Grant Agreement 3 - HBP SGA3 - - H20202020-01-01 - 2023-09-30 - 945539 - VALID
- Subjects
Auditory Cortex ,Neurons ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,General Neuroscience ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,MESH: Acoustic Stimulation ,MESH: Neurons ,MESH: Anesthetics ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,MESH: Perception ,Mice ,MESH: Auditory Perception ,MESH: Wakefulness ,Acoustic Stimulation ,Auditory Perception ,Animals ,Perception ,MESH: Animals ,MESH: Auditory Cortex ,Wakefulness ,MESH: Mice ,[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Anesthetics - Abstract
Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception.
- Published
- 2022
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