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2. Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets

Author

Halwe, Nico Joel, Hamberger, Lea, Sehl-Ewert, Julia, Mache, Christin, Schön, Jacob, Ulrich, Lorenz, Calvelage, Sten, Tönnies, Mario, Fuchs, Jonas, Bandawane, Pooja, Loganathan, Madhumathi, Abbad, Anass, Carreño, Juan Manuel, Bermúdez-González, Maria C., Simon, Viviana, Kandeil, Ahmed, El-Shesheny, Rabeh, Ali, Mohamed A., Kayali, Ghazi, Budt, Matthias, Hippenstiel, Stefan, Hocke, Andreas C., Krammer, Florian, Wolff, Thorsten, Schwemmle, Martin, Ciminski, Kevin, Hoffmann, Donata, and Beer, Martin

Published
2024
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5. varVAMP: automated pan-specific primer design for tiled full genome sequencing and qPCR of highly diverse viral pathogens.

Author

Fuchs, Jonas, primary, Kleine, Johanna, additional, Schemmerer, Mathias, additional, Kreibich, Julian, additional, Maier, Wolfgang, additional, Battur, Namuun, additional, Krannich, Thomas, additional, Sedaghatjoo, Somayyeh, additional, Jaki, Lena, additional, Maks, Anastasija, additional, Boehm, Christina, additional, Wilhelm, Carina, additional, Schulze, Jessica, additional, Mache, Christin, additional, Berger, Elischa, additional, Panajotov, Jessica, additional, Eidenschink, Lisa, additional, Gruening, Bjoern, additional, Bauswein, Markus, additional, Boettcher, Sindy, additional, Johne, Reimar, additional, Wenzel, Juergen, additional, Hoelzer, Martin, additional, and Panning, Marcus, additional

Published
2024
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6. SARS-CoV-2 Evolution on a Dynamic Immune Landscape

Author

von Kleist, Max, primary, Raharinirina, N. Alexia, additional, Gubela, Nils, additional, Börnigen, Daniela, additional, Smith, Maureen, additional, Oh, Djin-Ye, additional, Budt, Matthias, additional, Mache, Christin, additional, Schillings, Claudia, additional, Fuchs, Stephan, additional, Dürrwald, Ralf, additional, Wolff, Thorsten, additional, Hoelzer, Martin, additional, and Paraskevopoulou, Sofia, additional

Published
2023
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7. The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features

Author

Halwe, Nico, primary, Hamberger, Lea, additional, Sehl-Ewert, Julia, additional, Mache, Christin, additional, Schön, Jacob, additional, Ulrich, Lorenz, additional, Calvelage, Sten, additional, Fuchs, Jonas, additional, Bandawane, Pooja, additional, Loganathan, Madhumathi, additional, Abbad, Anass, additional, Carreño, Juan Manuel, additional, Simon, Viviana, additional, Kayali, Ghazi, additional, Tönnies, Mario, additional, Kandeil, Ahmed, additional, El-Shesheny, Rabeh, additional, Ali, Mohamed, additional, Wolff, Thorsten, additional, Budt, Matthias, additional, Hippenstiel, Stefan, additional, Hocke, Andreas, additional, Krammer, Florian, additional, Schwemmle, Martin, additional, Ciminski, Kevin, additional, Hoffmann, Donata, additional, Bermudez-Gonzalez, Maria, additional, and Beer, Martin, additional

Published
2023
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8. SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Author

Niemeyer, Daniela, primary, Stenzel, Saskia, additional, Veith, Talitha, additional, Schroeder, Simon, additional, Friedmann, Kirstin, additional, Weege, Friderike, additional, Trimpert, Jakob, additional, Heinze, Julian, additional, Richter, Anja, additional, Jansen, Jenny, additional, Emanuel, Jackson, additional, Kazmierski, Julia, additional, Pott, Fabian, additional, Jeworowski, Lara M., additional, Olmer, Ruth, additional, Jaboreck, Mark-Christian, additional, Tenner, Beate, additional, Papies, Jan, additional, Walper, Felix, additional, Schmidt, Marie L., additional, Heinemann, Nicolas, additional, Möncke-Buchner, Elisabeth, additional, Baumgardt, Morris, additional, Hoffmann, Karen, additional, Widera, Marek, additional, Thao, Tran Thi Nhu, additional, Balázs, Anita, additional, Schulze, Jessica, additional, Mache, Christin, additional, Jones, Terry C., additional, Morkel, Markus, additional, Ciesek, Sandra, additional, Hanitsch, Leif G., additional, Mall, Marcus A., additional, Hocke, Andreas C., additional, Thiel, Volker, additional, Osterrieder, Klaus, additional, Wolff, Thorsten, additional, Martin, Ulrich, additional, Corman, Victor M., additional, Müller, Marcel A., additional, Goffinet, Christine, additional, and Drosten, Christian, additional

Published
2022
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9. Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Author

Hönzke, Katja, primary, Obermayer, Benedikt, additional, Mache, Christin, additional, Fatykhova, Diana, additional, Kessler, Mirjana, additional, Dökel, Simon, additional, Wyler, Emanuel, additional, Baumgardt, Morris, additional, Löwa, Anna, additional, Hoffmann, Karen, additional, Graff, Patrick, additional, Schulze, Jessica, additional, Mieth, Maren, additional, Hellwig, Katharina, additional, Demir, Zeynep, additional, Biere, Barbara, additional, Brunotte, Linda, additional, Mecate-Zambrano, Angeles, additional, Bushe, Judith, additional, Dohmen, Melanie, additional, Hinze, Christian, additional, Elezkurtaj, Sefer, additional, Tönnies, Mario, additional, Bauer, Torsten T., additional, Eggeling, Stephan, additional, Tran, Hong-Linh, additional, Schneider, Paul, additional, Neudecker, Jens, additional, Rückert, Jens C., additional, Schmidt-Ott, Kai M., additional, Busch, Jonas, additional, Klauschen, Frederick, additional, Horst, David, additional, Radbruch, Helena, additional, Radke, Josefine, additional, Heppner, Frank, additional, Corman, Victor M., additional, Niemeyer, Daniela, additional, Müller, Marcel A., additional, Goffinet, Christine, additional, Mothes, Ronja, additional, Pascual-Reguant, Anna, additional, Hauser, Anja Erika, additional, Beule, Dieter, additional, Landthaler, Markus, additional, Ludwig, Stephan, additional, Suttorp, Norbert, additional, Witzenrath, Martin, additional, Gruber, Achim D., additional, Drosten, Christian, additional, Sander, Leif-Erik, additional, Wolff, Thorsten, additional, Hippenstiel, Stefan, additional, and Hocke, Andreas C., additional

Published
2022
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11. Deep Time Course Proteomics of SARS-CoV- and SARS-CoV-2-Infected Human Lung Epithelial Cells (Calu-3) Reveals Strong Induction of Interferon-Stimulated Gene Expression by SARS-CoV-2 in Contrast to SARS-CoV

Author

Grossegesse, Marica, primary, Bourquain, Daniel, additional, Neumann, Markus, additional, Schaade, Lars, additional, Schulze, Jessica, additional, Mache, Christin, additional, Wolff, Thorsten, additional, Nitsche, Andreas, additional, and Doellinger, Joerg, additional

Published
2022
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12. Analysis of BNT162b2‐ and CVnCoV‐elicited sera and of convalescent sera toward SARS‐CoV‐2 viruses.

Author

Hein, Sascha, Herrlein, Marie‐Luise, Mhedhbi, Ines, Bender, Daniela, Haberger, Vanessa, Benz, Nuka, Eisert, Jonathan, Stingl, Julia, Dreher, Michael, Oberle, Doris, Schulze, Jessica, Mache, Christin, Budt, Matthias, Hildt, Christoph, Wolff, Thorsten, and Hildt, Eberhard

Subjects
CONVALESCENT plasma, SARS-CoV-2, MEDICAL personnel, VIRAL antibodies, SURFACE plasmon resonance
Abstract

Summary: Background: The mRNA vaccine BNT162b2 (Comirnaty, BioNTech/Pfizer) and the vaccine candidate CVnCoV (Curevac) each encode a stabilized spike protein of SARS‐CoV2 as antigen but differ with respect to the nature of the mRNA (modified versus unmodified nucleotides) and the mRNA amount (30 μg versus 12 μg RNA). This study characterizes antisera elicited by these two vaccines in comparison to convalescent sera. Methods: Sera from BNT162b2 vaccinated healthcare workers, and sera from participants of a phase I trial vaccinated with 2, 4, 6, 8, or 12 μg CVnCoV and convalescent sera from hospitalized patients were analyzed by ELISA, neutralization tests, surface plasmon resonance (SPR), and peptide arrays. Results: BNT162b2‐elicited sera and convalescent sera have a higher titer of spike‐RBD‐specific antibodies and neutralizing antibodies as compared to the CVnCoV‐elicited sera. For all analyzed sera a reduction in binding and neutralizing antibodies was found for the lineage B.1.351 variant of concern. SPR analyses revealed that the CVnCoV‐elicited sera have a lower fraction of slow‐dissociating antibodies. Accordingly, the CVnCoV sera almost fail to compete with the spike‐ACE2 interaction. The significance of common VOC mutations K417N, E484K, or N501Y focused on linear epitopes was analyzed using a peptide array approach. The peptide arrays showed a strong difference between convalescent sera and vaccine‐elicited sera. Specifically, the linear epitope at position N501 was affected by the mutation and elucidates the escape of viral variants to antibodies against this linear epitope. Conclusion: These data reveal differences in titer, neutralizing capacity, and affinity of the antibodies between BNT162b2‐ and CVnCoV‐elicited sera, which could contribute to the apparent differences in vaccine efficacy. [ABSTRACT FROM AUTHOR]

Published
2022
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