28 results on '"Magalhaes, C"'
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2. A Review of the Ethnobotany, Phytochemistry, and Pharmacology of the Family Cleomaceae of Brazilian Origin
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dos Santos Magalhães, C., dos Santos Melo, D.F., da Silva, H.C.C., de Carvalho, R.R., da Silva, R.V.L., de Caldas Brandão Filho, J.O., da Silva, F.C.L., and Randau, K.P.
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- 2023
- Full Text
- View/download PDF
3. PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)
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Goilav, B., Marks, S., Oni, L., Smith, E.M.D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C.M., Kamphuis, S., Lambert, L., Levy, D.M., Lewandowski, L., Maxwell, N., Morand, E., Ozen, S., Pain, C.E., Ravelli, A., Saad Magalhaes, C., Pilkington, C., Schonenberg-Meinema, D., Scott, C., Tullus, K., and Beresford, M.W.
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- 2023
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- View/download PDF
4. Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
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Smith, E.M.D., primary, Aggarwal, A., additional, Ainsworth, J., additional, Al-Abadi, E., additional, Avcin, T., additional, Bortey, L., additional, Burnham, J., additional, Ciurtin, C., additional, Hedrich, C.M., additional, Kamphuis, S., additional, Lambert, L., additional, Levy, D.M., additional, Lewandowski, L., additional, Maxwell, N., additional, Morand, E., additional, Özen, S., additional, Pain, C.E., additional, Ravelli, A., additional, Saad Magalhaes, C., additional, Pilkington, C., additional, Schonenberg-Meinema, D., additional, Scott, C., additional, Tullus, K., additional, Beresford, M.W., additional, Goilav, B., additional, Goss, N., additional, Oni, L., additional, and Marks, S.D., additional
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- 2024
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5. Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial
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Cuttica, R, Akikusa, J, Chaitow, J, Wouters, C, Oliveira, S, Neiva, CLS, Santiago, M, Silva, CA, Terreri, MT, Magalhaes, C, De Souza, V, Bandeira, M, Chédeville, G, Houghton, K, Vazquez-Del Mercado, M, Rizo Rodriguez, J, Kobusinska, K, Alexeeva, E, Calvo Penades, I, Boteanu, AL, Kasapcopur, O, Poyrazoglu, MH, Erguven, M, Ozen, S, Al-Abadi, E, Bohnsack, J, Carrasco, R, Dare, J, Gottlieb, B, Wahezi, D, Jung, L, Klein-Gitelman, M, Zhang, Y, Wagner-Weiner, L, Tarvin, S, Vehe, RK, Chiraseveenuprapund, P, Rivas-Chacon, R, De La Pena, W, Sagcal-Gironella, ACP, Weiss, JE, Ruperto, Nicolino, Brunner, Hermine I, Synoverska, Olga, Ting, Tracy V, Mendoza, Carlos Abud, Spindler, Alberto, Vyzhga, Yulia, Marzan, Katherine, Grebenkina, Lyudmila, Tirosh, Irit, Imundo, Lisa, Jerath, Rita, Kingsbury, Daniel J, Sozeri, Betul, Vora, Sheetal S, Prahalad, Sampath, Zholobova, Elena, Butbul Aviel, Yonatan, Chasnyk, Vyacheslav, Lerman, Melissa, Nanda, Kabita, Schmeling, Heinrike, Tory, Heather, Uziel, Yosef, Viola, Diego O, Posner, Holly B, Kanik, Keith S, Wouters, Ann, Chang, Cheng, Zhang, Richard, Lazariciu, Irina, Hsu, Ming-Ann, Suehiro, Ricardo M, Martini, Alberto, and Lovell, Daniel J
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- 2021
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6. O USO DAS TECNOLOGIAS DE INFORMAÇÃO NO COMBATE À COVID-19 EM UM PROJETO DE EXTENSÃO UNIVERSITÁRIA
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TEIXEIRA, D. P., primary, ALVES, L. S., additional, CARLOS, C. A. L. V., additional, and SALVATERRA MAGALHAES, C., additional
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- 2022
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7. Defining remission in childhood-onset lupus:PReS-endorsed consensus definitions by an international task force
- Author
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Smith, E. M.D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C. M., Kamphuis, S., Lambert, L., Levy, D. M., Lewandowski, L., Maxwell, N., Morand, E., Özen, S., Pain, C. E., Ravelli, A., Saad Magalhaes, C., Pilkington, C., Schonenberg-Meinema, D., Scott, C., Tullus, K., Beresford, M. W., Goilav, B., Goss, N., Oni, L., Marks, S. D., Smith, E. M.D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C. M., Kamphuis, S., Lambert, L., Levy, D. M., Lewandowski, L., Maxwell, N., Morand, E., Özen, S., Pain, C. E., Ravelli, A., Saad Magalhaes, C., Pilkington, C., Schonenberg-Meinema, D., Scott, C., Tullus, K., Beresford, M. W., Goilav, B., Goss, N., Oni, L., and Marks, S. D.
- Abstract
Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria.Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.
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- 2024
8. Radiofrequency therapy as an effective treatment for granulomatous cheilitis: A CARE case report
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Silva Sousa, P., Magalhães, C., Cunha, A., and Castanheira, A.
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- 2024
- Full Text
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9. Tests of Lepton Universality Using B0 ? KS0 â„“+â„“- and B+ ?k*+â„“+â„“- Decays
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Aaij, R, Abdelmotteleb, A, Beteta, A, Abudinen, F, Ackernley, T, Adeva, B, Adinolfi, M, Afsharnia, H, Agapopoulou, C, Aidala, C, Aiola, S, Ajaltouni, Z, Akar, S, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Aliouche, Z, Alkhazov, G, Cartelle, A, Amato, S, Amey, J, Amhis, Y, An, L, Anderlini, L, Andersson, N, Andreianov, A, Andreotti, M, Archilli, F, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Bachmayer, M, Back, J, Rodriguez, B, Balagura, V, Baldini, W, Leite, B, Barbetti, M, Barlow, R, Barsuk, S, Barter, W, Bartolini, M, Baryshnikov, F, Basels, J, Bashir, S, Bassi, G, Batsukh, B, Battig, A, Bay, A, Beck, A, Becker, M, Bedeschi, F, Bediaga, I, Beiter, A, Belavin, V, Belin, S, Bellee, V, Belous, K, Belov, I, Belyaev, I, Bencivenni, G, Ben-Haim, E, Berezhnoy, A, Bernet, R, Berninghoff, D, Bernstein, H, Bertella, C, Bertolin, A, Betancourt, C, Betti, F, Bezshyiko, I, Bhasin, S, Bhom, J, Bian, L, Bieker, M, Biesuz, N, Bifani, S, Billoir, P, Biolchini, A, Birch, M, Bishop, F, Bitadze, A, Bizzeti, A, Bjorn, M, Blago, M, Blake, T, Blanc, F, Blusk, S, Bobulska, D, Boelhauve, J, Boente Garcia, O, Boettcher, T, Boldyrev, A, Bondar, A, Bondar, N, Borghi, S, Borisyak, M, Borsato, M, Borsuk, J, Bouchiba, S, Bowcock, T, Boyer, A, Bozzi, C, Bradley, M, Braun, S, Brodzicka, J, Gonzalo, B, Brundu, D, Buonaura, A, Buonincontri, L, Burke, A, Burr, C, Bursche, A, Butkevich, A, Butter, J, Buytaert, J, Byczynski, W, Cadeddu, S, Cai, H, Calabrese, R, Calefice, L, Cali, S, Calladine, R, Calvi, M, Gomez, C, Magalhaes, C, Campana, P, Quezada, C, Capelli, S, Capriotti, L, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carli, I, Carniti, P, Carus, L, Akiba, C, Vidal, C, Caspary, R, Casse, G, Cattaneo, M, Cavallero, G, Celani, S, Cerasoli, J, Cervenkov, D, Chadwick, A, Chapman, M, Charles, M, Charpentier, P, Chatzikonstantinidis, G, Barajas, C, Chefdeville, M, Chen, C, Chen, S, Chernov, A, Chobanova, V, Cholak, S, Chrzaszcz, M, Chubykin, A, Chulikov, V, Ciambrone, P, Cicala, M, Cid Vidal, X, Ciezarek, G, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Cobbledick, J, Coco, V, Coelho, J, Cogan, J, Cogneras, E, Cojocariu, L, Collins, P, Colombo, T, Congedo, L, Contu, A, Cooke, N, Coombs, G, Corredoira, I, Corti, G, Sobral, C, Couturier, B, Craik, D, Crkovska, J, Torres, C, Currie, R, Da Silva, C, Dadabaev, S, Dai, L, Dall'Occo, E, Dalseno, J, D'Ambrosio, C, Danilina, A, D'Argent, P, Dashkina, A, Davies, J, Davis, A, De Aguiar Francisco, O, De Bruyn, K, De Capua, S, De Cian, M, De Lucia, E, De Miranda, J, De Paula, L, De Serio, M, De Simone, D, De Simone, P, De Vellis, F, De Vries, J, Dean, C, Debernardis, F, Decamp, D, Dedu, V, Del Buono, L, Delaney, B, Dembinski, H, Dendek, A, Denysenko, V, Derkach, D, Deschamps, O, Desse, F, Dettori, F, Dey, B, Di Cicco, A, Di Nezza, P, Didenko, S, Maronas, D, Dijkstra, H, Dobishuk, V, Dong, C, Donohoe, A, Dordei, F, Dos Reis, A, Douglas, L, Dovbnya, A, Downes, A, Dudek, M, Dufour, L, Duk, V, Durante, P, Durham, J, Dutta, D, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, Eisenhardt, S, Ek-In, S, Eklund, L, Ely, S, Ene, A, Epple, E, Escher, S, Eschle, J, Esen, S, Evans, T, Falcao, L, Fan, Y, Fang, B, Farry, S, Fazzini, D, Feo, M, Prieto, F, Fernez, A, Ferrari, F, Lopes, L, Rodrigues, F, Sole, S, Ferrillo, M, Ferro-Luzzi, M, Filippov, S, Fini, R, Fiorini, M, Firlej, M, Fischer, K, Fitzgerald, D, Fitzpatrick, C, Fiutowski, T, Fkiaras, A, Fleuret, F, Fontana, M, Fontanelli, F, Forty, R, Foulds-Holt, D, Lima, F, Sevilla, F, Frank, M, Franzoso, E, Frau, G, Frei, C, Friday, D, Fu, J, Fuehring, Q, Gabriel, E, Galati, G, Torreira, G, Galli, D, Gambetta, S, Gan, Y, Gandelman, M, Gandini, P, Gao, Y, Garau, M, Martin, G, Oreno, G, Pardinas, G, Plana, G, Rosales, G, Garrido, L, Gaspar, C, Geertsema, R, Gerick, D, Gerken, L, Gersabeck, E, Gersabeck, M, Gershon, T, Gerstel, D, Giambastiani, L, Gibson, V, Giemza, H, Gilman, A, Giovannetti, M, Gioventu, A, Gironell, G, Giugliano, C, Gizdov, K, Gkougkousis, E, Gligorov, V, Gobel, C, Golobardes, E, Golubkov, D, Golutvin, A, Gomes, A, Fernandez, G, Abrantes, G, Goncerz, M, Gong, G, Gorbounov, P, Gorelov, I, Gotti, C, Govorkova, E, Grabowski, J, Grammatico, T, Cardoso, G, Grauges, E, Graverini, E, Graziani, G, Grecu, A, Greeven, L, Grieser, N, Grillo, L, Gromov, S, Cazon, G, Gu, C, Guarise, M, Guittiere, M, Gunther, P, Gushchin, E, Guth, A, Guz, Y, Gys, T, Hadavizadeh, T, Haefeli, G, Haen, C, Haimberger, J, Halewood-Leagas, T, Hamilton, P, Hammerich, J, Han, Q, Han, X, Hancock, T, Hansen, E, Hansmann-Menzemer, S, Harnew, N, Harrison, T, Hasse, C, Hatch, M, He, J, Hecker, M, Heijhoff, K, Heinicke, K, Henderson, R, Hennequin, A, Hennessy, K, Henry, L, Heuel, J, Hicheur, A, Hill, D, Hilton, M, Hollitt, S, Hou, R, Hou, Y, Hu, J, Hu, W, Hu, X, Huang, W, Huang, X, Hulsbergen, W, Hunter, R, Hushchyn, M, Hutchcroft, D, Hynds, D, Ibis, P, Idzik, M, Ilin, D, Ilten, P, Inglessi, A, Ishteev, A, Ivshin, K, Jacobsson, R, Jage, H, Jakobsen, S, Jans, E, Jashal, B, Jawahery, A, Jevtic, V, Jiang, X, John, M, Johnson, D, Jones, C, Jones, T, Jost, B, Jurik, N, Kadavath, K, Kandybei, S, Kang, Y, Karacson, M, Karpov, M, Kautz, J, Keizer, F, Keller, D, Kenzie, M, Ketel, T, Khanji, B, Kharisova, A, Kholodenko, S, Kirn, T, Kirsebom, V, Kitouni, O, Klaver, S, Kleijne, N, Klimaszewski, K, Kmiec, M, Koliiev, S, Kondybayeva, A, Konoplyannikov, A, Kopciewicz, P, Kopecna, R, Koppenburg, P, Korolev, M, Kostiuk, I, Kot, O, Kotriakhova, S, Kravchenko, P, Kravchuk, L, Krawczyk, R, Kreps, M, Kress, F, Kretzschmar, S, Krokovny, P, Krupa, W, Krzemien, W, Kubat, J, Kucharczyk, M, Kudryavtsev, V, Kuindersma, H, Kunde, G, Kvaratskheliya, T, Lacarrere, D, Lafferty, G, Lai, A, Lampis, A, Lancierini, D, Lane, J, Lane, R, Lanfranchi, G, Langenbruch, C, Langer, J, Lantwin, O, Latham, T, Lazzari, F, Le Gac, R, Lee, S, Lefevre, R, Leflat, A, Legotin, S, Leroy, O, Lesiak, T, Leverington, B, Li, H, Li, P, Li, S, Li, Y, Li, Z, Liang, X, Lin, T, Lindner, R, Lisovskyi, V, Litvinov, R, Liu, G, Liu, H, Liu, Q, Liu, S, Salvia, L, Loi, A, Castro, L, Longstaff, I, Lopes, J, Solino, L, Lovell, G, Lu, Y, Lucarelli, C, Lucchesi, D, Luchuk, S, Martinez, L, Lukashenko, V, Luo, Y, Lupato, A, Luppi, E, Lupton, O, Lusiani, A, Lyu, X, Ma, L, Ma, R, Maccolini, S, Machefert, F, Maciuc, F, Macko, V, Mackowiak, P, Maddrell-Mander, S, Madejczyk, O, Mohan, M, Maev, O, Maevskiy, A, Majewski, M, Malczewski, J, Malde, S, Malecki, B, Malinin, A, Maltsev, T, Malygina, H, Manca, G, Mancinelli, G, Manuzzi, D, Marangotto, D, Maratas, J, Marchand, J, Marconi, U, Mariani, S, Benito, M, Marinangeli, M, Marks, J, Marshall, A, Marshall, P, Martelli, G, Martellotti, G, Martinazzoli, L, Martinelli, M, Santos, M, Vidal, M, Massafferri, A, Materok, M, Matev, R, Mathad, A, Matiunin, V, Matteuzzi, C, Mattioli, K, Mauri, A, Maurice, E, Mauricio, J, Mazurek, M, Mccann, M, Mcconnell, L, Mcgrath, T, Mchugh, N, Mcnab, A, Mcnulty, R, Mead, J, Meadows, B, Meier, G, Melnychuk, D, Meloni, S, Merk, M, Merli, A, Garcia, M, Mikhasenko, M, Milanes, D, Millard, E, Milovanovic, M, Minard, M, Minotti, A, Minzoni, L, Mitchell, S, Mitreska, B, Mitzel, D, Modden, A, Mohammed, R, Moise, R, Mokhnenko, S, Mombacher, T, Monroy, I, Monteil, S, Morandin, M, Morello, G, Morello, M, Moron, J, Morris, A, Mountain, R, Mu, H, Muheim, F, Mulder, M, Muller, D, Muller, K, Murphy, C, Murray, D, Murta, R, Muzzetto, P, Naik, P, Nakada, T, Nandakumar, R, Nanut, T, Nasteva, I, Needham, M, Neri, N, Neubert, S, Neufeld, N, Newcombe, R, Niel, E, Nieswand, S, Nikitin, N, Nolte, N, Normand, C, Nunez, C, Oblakowska-Mucha, A, Obraztsov, V, Oeser, T, O'Hanlon, D, Okamura, S, Oldeman, R, Oliva, F, Olivares, M, Onderwater, C, O'Neil, R, Goicochea, O, Ovsiannikova, T, Owen, P, Oyanguren, A, Padeken, K, Pagare, B, Pais, P, Pajero, T, Palano, A, Palutan, M, Pan, Y, Panshin, G, Papanestis, A, Pappagallo, M, Pappalardo, L, Pappenheimer, C, Parker, W, Parkes, C, Passalacqua, B, Passaleva, G, Pastore, A, Patel, M, Patrignani, C, Pawley, C, Pearce, A, Pellegrino, A, Altarelli, P, Perazzini, S, Pereima, D, Castro, P, Perret, P, Petric, M, Petridis, K, Petrolini, A, Petrov, A, Petrucci, S, Petruzzo, M, Pham, T, Philippov, A, Piandani, R, Pica, L, Piccini, M, Pietrzyk, B, Pietrzyk, G, Pili, M, Pinci, D, Pisani, F, Pizzichemi, M, Resmi, P, Placinta, V, Plews, J, Casasus, P, Polci, F, Lener, P, Poliakova, M, Poluektov, A, Polukhina, N, Polyakov, I, Polycarpo, E, Ponce, S, Popov, D, Popov, S, Poslavskii, S, Prasanth, K, Promberger, L, Prouve, C, Pugatch, V, Puill, V, Punzi, G, Qi, H, Qian, W, Qin, N, Quagliani, R, Raab, N, Trejo, R, Rachwal, B, Rademacker, J, Rama, M, Pernas, R, Rangel, M, Ratnikov, F, Raven, G, Reboud, M, Redi, F, Reiss, F, Alepuz, R, Ren, Z, Renaudin, V, Ribatti, R, Ricci, A, Ricciardi, S, Rinnert, K, Robbe, P, Robertson, G, Rodrigues, A, Rodrigues, E, Lopez, R, Rodriguez, R, Rollings, A, Roloff, P, Romanovskiy, V, Romero Lamas, M, Romero Vidal, A, Roth, J, Rotondo, M, Rudolph, M, Ruf, T, Fernandez, R, Vidal, R, Ryzhikov, A, Ryzka, J, Silva, S, Sagidova, N, Sahoo, N, Saitta, B, Salomoni, M, Gras, S, Santacesaria, R, Rios, S, Santimaria, M, Santovetti, E, Saranin, D, Sarpis, G, Sarpis, M, Sarti, A, Satriano, C, Satta, A, Saur, M, Savrina, D, Sazak, H, Smead, S, Scarabotto, A, Schael, S, Scherl, S, Schiller, M, Schindler, H, Schmelling, M, Schmidt, B, Schmitt, S, Schneider, O, Schopper, A, Schubiger, M, Schulte, S, Schune, M, Schwemmer, R, Sciascia, B, Sellam, S, Semennikov, A, Senghi Soares, M, Sergi, A, Serra, N, Sestini, L, Seuthe, A, Shang, Y, Shangase, D, Shapkin, M, Shchemerov, I, Shchutska, L, Shears, T, Shekhtman, L, Shen, Z, Sheng, S, Shevchenko, V, Shields, E, Shimizu, Y, Shmanin, E, Shupperd, J, Siddi, B, Coutinho, S, Simi, G, Simone, S, Skidmore, N, Skwarnicki, T, Slater, M, Slazyk, I, Smallwood, J, Smeaton, J, Smetkina, A, Smith, E, Smith, M, Snoch, A, Lavra, S, Sokoloff, M, Soler, F, Solovev, A, Solovyev, I, De Almeida, S, De Paula, S, Spaan, B, Norella, S, Spradlin, P, Stagni, F, Stahl, M, Stahl, S, Stanislaus, S, Steinkamp, O, Stenyakin, O, Stevens, H, Stone, S, Strekalina, D, Suljik, F, Sun, J, Sun, L, Sun, Y, Svihra, P, Swallow, P, Swientek, K, Szabelski, A, Szumlak, T, Szymanski, M, Taneja, S, Tanner, A, Tat, M, Terentev, A, Teubert, F, Thomas, E, Thompson, D, Thomson, K, Tilquin, H, Tisserand, V, T'Jampens, S, Tobin, M, Tomassetti, L, Tong, X, Machado, T, Tou, D, Trifonova, E, Trilov, S, Trippl, C, Tuci, G, Tully, A, Tuning, N, Ukleja, A, Unverzagt, D, Ursov, E, Usachov, A, Ustyuzhanin, A, Uwer, U, Vagner, A, Vagnoni, V, Valassi, A, Valenti, G, Canudas, V, Beuzekom, V, Dijk, V, Hecke, V, Herwijnen, V, Veghel, V, Vazquez Gomez, R, Regueiro, V, Sierra, V, Vecchi, S, Velthuis, J, Veltri, M, Venkateswaran, A, Veronesi, M, Vesterinen, M, Vieira, D, Vieites Diaz, M, Viemann, H, Vilasis-Cardona, X, Vilella Figueras, E, Villa, A, Vincent, P, Volle, F, Bruch, V, Vorobyev, A, Vorobyev, V, Voropaev, N, Vos, K, Waldi, R, Walsh, J, Wang, C, Wang, J, Wang, M, Wang, R, Wang, Y, Wang, Z, Ward, J, Watson, N, Weber, S, Websdale, D, Weisser, C, Westhenry, B, White, D, Whitehead, M, Wiederhold, A, Wiedner, D, Wilkinson, G, Wilkinson, M, Williams, I, Williams, M, Wilson, F, Wislicki, W, Witek, M, Witola, L, Wormser, G, Wotton, S, Wu, H, Wyllie, K, Xiang, Z, Xiao, D, Xie, Y, Xu, A, Xu, J, Xu, L, Xu, M, Xu, Q, Xu, Z, Yang, D, Yang, S, Yang, Y, Yang, Z, Yao, Y, Yeomans, L, Yin, H, Yu, J, Yuan, X, Yushchenko, O, Zaffaroni, E, Zavertyaev, M, Zdybal, M, Zenaiev, O, Zeng, M, Zhang, D, Zhang, L, Zhang, S, Zhang, Y, Zharkova, A, Zhelezov, A, Zheng, Y, Zhou, T, Zhou, X, Zhou, Y, Zhovkovska, V, Zhu, X, Zhu, Z, Zhukov, V, Zonneveld, J, Zou, Q, Zucchelli, S, Zuliani, D, Zunica, G, Aaij R., Abdelmotteleb A. S. W., Beteta A. C., Abudinen F., Ackernley T., Adeva B., Adinolfi M., Afsharnia H., Agapopoulou C., Aidala C. A., Aiola S., Ajaltouni Z., Akar S., Albrecht J., Alessio F., Alexander M., Alfonso Albero A., Aliouche Z., Alkhazov G., Cartelle A. P., Amato S., Amey J. L., Amhis Y., An L., Anderlini L., Andersson N., Andreianov A., Andreotti M., Archilli F., Artamonov A., Artuso M., Arzymatov K., Aslanides E., Atzeni M., Audurier B., Bachmann S., Bachmayer M., Back J. J., Rodriguez B. P., Balagura V., Baldini W., Leite B. J., Barbetti M., Barlow R. J., Barsuk S., Barter W., Bartolini M., Baryshnikov F., Basels J. M., Bashir S., Bassi G., Batsukh B., Battig A., Bay A., Beck A., Becker M., Bedeschi F., Bediaga I., Beiter A., Belavin V., Belin S., Bellee V., Belous K., Belov I., Belyaev I., Bencivenni G., Ben-Haim E., Berezhnoy A., Bernet R., Berninghoff D., Bernstein H. C., Bertella C., Bertolin A., Betancourt C., Betti F., Bezshyiko I., Bhasin S., Bhom J., Bian L., Bieker M. S., Biesuz N. 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A., Millard E., Milovanovic M., Minard M. -N., Minotti A., Minzoni L., Mitchell S. E., Mitreska B., Mitzel D. S., Modden A., Mohammed R. A., Moise R. D., Mokhnenko S., Mombacher T., Monroy I. A., Monteil S., Morandin M., Morello G., Morello M. J., Moron J., Morris A. B., Morris A. G., Mountain R., Mu H., Muheim F., Mulder M., Muller D., Muller K., Murphy C. H., Murray D., Murta R., Muzzetto P., Naik P., Nakada T., Nandakumar R., Nanut T., Nasteva I., Needham M., Neri N., Neubert S., Neufeld N., Newcombe R., Niel E. M., Nieswand S., Nikitin N., Nolte N. S., Normand C., Nunez C., Oblakowska-Mucha A., Obraztsov V., Oeser T., O'Hanlon D. P., Okamura S., Oldeman R., Oliva F., Olivares M. E., Onderwater C. J. G., O'Neil R. H., Goicochea O. J. M., Ovsiannikova T., Owen P., Oyanguren A., Padeken K. O., Pagare B., Pais P. R., Pajero T., Palano A., Palutan M., Pan Y., Panshin G., Papanestis A., Pappagallo M., Pappalardo L. L., Pappenheimer C., Parker W., Parkes C., Passalacqua B., Passaleva G., Pastore A., Patel M., Patrignani C., Pawley C. J., Pearce A., Pellegrino A., Altarelli P. M., Perazzini S., Pereima D., Castro P. A., Perret P., Petric M., Petridis K., Petrolini A., Petrov A., Petrucci S., Petruzzo M., Pham T. T. H., Philippov A., Piandani R., Pica L., Piccini M., Pietrzyk B., Pietrzyk G., Pili M., Pinci D., Pisani F., Pizzichemi M., Resmi P. K., Placinta V., Plews J., Casasus P. M., Polci F., Lener P. M., Poliakova M., Poluektov A., Polukhina N., Polyakov I., Polycarpo E., Ponce S., Popov D., Popov S., Poslavskii S., Prasanth K., Promberger L., Prouve C., Pugatch V., Puill V., Punzi G., Qi H., Qian W., Qin N., Quagliani R., Raab N. V., Trejo R. R. I., Rachwal B., Rademacker J. H., Rama M., Pernas R. M., Rangel M. S., Ratnikov F., Raven G., Reboud M., Redi F., Reiss F., Alepuz R. C., Ren Z., Renaudin V., Ribatti R., Ricci A. M., Ricciardi S., Rinnert K., Robbe P., Robertson G., Rodrigues A. B., Rodrigues E., Lopez R. J. A., Rodriguez R. E. R. R., Rollings A., Roloff P., Romanovskiy V., Romero Lamas M., Romero Vidal A., Roth J. D., Rotondo M., Rudolph M. S., Ruf T., Fernandez R. R. A., Vidal R. J., Ryzhikov A., Ryzka J., Silva S. J. J., Sagidova N., Sahoo N., Saitta B., Salomoni M., Gras S. C., Santacesaria R., Rios S. C., Santimaria M., Santovetti E., Saranin D., Sarpis G., Sarpis M., Sarti A., Satriano C., Satta A., Saur M., Savrina D., Sazak H., Smead S. L. G., Scarabotto A., Schael S., Scherl S., Schiller M., Schindler H., Schmelling M., Schmidt B., Schmitt S., Schneider O., Schopper A., Schubiger M., Schulte S., Schune M. H., Schwemmer R., Sciascia B., Sellam S., Semennikov A., Senghi Soares M., Sergi A., Serra N., Sestini L., Seuthe A., Shang Y., Shangase D. M., Shapkin M., Shchemerov I., Shchutska L., Shears T., Shekhtman L., Shen Z., Sheng S., Shevchenko V., Shields E. B., Shimizu Y., Shmanin E., Shupperd J. D., Siddi B. G., Coutinho S. R., Simi G., Simone S., Skidmore N., Skwarnicki T., Slater M. W., Slazyk I., Smallwood J. C., Smeaton J. G., Smetkina A., Smith E., Smith M., Snoch A., Lavra S. L., Sokoloff M. D., Soler F. J. P., Solovev A., Solovyev I., De Almeida S. F. L., De Paula S. B., Spaan B., Norella S. E., Spradlin P., Stagni F., Stahl M., Stahl S., Stanislaus S., Steinkamp O., Stenyakin O., Stevens H., Stone S., Strekalina D., Suljik F., Sun J., Sun L., Sun Y., Svihra P., Swallow P. N., Swientek K., Szabelski A., Szumlak T., Szymanski M., Taneja S., Tanner A. R., Tat M. D., Terentev A., Teubert F., Thomas E., Thompson D. J. D., Thomson K. A., Tilquin H., Tisserand V., T'Jampens S., Tobin M., Tomassetti L., Tong X., Machado T. D., Tou D. Y., Trifonova E., Trilov S. M., Trippl C., Tuci G., Tully A., Tuning N., Ukleja A., Unverzagt D. J., Ursov E., Usachov A., Ustyuzhanin A., Uwer U., Vagner A., Vagnoni V., Valassi A., Valenti G., Canudas V. N., Beuzekom V. M., Dijk V. M., Hecke V. H., Herwijnen V. E., Veghel V. M., Vazquez Gomez R., Regueiro V. P., Sierra V. C., Vecchi S., Velthuis J. J., Veltri M., Venkateswaran A., Veronesi M., Vesterinen M., Vieira D., Vieites Diaz M., Viemann H., Vilasis-Cardona X., Vilella Figueras E., Villa A., Vincent P., Volle F. C., Bruch V. D., Vorobyev A., Vorobyev V., Voropaev N., Vos K., Waldi R., Walsh J., Wang C., Wang J., Wang M., Wang R., Wang Y., Wang Z., Ward J. A., Watson N. K., Weber S. G., Websdale D., Weisser C., Westhenry B. D. C., White D. J., Whitehead M., Wiederhold A. R., Wiedner D., Wilkinson G., Wilkinson M., Williams I., Williams M., Williams M. R. J., Wilson F. F., Wislicki W., Witek M., Witola L., Wormser G., Wotton S. A., Wu H., Wyllie K., Xiang Z., Xiao D., Xie Y., Xu A., Xu J., Xu L., Xu M., Xu Q., Xu Z., Yang D., Yang S., Yang Y., Yang Z., Yao Y., Yeomans L. E., Yin H., Yu J., Yuan X., Yushchenko O., Zaffaroni E., Zavertyaev M., Zdybal M., Zenaiev O., Zeng M., Zhang D., Zhang L., Zhang S., Zhang Y., Zharkova A., Zhelezov A., Zheng Y., Zhou T., Zhou X., Zhou Y., Zhovkovska V., Zhu X., Zhu Z., Zhukov V., Zonneveld J. B., Zou Q., Zucchelli S., Zuliani D., and Zunica G.
- Abstract
Tests of lepton universality in B0?KS0„“+“- and B+?K*+“+“- decays where“ is either an electron or a muon are presented. The differential branching fractions of B0?KS0e+e- and B+?K*+e+e- decays are measured in intervals of the dilepton invariant mass squared. The measurements are performed using proton-proton collision data recorded by the LHCb experiment, corresponding to an integrated luminosity of 9 fb-1. The results are consistent with the standard model and previous tests of lepton universality in related decay modes. The first observation of B0?KS0e+e- and B+?K*+e+e- decays is reported.
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- 2022
10. POS0748 TOWARD THE DEFINITION OF CUTOFF VALUES FOR DISEASE ACTIVITY STATES IN SYSTEMIC JADAS
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Rebollo Giménez, A. I., primary, Vyzhga, Y., additional, Carlini, L., additional, Rosina, S., additional, Patrone, E., additional, Katsikas, M., additional, Saad-Magalhaes, C., additional, El-Ghoneimy, D., additional, El Miedany, Y., additional, Khubchandani, R., additional, Pal, P., additional, Simonini, G., additional, Filocamo, G., additional, Gattinara, M., additional, De Benedetti, F., additional, Montin, D., additional, Civino, A., additional, Alsuweiti, M. O., additional, Stanevicha, V., additional, Chasnyk, V., additional, Alexeeva, E., additional, Al-Mayouf, S., additional, Vilaiyuk, S., additional, and Ravelli, A., additional
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- 2023
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11. PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)
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Smith, E.M.D., primary, Aggarwal, A., additional, Ainsworth, J., additional, Al-Abadi, E., additional, Avcin, T., additional, Bortey, L., additional, Burnham, J., additional, Ciurtin, C., additional, Hedrich, C.M., additional, Kamphuis, S., additional, Lambert, L., additional, Levy, D.M., additional, Lewandowski, L., additional, Maxwell, N., additional, Morand, E., additional, Ozen, S., additional, Pain, C.E., additional, Ravelli, A., additional, Saad Magalhaes, C., additional, Pilkington, C., additional, Schonenberg-Meinema, D., additional, Scott, C., additional, Tullus, K., additional, Beresford, M.W., additional, Goilav, B., additional, Oni, L., additional, and Marks, S., additional
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- 2023
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12. A window to the sea: environmental indicators for coastal risk management under the RAIA observatory (NW-Iberian Peninsula)
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Pardo, Paula C., Castro, Carmen G., Taboada, J., Lago, M. dlA., Almeida Costa, Alexandre, Montero, Pedro, Allen-Perkins, Silvia, Almécija, Clara, Álvares, M. T., Ayensa, Garbiñe, Baptista, P., Bastos, L., Bernabeu, A. M., Bernardes, C., Bio, A., Bode, Antonio, Carracedo, P., Coelho, C., Doval, M. Dolores, Dubert, Jesús, Bastero, Susana F., Fernández-Fernández, S., Gayoso, A., Macho-Eiras, M. Luz, Magalhaes, C. M., Mohamed, K., Mota-Lopes, A., Oliveira, Lino, Piedracoba, Silvia, Pinho, J., Pinto, J. P., Ruiz-Villarreal, Manuel, Santos, A. Miguel P., Silva, Alexandra, Rocha, Artur, Silva, Paulo A., Torres-López, S., Pardo, Paula C., Castro, Carmen G., Taboada, J., Lago, M. dlA., Almeida Costa, Alexandre, Montero, Pedro, Allen-Perkins, Silvia, Almécija, Clara, Álvares, M. T., Ayensa, Garbiñe, Baptista, P., Bastos, L., Bernabeu, A. M., Bernardes, C., Bio, A., Bode, Antonio, Carracedo, P., Coelho, C., Doval, M. Dolores, Dubert, Jesús, Bastero, Susana F., Fernández-Fernández, S., Gayoso, A., Macho-Eiras, M. Luz, Magalhaes, C. M., Mohamed, K., Mota-Lopes, A., Oliveira, Lino, Piedracoba, Silvia, Pinho, J., Pinto, J. P., Ruiz-Villarreal, Manuel, Santos, A. Miguel P., Silva, Alexandra, Rocha, Artur, Silva, Paulo A., and Torres-López, S.
- Abstract
The international RAIA Observatory (www.marnaraia.org) resulted from the effort of 12 research and academic institutions and public agencies (Spanish and Portuguese) working in the field of meteorology and oceanography. The RAIA Observatory serves the main maritime activities of the Galicia-Northern Portugal Euroregion and contributes to collaborative observational networks. Under the framework of coastal risk management, environmental indicators are fundamental tools for the evaluation and mitigation of environmental risks, showing the current state and helping to predict future changes on ecosystem health regarding environmental risks. In last years, the different partners of the RAIA Observatory have identified 38 environmental indicators, in which 12 key risks affecting the ecosystem services of the Galicia-Northern Portugal Euroregion are being evaluated. Data was analyzed and compiled by the various partners of the RAIA Observatory and the development and optimization of the environmental indicators has been done according to the specifications provided by the European Environmental Agency (EEA) and the International Panel for Climate Change (IPCC). The resulting environmental indicators are included and shared on a publicly-accessible Web service, georeferenced and accompanied by plots (https://marrisk.inesctec.pt/public/#!/indicators). So far, the current status of the indicators has allowed us to establish risk assessment protocols for the Euroregion, and identify critical gaps in a temporal and spatial coverage. The inclusion of the environmental indicators in the RAIA Observatory is of great relevance for national and international data exchange and promotes future collaborations
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- 2022
13. A window to the sea: optimizing environmental indicators for the evaluation of coastal risks in the Galicia-Northern Portugal euroregion
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European Commission, Pardo, Paula C., Castro, Carmen G., Taboada, J., Lago, M. dlA., Almeida Costa, Alexandre, Oliveira, Lino, Montero, Pedro, Allen-Perkins, Silvia, Bastero, Susana F., Macho-Eiras, M. Luz, Almécija, Clara, Álvares, M. T., Baptista, P., Bastos, L., Bernabeu, A. M., Bernardes, C., Bio, A., Bode, Antonio, Cardona, Federico, Carracedo, P., Coelho, C., Doval, M. Dolores, Dubert, Jesús, Fernández-Fernández, S., Gayoso, A., Jorge da Silva, A., Magalhaes, C. M., Mohamed, K., Mota-Lopes, A., Piedracoba, Silvia, Pinho, J., Pinto, J. P., Ruiz-Villarreal, Manuel, Santos, A. Miguel P., Silva, A., Rocha, Artur, Silva, M. J., Silva, Paulo A., Torres-López, S., Vila, Begoña, European Commission, Pardo, Paula C., Castro, Carmen G., Taboada, J., Lago, M. dlA., Almeida Costa, Alexandre, Oliveira, Lino, Montero, Pedro, Allen-Perkins, Silvia, Bastero, Susana F., Macho-Eiras, M. Luz, Almécija, Clara, Álvares, M. T., Baptista, P., Bastos, L., Bernabeu, A. M., Bernardes, C., Bio, A., Bode, Antonio, Cardona, Federico, Carracedo, P., Coelho, C., Doval, M. Dolores, Dubert, Jesús, Fernández-Fernández, S., Gayoso, A., Jorge da Silva, A., Magalhaes, C. M., Mohamed, K., Mota-Lopes, A., Piedracoba, Silvia, Pinho, J., Pinto, J. P., Ruiz-Villarreal, Manuel, Santos, A. Miguel P., Silva, A., Rocha, Artur, Silva, M. J., Silva, Paulo A., Torres-López, S., and Vila, Begoña
- Abstract
Environmental indicators are fundamental tools for the evaluation and mitigation of environmental risks, showing the current state and helping to predict future changes on ecosystem health regarding environmental risks The framework of the RAIA observatory www marnaraia org identified 38 environmental indicators, in which 12 key risks affecting the ecosystem services of the Euroregion Galicia Northern Portugal have been evaluated The objective of this initiative is to optimize and analyze the environmental indicators identified for the Euroregion and make them available through a Web service that allows users to get information on the current state and evolution of the ecosystem health
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- 2022
14. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis
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Chalhoub, N.E. Wenderfer, S.E. Levy, D.M. Rouster-Stevens, K. Aggarwal, A. Savani, S.I. Ruth, N.M. Arkachaisri, T. Qiu, T. Merritt, A. Onel, K. Goilav, B. Khubchandani, R.P. Deng, J. Fonseca, A.R. Ardoin, S.P. Ciurtin, C. Kasapcopur, O. Jelusic, M. Huber, A.M. Ozen, S. Klein-Gitelman, M.S. Appenzeller, S. Cavalcanti, A. Fotis, L. Lim, S.C. Silva, R.M. Miramontes, J.R. Rosenwasser, N.L. Saad-Magalhaes, C. Schonenberg-Meinema, D. Scott, C. Silva, C.A. Enciso, S. Terreri, M.T. Torres-Jimenez, A.-R. Trachana, M. Al-Mayouf, S.M. Devarajan, P. Huang, B. Brunner, H.I. Abulaban, K. Aguiar, C. Ahn, S.-Y. Akoghlanian, S. Al-Abrawi, S. Aljaberi, N. Alperin, R. Angeles-Han, S. Ardalan, K. Bader-Meunier, B. Balboni, I. Barbar-Smiley, F. Baxter, S. Beary, J. Boneparth, A. Brakeman, P. Bridges, J. Burgos-Vargas, R. Cabral, D.A. Cameto, J. Carter, C. Chang, J. Chédeville, G. Chhakchhuak, C. Chiraseveenuprapund, P. Cifuentes Alvarado, M. Concannon, A. Cooper, J. Cron, R. De Carvalho, L.M. De Quattro, K. De Ranieri, D. Dizon, B. Donnelly Wrigley, C. Duong, M.D. Eberhard, A. Ede, K. Edelheit, B. Edens, C. Espada, G. Farhey, Y. Flores, F. Fritz, D. Ganguli, S. Gilbert, M. Gittar, P. Greenbaum, L. Grom, A. Gulati, G. Harry, O. Hayward, K. Henrickson, M. Hersh, A. Hiraki, L. Hiskey, M. Hoffmann, S. Hollander, M. Hom, C. Houk, L. Houk, J.B. Hsieh, E.W.Y. Hsu, J. Jensen, P. Joos, R. Jurado, R. Jusan Fiorot, F. Kallash, M. Kamphuis, S. Keltsev, V., (deceased) Khanna, S. Kim, S. Kimseng, K.J. Knight, A. Kunder, R. Lai, J. Laskin, B. Lewandowski, L. Lim, L. Linda, W.-W. Lo, M. Lovell, D. Luggen, M. Madison, J. Mansuri, A. Martin, L. Mason, S. Miller, M. Mina, R. Mohammed, A. Moncrieffe, H. Moorthy, L. Morgan, E. Mosquera, A. Muntel, E. Muscal, E. Myones, B. Nocton, J. Ogbu, E. Okamura, D. Olson, J. Orrock, J. Paim-Marques, L. Pain, C. Park, C. Patel, P. Pereira, M. Prado, R.D. Radhakrishna, S. Rheault, M. Ridgway, W. Riskalla, M. Ronis, T. Sadun, R. Sagcal-Gironella, A.C. Santos, M.C. Schikler, K. AL Suwairi, W. Siddiqi, N. Silva, M.F. Singh-Grewal, D. Smitherman, E. Smolewska, E. Son, M.B. Srinivasalu, H. Sule, S. Susic, G. Syed, R. Thatayatikom, A. Ting, T. Toth, M. Turnier, J. Vashisht, P. Vega Fernandez, P. Velasquez, M. von Scheven, E. Wahezi, D. Ware, A. Wu, E. Yan, J. Yildirim-Toruner, C. Zamparo, C. Zhang, Y. Lawson, E. for the Childhood Arthritis Rheumatology Research Alliance Lupus Nephritis Work Group the Pediatric Rheumatology European Society Lupus Working Party
- Abstract
Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials. © 2021, American College of Rheumatology
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- 2022
15. Accuracy and safety of C1 and C2 screws placement without computerized navigation
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Pinto, V., Magalhães, C., Pereira, L., Kitumba, D., Reinas, R., and Alves, Ó.L.
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- 2022
- Full Text
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16. IR Thermal and UV imaging characterization of melanocytic lesions
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Magalhaes, C, primary, Mendes, J, additional, and Vardasca, R, additional
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- 2022
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17. Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial
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Ruperto, Nicolino, primary, Brunner, Hermine I, additional, Synoverska, Olga, additional, Ting, Tracy V, additional, Mendoza, Carlos Abud, additional, Spindler, Alberto, additional, Vyzhga, Yulia, additional, Marzan, Katherine, additional, Grebenkina, Lyudmila, additional, Tirosh, Irit, additional, Imundo, Lisa, additional, Jerath, Rita, additional, Kingsbury, Daniel J, additional, Sozeri, Betul, additional, Vora, Sheetal S, additional, Prahalad, Sampath, additional, Zholobova, Elena, additional, Butbul Aviel, Yonatan, additional, Chasnyk, Vyacheslav, additional, Lerman, Melissa, additional, Nanda, Kabita, additional, Schmeling, Heinrike, additional, Tory, Heather, additional, Uziel, Yosef, additional, Viola, Diego O, additional, Posner, Holly B, additional, Kanik, Keith S, additional, Wouters, Ann, additional, Chang, Cheng, additional, Zhang, Richard, additional, Lazariciu, Irina, additional, Hsu, Ming-Ann, additional, Suehiro, Ricardo M, additional, Martini, Alberto, additional, Lovell, Daniel J, additional, Cuttica, R, additional, Akikusa, J, additional, Chaitow, J, additional, Wouters, C, additional, Oliveira, S, additional, Neiva, CLS, additional, Santiago, M, additional, Silva, CA, additional, Terreri, MT, additional, Magalhaes, C, additional, De Souza, V, additional, Bandeira, M, additional, Chédeville, G, additional, Houghton, K, additional, Vazquez-Del Mercado, M, additional, Rizo Rodriguez, J, additional, Kobusinska, K, additional, Alexeeva, E, additional, Calvo Penades, I, additional, Boteanu, AL, additional, Kasapcopur, O, additional, Poyrazoglu, MH, additional, Erguven, M, additional, Ozen, S, additional, Al-Abadi, E, additional, Bohnsack, J, additional, Carrasco, R, additional, Dare, J, additional, Gottlieb, B, additional, Wahezi, D, additional, Jung, L, additional, Klein-Gitelman, M, additional, Zhang, Y, additional, Wagner-Weiner, L, additional, Tarvin, S, additional, Vehe, RK, additional, Chiraseveenuprapund, P, additional, Rivas-Chacon, R, additional, De La Pena, W, additional, Sagcal-Gironella, ACP, additional, and Weiss, JE, additional
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- 2021
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18. TOWARD THE DEFINITION OF CUTOFF VALUES FOR DISEASE ACTIVITY STATES IN SYSTEMIC JADAS.
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Giménez, A. I. Rebollo, Vyzhga, Y., Carlini, L., Rosina, S., Patrone, E., Katsikas, M., Saad-Magalhaes, C., El-Ghoneimy, D., El Miedany, Y., Khubchandani, R., Pal, P., Simonini, G., Filocamo, G., Gattinara, M., De Benedetti, F., Montin, D., Civino, A., Alsuweiti, M. O., Stanevicha, V., and Chasnyk, V.
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- 2023
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19. A protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies.
- Author
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Essouma M, de Araujo DB, Day J, Conticini E, Riopel MA, Elias AM, Paula VT, Omori CH, Guimarães JB, Gibson D, Saad-Magalhaes C, Appenzeller S, Schiffenbauer A, Machado PM, Feldman BM, Paik JJ, Christopher-Stine L, Rider LG, Reed A, van der Kooi AJ, Marrani E, Naddaf E, Kirkhus E, Sanner H, Bauer-Ventura I, Lilleker JB, Gupta L, Lucchini M, Dimachkie MM, Tolend M, Arabi TMA, Moghadam-Kia S, O'Hanlon S, Phaneuf S, Shinjo SK, and Doria AS
- Subjects
- Humans, Child, Adult, Whole Body Imaging methods, Research Design, Magnetic Resonance Imaging methods, Myositis diagnostic imaging, Muscle, Skeletal diagnostic imaging
- Abstract
Currently, standardized magnetic resonance imaging (MRI) scoring systems and protocols for assessment of idiopathic inflammatory myopathies (IIMs) in children and adults are lacking. Therefore, we will perform a scoping review of the literature to collate and evaluate the existing semi-quantitative and quantitative MRI scoring systems and protocols for the assessment and monitoring of skeletal muscle involvement in patients with IIMs. The aim is to compile evidence-based information that will facilitate the future development of a universal standardized MRI scoring system for both research and clinical applications in IIM. A systematic search of electronic databases (PubMed, EMBASE, and Cochrane) will be undertaken to identify relevant articles published between January 2000 and October 2023. Data will be synthesized narratively. This scoping review seeks to comprehensively summarize and evaluate the evidence on the scanning protocols and scoring systems used in the assessment of diagnosis, disease activity, and damage using skeletal muscle MRI in IIMs. The results will allow the development of consensus recommendations for clinical practice and enable the standardization of research methods for the MRI assessment of skeletal muscle changes in patients with IIMs., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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20. Development of CARRA/PReS-endorsed consensus Core and Expanded Datasets in childhood-onset systemic lupus erythematosus for international registry-based research.
- Author
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Sadun RE, Cooper JC, Belot A, Avcin T, Aggarwal A, Ainsworth J, Akinsete A, Ardoin SP, Beresford MW, Bortey L, Brunner HI, Chang JC, Ciurtin C, Daftary A, Eberhard B, Feldman CH, Hedrich CM, Hersh AO, Hiraki LT, Isenberg DA, Kamphuis S, Knight AM, Lambert L, Levy DM, Marks SD, Maxwell N, Migowa A, Moore K, Ozen S, Ramsey-Goldman R, Ravelli A, Reeve BB, Rubinstein TB, Saad-Magalhaes C, Sawhney S, Schanberg LE, von Scheven E, Scott C, Son MB, Tony G, Weitzman ER, Wenderfer SE, Woodside A, Lewandowski LB, and Smith EM
- Abstract
Objectives: Childhood-onset systemic lupus erythematosus (cSLE), representing 15%-20% of individuals with SLE, has been difficult to study globally due to differences between registries. This initiative, supported by Childhood Arthritis Rheumatology Research Alliance (CARRA) and Paediatric Rheumatology European Society (PReS), aims to create Core and Expanded cSLE Datasets to standardise and enhance research worldwide., Methods: 21 international cSLE experts and 4 patients participated in a Delphi process (questionnaires, 2 topic-specific focus groups and 3 virtual consensus meetings) to create 2 standardised cSLE datasets. The Core cSLE Dataset was designed to include data essential to meaningful clinical research across many settings. The Expanded cSLE Dataset was designed for centres able to consistently collect data to address broader research questions. Final data items for the Core and Expanded datasets were determined by consensus defined as >80% agreement) using an adapted nominal group technique and voting., Results: The resulting Core cSLE Dataset contains 46 items, including demographics, clinical features, laboratory results, medications and significant adverse events. The Expanded cSLE Dataset adds 26 additional items and includes patient-reported outcomes. Consensus was also achieved regarding the frequency and time points for data collection: baseline, quarterly follow-up visits, annually and flare visits., Conclusion: Standardised Core and Expanded cSLE Datasets for registry-based international cSLE research were defined through the consensus of global experts and patient/caregiver representatives, endorsed by CARRA and PReS. These datasets incorporate disease-specific and patient-specific features, optimised for diverse settings to facilitate international collaborative research for children and adolescents with SLE worldwide., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.)
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- 2024
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21. Longitudinal assessment of disease activity and muscle strength in juvenile dermatomyositis: a multicentre registry study.
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Hortelan Antonio D, Carneiro BOL, Fernandes TAP, Elias AM, Pantoja de Moraes AJ, Vecchi AP, Cavalcanti A, Rabelo CN Jr, Magalhaes CM, Sztajnbok FR, Carvalho LM, Paim Marques L, Terreri MT, Fraga MM, de Oliveira SKF, Sacchetti SB, Appenzeller S, Robazzi T, Ferriani VPL, Len CA, Silva CAA, and Saad-Magalhaes C
- Abstract
Objectives: To define disease activity measures, muscle strength and functional assessments in new-onset juvenile dermatomyositis (JDM) patients, at disease onset and follow up., Methods: A registry was set up in 18 hospitals, enrolling patients over 3-years (2015-2018). Clinical assessments were performed at baseline, and at 6, 12, 18 and 24 months after diagnosis. Disease Activity Score (DAS20), skin and musculoskeletal DAS sub-scales; Manual Muscle Test (MMT8); Childhood Myositis Assessment Scale (CMAS); Childhood Health Assessment Questionnaire disability index (CHAQ_DI 0-3) and 10 cm Visual Analog Scale (VAS) for overall wellbeing scores were compared by Poisson Model and Wald post-test for repeated measures., Results: Ninety-six cases, being 61 (64%) females, median age 10 years had JDM diagnosis and 12 (13%) onset calcinosis. Mean ±SD scores at diagnosis and 6 months intervals for DAS20 (0-20) were 7.8±5, 6.3 ±4.8, 5±4, 4.9 ±5 and 0.5 ±2.3; with significant difference from baseline (p<0.01). Skin DAS subscales were 2.8±3.3, 1.8±2.9, 1,1±2.2, 0.6±1.8, 0.4±1.5. MMT (0-80) 62.6±20.4, 70.2±13.5, 73.3±11, 75.7±7.9 and 74.8±7.8, with significant difference from baseline up to 6 months (p=0.016); CMAS (0-53) 29.5±11.4, 33.1±8.3, 34.2±5.8, 34±6 and 33.3±5.4. CHAQ-DI (0-3) 1±0.9, 0.6±0.7, 0.8±0.8, 1±0.8 and 1±0.3; parents VAS 4.1±2.5, 2±2.1; 1.3±2.8, 4.1±3.1, 1.7±2.2. There was no significant difference for CMAS, CHAQ-DI and parents VAS from baseline up to 24-month assessment., Conclusions: DAS20 scores improved gradually during follow up, MMT8 improved significantly during the first 6 months and CMAS, CHAQ-DI and parents VAS scores had no significant improvement with persistent functional impairment over 2-years.
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- 2024
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22. Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse.
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Amargant F, Magalhaes C, Pritchard MT, and Duncan FE
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The female reproductive system is one of the first to age in humans, resulting in infertility and endocrine disruptions. The aging ovary assumes a fibro-inflammatory milieu which negatively impacts gamete quantity and quality as well as ovulation. Here, we tested whether the systemic delivery of anti-inflammatory (Etanercept) or anti-fibrotic (Pirfenidone) drugs attenuates ovarian aging in mice. We first evaluated the ability of these drugs to decrease the expression of fibro-inflammatory genes in primary ovarian stromal cells treated with a pro-fibrotic or a pro-inflammatory stimulus. Whereas Etanercept did not block Tnf expression in ovarian stromal cells, Pirfenidone significantly reduced Col1a1 expression. We then tested Pirfenidone in vivo where the drug was delivered systemically via mini-osmotic pumps for 6 weeks. Pirfenidone mitigated the age-dependent increase in ovarian fibrosis without impacting overall health parameters. Ovarian function was improved in Pirfenidone-treated mice as evidenced by increased follicle and corpora lutea number, AMH levels, and improved estrous cyclicity. Transcriptomic analysis revealed that Pirfenidone treatment resulted in an upregulation of reproductive function-related genes at 8.5 months and a downregulation of inflammatory genes at 12 months of age. These findings demonstrate that reducing the fibroinflammatory ovarian microenvironment improves ovarian function, thereby supporting modulating the ovarian environment as a therapeutic avenue to extend reproductive longevity., (© 2024. The Author(s), under exclusive licence to American Aging Association.)
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- 2024
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23. Effect of T2-T4 sympathicotomy in skin temperature of pediatric patients with hyperhidrosis: a thermographic follow-up.
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Carvalho F, Magalhaes C, Fernandez-Llimos F, Mendes J, and Gonçalves J
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- Humans, Child, Male, Female, Follow-Up Studies, Adolescent, Thoracic Vertebrae surgery, Hyperhidrosis surgery, Hyperhidrosis physiopathology, Skin Temperature physiology, Sympathectomy methods, Thermography methods
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- 2024
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24. Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review.
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Brufatto MZ, Lanças SHS, de Albuquerque Pedrosa Fernandes T, Sallum AME, Campos LMA, Sakamoto AP, Terreri MT, Sztajnbok FR, Bica BERG, Ferriani VPL, de Carvalho LM, Silva CAA, and Saad-Magalhaes C
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- Child, Female, Humans, Male, Young Adult, Age of Onset, Retrospective Studies, Carcinoma complications, Lupus Erythematosus, Systemic complications
- Abstract
Background: Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis., Method: A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol., Results: Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min-max) SLEDAI-2 K scores were 9 (0-38), median (min-max) SLICC/ACR-DI (SDI) score were 1 (1-5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma., Conclusion: Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series., (© 2024. The Author(s).)
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- 2024
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25. Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force.
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Smith EMD, Aggarwal A, Ainsworth J, Al-Abadi E, Avcin T, Bortey L, Burnham J, Ciurtin C, Hedrich CM, Kamphuis S, Levy DM, Lewandowski LB, Maxwell N, Morand EF, Ozen S, Pain CE, Ravelli A, Saad Magalhaes C, Pilkington CA, Schonenberg-Meinema D, Scott C, Tullus K, and Beresford MW
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- Adult, Child, Humans, Surveys and Questionnaires, Remission Induction, Advisory Committees, Quality of Life, Lupus Erythematosus, Systemic drug therapy
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Objectives: Application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) may improve care and health outcomes. This initiative aimed to harmonise existing evidence and expert opinion regarding T2T for cSLE., Methods: An international T2T Task Force was formed of specialists in paediatric rheumatology, paediatric nephrology, adult rheumatology, patient and parent representatives. A steering committee formulated a set of draft overarching principles and points-to-consider, based on evidence from systematic literature review. Two on-line preconsensus meeting Delphi surveys explored healthcare professionals' views on these provisional overarching principles and points-to-consider. A virtual consensus meeting employed a modified nominal group technique to discuss, modify and vote on each overarching principle/point-to-consider. Agreement of >80% of Task Force members was considered consensus., Results: The Task Force agreed on four overarching principles and fourteen points-to-consider. It was agreed that both treatment targets and therapeutic strategies should be subject to shared decision making with the patient/caregivers, with full remission the preferred target, and low disease activity acceptable where remission cannot be achieved. Important elements of the points-to-consider included: aiming for prevention of flare and organ damage; glucocorticoid sparing; proactively addressing factors that impact health-related quality of life (fatigue, pain, mental health, educational challenges, medication side effects); and aiming for maintenance of the target over the long-term. An extensive research agenda was also formulated., Conclusions: These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
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- 2023
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26. Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients.
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Sakamoto AP, Silva CA, Pita AC, Trindade VC, Islabao AG, Fiorot FJ, Lopes SR, Pereira RM, Saad-Magalhaes C, Russo GC, Len CA, Prado RD, Campos LM, Aikawa NE, Appenzeller S, Ferriani VP, Silva MF, Felix M, Fonseca AR, Assad AP, Sztajnbok FR, Santos MC, Bica BE, Sena EG, Moraes AJ, Fraga MM, Robazzi TC, Spelling PF, Scheibel IM, Cavalcanti AS, Matos EN, Guimaraes LJ, Santos FP, Mota LM, Bonfa E, and Terreri MT
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- Child, Humans, Female, Male, Brazil epidemiology, Retrospective Studies, Age of Onset, Risk Factors, Lupus Erythematosus, Systemic complications, Renal Insufficiency, Chronic complications
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Objectives: To identify associations between mortality in cSLE patients and their characteristics: clinical and laboratory features, disease activity and damage scores, and treatment; to evaluate risk factors associated with mortality in cSLE; and to determine the most frequent causes of death in this group of patients., Methods: We performed a multicenter retrospective cohort using data from 1,528 cSLE patients followed in 27 pediatric rheumatology tertiary centers in Brazil. Patients' medical records were reviewed according to a standardized protocol, in which information regarding demographic and clinical features, disease activity and damage scores, and treatment were collected and compared between deceased cSLE patients and survivors. Univariate and multivariate analyses by Cox regression model were used to calculate risk factors for mortality, whereas survival rates were analyzed by Kaplan-Meier plots., Results: A total of 63/1,528 (4.1%) patients deceased, 53/63 were female (84.1%), median age at death was 11.9 (9.4-13.1) years and median time interval between cSLE diagnosis and death was 3.2 (0.5-5.3) years. Sepsis was the main cause of death in 27/63 (42.8%) patients, followed by opportunistic infections in 7/63 (11.1%), and alveolar hemorrhage in 6/63 (9.5%) patients. The regression models resulted in neuropsychiatric lupus (NP-SLE) (HR = 2.56, 95% CI = 1.48-4.42) and chronic kidney disease (CKD) (HR = 4.33, 95% CI = 2.33-4.72), as risk factors significantly associated with mortality. Overall patient survival after cSLE diagnosis at 5, 10, and 15 years were 97%, 95.4%, and 93.8%, respectively., Conclusions: This study confirmed that the recent mortality rate in cSLE in Brazil is low, but still of concern. NP-SLE and CKD were the main risk factors for mortality, indicating that the magnitude of these manifestations was significantly high.
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- 2023
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27. Skin temperature response to thermal stimulus in patients with hyperhidrosis: A comparative study.
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Carvalho F, Magalhaes C, Fernandez-Llimos F, Mendes J, and Gonçalves J
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- Body Temperature Regulation physiology, Child, Humans, Skin blood supply, Sweating, Temperature, Hyperhidrosis diagnosis, Hyperhidrosis surgery, Skin Temperature
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Primary hyperhidrosis (HH), the excessive sweating exceeding physiological demand, has been associated to a complex dysfunction of the autonomic nervous system which may explain the disfunction in sweating but may also cause unrevealed alterations in skin blood flow regulation. In fact, HH patients present a sympathetic over-function with less reflex bradycardia in response to the Valsalva maneuver and higher sympathetic skin responses. We aimed to identify response patterns to room thermal stimulus in HH patients compared to a control group in order to investigate putative differences in blood flow assuming that skin temperature in glabrous (non-hairy) areas reflect the sympathetic tone in arteriovenous anastomoses (AVAs). Infrared thermography images were obtained from a cohort of patients diagnosed with HH, followed at a hospital pediatric surgical department and to a sex- and age-matched control group of patients admitted for other surgical procedures. With the participants in Fowler's position, a set of 3 images were captured simultaneously and 44 regions of interest were analyzed, distributed on the palms of the hands, soles of the feet, axilla, and inner canthus. After an acclimatization period at 20 °C, the room temperature was increased to 24, 28 and 32 °C to obtain similar sets of thermograms. A total of 37 patients with HH and 16 participants in the control group were included in the study. At baseline (20 °C), body core temperature (measured in the inner canthus) was significantly higher in the HH patients compared to the controls (p = 0.019 and p = 0.003 in right and left inner canthi, respectively), without any significant differences in the other thermograms. When room temperature was increased, differences in core temperature disappeared, while differences appeared in axilla and palms of the hands with HH patients presenting significantly lower temperature at the three thermal stimulus stages. Patients with HH presented a lower thermoregulatory response when submitted to room temperature increase, which may reflect a vasomotor sympathetic over-function in AVAs., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Fatima Carvalho reports financial support was provided by Fundação para a Ciência e Tecnologia., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2022
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28. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.
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Chalhoub NE, Wenderfer SE, Levy DM, Rouster-Stevens K, Aggarwal A, Savani SI, Ruth NM, Arkachaisri T, Qiu T, Merritt A, Onel K, Goilav B, Khubchandani RP, Deng J, Fonseca AR, Ardoin SP, Ciurtin C, Kasapcopur O, Jelusic M, Huber AM, Ozen S, Klein-Gitelman MS, Appenzeller S, Cavalcanti A, Fotis L, Lim SC, Silva RM, Miramontes JR, Rosenwasser NL, Saad-Magalhaes C, Schonenberg-Meinema D, Scott C, Silva CA, Enciso S, Terreri MT, Torres-Jimenez AR, Trachana M, Al-Mayouf SM, Devarajan P, Huang B, and Brunner HI
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- Adolescent, Age of Onset, Child, Female, Humans, Male, Retrospective Studies, Glucocorticoids administration & dosage, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic drug therapy, Lupus Nephritis etiology
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Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology., Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%., Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3-5). Validation of the SSR for up to 6 months post-kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6)., Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials., (© 2021, American College of Rheumatology.)
- Published
- 2022
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