1. The association between type 2 diabetes and attention- deficit/hyperactivity disorder:A systematic review, meta-analysis, and population-based sibling study
- Author
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Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson, Institut Català de la Salut, [Garcia-Argibay M, Li L] School of Medical Sciences, Örebro University, Faculty of Medicine and Health, Örebro, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [Du Rietz E, Zhang L, Yao H] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [Jendle J] School of Medical Sciences, Örebro University, Faculty of Medicine and Health, Örebro, Sweden. [Ramos-Quiroga JA] Departament de Psiquiatria i Medicina Forense, Universitat Autònoma de Barcelona, Bellaterra, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain. Servei de Psiquiatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Unitat de Genètica Psiquiàtrica, Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ribasés M] Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain. Servei de Psiquiatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Unitat de Genètica Psiquiàtrica, Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo II [ENFERMEDADES] ,Other subheadings::Other subheadings::/epidemiology [Other subheadings] ,Cognitive Neuroscience ,Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 [DISEASES] ,Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores] ,Type 2 diabetes ,Trastorn per dèficit d'atenció amb hiperactivitat - Epidemiologia ,técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Diabetis no-insulinodependent - Epidemiologia ,Attention deficit hyperactivity disorder ,Behavioral Neuroscience ,Meta-analysis ,Neuropsychology and Physiological Psychology ,Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [PSYCHIATRY AND PSYCHOLOGY] ,Malalties - Factors de risc ,Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad [PSIQUIATRÍA Y PSICOLOGÍA] ,Cardiovascular risk factors - Abstract
Attention deficit hyperactivity disorder; Cardiovascular risk factors; Type 2 diabetes Trastorno por déficit de atención con hiperactividad; Factores de riesgo cardiovascular; Diabetes tipo 2 Trastorn per dèficit d'atenció amb hiperactivitat; Factors de risc cardiovascular; Diabetis tipus 2 We conducted a systematic review and a meta-analysis to quantitatively summarize evidence on the association between attention-deficit/hyperactivity disorder (ADHD) and type 2 diabetes (T2D). Moreover, a register-based sibling study was conducted to simultaneously control for confounding factors. A systematic search identified four eligible observational studies (N = 5738,287). The meta-analysis showed that individuals with ADHD have a more than doubled risk of T2D when considering adjusted estimates (OR=2.29 [1.48–3.55], d=0.46). Results from the register-based Swedish data showed a significant association between ADHD and T2D (HR=2.35 [2.14–2.58]), with substance use disorder, depression, and anxiety being the main drivers of the association, and cardiovascular and familiar risk playing a smaller role. While results from the meta-analysis provide evidence for an increased risk of T2D in individuals with ADHD, the register-based analyses show that the association between ADHD and T2D is largely explained by psychiatric comorbidities. Pending further evidence of causal association, our findings suggest that early identification and treatment of ADHD comorbidities might greatly reduce the risk of developing T2D in individuals with ADHD. The project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 965381. This report reflects only the author’s view, and the European Union is not responsible for any use that may be made of the information it contains. Henrik Larsson acknowledges financial support from the Swedish Research Council (2018-02599) and the Swedish Brain Foundation (FO2021-0115). Zheng Chang acknowledges financial support from the Swedish Council for Health, Working Life and Welfare (2019-00176). Ebba Du Rietz was supported by grant PD20-0036 from the Swedish Society for Medical Research (SSMF), Funds from the Strategic Research Program in Epidemiology at Karolinska Institutet, Fredrik & Ingrid Thurings Stiftelse and Fonden för Psykisk Hälsa.
- Published
- 2023
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