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Hydrolyzed milk proteins include hydrolyzed whey protein and hydrolyzed casein. Hydrolyzed whey protein can be divided into partial （moderate） hydrolyzed whey protein and extensive hydrolyzed whey protein. Hydrolyzed milk protein is used as raw material in infant formula for special medical purpose in China， while partially hydrolyzed milk protein can be used as raw material for standard infant formula in Europe， America， Australia， New Zealand， Japan and Korea. Extensively hydrolyzed milk protein can only be used as raw material for special medical use formula food. The quality of different types of hydrolyzed milk protein ingredients provided by different manufacturers varies a lot. And there is no one-to-one correspondence between their physiological effects related to allergy and gastrointestinal symptoms in healthy infants and infants with high allergy risk. This article reviews the progress of research and regulatory management of hydrolyzed milk protein infant formula powder on allergy and functional gastrointestinal disorders of infants and toddlers.

This study introduces the concept of "energy level" into the analysis of innovation ecosystems. Drawing on the theory of "architects", we have identified the key architects of regional digital innovation ecosystems. By integrating Necessary Condition Analysis (NCA) and Fuzzy-set Qualitative Comparative Analysis (fsQCA), we examined the configuration effects of internal architects, external architects, and digital innovation habitats on the energy level of these ecosystems, utilizing data from 30 provinces in China as case studies. The results indicate that the contribution of a single architect to achieving a high energy level in a regional digital innovation ecosystem is limited and cannot be regarded as a necessary condition for driving a high energy level. However, core innovation actors and digital infrastructures emerge as more significant core conditions. The architects of regional digital innovation ecosystems exhibit multiple concurrent causal relationships. The configuration paths of high and non-high energy levels of ecosystems display a causally asymmetric "multiple paths to the same outcome" relationship. The three identified paths for driving high energy levels are categorized as "core actor-infrastructure"-driven paths. The findings of this paper hold substantial theoretical and practical significance for fostering the healthy development of regional digital innovation ecosystems. [ABSTRACT FROM AUTHOR]

This study uses the Multi-Level Perspective (MLP) on socio-technical transitions to develop a theoretical model for analyzing the stable operation of regional innovation ecosystems. Focusing on 30 provinces in China, it employs Necessary Condition Analysis (NCA) and Fuzzy-set Qualitative Comparative Analysis (fsQCA) to systematically examine the configuration paths driving their stability. First, the findings reveal that innovation actors, resources, driving policies, industrial regulations, infrastructures, and the innovation environment are not individually necessary for stability. However, infrastructure is identified as a critical core condition. The study highlights a complex causal relationship and synergistic interplay among the six antecedent conditions. Second, the research identifies two paths to highly stable operation in regional innovation ecosystems: the ‘Innovation Actor + Infrastructure’ path and the ‘Infrastructure’ path. Finally, the results show that configurations for highly and non-highly stable operations exhibit causal asymmetry, indicating ‘different paths to the same destination.’ This study deepens theoretical insights into regional innovation ecosystems and offers actionable strategies for their stable operation. [ABSTRACT FROM AUTHOR]

Diverse clinical observations and basic studies have been conducted to explore the implications of analgesic medications in liver diseases. However, the direct causal relationship between prescription analgesic use (PAU) and the risk of liver cancer and precancerosis remains unclear. Thus, we aimed to reveal the conceivable causal effect of PAU on liver cancer and precancerosis, with immune cells as mediating factors. Two-sample Mendelian randomization (MR) analyses were performed to ascertain the causality of PAU on liver cancer and precancerosis. Sensitivity analysis approaches were employed to assess the heterogeneity and pleiotropy of results. Our findings revealed a causal correlation between different PAUs and the risk of liver cancer and alcoholic liver disease (ALD). Specifically, salicylic acid derivatives (SADs) and anilide medications were found to have a protective effect on liver cancer. And non-steroidal anti-inflammatory drugs (NSAIDs) and anilide medications showed a causal impact on ALD. Finally, mediation analyses found that anilide medications influence liver cancer through different immune cell phenotypes. Our research provides new genetic evidence for the causal impact of PAU on liver cancer and precancerosis, with the mediating role of immune cells demonstrated, offering a valuable foundation for researching analgesic medications in liver cancer and precancerosis treatment. [ABSTRACT FROM AUTHOR]

Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death, highlighting the urgent clinical need for effective therapies. Recently, tanshinone IIA has been identified as a promising therapeutic agent for myocardial infarction. However, efficient delivery remains a major issue that limits clinical translation. To address this problem, an injectable thermosensitive poly (lactic acid‐co‐glycolic acid)‐block‐poly (ethylene glycol)‐block‐poly (lactic acid‐co‐glycolic acid) gel (PLGA‐PEG‐PLGA) system encapsulating tanshinone IIA‐loaded reactive oxygen species‐sensitive microspheres (Gel−MS/tanshinone IIA) has been designed and synthesized in this study. The thermosensitive hydrogel exhibits good mechanical properties after reaching body temperature. Microspheres initially immobilized by the gel exhibit excellent reactive oxygen species‐triggered release properties in a high‐reactive oxygen species environment after myocardial infarction onset. As a result, encapsulated tanshinone IIA is effectively released into the infarcted myocardium, where it exerts local anti‐pyroptotic and anti‐inflammatory effects. Importantly, the combined advantages of this technique contribute to the mitigation of left ventricular remodeling and the restoration of cardiac function following tanshinone IIA. Therefore, this novel, precision‐guided intra‐tissue therapeutic system allows for customized local release of tanshinone IIA, presenting a promising alternative treatment strategy aimed at inducing beneficial ventricular remodeling in the post‐infarct heart. [ABSTRACT FROM AUTHOR]