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24 results on '"Marconi, Peggy"'

8. A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties

Author

Sciabica, Sabrina, primary, Barbari, Riccardo, additional, Fontana, Riccardo, additional, Tafuro, Giovanni, additional, Semenzato, Alessandra, additional, Traini, Daniela, additional, Silva, Dina M., additional, Reis, Larissa Gomes Dos, additional, Canilli, Luisa, additional, Terno, Massimo, additional, Marconi, Peggy, additional, Baldisserotto, Anna, additional, Vertuani, Silvia, additional, and Manfredini, Stefano, additional

Published
2023
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9. Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target

Author

Fontana, Riccardo, primary, Mattioli, Laura Beatrice, additional, Biotti, Giulia, additional, Budriesi, Roberta, additional, Gotti, Roberto, additional, Micucci, Matteo, additional, Corazza, Ivan, additional, Marconi, Peggy, additional, Frosini, Maria, additional, Manfredini, Stefano, additional, Buzzi, Raissa, additional, and Vertuani, Silvia, additional

Published
2023
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12. The Lesson Learned from the COVID-19 Pandemic: Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid

Author

Benedusi, Mascia, primary, Tamburini, Elena, additional, Sicurella, Mariaconcetta, additional, Summa, Daniela, additional, Ferrara, Francesca, additional, Marconi, Peggy, additional, Cervellati, Franco, additional, Costa, Stefania, additional, and Valacchi, Giuseppe, additional

Published
2022
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17. Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

Author

Nicoli, Francesco, primary, Clave, Emmanuel, additional, Wanke, Kerstin, additional, von Braun, Amrei, additional, Bondet, Vincent, additional, Alanio, Cécile, additional, Douay, Corinne, additional, Baque, Margaux, additional, Lependu, Claire, additional, Marconi, Peggy, additional, Stiasny, Karin, additional, Heinz, Franz X., additional, Muetsch, Margot, additional, Duffy, Darragh, additional, Boddaert, Jacques, additional, Sauce, Delphine, additional, Toubert, Antoine, additional, Karrer, Urs, additional, and Appay, Victor, additional

Published
2022
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18. Analysis of Civil Environments Cleaning Services—Microbiological and LCA Analysis after Traditional and Sustainable Procedures.

Author

Fontana, Riccardo, Marzola, Marco, Buratto, Mattia, Trioschi, Giulia, Caproni, Anna, Nordi, Chiara, Buffone, Cesare, Bandera, Beatrice, Vogli, Luciano, and Marconi, Peggy

Abstract

The development of sustainable processes has an important role to play in balancing social productivity requirements, protecting the environment and natural resources. Up to date, efforts to combat microbial contamination have focused on the use of chemical-based sanitation procedures, which may have various limitations, as testified by the persistence of contamination itself, by the growing antimicrobial resistance of microbes and by the chemical related pollution. The purpose of this paper is to present a comparative analysis of the use of conventional and sustainable cleaning products and processes in civilian environments. The sampling campaign is conducted in a sports hall in Turin, Italy. Each sample comes from a specific environment, surface, furniture and sanitary and is taken using RODAC contact plates and swabs with a neutralizing agent in order to standardize the result of the microbiological evaluation. Sampling occurred before and after traditional and sustainable cleaning procedures. The sustainable experimental design using ecological products in the cleaning procedures of the analyzed areas proved to be a relevant technique. From CAM (minimal environmental criteria) requirements, the sustainable protocol must give equal or better results than the traditional protocol from both microbiological and environmental (LCA) point of view. It can be concluded that the ecological experimental system meets this criterion and has demonstrated better performance both in antimicrobial activity and in environmental impact than the conventional system: all findings are in an acceptable state of sanitation, with no evidence of pathogenic micro-organisms specified in the guideline. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Mangiferin-Loaded Smart Gels for HSV-1 Treatment

Author

Sicurella, Mariaconcetta, primary, Sguizzato, Maddalena, additional, Cortesi, Rita, additional, Huang, Nicolas, additional, Simelière, Fanny, additional, Montesi, Leda, additional, Marconi, Peggy, additional, and Esposito, Elisabetta, additional

Published
2021
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22. Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

Author

Gallerani, Eleonora, Proietto, Davide, Dallan, Beatrice, Campagnaro, Marco, Pacifico, Salvatore, Albanese, Valentina, Marzola, Erika, Marconi, Peggy Carla Raffaella, Caputo, Antonella, Victor, Appay, Gavioli, Riccardo, and Nicoli, Francesco

Subjects
Adult, Aging, Enzyme-Linked Immunospot Assay, viruses, Immunology, Epitopes, T-Lymphocyte, cellular immunity, CD8-Positive T-Lymphocytes, CD8+ T cells, Lymphocyte Activation, NO, Interferon-gamma, Young Adult, Humans, Antigens, Viral, primary responses, Cells, Cultured, Original Research, Aged, SARS-CoV-2, COVID-19, RC581-607, epitopes, Middle Aged, Healthy Volunteers, naive T cells, Gene Expression Regulation, Immunologic diseases. Allergy, SARS-CoV-2, immune aging, naive T cells, cellular immunity, epitopes, primary responses, CD8+ T cells, immune aging, Peptides
Abstract

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses.

Published
2021

23. Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects.

Author

Gallerani, Eleonora, Proietto, Davide, Dallan, Beatrice, Campagnaro, Marco, Pacifico, Salvatore, Albanese, Valentina, Marzola, Erika, Marconi, Peggy, Caputo, Antonella, Appay, Victor, Gavioli, Riccardo, and Nicoli, Francesco

Subjects
T cells, COVID-19, CELLULAR immunity, SARS-CoV-2, AGE groups
Abstract

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Impaired Priming of SARS-CoV-2-Specific Naive CD8 + T Cells in Older Subjects.

Author

Gallerani E, Proietto D, Dallan B, Campagnaro M, Pacifico S, Albanese V, Marzola E, Marconi P, Caputo A, Appay V, Gavioli R, and Nicoli F

Subjects
Adult, Aged, Antigens, Viral immunology, Cells, Cultured, Enzyme-Linked Immunospot Assay, Epitopes, T-Lymphocyte immunology, Gene Expression Regulation, Healthy Volunteers, Humans, Interferon-gamma genetics, Interferon-gamma metabolism, Lymphocyte Activation, Middle Aged, Peptides immunology, Young Adult, Aging immunology, CD8-Positive T-Lymphocytes immunology, COVID-19 immunology, SARS-CoV-2 immunology
Abstract

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8 + T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8 + T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8 + T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8 + T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8 + T-cell responses., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Gallerani, Proietto, Dallan, Campagnaro, Pacifico, Albanese, Marzola, Marconi, Caputo, Appay, Gavioli and Nicoli.)

Published
2021
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