Search

This work aimed to evaluate the in vitro anthelmintic effect of carvone nanoemulsions on Haemonchus contortus. Three R-carvone nanoemulsions were prepared: uncoated R-carvone nanoemulsions homogenized in a sonicator (UNAlg-son) and homogenized in an ultrahomogenizer (UNAlg-ultra) and sodium alginate-coated R-carvone (CNAlg-ultra). The physicochemical characterizations of the nanoemulsions were carried out. The anthelmintic activity was evaluated using egg hatch test (EHT), larval development test (LDT) and adult worm motility test (AWMT). Changes in cuticle induced in adult H. contortus were evaluated by scanning electron microscopy (SEM). The results were subjected to analysis of variance and compared using the Tukey test (P < 0.05). The effective concentration to inhibit 50% (EC50) of egg hatching and larval development was calculated. The particle sizes were 281.1 nm (UNAlg-son), 152.7 nm (UNAlg-ultra) and 557.8 nm (CNAlg-ultra), and the zeta potentials were −15 mV (UNAlg-son), −10.8 mV (UNAlg-ultra) and −24.2 mV (CNAlg-ultra). The encapsulation efficiency was 99.84 ± 0.01%. SEM of the nanoemulsions showed an increase in size. In EHT, the EC50 values of UNAlg-son, UNAlg-ultra and CNAlg-ultra were 0.19, 0.02 and 0.17 mg mL−1, respectively. In LDT, they were 0.29, 0.31 and 0.95 mg mL−1 for UNAlg-son, UNAlg-ultra and CNAlg-ultra, respectively. The adult motility inhibition was 100% after 12 h of exposure to UNAlg-ultra and CNAlg-ultra, while for UNAlg-son, it was 79.16%. SEM showed changes in the buccal capsule and cuticular damage. It was concluded that R-carvone nanoemulsions showed antiparasitic action demonstrating promise for the control of infections caused by gastrointestinal nematodes in small ruminants.

The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca

The use of mushrooms in medicine is quite old and the first report about the use of genus Agaricus in treatment of ulcers occurred in Byzantine period. This mushroom is widely consumed as food, tea, food supplements, as well as nutraceutical and cosmeceutical applications, being cultivated and appreciated in several countries such as Brazil, Korea, Japan and China.This study aimed to characterize the chemical profile and the potential gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill (HEAb).The extract was chemically characterized by elemental analysis, UPLC-QTOF-MSMannitol, malic acid, pyroglutamic acid, L-agaritine and L-valine were putatively identified by UPLC-QTOF-MSIn this study was possible to conclude that HEAb has gastroprotective effect related to the involvement of NO and PG pathways in the ethanol-induced gastric ulcer model in mice.

A questão ambiental está intimamente ligada aos conceitos químicos, assim como a alta relevância de sua abordagem em todas as esferas da sociedade. Associado a isso, sabe-se que, para um ensino eficaz e significativo de Química, é preciso conhecer e testar novas ferramentas com o objetivo de melhorar o aprendizado dos alunos. Nesse sentido, a gamificação pode ser uma boa estratégia no ensino. A usabilidade do jogo didático como ferramenta pedagógica e suas contribuições para o processo de ensino e aprendizagem, devem ser verificadas usando de análises adequadas. Nesta perspectiva, o objetivo deste trabalho foi desenvolver um jogo de computador utilizando o software livre 001 Game Creator® para abordar a temática da Educação Ambiental (EA) para alunos do Ensino Médio Técnico (EMT). Além disso, foi utilizado a Análise Fatorial (FA) de Máxima Verossimilhança (ML), como ferramenta analítica para avaliação dos resultados obtidos. Participaram da pesquisa 90 alunos de três turmas do EMT, sendo aplicado um questionário para coletar os dados sobre os conhecimentos prévios de EA e as percepções do jogo desenvolvido. Diante do trabalho realizado, foi possível evidenciar que a técnica de análise ML foi uma ferramenta hábil e rápida para o entendimento da avaliação de jogos educativos, identificando que a aplicação do jogo “Um passeio na Comptrônica” despertou o interesse dos alunos e proporcionou uma aprendizagem dinâmica e prazerosa, de forma cooperativa e bastante imersiva.