1. Cell type ontologies of the Human Cell Atlas
- Author
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Ed S. Lein, Chuan Xu, Maria Keays, Sarah A. Teichmann, Peter V. Kharchenko, David Osumi-Sutherland, Adam P. Levine, and Aviv Regev
- Subjects
Cell type ,Computer science ,Cells ,Ontology (information science) ,03 medical and health sciences ,Atlases as Topic ,0302 clinical medicine ,Data Mining ,Humans ,Profiling (information science) ,Cell Lineage ,Disease ,030304 developmental biology ,0303 health sciences ,Cellular composition ,Atlas (topology) ,High-Throughput Nucleotide Sequencing ,Reference cell ,Genomics ,Cell Biology ,Human cell ,Data science ,Cell biology ,Systems Integration ,Gene Ontology ,Phenotype ,Biological Ontologies ,Single-Cell Analysis ,Transcriptome ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and states into a reference cell ontology. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains.
- Published
- 2021