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15 results on '"Marsh, Anna-Marie"'

3. Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L., Gulsin, Gaurav S., Brady, Emer M., Dattani, Abhishek, Bilak, Joanna M., Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S., Wormleighton, Joanne, Graham-Brown, Matthew P. M., Singh, Anvesha, Arnold, J. Ranjit, Lawson, Claire, Davies, Melanie J., Xue, Hui, Kellman, Peter, and McCann, Gerry P.

Published
2022
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4. Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers

Author

Dattani, Abhishek, primary, Brady, Emer M., additional, Kanagala, Prathap, additional, Stoma, Svetlana, additional, Parke, Kelly S., additional, Marsh, Anna-Marie, additional, Singh, Anvesha, additional, Arnold, Jayanth R., additional, Moss, Alastair J., additional, Zhao, Lei, additional, Cvijic, Mary Ellen, additional, Fronheiser, Matthew, additional, Du, Shuyan, additional, Costet, Philippe, additional, Schafer, Peter, additional, Carayannopoulos, Leon, additional, Chang, Ching-Pin, additional, Gordon, David, additional, Ramirez-Valle, Francisco, additional, Jerosch-Herold, Michael, additional, Nelson, Christopher P., additional, Squire, Iain B., additional, Ng, Leong L., additional, Gulsin, Gaurav S., additional, and McCann, Gerry P., additional

Published
2024
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6. Do Lean People with Type 2 Diabetes (T2D) Have Cardiomyopathy? Assessing the Impact of BMI on Cardiac Remodelling and Quantitative Myocardial Blood Flow in T2D

Author

Cowley, Alice, primary, Dattani, Abhishek, additional, Yeo, Jian, additional, Brady, Emer, additional, Marsh, Anna-Marie, additional, Sian, Manjit, additional, Parke, Kelly, additional, Wormleighton, Joanne, additional, Gulsin, Gaurav, additional, Singh, Anvesha, additional, Arnold, Jayanath, additional, and McCann, Gerry, additional

Published
2024
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8. Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis

Author

Bilak, Joanna M., primary, Yeo, Jian L., additional, Gulsin, Gaurav S., additional, Marsh, Anna-Marie, additional, Sian, Manjit, additional, Dattani, Abhishek, additional, Ayton, Sarah L., additional, Parke, Kelly S., additional, Bain, Moira, additional, Pang, Wenjie, additional, Boulos, Sherif, additional, Pierre, Tim G. St, additional, Davies, Melanie J., additional, Yates, Thomas, additional, McCann, Gerry P., additional, and Brady, Emer M., additional

Published
2023
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11. PHACTR1 modulates vascular compliance but not endothelial function: a translational study

Author

Wood, Alice, primary, Antonopoulos, Alexios, additional, Chuaiphichai, Surawee, additional, Kyriakou, Theodosios, additional, Diaz, Rebeca, additional, Al Hussaini, Abtehale, additional, Marsh, Anna Marie, additional, Sian, Manjit, additional, Meisuria, Mitul, additional, McCann, Gerry, additional, Rashbrook, Victoria S, additional, Drydale, Edward, additional, Draycott, Sally, additional, Polkinghorne, Murray David, additional, Akoumianakis, Ioannis, additional, Antoniades, Charalambos, additional, Watkins, Hugh, additional, Channon, Keith M, additional, Adlam, David, additional, and Douglas, Gillian, additional

Published
2022
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12. PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Author

Wood, Alice, Antonopoulos, Alexios, Chuaiphichai, Surawee, Kyriakou, Theodosios, Diaz, Rebeca, Hussaini, Abtehale Al, Marsh, Anna-Marie, Sian, Manjit, Meisuria, Mitul, McCann, Gerry, Rashbrook, Victoria S, Drydale, Edward, Draycott, Sally, Polkinghorne, Murray David, Akoumianakis, Ioannis, Antoniades, Charalambos, Watkins, Hugh, Channon, Keith M, Adlam, David, and Douglas, Gillian

Subjects
SPONTANEOUS coronary artery dissection, CAROTID intima-media thickness, THORACIC aorta, VASCULAR remodeling, CELL physiology, CAROTID artery
Abstract

Aims The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele in myocardial infarction and multiple other vascular diseases. Recent murine studies have identified a role for Phactr1 in the development of atherosclerosis. However, the role of PHACTR1 in vascular tone and in vivo vascular remodelling has yet to be established. The aim of this study was to investigate the role of PHACTR1 in vascular function. Methods and results Prospectively recruited coronary artery disease (CAD) patients undergoing bypass surgery and retrospectively recruited spontaneous coronary artery dissection (SCAD) patients and matched healthy volunteers were genotyped at the PHACTR1 rs9349379 locus. We observed a significant association between the PHACTR1 loci and changes in distensibility in both the ascending aorta (AA = 0.0053 ± 0.0004, AG = 0.0041 ± 0.003, GG = 0.0034 ± 0.0009, P < 0.05, n = 58, 54, and 7, respectively) and carotid artery (AA = 12.83 ± 0.51, AG = 11.14 ± 0.38, GG = 11.69 ± 0.66, P < 0.05, n = 70, 65, and 18, respectively). This association was not observed in the descending aorta or in SCAD patients. In contrast, the PHACTR1 locus was not associated with changes in endothelial cell function with no association between the rs9349379 locus and in vivo or ex vivo vascular function observed in CAD patients. This finding was confirmed in our murine model where the loss of Phactr1 on the pro-atherosclerosis ApoE −/− background did not alter ex vivo vascular function. Conclusion In conclusion, we have shown a role for PHACTR1 in arterial compliance across multiple vascular beds. Our study suggests that PHACTR1 has a key structural role within the vasculature. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L, primary, Gulsin, Gaurav S, additional, Brady, Emer M, additional, Dattani, Abhishek, additional, Bilak, Joanna M, additional, Marsh, Anna-Marie, additional, Sian, Manjit, additional, Athithan, Lavanya, additional, Parke, Kelly S, additional, Wormleighton, Joanne, additional, Graham-Brown, Matthew PM, additional, Singh, Anvesha, additional, Arnold, J Ranjit, additional, Lawson, Claire, additional, Davies, Melanie J, additional, Xue, Hui, additional, Kellman, Peter, additional, and McCann, Gerry P, additional

Published
2022
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14. Additional file 1 of Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L., Gulsin, Gaurav S., Brady, Emer M., Dattani, Abhishek, Bilak, Joanna M., Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S., Wormleighton, Joanne, Graham-Brown, Matthew P. M., Singh, Anvesha, Arnold, J. Ranjit, Lawson, Claire, Davies, Melanie J., Xue, Hui, Kellman, Peter, and McCann, Gerry P.

Abstract

Additional file 1: Table S1. Percentages of successful ambulatory blood pressure recordings. Table S2. Intra- and interobserver variability for E/A and E/e'. Table S3. Univariable correlation of blood pressure with MRI and echocardiographic parameters in T2D.

Published
2022
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