Search

Your search keyword '"Martje M. Suverein"' showing total 3 results
Start Over Author "Martje M. Suverein" Publication Year Range Last 3 years
3 results on '"Martje M. Suverein"'

1. Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Author

Anina F. van de Koolwijk, Thijs S.R. Delnoij, Martje M. Suverein, Brigitte A.B. Essers, Renicus C. Hermanides, Luuk C. Otterspoor, Carlos V. Elzo Kraemer, Alexander P.J. Vlaar, Joris J. van der Heijden, Erik Scholten, Corstiaan A. den Uil, Dinis Dos Reis Miranda, Sakir Akin, Jesse de Metz, Iwan C.C. van der Horst, Bjorn Winkens, Jos G. Maessen, Roberto Lorusso, and Marcel C.G. van de Poll

Subjects
Out-of-hospital cardiac arrest, Refractory arrest, Extracorporeal cardiopulmonary resuscitation, Health-related quality of life, Specialties of internal medicine, RC581-951
Abstract

Background: Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional CPR (CCPR) are scarce. We aimed to determine HRQoL during 1-year after refractory OHCA in patients treated with ECPR and CCPR. Methods: We present a secondary analysis of the multicenter INCEPTION-trial, which studied the effectiveness of ECPR versus CCPR in patients with refractory OHCA. HRQoL was prospectively assessed using the EQ-5D-5L questionnaire. Poor HRQoL was pragmatically defined as an EQ-5D-5L health utility index (HUI) > 1 SD below the age-adjusted norm. We used mixed linear models to assess the difference in HRQoL over time and univariable analyses to assess factors potentially associated with poor HRQoL. Results: A total of 134 patients were enrolled, and hospital survival was 20% (27 patients). EQ-5D-5L data were available for 25 patients (5 ECPR and 20 CCPR). One year after OHCA, the estimated mean HUI was 0.73 (0.05) in all patients, 0.84 (0.12) in ECPR survivors, and 0.71 (0.05) in CCPR survivors (p-value 0.31). Eight (32%) survivors had a poor HRQoL. HRQoL was good in 17 (68%) patients, with 100% in ECPR survivors versus 60% in CCPR survivors (p-value 0.14). Conclusion: One year after refractory OHCA, 68% of the survivors had a good HRQoL. We found no statistically significant difference in HRQoL one year after OHCA in patients treated with ECPR compared to CCPR. However, numerical differences may be clinically relevant in favor of ECPR.

Published
2024
Full Text
View/download PDF

2. Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial

Author

Johannes F.H. Ubben, Samuel Heuts, Thijs S.R. Delnoij, Martje M. Suverein, Renicus C. Hermanides, Luuk C. Otterspoor, Carlos V. Elzo Kraemer, Alexander P.J. Vlaar, Joris J. van der Heijden, Erik Scholten, Corstiaan den Uil, Dinis Dos Reis Miranda, Sakir Akin, Jesse de Metz, Iwan C.C. van der Horst, Bjorn Winkens, Jos G. Maessen, Roberto Lorusso, and Marcel C.G. van de Poll

Subjects
ECPR, Refractory Arrest, Ventricular Arrhytmias, OHCA, Resuscitation, Prognostic factors, Specialties of internal medicine, RC581-951
Abstract

Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used as a supportive treatment for refractory out-of-hospital cardiac arrest (OHCA). Still, there is a paucity of data evaluating favorable and unfavorable prognostic characteristics in patients considered for ECPR. Methods: We performed a previously unplanned post-hoc analysis of the multicenter randomized controlled INCEPTION-trial. The study group consisted of patients receiving ECPR, irrespective of initial group randomization. The patients were divided into favorable survivors (cerebral performance category [CPC] 1–2) and unfavorable or non-survivors (CPC 3–5). Results: In the initial INCEPTION-trial, 134 patients were randomized. ECPR treatment was started in 46 (66%) of 70 patients in the ECPR treatment arm and 3 (4%) of 74 patients in the conventional treatment arm. No statistically significant differences in baseline characteristics, medical history, or causes of arrest were observed between survivors (n = 5) and non-survivors (n = 44). More patients in the surviving group had a shockable rhythm at the time of cannulation (60% vs. 14%, p = 0.037), underwent more defibrillation attempts (13 vs. 6, p = 0.002), and received higher dosages of amiodarone (450 mg vs 375 mg, p = 0.047) despite similar durations of resuscitation maneuvers. Furthermore, non-survivors more frequently had post-ECPR implantation adverse events. Conclusion: The persistence of ventricular arrhythmia is a favorable prognostic factor in patients with refractory OHCA undergoing an ECPR-based treatment. Future studies are warranted to confirm this finding and to establish additional prognostic factors.Clinical trial Registration: clinicaltrials.gov registration number NCT03101787

Published
2024
Full Text
View/download PDF

3. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest

Author

Martje M. Suverein, Thijs S.R. Delnoij, Roberto Lorusso, George J. Brandon Bravo Bruinsma, Luuk Otterspoor, Carlos V. Elzo Kraemer, Alexander P.J. Vlaar, Joris J. van der Heijden, Erik Scholten, Corstiaan den Uil, Tim Jansen, Bas van den Bogaard, Marijn Kuijpers, Ka Yan Lam, José M. Montero Cabezas, Antoine H.G. Driessen, Saskia Z.H. Rittersma, Bram G. Heijnen, Dinis Dos Reis Miranda, Gabe Bleeker, Jesse de Metz, Renicus S. Hermanides, Jorge Lopez Matta, Susanne Eberl, Dirk W. Donker, Robert J. van Thiel, Sakir Akin, Oene van Meer, José Henriques, Karen C. Bokhoven, Loes Mandigers, Jeroen J.H. Bunge, Martine E. Bol, Bjorn Winkens, Brigitte Essers, Patrick W. Weerwind, Jos G. Maessen, Marcel C.G. van de Poll, Cardiology, Intensive Care, Neurosciences, Intensive Care Medicine, ACS - Microcirculation, AII - Inflammatory diseases, Cardiothoracic Surgery, ACS - Pulmonary hypertension & thrombosis, Anesthesiology, ACS - Diabetes & metabolism, APH - Quality of Care, ACS - Atherosclerosis & ischemic syndromes, Cardiovascular and Respiratory Physiology, and TechMed Centre

Subjects
Cardiology General, 2023 OA procedure, Cardiac Arrest, Cardiology, Emergency Medicine, General Medicine, Emergency Medicine General
Abstract

BACKGROUND: Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive. METHODS: In this multicenter, randomized, controlled trial conducted in the Netherlands, we assigned patients with an out-of-hospital cardiac arrest to receive extracorporeal CPR or conventional CPR (standard advanced cardiac life support). Eligible patients were between 18 and 70 years of age, had received bystander CPR, had an initial ventricular arrhythmia, and did not have a return of spontaneous circulation within 15 minutes after CPR had been initiated. The primary outcome was survival with a favorable neurologic outcome, defined as a Cerebral Performance Category score of 1 or 2 (range, 1 to 5, with higher scores indicating more severe disability) at 30 days. Analyses were performed on an intention-to-treat basis. RESULTS: Of the 160 patients who underwent randomization, 70 were assigned to receive extracorporeal CPR and 64 to receive conventional CPR; 26 patients who did not meet the inclusion criteria at hospital admission were excluded. At 30 days, 14 patients (20%) in the extracorporeal-CPR group were alive with a favorable neurologic outcome, as compared with 10 patients (16%) in the conventional-CPR group (odds ratio, 1.4; 95% confidence interval, 0.5 to 3.5; P = 0.52). The number of serious adverse events per patient was similar in the two groups. CONCLUSIONS: In patients with refractory out-of-hospital cardiac arrest, extracorporeal CPR and conventional CPR had similar effects on survival with a favorable neurologic outcome. (Funded by the Netherlands Organization for Health Research and Development and Maquet Cardiopulmonary [Getinge]; INCEPTION ClinicalTrials.gov number, NCT03101787.).

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results