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1. Plasma procalcitonin levels remain low at the onset of gram-positive bacteremia regardless of severity or the presence of shock: A retrospective analysis of patients with detailed clinical characteristics

Author

Yusuke Koizumi, Daisuke Sakanashi, Tomoko Ohno, Akiko Nakamura, Atsuko Yamada, Yuichi Shibata, Arufumi Shiota, Hideo Kato, Mao Hagihara, Nobuhiro Asai, Masaya Watarai, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu, and Hiroshige Mikamo

Subjects
Procalcitonin, C-reactive protein, Bacteremia, Gram-negative, Gram-positive, Sequential organ failure assessment (SOFA) score, Microbiology, QR1-502
Abstract

Objectives: Procalcitonin (PCT) is an early diagnosis marker of sepsis/bacteremia. However, some reports refer to its lower responsiveness to gram-positive bacteremia. We retrospectively evaluated the PCT values at the onset of bacteremia in relation to severity index. Methods: Patients with bacteremia caused by two gram-negative bacteria (46 E. coli and 50 Klebsiella pneumoniae) and three gram-positive bacteria (45 S. aureus, 56 S. epidermidis, and 10 S. mitis) were studied. The plasma PCT and C-reactive protein (CRP) levels were compared between species and different Sequential Organ Failure Assessment (SOFA) score groups. Results: The median PCT level was higher in gram-negative than in gram-positive bacteremia in overall (13.09 vs. 0.50 ng/mL, p

Published
2021
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2. Plasma procalcitonin levels remain low at the onset of gram-positive bacteremia regardless of severity or the presence of shock: A retrospective analysis of patients with detailed clinical characteristics

Author

Atsuko Yamada, Mao Hagihara, Hiroyuki Suematsu, Kenta Murotani, Yusuke Koizumi, Yuichi Shibata, Arufumi Shiota, Tomoko Ohno, Akiko Nakamura, Hideo Kato, Yuka Yamagishi, Daisuke Sakanashi, Masaya Watarai, Hiroshige Mikamo, and Nobuhiro Asai

Subjects
Male, 0301 basic medicine, Sequential organ failure assessment (SOFA) score, Organ Dysfunction Scores, Klebsiella pneumoniae, Bacteremia, Gastroenterology, Procalcitonin, Gram-positive, 0302 clinical medicine, Retrospective analysis, Immunology and Allergy, 030212 general & internal medicine, Gram, Aged, 80 and over, biology, Shock, General Medicine, Middle Aged, Gram-negative, QR1-502, Infectious Diseases, Shock (circulatory), Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, Gram-Positive Bacteria, Microbiology, C-reactive protein, Sepsis, 03 medical and health sciences, Internal medicine, Gram-Negative Bacteria, medicine, Humans, Aged, Retrospective Studies, General Immunology and Microbiology, business.industry, medicine.disease, biology.organism_classification, bacterial infections and mycoses, ROC Curve, biology.protein, business, Biomarkers
Abstract

Objectives: Procalcitonin (PCT) is an early diagnosis marker of sepsis/bacteremia. However, some reports refer to its lower responsiveness to gram-positive bacteremia. We retrospectively evaluated the PCT values at the onset of bacteremia in relation to severity index. Methods: Patients with bacteremia caused by two gram-negative bacteria (46 E. coli and 50 Klebsiella pneumoniae) and three gram-positive bacteria (45 S. aureus, 56 S. epidermidis, and 10 S. mitis) were studied. The plasma PCT and C-reactive protein (CRP) levels were compared between species and different Sequential Organ Failure Assessment (SOFA) score groups. Results: The median PCT level was higher in gram-negative than in gram-positive bacteremia in overall (13.09 vs. 0.50 ng/mL, p

Published
2021

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