4 results on '"Massimiliano Braga"'
Search Results
2. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke
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Valeria De Giuli, Mario Grassi, Michele Besana, Marialuisa Zedde, Andrea Zini, Corrado Lodigiani, Simona Marcheselli, Anna Cavallini, Giuseppe Micieli, Maurizia Rasura, Maria Luisa DeLodovici, Giampaolo Tomelleri, Nicoletta Checcarelli, Alberto Chiti, Elisa Giorli, Massimo Del Sette, Lucia Tancredi, Antonella Toriello, Massimiliano Braga, Andrea Morotti, Debora Pezzini, Martina Locatelli, Valentina Mazzoleni, Sonia Bonacina, Massimo Gamba, Mauro Magoni, Rosalba Patella, Alessandra Spalloni, Anna Maria Simone, Rosario Pascarella, Sandro Beretta, Alessandro Padovani, Roberto Gasparotti, Alessandro Pezzini, Nicola Gilberti, Paola Ferrazzi, Elena Banfi, Luca Librè, Elisabetta Traverso, Erika Schirinzi, Federico Carimati, Manuel Cappellari, Giampiero Locatelli, Laura Demelas, Davide Ferrario, Alessandra Persico, Giovanni Orlandi, Manuela Napoli, Claudio Moratti, and Mario Guidotti
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Adult ,Male ,medicine.medical_specialty ,Brain Ischemia ,Brain ischemia ,White matter ,Young Adult ,Internal medicine ,medicine ,Humans ,Myocardial infarction ,Young adult ,Stroke ,Acute ischemic stroke ,Aged ,Ischemic Stroke ,Subclinical infection ,Advanced and Specialized Nursing ,business.industry ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Cerebral Small Vessel Diseases ,Cardiology ,Brain lesions ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Subclinical vascular brain lesions are highly prevalent in elderly patients with stroke. Little is known about predisposing factors and their impact on long-term outcome of patients with stroke at a young age. Methods: We quantified magnetic resonance-defined subclinical vascular brain lesions, including lacunes and white matter hyperintensities, perivascular spaces and cerebral microbleeds, and assessed total small-vessel disease (SVD) score in patients with first-ever acute ischemic stroke aged 18 to 45 years, and followed them up, as part of the multicentre Italian Project on Stroke in Young Adults. The primary end point was a composite of ischemic stroke, transient ischemic attack, myocardial infarction, or other arterial events. We assessed the predictive accuracy of magnetic resonance features and whether the addition of these markers improves outcome prediction over a validated clinical tool, such as the Italian Project on Stroke in Young Adults score. Results: Among 591 patients (males, 53.8%; mean age, 37.5±6.4 years), 117 (19.8%) had subclinical vascular brain lesions. Family history of stroke was associated with lacunes (odds ratio, 2.24 [95% CI, 1.30–3.84]) and total SVD score (odds ratio, 2.06 [95% CI, 1.20–3.53] for score≥1), hypertension with white matter hyperintensities (odds ratio, 2.29 [95% CI, 1.22–4.32]). After a median follow-up of 36.0 months (25th–75th percentile, 38.0), lacunes and total SVD score were associated with primary end point (hazard ratio, 2.13 [95% CI, 1.17–3.90] for lacunes; hazard ratio, 2.17 [95% CI, 1.20–3.90] for total SVD score ≥1), and the secondary end point brain ischemia (hazard ratio, 2.55 [95% CI, 1.36–4.75] for lacunes; hazard ratio, 2.61 [95% CI, 1.42–4.80] for total SVD score ≥1). The predictive performances of the models, including magnetic resonance features were comparable to those of the random model. Adding individual magnetic resonance features to the Italian Project on Stroke in Young Adults score did not improve model prediction. Conclusions: Subclinical vascular brain lesions affect ≈2 in 10 young adults with ischemic stroke. Although lacunes and total SVD score are associated with thrombotic recurrence, they do not improve accuracy of outcome prediction over validated clinical predictors.
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- 2022
3. Antithrombotic therapy in the postacute phase of cervical artery dissection: the Italian Project on Stroke in Young Adults Cervical Artery Dissection
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Debora Pezzini, Mario Grassi, Maria Luisa Zedde, Andrea Zini, Anna Bersano, Carlo Gandolfo, Giorgio Silvestrelli, Claudio Baracchini, Paolo Cerrato, Corrado Lodigiani, Simona Marcheselli, Maurizio Paciaroni, Maurizia Rasura, Manuel Cappellari, Massimo Del Sette, Anna Cavallini, Andrea Morotti, Giuseppe Micieli, Enrico Maria Lotti, Maria Luisa Delodovici, Mauro Gentile, Mauro Magoni, Cristiano Azzini, Maria Vittoria Calloni, Elisa Giorli, Massimiliano Braga, Paolo La Spina, Fabio Melis, Rossana Tassi, Valeria Terruso, Rocco Salvatore Calabrò, Valeria Piras, Alessia Giossi, Martina Locatelli, Valentina Mazzoleni, Sandro Sanguigni, Carla Zanferrari, Marina Mannino, Irene Colombo, Carlo Dallocchio, Patrizia Nencini, Valeria Bignamini, Alessandro Adami, Paolo Costa, Rita Bella, Rosario Pascarella, Alessandro Padovan, and Alessandro Pezzini
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Vertebral Artery Dissection ,Young Adult ,Psychiatry and Mental health ,Fibrinolytic Agents ,Humans ,Surgery ,CEREBROVASCULAR DISEASE ,Arteries ,Neurology (clinical) ,CLINICAL NEUROLOGY ,STROKE ,Brain Ischemia - Abstract
ObjectiveTo explore the impact of antithrombotic therapy discontinuation in the postacute phase of cervical artery dissection (CeAD) on the mid-term outcome of these patients.MethodsIn a cohort of consecutive patients with first-ever CeAD, enrolled in the setting of the multicentre Italian Project on Stroke in Young Adults Cervical Artery Dissection, we compared postacute (beyond 6 months since the index CeAD) outcomes between patients who discontinued antithrombotic therapy and patients who continued taking antithrombotic agents during follow-up. Primary outcome was a composite of ischaemic stroke and transient ischaemic attack. Secondary outcomes were (1) Brain ischaemia ipsilateral to the dissected vessel and (2) Recurrent CeAD. Associations with the outcome of interest were assessed by the propensity score (PS) method.ResultsOf the 1390 patients whose data were available for the outcome analysis (median follow-up time in patients who did not experience outcome events, 36.0 months (25th–75th percentile, 62.0)), 201 (14.4%) discontinued antithrombotic treatment. Primary outcome occurred in 48 patients in the postacute phase of CeAD. In PS-matched samples (201 vs 201), the incidence of primary outcomes among patients taking antithrombotics was comparable with that among patients who discontinued antithrombotics during follow-up (5.0% vs 4.5%; p(log rank test)=0.526), and so was the incidence of the secondary outcomes ipsilateral brain ischaemia (4.5% vs 2.5%; p(log rank test)=0.132) and recurrent CeAD (1.0% vs 1.5%; p(log rank test)=0.798).ConclusionsDiscontinuation of antithrombotic therapy in the postacute phase of CeAD does not appear to increase the risk of brain ischaemia during follow-up.
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- 2022
4. Neurological disorders associated with COVID-19 infection: An Italian multi-center cohort study (NEURO-COVID)
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Simone Beretta, Andrea Zini, Elisa Bianchi, Viviana Cristillo, Alberto Priori, Giacomo Sferruzza, Massimiliano Braga, Maria Cotelli, Ludovico Ciolli, Matteo Pardini, Francesco Bax, Maria Sessa, Gioacchino Tedeschi, Andrea Pilotto, Susanna Guttmann, Angelo Schenone, Mario Orrico, Marinella Turla, Stefania Maffei, Lucia Tancredi, Martina Viganò, Guido Primiano, Ettore Beghi, Luana Benedetti, Valeria De Giuli, Stefano Meletti, Beatrice Viti, Emanuele Bartolini, Gian Luigi Gigli, Carlo Morotti Colleoni, Massimo Filippi, Narghes Calcagno, Prabha Cristina Ranchicchio, Sandro Beretta, Edoardo Barvas, Vincenzo Silani, Pasquale Palumbo, Bruno Censori, Carlo Ferrarese, Alessandro Padovani, Francesca Trogu, Pietro Cortelli, Stefano Caproni, Serenella Servidei, and Mauro Gentile
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Pediatrics ,medicine.medical_specialty ,Neurology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Medicine ,Center (algebra and category theory) ,Neurology (clinical) ,business ,Article ,Cohort study - Published
- 2021
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