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Your search keyword '"Mehta, Sanjoy"' showing total 8 results
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8 results on '"Mehta, Sanjoy"'

1. CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Author

Quintanal-Villalonga, Alvaro, Kawasaki, Kenta, Redin, Esther, Uddin, Fathema, Rakhade, Swanand, Durani, Vidushi, Sabet, Amin, Shafer, Moniquetta, Karthaus, Wouter R., Zaidi, Samir, Zhan, Yingqian A., Manoj, Parvathy, Sridhar, Harsha, Kinyua, Dennis, Zhong, Hong, Mello, Barbara P., Ciampricotti, Metamia, Bhanot, Umesh K., Linkov, Irina, Qiu, Juan, Patel, Radhika A., Morrissey, Colm, Mehta, Sanjoy, Barnes, Jesse, Haffner, Michael C., Socci, Nicholas D., Koche, Richard P., de Stanchina, Elisa, Molina-Pinelo, Sonia, Salehi, Sohrab, Yu, Helena A., Chan, Joseph M., and Rudin, Charles M.

Published
2024
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3. GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies

Author

Benbarche, Salima, Pineda, Jose Mario Bello, Galvis, Laura Baquero, Biswas, Jeetayu, Liu, Bo, Wang, Eric, Zhang, Qian, Hogg, Simon J., Lyttle, Kadeen, Dahi, Ariana, Lewis, Alexander M., Sarchi, Martina, Rahman, Jahan, Fox, Nina, Ai, Yuxi, Mehta, Sanjoy, Garippa, Ralph, Ortiz-Pacheco, Juliana, Li, Zhuoning, Monetti, Mara, Stanley, Robert F., Doulatov, Sergei, Bradley, Robert K., and Abdel-Wahab, Omar

Published
2024
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4. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma

Author

Erazo, Tatiana, Evans, Chiara M., Zakheim, Daniel, Chu, Eren L., Refermat, Alice Yunsi, Asgari, Zahra, Yang, Xuejing, Da Silva Ferreira, Mariana, Mehta, Sanjoy, Russo, Marco Vincenzo, Knezevic, Andrea, Zhang, Xi-Ping, Chen, Zhengming, Fennell, Myles, Garippa, Ralph, Seshan, Venkatraman, de Stanchina, Elisa, Barbash, Olena, Batlevi, Connie Lee, Leslie, Christina S., Melnick, Ari M., Younes, Anas, and Kharas, Michael G.

Published
2022
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5. Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

Author

Montoya, Skye, primary, Bourcier, Jessie, additional, Noviski, Mark, additional, Lu, Hao, additional, Thompson, Meghan C., additional, Chirino, Alexandra, additional, Jahn, Jacob, additional, Sondhi, Anya K., additional, Gajewski, Stefan, additional, Tan, Ying Siow (May), additional, Yung, Stephanie, additional, Urban, Aleksandra, additional, Wang, Eric, additional, Han, Cuijuan, additional, Mi, Xiaoli, additional, Kim, Won Jun, additional, Sievers, Quinlan, additional, Auger, Paul, additional, Bousquet, Hugo, additional, Brathaban, Nivetha, additional, Bravo, Brandon, additional, Gessner, Melissa, additional, Guiducci, Cristiana, additional, Iuliano, James N., additional, Kane, Tim, additional, Mukerji, Ratul, additional, Reddy, Panga Jaipal, additional, Powers, Janine, additional, Sanchez Garcia de los Rios, Mateo, additional, Ye, Jordan, additional, Barrientos Risso, Carla, additional, Tsai, Daniel, additional, Pardo, Gabriel, additional, Notti, Ryan Q., additional, Pardo, Alejandro, additional, Affer, Maurizio, additional, Nawaratne, Vindhya, additional, Totiger, Tulasigeri M., additional, Pena-Velasquez, Camila, additional, Rhodes, Joanna M., additional, Zelenetz, Andrew D., additional, Alencar, Alvaro, additional, Roeker, Lindsey E., additional, Mehta, Sanjoy, additional, Garippa, Ralph, additional, Linley, Adam, additional, Soni, Rajesh Kumar, additional, Skånland, Sigrid S., additional, Brown, Robert J., additional, Mato, Anthony R., additional, Hansen, Gwenn M., additional, Abdel-Wahab, Omar, additional, and Taylor, Justin, additional

Published
2024
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6. TNF-NFkB-p53 axis restrictsin vivosurvival of hPSC-derived dopamine neuron

Author

Kim, Tae Wan, primary, Koo, So Yeon, additional, Riessland, Markus, additional, Cho, Hyunwoo, additional, Chaudhry, Fayzan, additional, Kolisnyk, Benjamin, additional, Russo, Marco Vincenzo, additional, Saurat, Nathalie, additional, Mehta, Sanjoy, additional, Garippa, Ralph, additional, Betel, Doron, additional, and Studer, Lorenz, additional

Published
2023
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8. TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron.

Author

Kim TW, Koo SY, Riessland M, Cho H, Chaudhry F, Kolisnyk B, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, and Studer L

Abstract

Ongoing, first-in-human clinical trials illustrate the feasibility and translational potential of human pluripotent stem cell (hPSC)-based cell therapies in Parkinson's disease (PD). However, a major unresolved challenge in the field is the extensive cell death following transplantation with <10% of grafted dopamine neurons surviving. Here, we performed a pooled CRISPR/Cas9 screen to enhance survival of postmitotic dopamine neurons in vivo . We identified p53-mediated apoptotic cell death as major contributor to dopamine neuron loss and uncovered a causal link of TNFa-NFκB signaling in limiting cell survival. As a translationally applicable strategy to purify postmitotic dopamine neurons, we performed a cell surface marker screen that enabled purification without the need for genetic reporters. Combining cell sorting with adalimumab pretreatment, a clinically approved and widely used TNFa inhibitor, enabled efficient engraftment of postmitotic dopamine neurons leading to extensive re-innervation and functional recovery in a preclinical PD mouse model. Thus, transient TNFa inhibition presents a clinically relevant strategy to enhance survival and enable engraftment of postmitotic human PSC-derived dopamine neurons in PD., Highlights: In vivo CRISPR-Cas9 screen identifies p53 limiting survival of grafted human dopamine neurons. TNFα-NFκB pathway mediates p53-dependent human dopamine neuron deathCell surface marker screen to enrich human dopamine neurons for translational use. FDA approved TNF-alpha inhibitor rescues in vivo dopamine neuron survival with in vivo function.

Published
2023
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