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4. Availability of Cognitive Resources in Early Life Predicts Transitions Between Cognitive States in Middle and Older Adults From Europe

Author

Lewis, Nathan A, Yoneda, Tomiko, Melis, René JF, Mroczek, Daniel K, Hofer, Scott M, and Muniz-Terrera, Graciela

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Behavioral and Social Science, Basic Behavioral and Social Science, Quality Education, Cognitive reserve, Cognitive resilience, Cognitive resources, Clinical sciences
Abstract

Background and objectivesThe existing literature highlights the importance of reading books in middle-to-older adulthood for cognitive functioning; very few studies, however, have examined the importance of childhood cognitive resources for cognitive outcomes later in life.Research design and methodsUsing data from 11 countries included in the Survey of Health, Ageing, and Retirement in Europe (SHARE) data set (N = 32,783), multistate survival models (MSMs) were fit to examine the importance of access to reading material in childhood on transitions through cognitive status categories (no cognitive impairment and impaired cognitive functioning) and death. Additionally, using the transition probabilities estimated by the MSMs, we estimated the remaining years of life without cognitive impairment and total longevity. All models were fit individually in each country, as well as within the pooled SHARE sample.ResultsAdjusting for age, sex, education, and childhood socioeconomic status, the overall pooled estimate indicated that access to more books at age 10 was associated with a decreased risk of developing cognitive impairment (adjusted hazard ratio = 0.79, confidence interval: 0.76-0.82). Access to childhood books was not associated with risk of transitioning from normal cognitive functioning to death, or from cognitive impairment to death. Total longevity was similar between participants reporting high (+1 standard deviation [SD]) and low (-1 SD) number of books in the childhood home; however, individuals with more access to childhood books lived a greater proportion of this time without cognitive impairment.Discussion and implicationsFindings suggest that access to cognitive resources in childhood is protective for cognitive aging processes in older adulthood.

Published
2023

5. A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting

Author

Zahra, Anum, Luijken, Kim, Abbink, Evertine J., van den Berg, Jesse M., Blom, Marieke T., Elders, Petra, Festen, Jan, Gussekloo, Jacobijn, Joling, Karlijn J., Melis, René, Mooijaart, Simon, Peters, Jeannette B., Polinder-Bos, Harmke A., van Raaij, Bas F. M., Smorenberg, Annemieke, la Roi-Teeuw, Hannah M., Moons, Karel G. M., and van Smeden, Maarten

Published
2023
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10. External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting

Author

Zahra, Anum, van Smeden, Maarten, Abbink, Evertine J., van den Berg, Jesse M., Blom, Marieke T., van den Dries, Carline J., Gussekloo, Jacobijn, Wouters, Fenne, Joling, Karlijn J., Melis, René, Mooijaart, Simon P., Peters, Jeannette B., Polinder-Bos, Harmke A., van Raaij, Bas F.M., Appelman, Brent, la Roi-Teeuw, Hannah M., Moons, Karel G.M., and Luijken, Kim

Published
2024
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28. DementiaNet facilitates a sustainable transition toward integrated primary dementia care: A long‐term evaluation.

Author

Oostra, Dorien L., Nieuwboer, Minke S., Melis, René J. F., Remers, Toine E. P., Olde Rikkert, Marcel G. M., and Perry, Marieke

Abstract

INTRODUCTION: Care integration is a promising strategy to achieve sustainable health‐care systems. With DementiaNet, a 2‐year program, we facilitated collaboration between primary health‐care professionals. We studied changes in primary dementia care integration during and after DementiaNet participation. METHODS: A longitudinal follow‐up study was performed. Networks started between 2015 and 2020; follow‐up ended in 2021. Quantitative and quantitative data were collected annually to assess quality of care, network collaboration, and number of crisis admissions. Growth modeling was used to identify changes over time. RESULTS: Thirty‐five primary care networks participated. Network collaboration and quality of care of newly formed networks increased significantly in the first 2 years (respectively, 0.35/year, P <.001; 0.29/year, P <.001) and thereafter stabilized. CONCLUSION: Primary care networks improved their collaboration and quality of care during DementiaNet participation, which persisted after the program ended. This indicates that DementiaNet facilitated a sustainable transition toward integrated primary dementia care. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Physical Resilience in Daily Functioning Among Acutely Ill Hospitalized Older Adults: The Hospital-ADL Study

Author

Reichardt, Lucienne A., Aarden, Jesse, van Seben, Rosanne, van der Schaaf, Marike, van der Esch, Martin, Engelbert, Raoul H.H., Twisk, Jos W.R., Bosch, Jos A., Kuper, Ingeborg, de Jonghe, Annemarieke, Leguit-Elberse, Maike, Kamper, Ad, Posthuma, Nynke, Brendel, Nienke, Wold, Johan, Kolk, Daisy, Melis, René J.F., MacNeil-Vroomen, Janet L., and Buurman, Bianca M.

Published
2022
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36. Supporting Resilience of Older Adults with Cognitive Decline Requires a Multi-Level System Approach

Author

Peeters, Geeske, primary, Kok, Almar, additional, de Bruin, Simone R., additional, van Campen, Crétien, additional, Graff, Maud, additional, Nieuwboer, Minke, additional, Huisman, Martijn, additional, van Munster, Barbara, additional, van der Zee, Eddy A., additional, Kas, Martien J., additional, Perry, Marieke, additional, Gerritsen, Debby L., additional, Vreede-Chabot, Elisabeth, additional, The, Anne-Mei, additional, van Hout, Hein, additional, Bakker, Franka C., additional, Achterberg, Wilco P., additional, van der Steen, Jenny T., additional, Smits, Carolien, additional, Melis, René, additional, and Olde Rikkert, Marcel, additional

Published
2023
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37. Correction to:Capturing postural blood pressure dynamics with near‑infrared spectroscopy‑measured cerebral oxygenation (GeroScience, (2023), 10.1007/s11357-023-00791-9)

Author

Klop, Marjolein, de Heus, Rianne A. A., Maier, Andrea B., van Alphen, Anne, Floor‑Westerdijk, Marianne J., Bronkhorst, Mathijs, Melis, René J. F., Meskers, Carel G. M., Claassen, Jurgen A. H. R., van Wezel, Richard J. A., Rehabilitation medicine, AMS - Ageing & Vitality, AMS - Rehabilitation & Development, and Amsterdam Neuroscience - Neurovascular Disorders

Abstract

In the article version originally published online, Table 2 was switched in the publication process. The correct version of Table 2 is shown below. (Table presented.) Heat map of average correlations for supine-stand and sit-stand transitions, during initial response (0-30 seconds after standing up) and late response (30-175 seconds after standing up) * Significantly different (p

Published
2023

38. Determinants of quality of life in family caregivers in MCI:a comparison with mild dementia

Author

Tan, Eva Y. L., Janssen, Niels, Handels, Ron, Ramakers, Inez H. G. B., Verhey, Frans R. J., van der Flier, Wiesje M., Melis, René J. F., Olde Rikkert, Marcel G. M., Schols, Jos M. G. A., and de Vugt, Marjolein E.

Abstract

Objectives: The aim of the current study was to investigate the health-related quality of life (HRQol) of the family caregiver in MCI, explore possible determinants and study possible differences with mild dementia. Methods: This secondary data analysis included 145 persons with MCI and 154 persons with dementia and their family caregivers from two Dutch cohort studies. HRQoL was measured with the VAS of the EuroQol-5D-3L version. Regressions analyses were conducted to examine potential demographic and clinical determinants of the caregiver’s HRQoL. Results: The mean EQ5D-VAS in family caregivers of persons with MCI was 81.1 (SD 15.7), and did not significantly differ from family caregivers in mild dementia (81.9 (SD 13.0)). In MCI, patient measurements were not significantly associated with caregiver mean EQ5D-VAS. Concerning caregiver characteristics, being a spouse and a lower educational level were associated with a lower mean EQ5D-VAS (in a multiple linear regression model: unstandardized B −8.075, p = 0.013 and unstandardized B −6.162, p = 0.037 resp.). In mild dementia, the NPI item irritability showed an association with caregiver EQ5D-VAS in bivariate linear regression analyses. Conclusion: Results indicate that especially family caregiver characteristics seem to influence family caregiver HRQoL in MCI. Future research should include other potential determinants such as burden, coping strategies and relationship quality.

Published
2023

39. Simulating the multicausality of Alzheimer's disease with system dynamics.

Author

Uleman, Jeroen F., Melis, René J. F., Ntanasi, Eva, Scarmeas, Nikolaos, Hoekstra, Alfons G., Quax, Rick, and Rikkert, Marcel G. M. Olde

Abstract

Introduction: In Alzheimer's disease (AD), cognitive decline is driven by various interlinking causal factors. Systems thinking could help elucidate this multicausality and identify opportune intervention targets. Methods: We developed a system dynamics model (SDM) of sporadic AD with 33 factors and 148 causal links calibrated with empirical data from two studies. We tested the SDM's validity by ranking intervention outcomes on 15 modifiable risk factors to two sets of 44 and 9 validation statements based on meta‐analyses of observational data and randomized controlled trials, respectively. Results: The SDM answered 77% and 78% of the validation statements correctly. Sleep quality and depressive symptoms yielded the largest effects on cognitive decline with which they were connected through strong reinforcing feedback loops, including via phosphorylated tau burden. Discussion: SDMs can be constructed and validated to simulate interventions and gain insight into the relative contribution of mechanistic pathways. [ABSTRACT FROM AUTHOR]

Published
2023
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40. A study protocol of external validation of eight COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting

Author

Zahra, Anum, primary, Luijken, Kim, additional, Abbink, Evertine J., additional, Berg, Jesse M. van den, additional, Blom, Marieke T., additional, Elders, Petra, additional, Festen, Jan, additional, Gussekloo, Jacobijn, additional, Joling, Karlijn J., additional, Melis, René, additional, Mooijaart, Simon, additional, Peters, Jeannette B., additional, Polinder-Bos, Harmke, additional, Raaij, Bas F. M. van, additional, Smorenberg, Annemieke, additional, Roi-Teeuw, Hannah M. la, additional, Moons, Karel G.M., additional, and Smeden, Maarten van, additional

Published
2022
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44. What Do We Know about Social and Non-Social Factors Influencing the Pathway from Cognitive Health to Dementia? A Systematic Review of Reviews

Author

Lenart-Bugla, Marta, primary, Łuc, Mateusz, additional, Pawłowski, Marcin, additional, Szcześniak, Dorota, additional, Seifert, Imke, additional, Wiegelmann, Henrik, additional, Gerhardus, Ansgar, additional, Wolf-Ostermann, Karin, additional, Rouwette, Etiënne A. J. A., additional, Ikram, M. Arfan, additional, Brodaty, Henry, additional, Jeon, Yun-Hee, additional, Maddock, Jane, additional, Marseglia, Anna, additional, Melis, René J. F., additional, Samtani, Suraj, additional, Wang, Hui-Xin, additional, Welmer, Anna-Karin, additional, Vernooij-Dassen, Myrra, additional, and Rymaszewska, Joanna, additional

Published
2022
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45. Physical Resilience in Daily Functioning Among Acutely Ill Hospitalized Older Adults: The Hospital-ADL Study

Author

Kolk, Daisy, primary, Melis, René J.F., additional, MacNeil-Vroomen, Janet L., additional, Buurman, Bianca M., additional, Reichardt, Lucienne A., additional, Aarden, Jesse, additional, van Seben, Rosanne, additional, van der Schaaf, Marike, additional, van der Esch, Martin, additional, Engelbert, Raoul H.H., additional, Twisk, Jos W.R., additional, Bosch, Jos A., additional, Kuper, Ingeborg, additional, de Jonghe, Annemarieke, additional, Leguit-Elberse, Maike, additional, Kamper, Ad, additional, Posthuma, Nynke, additional, Brendel, Nienke, additional, and Wold, Johan, additional

Published
2022
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47. Why illness is more important than disease in old age

Author

Olde Rikkert, Marcel G M, Melis, René J F, Cohen, Alan A, and (Geeske) Peeters, G M E E

Subjects
Age and Ageing journal 50th anniversary commentary series, Aged, 80 and over, Aging, illness, General Medicine, older people, AcademicSubjects/MED00280, Anniversaries and Special Events, well-being, Alzheimer Disease, Geriatrics, networks, Commentary, Humans, Geriatrics and Gerontology, complexity, ageing/15, Aged
Abstract

Clinical reasoning and research in modern geriatrics often prioritises the disease concept. This is understandable as it has brought impressive advances in medicine (e.g. antibiotics, vaccines, successful cancer treatment and many effective surgeries). However, so far the disease framework has not succeeded in getting us to root causes of many age-related chronic diseases (e.g. Alzheimer’s disease, diabetes, osteoarthritis). Moreover, in aging and disease constructs alone fail to explain the variability in illness presentations. Therefore, we propose to apply the underused illness concept in a new way by reconsidering the importance of common symptoms in the form of a dynamic network of symptoms as a complementary framework. We show that concepts and methods of complex system thinking now enable to fruitfully monitor and analyse the multiple interactions between symptoms in such in networks, offering new routes for prognosis and treatment. Moreover, close attention to the symptoms that bother older persons may also improve weighing the therapeutic objectives of well-being and survival and aligning treatment targets with the patients’ priorities.

Published
2022

48. Additional file 1 of Mapping the complexity of dementia: factors influencing cognitive function at the onset of dementia

Author

Seifert, Imke, Wiegelmann, Henrik, Lenart-Bugla, Marta, Łuc, Mateusz, Pawłowski, Marcin, Rouwette, Etienne, Rymaszewska, Joanna, Szcześniak, Dorota, Vernooij-Dassen, Myrra, Perry, Marieke, Melis, René, Wolf-Ostermann, Karin, and Gerhardus, Ansgar

Abstract

Additional file 1. (1. Search strategy. 2. Flowchart. 3. Clusters and related factors of the model).

Published
2022
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