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Your search keyword '"Meregalli, Chiara"' showing total 8 results
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8 results on '"Meregalli, Chiara"'

1. Tessuto adiposo epicardico: dagli aspetti biomolecolari alla pratica clinica

Author

Malavazos, Alexis Elias, Dubini, Carola, Meregalli, Chiara, Boniardi, Federico, Secchi, Francesco, Piepoli, Massimo, Salvetti, Guido, Menicanti, Lorenzo, Chessa, Massimo, Spagnolo, Pietro, Scravaglieri, Valentina, Trevisan, Manuel Bruno, Fierabracci, Paola, Dozio, Elena, Buscemi, Paolo, Castelvecchio, Serenella, Ruocco, Chiara, Randazzo, Cristiana, Morricone, Lelio, Santini, Ferruccio, Cinti, Saverio, Buscemi, Silvio, Guazzi, Marco, Romanelli, Massimiliano Marco Corsi, Carruba, Michele Olivo, and Nisoli, Enzo

Published
2024
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2. BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection

Author

Malavazos, Alexis Elias, primary, Dubini, Carola, additional, Milani, Valentina, additional, Boveri, Sara, additional, Meregalli, Chiara, additional, Bertolini, Caterina, additional, Buscemi, Carola, additional, Cardani, Rosanna, additional, Renna, Laura Valentina, additional, Trevisan, Manuel Bruno, additional, Scravaglieri, Valentina, additional, Cuppone, Maria Teresa, additional, Menicanti, Lorenzo, additional, Costa, Elena, additional, Ambrogi, Federico, additional, Ruocco, Chiara, additional, Carruba, Michele, additional, Iacobellis, Gianluca, additional, Nisoli, Enzo, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2023
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4. Semaglutide therapy decreases epicardial fat inflammation and improves psoriasis severity in patients affected by abdominal obesity and type-2 diabetes

Author

Malavazos, Alexis Elias, primary, Meregalli, Chiara, additional, Sorrentino, Fabio, additional, Vignati, Andrea, additional, Dubini, Carola, additional, Scravaglieri, Valentina, additional, Basilico, Sara, additional, Boniardi, Federico, additional, Spagnolo, Pietro, additional, Malagoli, Piergiorgio, additional, Romanelli, Paolo, additional, Secchi, Francesco, additional, and Iacobellis, Gianluca, additional

Published
2023
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5. BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection.

Author

Malavazos, Alexis Elias, Dubini, Carola, Milani, Valentina, Boveri, Sara, Meregalli, Chiara, Bertolini, Caterina, Buscemi, Carola, Cardani, Rosanna, Renna, Laura Valentina, Trevisan, Manuel Bruno, Scravaglieri, Valentina, Cuppone, Maria Teresa, Menicanti, Lorenzo, Costa, Elena, Ambrogi, Federico, Ruocco, Chiara, Carruba, Michele, Iacobellis, Gianluca, Nisoli, Enzo, and Corsi Romanelli, Massimiliano Marco

Subjects
BOOSTER vaccines, ANTIBODY formation, COVID-19 vaccines, ABDOMINAL adipose tissue, SARS-CoV-2
Abstract

Little is known about the long-term durability of the induced immune response in subjects with obesity, particularly in those with an abdominal distribution of adipose tissue. We evaluated SARS-CoV-2-specific antibody responses after BNT162b2 vaccine booster dose, comparing individuals with and without abdominal obesity (AO), discerning between individuals previously infected or not. IgG-TrimericS were measured in 511 subjects at baseline, on the 21st day after vaccine dose 1, and at 1, 3, 6, and 9 months from dose 2, and at 1 and 3 months following the booster dose. To detect SARS-CoV-2 infection, nucleocapsid antibodies were measured at baseline and at the end of the study. Multivariable linear regression evaluated the three-month difference in the absolute variation in IgG-TrimericS levels from booster dose, showing AO and SARS-CoV-2 infection status interactions (p = 0.016). Regardless of possible confounding factors and IgG-TrimericS levels at the booster dose, AO is associated with a higher absolute change in IgG-TrimericS in prior infected individuals (p = 0.0125). In the same regression model, no interaction is highlighted using BMI (p = 0.418). The robust response in the development of antibodies after booster dose, observed in people with AO and previous infection, may support the recommendations to administer a booster dose in this population group. [ABSTRACT FROM AUTHOR]

Published
2023
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6. High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures

Author

Torsello, B, De Marco, S, Bombelli, S, Cifola, I, Morabito, I, Invernizzi, L, Meregalli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Cifola, Ingrid, Morabito, Ivana, Invernizzi, Lara, Meregalli, Chiara, Zucchini, Nicola, Strada, Guido, Perego, Roberto A, Bianchi, Cristina, Torsello, B, De Marco, S, Bombelli, S, Cifola, I, Morabito, I, Invernizzi, L, Meregalli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Cifola, Ingrid, Morabito, Ivana, Invernizzi, Lara, Meregalli, Chiara, Zucchini, Nicola, Strada, Guido, Perego, Roberto A, and Bianchi, Cristina

Abstract

Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this study, we investigated the phenotypic and molecular EMT-like changes and the alteration of inflammatory and fibrogenic secretome induced by HG in human primary tubular cell cultures. Taking advantage of this in vitro cell model composed of proximal and distal tubular cells, we showed that HG-treated tubular cells acquired a fibroblast-like morphology with increased cytoplasmic stress fibers, maintaining the expression of the epithelial markers specific of proximal and distal tubular cells. HG increased Snail1, miRNA210 and Vimentin mesenchymal markers, decreased N-cadherin expression and migration ability of primary tubular cells, while E-cadherin expression and focal adhesion distribution were not affected. Furthermore, HG treatment of tubular cells altered the inflammatory cytokine secretion creating a secretome able to enhance the proliferation and migration of fibroblasts. Our findings show that HG promotes an activated state of partial EMT in human tubular primary cells and induces a pro-inflammatory and pro-fibrogenic microenvironment, supporting the active role of tubular cells in diabetic nephropathy onset.

Published
2023

7. High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures

Author

Torsello, Barbara, primary, De Marco, Sofia, additional, Bombelli, Silvia, additional, Cifola, Ingrid, additional, Morabito, Ivana, additional, Invernizzi, Lara, additional, Meregalli, Chiara, additional, Zucchini, Nicola, additional, Strada, Guido, additional, Perego, Roberto A., additional, and Bianchi, Cristina, additional

Published
2023
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8. Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies

Author

Malavazos, Alexis Elias, primary, Iacobellis, Gianluca, additional, Dozio, Elena, additional, Basilico, Sara, additional, Di Vincenzo, Angelica, additional, Dubini, Carola, additional, Menicanti, Lorenzo, additional, Vianello, Elena, additional, Meregalli, Chiara, additional, Ruocco, Chiara, additional, Ragni, Maurizio, additional, Secchi, Francesco, additional, Spagnolo, Pietro, additional, Castelvecchio, Serenella, additional, Morricone, Lelio, additional, Buscemi, Silvio, additional, Giordano, Antonio, additional, Goldberger, Jeffrey J, additional, Carruba, Michele, additional, Cinti, Saverio, additional, Corsi Romanelli, Massimiliano Marco, additional, and Nisoli, Enzo, additional

Published
2023
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