44 results on '"Messina, Nicole L."'
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2. Accelerated Bacille Calmette-Guérin reactions: More than meets the eye
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Villanueva, Paola, Crawford, Nigel W., Croda, Mariana Garcia, Croda, Julio, Dalcolmo, Margareth, Jardim, Bruno Araújo, Jardim, Tyane de Almeida Pinto, Marshall, Helen, Prat-Aymerich, Cristina, Sawka, Alice, Sharma, Ketaki, Troeman, Darren, Warris, Adilia, Wood, Nicholas, Messina, Nicole L., Pittet, Laure F., and Curtis, Nigel
- Published
- 2024
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3. Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial
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Curtis, Nigel, Davidson, Andrew, Gardiner, Kaya, Gwee, Amanda, Jamieson, Tenaya, Messina, Nicole, Morawakage, Thilanka, Perlen, Susan, Perrett, Kirsten, Pittet, Laure, Sastry, Amber, Teo, Jia Wei, Orsini, Francesca, Lee, Katherine, Moore, Cecilia, Vidmar, Suzanna, PITTET, Laure, Ali, Rashida, Dunn, Ross, Edler, Peta, Gell, Grace, Goodall, Casey, Hall, Richard, Krastev, Ann, La, Nathan, McDonald, Ellie, McPhate, Nick, Nguyen, Thao, Ren, Jack, Stevens, Luke, Alamrousi, Ahmed, Bonnici, Rhian, Dang, Thanh, Germano, Susie, Hua, Jenny, McElroy, Rebecca, Razmovska, Monica, Reddiex, Scott, Wang, Xiaofang, Anderson, Jeremy, Azzopardi, Kristy, Bennett-Wood, Vicki, Czajko, Anna, Mazarakis, Nadia, McCafferty, Conor, Oppedisano, Frances, Ortika, Belinda, Pell, Casey, Spry, Leena, Toh, Ryan, Velagapudi, Sunitha, Vlahos, Amanda, Wee-Hee, Ashleigh, Ramos, Pedro, De La Cruz, Karina, Gamage, Dinusha, Karunanayake, Anushka, Mezzetti, Isabella, Ong, Benjamin, Singh, Ronita, Sooriyarachchi, Enoshini, Nicholson, Suellen, Cain, Natalie, Brizuela, Rianne, Huang, Han, Abruzzo, Veronica, Bealing, Morgan, Bimboese, Patricia, Bowes, Kirsty, Burrell, Emma, Chan, Joyce, Cushnahan, Jac, Elborough, Hannah, Elkington, Olivia, Fahey, Kieran, Fernandez, Monique, Flynn, Catherine, Fowler, Sarah, Andrit, Marie Gentile, Gladanac, Bojana, Hammond, Catherine, Ma, Norine, Macalister, Sam, Milojevic, Emmah, Mojeed, Jesutofunmi, Nguyen, Jill, O'Donnell, Liz, Olivier, Nadia, Ooi, Isabelle, Reynolds, Stephanie, Shen, Lisa, Sherry, Barb, Spotswood, Judith, Wedderburn, Jamie, Younes, Angela, Legge, Donna, Bell, Jason, Cheah, Jo, Cobbledick, Annie, Lim, Kee, Elia, Sonja, Addlem, Lynne, Bourke, Anna, Brophy, Clare, Henare, Nadine, Jenkins, Narelle, Machingaifa, Francesca, Miller, Skye, Mitchell, Kirsten, Pitkin, Sigrid, Wall, Kate, Villanueva, Paola, Crawford, Nigel, Norton, Wendy, Tan, Niki, Chengodu, Thilakavathi, Dawson, Diane, Gordon, Victoria, Korman, Tony, O'Bryan, Jess, Agius, Sophie, Bannister, Samantha, Bucholc, Jess, Burns, Alison, Camesella, Beatriz, Carlin, John, Ciaverella, Marianna, Curtis, Maxwell, Firth, Stephanie, Guo, Christina, Hannan, Matthew, Hill, Erin, Joshi, Sri, Lieschke, Katherine, Mathers, Megan, Odoi, Sasha, Rak, Ashleigh, Richards, Chris, Steve, Leah, Stewart, Carolyn, Sudbury, Eva, Thomson, Helen, Watts, Emma, Williams, Fiona, Young, Angela, Glenn, Penny, Kaynes, Andrew, De Floy, Amandine Philippart, Buchanan, Sandy, Sondag, Thijs, Xie, Ivy, Edmund, Harriet, Byrne, Bridie, Keeble, Tom, Ngien, Belle, Noonan, Fran, Wearing-Smith, Michelle, Clarke, Alison, Davies, Pemma, Eastwood, Oliver, Ellinghaus, Alric, Ghieh, Rachid, Hilton, Zahra, Jennings, Emma, Kakkos, Athina, Liang, Iris, Nicol, Katie, O'Callaghan, Sally, Osman, Helen, Rajaram, Gowri, Ratcliffe, Sophia, Rayner, Victoria, Salmon, Ashleigh, Scheppokat, Angela, Stevens, Aimee, Street, Rebekah, Toogood, Nicholas, Wood, Nicholas, Bahaduri, Twinkle, Baulman, Therese, Byrne, Jennifer, Carter, Candace, Corbett, Mary, Dao, Aiken, Desylva, Maria, Dunn, Andrew, Gardiner, Evangeline, Joyce, Rosemary, Kandasamy, Rama, Munns, Craig, Pelayo, Lisa, Sharma, Ketaki, Sterling, Katrina, Uren, Caitlin, Colaco, Clinton, Douglas, Mark, Hamilton, Kate, Bartlett, Adam, McMullan, Brendan, Palasanthiran, Pamela, Williams, Phoebe, Beardsley, Justin, Bergant, Nikki, Lagunday, Renier, Overton, Kristen, Post, Jeffrey, Al-Hindawi, Yasmeen, Barney, Sarah, Byrne, Anthony, Mead, Lee, Plit, Marshall, Lynn, David, Benson, Saoirse, Blake, Stephen, Botten, Rochelle, Chern, Tee Yee, Eden, Georgina, Griffith, Liddy, James, Jane, Lynn, Miriam, Markow, Angela, Sacca, Domenic, Stevens, Natalie, Wesselingh, Steve, Doran, Catriona, Barry, Simone, Sawka, Alice, Evans, Sue, Goodchild, Louise, Heath, Christine, Krieg, Meredith, Marshall, Helen, McMillan, Mark, Walker, Mary, Richmond, Peter, Amenyogbe, Nelly, Anthony, Christina, Arnold, Annabelle, Arrowsmith, Beth, Ben-Othman, Rym, Clark, Sharon, Dunnill, Jemma, Eiffler, Nat, Ewe, Krist, Finucane, Carolyn, Flynn, Lorraine, Gibson, Camille, Hartnell, Lucy, Hollams, Elysia, Hutton, Heidi, Jarvis, Lance, Jones, Jane, Jones, Jan, Jones, Karen, Kent, Jennifer, Kollmann, Tobias, Lalich, Debbie, Lee, Wenna, Lim, Rachel, McAlister, Sonia, McDonald, Fiona, Meehan, Andrea, Minhaj, Asma, Montgomery, Lisa, O'Donnell, Melissa, Ong, Jaslyn, Ong, Joanne, Parkin, Kimberley, Perez, Glady, Power, Catherine, Rezazadeh, Shadie, Richmond, Holly, Rogers, Sally, Schultz, Nikki, Shave, Margaret, Skut, Patrycja, Stiglmayer, Lisa, Truelove, Alexandra, Wadia, Ushma, Wallace, Rachael, Waring, Justin, England, Michelle, Latkovic, Erin, Manning, Laurens, Herrmann, Susan, Lucas, Michaela, Lacerda, Marcus, Andrade, Paulo Henrique, Barbosa, Fabiane Bianca, Barros, Dayanne, Brasil, Larissa, Capella, Ana Greyce, Castro, Ramon, Costa, Erlane, de Souza, Dilcimar, Dias, Maianne, Dias, José, Ferreira, Klenilson, Figueiredo, Paula, Freitas, Thamires, Furtado, Ana Carolina, Gama, Larissa, Godinho, Vanessa, Gouy, Cintia, Hinojosa, Daniele, Jardim, Bruno, Jardim, Tyane, Junior, Joel, Lima, Augustto, Maia, Bernardo, Marins, Adriana, Mazurega, Kelry, Medeiros, Tercilene, Melo, Rosangela, Moraes, Marinete, Nascimento, Elizandra, Neves, Juliana, Oliveira, Maria Gabriela, Oliveira, Thais, Oliveira, Ingrid, Otsuka, Arthur, Paes, Rayssa, Pereira, Handerson, Pereira, Gabrielle, Prado, Christiane, Queiroz, Evelyn, Rodrigues, Laleyska, Rodrigues, Bebeto, Sampaio, Vanderson, Santos, Anna Gabriela, Santos, Daniel, Santos, Tilza, Santos, Evelyn, Sartim, Ariandra, Silva, Ana Beatriz, Silva, Juliana, Silva, Emanuelle, Simão, Mariana, Soares, Caroline, Sousa, Antonny, Trindade, Alexandre, Val, Fernando, Vasconcelos, Adria, Vasconcelos, Heline, Croda, Julio, Abreu, Carolinne, Almeida, Katya Martinez, Bitencourt de Andrade, Camila, Campos Angelo, Jhenyfer Thalyta, Gonçalvez de Araújo Arcanjo, Ghislaine, Silva Menezes Arruda, Bianca Maria, Ayala, Wellyngthon Espindola, Refosco Barbosa, Adelita Agripina, Vieira Batista, Felipe Zampieri, de Morais Batista, Fabiani, de Jesus Costa, Miriam, Croda, Mariana Garcia, Alves da Cruz, Lais, Pereira Diogo, Roberta Carolina, Dutra Escobar, Rodrigo Cezar, Fernandes, Iara Rodrigues, Figueiredo, Leticia Ramires, Cavalcanti Gonçalves, Leandro Galdino, Lahdo, Sarita, Lencina, Joyce dos Santos, Teodoro de Lima, Guilherme, LEOPOLDINA MEIRELES, Bruna Tayara, Moreira, Debora Quadros, Silva Muranaka, Lilian Batista, de Oliveira, Adriely, Warszawski de Oliveira, Karla Regina, Vieira de Oliveira, Matheus, Dias de Oliveira, Roberto, Pereira, Andrea Antonia Souza de Almeida dos Reis, Puga, Marco, Ramos, Caroliny Veron, Souza da Rosa, Thaynara Haynara, Lopes dos Santos, Karla, Ribeiro dos Santos, Claudinalva, Leopoldina dos Santos, Dyenyffer Stéffany, Santos, Karina Marques, Pereira da Silva, Paulo César, Rocha da Silva, Paulo Victor, Silva, Débora dos Santos, Vieira da Silva, Patricia, Freitas da Rosa Soares, Bruno, Sperotto, Mariana Gazzoni, Tadokoro, Mariana Mayumi, Tsuha, Daniel, Ramos Vieira, Hugo Miguel, Pretti Dalcolmo, Margareth Maria, Lopes Alves da Paixão, Cíntia Maria, Corrêa E Castro, Gabriela, Collopy, Simone Silva, da Costa Silva, Renato, Almeida da Silveira, Samyra, Da-Cruz, Alda Maria, Maria da Silva Passos de Carvalho, Alessandra, de Cássia Batista, Rita, Silva De Freitas, Maria Luciana, Gerhardt de Oliveira Ferreira, Aline, Conceição de Souza, Ana Paula, Doblas, Paola Cerbino, Alcoforado da Silva dos Santos, Ayla, Cristine de Moraes dos Santos, Vanessa, Alves dos Santos Gomes, Dayane, Fortunato, Anderson Lage, Gomes-Silva, Adriano, Gonçalves, Monique Pinto, Garcia Meireless Junior, Paulo Leandro, Martins da Costa Carvalho, Estela, Motta, Fernando do Couto, Olivo de Mendonça, Ligia Maria, Pandine, Girlene dos Santos, Plácido Pereira, Rosa Maria, Maia, Ivan Ramos, Luiz da Rocha, Jorge, Paiva Romano, João Victor, Santos, Glauce dos, Fernandes da Silva, Erica, Mendonça Teixeira de Siqueira, Marilda Agudo, Prudêncio Soares, Ágatha Cristinne, Bonten, Marc, Arroyo, Sandra Franch, Besten, Henny Ophorst-den, Boon, Anna, Brakke, Karin M., Janssen, Axel, Koopmans, Marijke A.H., Lemmens, Toos, Leurink, Titia, Prat-Aymerich, Cristina, Septer-Bijleveld, Engelien, Stadhouders, Kimberly, Troeman, Darren, van der Waal, Marije, van Opdorp, Marjoleine, van Sluis, Nicolette, Wolters, Beatrijs, Kluytmans, Jan, Romme, Jannie, van den Bijllaardt, Wouter, van Mook, Linda, Rijen, M.M.L (Miranda) van, Filius, P.M.G., Gisolf, Jet, Greven, Frances, Huijbens, Danique, Hassing, Robert Jan, Pon, R.C., Preijers, Lieke, van Leusen, J.H., Verheij, Harald, Boersma, Wim, Brans, Evelien, Kloeg, Paul, Molenaar-Groot, Kitty, Nguyen, Nhat Khanh, Paternotte, Nienke, Rol, Anke, Stooper, Lida, Dijkstra, Helga, Eggenhuizen, Esther, Huijs, Lucas, Moorlag, Simone, Netea, Mihai, Pranger, Eva, Taks, Esther, Oever, Jaap ten, Heine, Rob ter, Blauwendraat, Kitty, Meek, Bob, Erkaya, Isil, Harbech, Houda, Roescher, Nienke, Peeters, Rifka, Riele, Menno te, Zhou, Carmen, Calbo, Esther, Marti, Cristina Badia, Palomares, Emma Triviño, Porcuna, Tomás Perez, Barriocanal, Anabel, Barriocanal, Ana Maria, Casas, Irma, Dominguez, Jose, Esteve, Maria, Lacoma, Alicia, Latorre, Irene, Molina, Gemma, Molina, Barbara, Rosell, Antoni, Vidal, Sandra, Barrera, Lydia, Bustos, Natalia, Calderón, Ines Portillo, Campos, David Gutierrez, Carretero, Jose Manuel, Castellano, Angel Dominguez, Compagnone, Renato, Ramirez de Arellano, Encarnacion, Serna, Almudena de la, del Toro Lopez, Maria Dolores, Clement Espindola, Marie-Alix, Martin Gutierrez, Ana Belen, Hernandez, Alvaro Pascual, Jiménez, Virginia Palomo, Moreno, Elisa, Navarrete, Nicolas, Paño, Teresa Rodriguez, Rodríguez-Baño, Jesús, Tristán, Enriqueta, Rios Villegas, Maria Jose, Garces, Atsegiñe Canga, Amo, Erika Castro, Guerrero, Raquel Coya, Goikoetxea, Josune, Jorge, Leticia, Perez, Cristina, Fariñas Álvarez, María Carmen, Cuadra, Manuel Gutierrez, Arnaiz de las Revillas Almajano, Francisco, Garcia, Pilar Bohedo, Poderos, Teresa Giménez, Rico, Claudia González, Sanchez, Blanca, Valero, Olga, Vega, Noelia, Campbell, John, Barnes, Anna, Catterick, Helen, Cranston, Tim, Dawe, Phoebe, Fletcher, Emily, Fouracre, Liam, Gifford, Alison, Gow, Neil, Kirkwood, John, Martin, Christopher, McAnew, Amy, Mitchell, Marcus, Newman, Georgina, O'Connell, Abby, Onysk, Jakob, Quinn, Lynne, Rhodes, Shelley, Stone, Samuel, Symons, Lorrie, Tripp, Harry, Watkins, Darcy, Whale, Bethany, Harding, Alex, Lockhart, Gemma, Sidaway-Lee, Kate, Hilton, Sam, Manton, Sarah, Webber-Rookes, Daniel, Winder, Rachel, Moore, James, Bateman, Freya, Gibbons, Michael, Knight, Bridget, Moss, Julie, Statton, Sarah, Studham, Josephine, Hall, Lydia, Moyle, Will, Venton, Tamsin, Pittet, Laure F., Messina, Nicole L., Croda, Mariana G., Dalcolmo, Margareth, Lacerda, Marcus V.G., Lynn, David J., Perrett, Kirsten P., Post, Jeffrey J., Richmond, Peter C., Rocha, Jorge L., Rodriguez-Baño, Jesus, Warris, Adilia, and Wood, Nicholas J.
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- 2024
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4. The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial
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Zimmermann, Petra, Pittet, Laure F., Jakob, William, Messina, Nicole L., Falquet, Laurent, and Curtis, Nigel
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- 2024
- Full Text
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5. Using BCG vaccination to protect against COVID-19: when reality fails to meet expectation
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Pittet, Laure F., Noble, Christie C. A., Messina, Nicole L., and Curtis, Nigel
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- 2024
- Full Text
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6. The Effect of Bacille Calmette-Guérin Vaccination on the Composition of the Intestinal Microbiome in Neonates From the MIS BAIR Trial
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Zimmermann, Petra, Pittet, Laure F., Jakob, William, Messina, Nicole L., Falquet, Laurent, and Curtis, Nigel
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- 2023
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7. Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines—an exploratory sub-study of the BRACE trial
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Curtis, Nigel, Davidson, Andrew, Gardiner, Kaya, Gwee, Amanda, Jamieson, Tenaya, Messina, Nicole, Morawakage, Thilanka, Perlen, Susan, Perrett, Kirsten, Pittet, Laure, Sastry, Amber, Teo, Jia Wei, Orsini, Francesca, Lee, Katherine, Moore, Cecilia, Vidmar, Suzanna, Ali, Rashida, Dunn, Ross, Edler, Peta, Gell, Grace, Goodall, Casey, Hall, Richard, Krastev, Ann, La, Nathan, McDonald, Ellie, McPhate, Nick, Nguyen, Thao, Ren, Jack, Stevens, Luke, Alamrousi, Ahmed, Bonnici, Rhian, Dang, Thanh, Germano, Susie, Hua, Jenny, McElroy, Rebecca, Razmovska, Monica, Reddiex, Scott, Wang, Xiaofang, Anderson, Jeremy, Azzopardi, Kristy, Bennett-Wood, Vicki, Czajko, Anna, Mazarakis, Nadia, McCafferty, Conor, Oppedisano, Frances, Ortika, Belinda, Pell, Casey, Spry, Leena, Toh, Ryan, Velagapudi, Sunitha, Vlahos, Amanda, Wee-Hee, Ashleigh, Ramos, Pedro, De La Cruz, Karina, Gamage, Dinusha, Karunanayake, Anushka, Mezzetti, Isabella, Ong, Benjamin, Singh, Ronita, Sooriyarachchi, Enoshini, Nicholson, Suellen, Cain, Natalie, Brizuela, Rianne, Huang, Han, Abruzzo, Veronica, Bealing, Morgan, Bimboese, Patricia, Bowes, Kirsty, Burrell, Emma, Chan, Joyce, Cushnahan, Jac, Elborough, Hannah, Elkington, Olivia, Fahey, Kieran, Fernandez, Monique, Flynn, Catherine, Fowler, Sarah, Andrit, Marie Gentile, Gladanac, Bojana, Hammond, Catherine, Ma, Norine, Macalister, Sam, Milojevic, Emmah, Mojeed, Jesutofunmi, Nguyen, Jill, O’Donnell, Liz, Olivier, Nadia, Ooi, Isabelle, Reynolds, Stephanie, Shen, Lisa, Sherry, Barb, Spotswood, Judith, Wedderburn, Jamie, Younes, Angela, Legge, Donna, Bell, Jason, Cheah, Jo, Cobbledick, Annie, Lim, Kee, Elia, Sonja, Addlem, Lynne, Bourke, Anna, Brophy, Clare, Henare, Nadine, Jenkins, Narelle, Machingaifa, Francesca, Miller, Skye, Mitchell, Kirsten, Pitkin, Sigrid, Wall, Kate, Villanueva, Paola, Crawford, Nigel, Norton, Wendy, Tan, Niki, Chengodu, Thilakavathi, Dawson, Diane, Gordon, Victoria, Korman, Tony, O’Bryan, Jess, Agius, Sophie, Bannister, Samantha, Bucholc, Jess, Burns, Alison, Camesella, Beatriz, Carlin, John, Ciaverella, Marianna, Curtis, Maxwell, Firth, Stephanie, Guo, Christina, Hannan, Matthew, Hill, Erin, Joshi, Sri, Lieschke, Katherine, Mathers, Megan, Odoi, Sasha, Rak, Ashleigh, Richards, Chris, Steve, Leah, Stewart, Carolyn, Sudbury, Eva, Thomson, Helen, Watts, Emma, Williams, Fiona, Young, Angela, Glenn, Penny, Kaynes, Andrew, De Floy, Amandine Philippart, Buchanan, Sandy, Sondag, Thijs, Xie, Ivy, Edmund, Harriet, Byrne, Bridie, Keeble, Tom, Ngien, Belle, Noonan, Fran, Wearing-Smith, Michelle, Clarke, Alison, Davies, Pemma, Eastwood, Oliver, Ellinghaus, Alric, Ghieh, Rachid, Hilton, Zahra, Jennings, Emma, Kakkos, Athina, Liang, Iris, Nicol, Katie, O’Callaghan, Sally, Osman, Helen, Rajaram, Gowri, Ratcliffe, Sophia, Rayner, Victoria, Salmon, Ashleigh, Scheppokat, Angela, Stevens, Aimee, Street, Rebekah, Toogood, Nicholas, Wood, Nicholas, Bahaduri, Twinkle, Baulman, Therese, Byrne, Jennifer, Carter, Candace, Corbett, Mary, Dao, Aiken, Desylva, Maria, Dunn, Andrew, Gardiner, Evangeline, Joyce, Rosemary, Kandasamy, Rama, Munns, Craig, Pelayo, Lisa, Sharma, Ketaki, Sterling, Katrina, Uren, Caitlin, Colaco, Clinton, Douglas, Mark, Hamilton, Kate, Bartlett, Adam, McMullan, Brendan, Palasanthiran, Pamela, Williams, Phoebe, Beardsley, Justin, Bergant, Nikki, Lagunday, Renier, Overton, Kristen, Post, Jeffrey, Al-Hindawi, Yasmeen, Barney, Sarah, Byrne, Anthony, Mead, Lee, Plit, Marshall, Lynn, David, Benson, Saoirse, Blake, Stephen, Botten, Rochelle, Chern, Tee Yee, Eden, Georgina, Griffith, Liddy, James, Jane, Lynn, Miriam, Markow, Angela, Sacca, Domenic, Stevens, Natalie, Wesselingh, Steve, Doran, Catriona, Barry, Simone, Sawka, Alice, Evans, Sue, Goodchild, Louise, Heath, Christine, Krieg, Meredith, Marshall, Helen, McMillan, Mark, Walker, Mary, Richmond, Peter, Amenyogbe, Nelly, Anthony, Christina, Arnold, Annabelle, Arrowsmith, Beth, Ben-Othman, Rym, Clark, Sharon, Dunnill, Jemma, Eiffler, Nat, Ewe, Krist, Finucane, Carolyn, Flynn, Lorraine, Gibson, Camille, Hartnell, Lucy, Hollams, Elysia, Hutton, Heidi, Jarvis, Lance, Jones, Jane, Jones, Jan, Jones, Karen, Kent, Jennifer, Kollmann, Tobias, Lalich, Debbie, Lee, Wenna, Lim, Rachel, McAlister, Sonia, McDonald, Fiona, Meehan, Andrea, Minhaj, Asma, Montgomery, Lisa, O’Donnell, Melissa, Ong, Jaslyn, Ong, Joanne, Parkin, Kimberley, Perez, Glady, Power, Catherine, Rezazadeh, Shadie, Richmond, Holly, Rogers, Sally, Schultz, Nikki, Shave, Margaret, Skut, Patrycja, Stiglmayer, Lisa, Truelove, Alexandra, Wadia, Ushma, Wallace, Rachael, Waring, Justin, England, Michelle, Latkovic, Erin, Manning, Laurens, Herrmann, Susan, Lucas, Michaela, Lacerda, Marcus, Andrade, Paulo Henrique, Barbosa, Fabiane Bianca, Barros, Dayanne, Brasil, Larissa, Capella, Ana Greyce, Castro, Ramon, Costa, Erlane, de Souza, Dilcimar, Dias, Maianne, Dias, José, Ferreira, Klenilson, Figueiredo, Paula, Freitas, Thamires, Furtado, Ana Carolina, Gama, Larissa, Godinho, Vanessa, Gouy, Cintia, Hinojosa, Daniele, Jardim, Bruno, Jardim, Tyane, Junior, Joel, Lima, Augustto, Maia, Bernardo, Marins, Adriana, Mazurega, Kelry, Medeiros, Tercilene, Melo, Rosangela, Moraes, Marinete, Nascimento, Elizandra, Neves, Juliana, Oliveira, Maria Gabriela, Oliveira, Thais, Oliveira, Ingrid, Otsuka, Arthur, Paes, Rayssa, Pereira, Handerson, Pereira, Gabrielle, Prado, Christiane, Queiroz, Evelyn, Rodrigues, Laleyska, Rodrigues, Bebeto, Sampaio, Vanderson, Santos, Anna Gabriela, Santos, Daniel, Santos, Tilza, Santos, Evelyn, Sartim, Ariandra, Silva, Ana Beatriz, Silva, Juliana, Silva, Emanuelle, Simão, Mariana, Soares, Caroline, Sousa, Antonny, Trindade, Alexandre, Val, Fernando, Vasconcelos, Adria, Vasconcelos, Heline, Croda, Julio, Abreu, Carolinne, Almeida, Katya Martinez, Bitencourt de Andrade, Camila, Campos Angelo, Jhenyfer Thalyta, Gonçalvez de Araújo Arcanjo, Ghislaine, Silva Menezes Arruda, Bianca Maria, Ayala, Wellyngthon Espindola, Refosco Barbosa, Adelita Agripina, Vieira Batista, Felipe Zampieri, de Morais Batista, Fabiani, de Jesus Costa, Miriam, Croda, Mariana Garcia, Alves da Cruz, Lais, Pereira Diogo, Roberta Carolina, Dutra Escobar, Rodrigo Cezar, Fernandes, Iara Rodrigues, Figueiredo, Leticia Ramires, Cavalcanti Gonçalves, Leandro Galdino, Lahdo, Sarita, Lencina, Joyce dos Santos, Teodoro de Lima, Guilherme, Matos, Larissa Santos, Leopoldina Meireles, Bruna Tayara, Moreira, Debora Quadros, Silva Muranaka, Lilian Batista, de Oliveira, Adriely, Warszawski de Oliveira, Karla Regina, Vieira de Oliveira, Matheus, Dias de Oliveira, Roberto, Souza de Almeida dos Reis Pereira, Andrea Antonia, Puga, Marco, Ramos, Caroliny Veron, Souza da Rosa, Thaynara Haynara, Lopes dos Santos, Karla, Ribeiro dos Santos, Claudinalva, Leopoldina dos Santos, Dyenyffer Stéffany, Santos, Karina Marques, Pereira da Silva, Paulo César, Rocha da Silva, Paulo Victor, Silva, Débora dos Santos, Vieira da Silva, Patricia, Freitas da Rosa Soares, Bruno, Sperotto, Mariana Gazzoni, Tadokoro, Mariana Mayumi, Tsuha, Daniel, Ramos Vieira, Hugo Miguel, Pretti Dalcolmo, Margareth Maria, Lopes Alves da Paixão, Cíntia Maria, Corrêa E Castro, Gabriela, Collopy, Simone Silva, da Costa Silva, Renato, Almeida da Silveira, Samyra, Da-Cruz, Alda Maria, Maria da Silva Passos de Carvalho, Alessandra, de Cássia Batista, Rita, Silva De Freitas, Maria Luciana, Gerhardt de Oliveira Ferreira, Aline, Conceição de Souza, Ana Paula, Doblas, Paola Cerbino, Alcoforado da Silva dos Santos, Ayla, Cristine de Moraes dos Santos, Vanessa, Alves dos Santos Gomes, Dayane, Fortunato, Anderson Lage, Gomes-Silva, Adriano, Gonçalves, Monique Pinto, Garcia Meireless Junior, Paulo Leandro, Martins da Costa Carvalho, Estela, Motta, Fernando do Couto, Olivo de Mendonça, Ligia Maria, Pandine, Girlene dos Santos, Plácido Pereira, Rosa Maria, Maia, Ivan Ramos, Luiz da Rocha, Jorge, Paiva Romano, João Victor, Santos, Glauce dos, Fernandes da Silva, Erica, Mendonça Teixeira de Siqueira, Marilda Agudo, Prudêncio Soares, Ágatha Cristinne, Bonten, Marc, Arroyo, Sandra Franch, Besten, Henny Ophorst-den, Boon, Anna, Brakke, Karin M., Janssen, Axel, Koopmans, Marijke A.H., Lemmens, Toos, Leurink, Titia, Prat-Aymerich, Cristina, Septer-Bijleveld, Engelien, Stadhouders, Kimberly, Troeman, Darren, van der Waal, Marije, van Opdorp, Marjoleine, van Sluis, Nicolette, Wolters, Beatrijs, Kluytmans, Jan, Romme, Jannie, van den Bijllaardt, Wouter, van Mook, Linda, Rijen, M.M.L (Miranda) van, Filius, Margreet, Gisolf, Jet, Greven, Frances, Huijbens, Danique, Hassing, Robert Jan, Pon, Roos, Preijers, Lieke, van Leusen, Joke, Verheij, Harald, Boersma, Wim, Brans, Evelien, Kloeg, Paul, Molenaar-Groot, Kitty, Nguyen, Nhat Khanh, Paternotte, Nienke, Rol, Anke, Stooper, Lida, Dijkstra, Helga, Eggenhuizen, Esther, Huijs, Lucas, Moorlag, Simone, Netea, Mihai, Pranger, Eva, Taks, Esther, Oever, Jaap ten, Heine, Rob ter, Blauwendraat, Kitty, Meek, Bob, Erkaya, Isil, Harbech, Houda, Roescher, Nienke, Peeters, Rifka, Riele, Menno te, Zhou, Carmen, Calbo, Esther, Marti, Cristina Badia, Palomares, Emma Triviño, Porcuna, Tomás Perez, Barriocanal, Anabel, Barriocanal, Ana Maria, Casas, Irma, Dominguez, Jose, Esteve, Maria, Lacoma, Alicia, Latorre, Irene, Molina, Gemma, Molina, Barbara, Rosell, Antoni, Vidal, Sandra, Barrera, Lydia, Bustos, Natalia, Calderón, Ines Portillo, Campos, David Gutierrez, Carretero, Jose Manuel, Castellano, Angel Dominguez, Compagnone, Renato, Ramirez de Arellano, Encarnacion, Serna, Almudena de la, Dolores del Toro Lopez, Maria, Clement Espindola, Marie-Alix, Martin Gutierrez, Ana Belen, Hernandez, Alvaro Pascual, Jiménez, Virginia Palomo, Moreno, Elisa, Navarrete, Nicolas, Paño, Teresa Rodriguez, Rodríguez-Baño, Jesús, Tristán, Enriqueta, Rios Villegas, Maria Jose, Garces, Atsegiñe Canga, Amo, Erika Castro, Guerrero, Raquel Coya, Goikoetxea, Josune, Jorge, Leticia, Perez, Cristina, Fariñas Álvarez, María Carmen, Cuadra, Manuel Gutierrez, Arnaiz de las Revillas Almajano, Francisco, Garcia, Pilar Bohedo, Poderos, Teresa Giménez, Rico, Claudia González, Sanchez, Blanca, Valero, Olga, Vega, Noelia, Campbell, John, Barnes, Anna, Catterick, Helen, Cranston, Tim, Dawe, Phoebe, Fletcher, Emily, Fouracre, Liam, Gifford, Alison, Kirkwood, John, Martin, Christopher, McAnew, Amy, Mitchell, Marcus, Newman, Georgina, O’Connell, Abby, Onysk, Jakob, Quinn, Lynne, Rhodes, Shelley, Stone, Samuel, Symons, Lorrie, Tripp, Harry, Warris, Adilia, Watkins, Darcy, Whale, Bethany, Harding, Alex, Lockhart, Gemma, Sidaway-Lee, Kate, Hilton, Sam, Manton, Sarah, Webber-Rookes, Daniel, Winder, Rachel, Moore, James, Bateman, Freya, Gibbons, Michael, Knight, Bridget, Moss, Julie, Statton, Sarah, Studham, Josephine, Hall, Lydia, Moyle, Will, Venton, Tamsin, Messina, Nicole L., Grubor-Bauk, Branka, Lynn, David J., Perrett, Kirsten P., Pittet, Laure F., Rudraraju, Rajeev, Stevens, Natalie E., and Subbarao, Kanta
- Published
- 2024
- Full Text
- View/download PDF
8. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
- Author
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Curtis, Nigel, Davidson, Andrew, Gardiner, Kaya, Gwee, Amanda, Jamieson, Tenaya, Messina, Nicole, Morawakage, Thilanka, Perlen, Susan, Perrett, Kirsten, Pittet, Laure, Sastry, Amber, Teo, Jia Wei, Orsini, Francesca, Lee, Katherine, Moore, Cecilia, Vidmar, Suzanna, Ali, Rashida, Dunn, Ross, Edler, Peta, Gell, Grace, Goodall, Casey, Hall, Richard, Krastev, Ann, La, Nathan, McDonald, Ellie, McPhate, Nick, Nguyen, Thao, Ren, Jack, Stevens, Luke, Alamrousi, Ahmed, Bonnici, Rhian, Dang, Thanh, Germano, Susie, Hua, Jenny, McElroy, Rebecca, Razmovska, Monica, Reddiex, Scott, Wang, Xiaofang, Anderson, Jeremy, Azzopardi, Kristy, Bennett-Wood, Vicki, Czajko, Anna, Mazarakis, Nadia, McCafferty, Conor, Oppedisano, Frances, Ortika, Belinda, Pell, Casey, Spry, Leena, Toh, Ryan, Velagapudi, Sunitha, Vlahos, Amanda, Wee-Hee, Ashleigh, Ramos, Pedro, De La Cruz, Karina, Gamage, Dinusha, Karunanayake, Anushka, Mezzetti, Isabella, Ong, Benjamin, Singh, Ronita, Sooriyarachchi, Enoshini, Nicholson, Suellen, Cain, Natalie, Brizuela, Rianne, Huang, Han, Abruzzo, Veronica, Bealing, Morgan, Bimboese, Patricia, Bowes, Kirsty, Burrell, Emma, Chan, Joyce, Cushnahan, Jac, Elborough, Hannah, Elkington, Olivia, Fahey, Kieran, Fernandez, Monique, Flynn, Catherine, Fowler, Sarah, Andrit, Marie Gentile, Gladanac, Bojana, Hammond, Catherine, Ma, Norine, Macalister, Sam, Milojevic, Emmah, Mojeed, Jesutofunmi, Nguyen, Jill, O'Donnell, Liz, Olivier, Nadia, Ooi, Isabelle, Reynolds, Stephanie, Shen, Lisa, Sherry, Barb, Spotswood, Judith, Wedderburn, Jamie, Younes, Angela, Legge, Donna, Bell, Jason, Cheah, Jo, Cobbledick, Annie, Lim, Kee, Elia, Sonja, Addlem, Lynne, Bourke, Anna, Brophy, Clare, Henare, Nadine, Jenkins, Narelle, Machingaifa, Francesca, Miller, Skye, Mitchell, Kirsten, Pitkin, Sigrid, Wall, Kate, Villanueva, Paola, Crawford, Nigel, Norton, Wendy, Tan, Niki, Chengodu, Thilakavathi, Dawson, Diane, Gordon, Victoria, Korman, Tony, O'Bryan, Jess, Agius, Sophie, Bannister, Samantha, Bucholc, Jess, Burns, Alison, Camesella, Beatriz, Carlin, John, Ciaverella, Marianna, Curtis, Maxwell, Firth, Stephanie, Guo, Christina, Hannan, Matthew, Hill, Erin, Joshi, Sri, Lieschke, Katherine, Mathers, Megan, Odoi, Sasha, Rak, Ashleigh, Richards, Chris, Steve, Leah, Stewart, Carolyn, Sudbury, Eva, Thomson, Helen, Watts, Emma, Williams, Fiona, Young, Angela, Glenn, Penny, Kaynes, Andrew, Philippart De Floy, Amandine, Buchanan, Sandy, Sondag, Thijs, Xie, Ivy, Edmund, Harriet, Byrne, Bridie, Keeble, Tom, Ngien, Belle, Noonan, Fran, Wearing-Smith, Michelle, Clarke, Alison, Davies, Pemma, Eastwood, Oliver, Ellinghaus, Alric, Ghieh, Rachid, Hilton, Zahra, Jennings, Emma, Kakkos, Athina, Liang, Iris, Nicol, Katie, O'Callaghan, Sally, Osman, Helen, Rajaram, Gowri, Ratcliffe, Sophia, Rayner, Victoria, Salmon, Ashleigh, Scheppokat, Angela, Stevens, Aimee, Street, Rebekah, Toogood, Nicholas, Wood, Nicholas, Bahaduri, Twinkle, Baulman, Therese, Byrne, Jennifer, Carter, Candace, Corbett, Mary, Dao, Aiken, Desylva, Maria, Dunn, Andrew, Gardiner, Evangeline, Joyce, Rosemary, Kandasamy, Rama, Munns, Craig, Pelayo, Lisa, Sharma, Ketaki, Sterling, Katrina, Uren, Caitlin, Colaco, Clinton, Douglas, Mark, Hamilton, Kate, Bartlett, Adam, McMullan, Brendan, Palasanthiran, Pamela, Williams, Phoebe, Beardsley, Justin, Bergant, Nikki, Lagunday, Renier, Overton, Kristen, Post, Jeffrey, Al-Hindawi, Yasmeen, Barney, Sarah, Byrne, Anthony, Mead, Lee, Plit, Marshall, Lynn, David, Benson, Saoirse, Blake, Stephen, Botten, Rochelle, Chern, Tee Yee, Eden, Georgina, Griffith, Liddy, James, Jane, Lynn, Miriam, Markow, Angela, Sacca, Domenic, Stevens, Natalie, Wesselingh, Steve, Doran, Catriona, Barry, Simone, Sawka, Alice, Evans, Sue, Goodchild, Louise, Heath, Christine, Krieg, Meredith, Marshall, Helen, McMillan, Mark, Walker, Mary, Richmond, Peter, Amenyogbe, Nelly, Anthony, Christina, Arnold, Annabelle, Arrowsmith, Beth, Ben-Othman, Rym, Clark, Sharon, Dunnill, Jemma, Eiffler, Nat, Ewe, Krist, Finucane, Carolyn, Flynn, Lorraine, Gibson, Camille, Hartnell, Lucy, Hollams, Elysia, Hutton, Heidi, Jarvis, Lance, Jones, Jane, Jones, Jan, Jones, Karen, Kent, Jennifer, Kollmann, Tobias, Lalich, Debbie, Lee, Wenna, Lim, Rachel, McAlister, Sonia, McDonald, Fiona, Meehan, Andrea, Minhaj, Asma, Montgomery, Lisa, O'Donnell, Melissa, Ong, Jaslyn, Ong, Joanne, Parkin, Kimberley, Perez, Glady, Power, Catherine, Rezazadeh, Shadie, Richmond, Holly, Rogers, Sally, Schultz, Nikki, Shave, Margaret, Skut, Patrycja, Stiglmayer, Lisa, Truelove, Alexandra, Wadia, Ushma, Wallace, Rachael, Waring, Justin, England, Michelle, Latkovic, Erin, Manning, Laurens, Herrmann, Susan, Lucas, Michaela, Lacerda, Marcus, Andrade, Paulo Henrique, Barbosa, Fabiane Bianca, Barros, Dayanne, Brasil, Larissa, Capella, Ana Greyce, Castro, Ramon, Costa, Erlane, de Souza, Dilcimar, Dias, Maianne, Dias, José, Ferreira, Klenilson, Figueiredo, Paula, Freitas, Thamires, Furtado, Ana Carolina, Gama, Larissa, Godinho, Vanessa, Gouy, Cintia, Hinojosa, Daniele, Jardim, Bruno, Jardim, Tyane, Junior, Joel, Lima, Augustto, Maia, Bernardo, Marins, Adriana, Mazurega, Kelry, Medeiros, Tercilene, Melo, Rosangela, Moraes, Marinete, Nascimento, Elizandra, Neves, Juliana, Oliveira, Maria Gabriela, Oliveira, Thais, Oliveira, Ingrid, Otsuka, Arthur, Paes, Rayssa, Pereira, Handerson, Pereira, Gabrielle, Prado, Christiane, Queiroz, Evelyn, Rodrigues, Laleyska, Rodrigues, Bebeto, Sampaio, Vanderson, Santos, Anna Gabriela, Santos, Daniel, Santos, Tilza, Santos, Evelyn, Sartim, Ariandra, Silva, Ana Beatriz, Silva, Juliana, Silva, Emanuelle, Simão, Mariana, Soares, Caroline, Sousa, Antonny, Trindade, Alexandre, Val, Fernando, Vasconcelos, Adria, Vasconcelos, Heline, Croda, Julio, Abreu, Carolinne, Almeida, Katya Martinez, Bitencourt de Andrade, Camila, Campos Angelo, Jhenyfer Thalyta, Gonçalvez de Araújo Arcanjo, Ghislaine, Silva Menezes Arruda, Bianca Maria, Ayala, Wellyngthon Espindola, Refosco Barbosa, Adelita Agripina, Vieira Batista, Felipe Zampieri, de Morais Batista, Fabiani, de Jesus Costa, Miriam, Croda, Mariana Garcia, Alves da Cruz, Lais, Pereira Diogo, Roberta Carolina, Dutra Escobar, Rodrigo Cezar, Fernandes, Iara Rodrigues, Figueiredo, Leticia Ramires, Cavalcanti Gonçalves, Leandro Galdino, Lahdo, Sarita, Lencina, Joyce dos Santos, Teodoro de Lima, Guilherme, Matos, Larissa Santos, Leopoldina Meireles, Bruna Tayara, Moreira, Debora Quadros, Silva Muranaka, Lilian Batista, de Oliveira, Adriely, Warszawski de Oliveira, Karla Regina, Vieira de Oliveira, Matheus, Dias de Oliveira, Roberto, Souza de Almeida dos Reis Pereira, Andrea Antonia, Puga, Marco, Ramos, Caroliny Veron, Souza da Rosa, Thaynara Haynara, Lopes dos Santos, Karla, Ribeiro dos Santos, Claudinalva, Leopoldina dos Santos, Dyenyffer Stéffany, Santos, Karina Marques, Pereira da Silva, Paulo César, Rocha da Silva, Paulo Victor, Silva, Débora dos Santos, Vieira da Silva, Patricia, Freitas da Rosa Soares, Bruno, Sperotto, Mariana Gazzoni, Tadokoro, Mariana Mayumi, Tsuha, Daniel, Ramos Vieira, Hugo Miguel, Pretti Dalcolmo, Margareth Maria, Lopes Alves da Paixão, Cíntia Maria, Corrêa E Castro, Gabriela, Collopy, Simone Silva, da Costa Silva, Renato, Almeida da Silveira, Samyra, Da-Cruz, Alda Maria, Maria da Silva Passos de Carvalho, Alessandra, de Cássia Batista, Rita, Silva De Freitas, Maria Luciana, Gerhardt de Oliveira Ferreira, Aline, Conceição de Souza, Ana Paula, Doblas, Paola Cerbino, Alcoforado da Silva dos Santos, Ayla, Cristine de Moraes dos Santos, Vanessa, Alves dos Santos Gomes, Dayane, Fortunato, Anderson Lage, Gomes-Silva, Adriano, Gonçalves, Monique Pinto, Garcia Meireless Junior, Paulo Leandro, Martins da Costa Carvalho, Estela, Motta, Fernando do Couto, Olivo de Mendonça, Ligia Maria, Pandine, Girlene dos Santos, Plácido Pereira, Rosa Maria, Maia, Ivan Ramos, Luiz da Rocha, Jorge, Paiva Romano, João Victor, Santos, Glauce dos, Fernandes da Silva, Erica, Mendonça Teixeira de Siqueira, Marilda Agudo, Prudêncio Soares, Ágatha Cristinne, Bonten, Marc, Arroyo, Sandra Franch, Besten, Henny Ophorst-den, Boon, Anna, Brakke, Karin M., Janssen, Axel, Koopmans, Marijke A.H., Lemmens, Toos, Leurink, Titia, Prat-Aymerich, Cristina, Septer-Bijleveld, Engelien, Stadhouders, Kimberly, Troeman, Darren, van der Waal, Marije, van Opdorp, Marjoleine, van Sluis, Nicolette, Wolters, Beatrijs, Kluytmans, Jan, Romme, Jannie, van den Bijllaardt, Wouter, van Mook, Linda, Rijen, M.M.L (Miranda) van, Filius, P.M.G., Gisolf, Jet, Greven, Frances, Huijbens, Danique, Hassing, Robert Jan, Pon, R.C., Preijers, Lieke, van Leusen, J.H., Verheij, Harald, Boersma, Wim, Brans, Evelien, Kloeg, Paul, Molenaar-Groot, Kitty, Nguyen, Nhat Khanh, Paternotte, Nienke, Rol, Anke, Stooper, Lida, Dijkstra, Helga, Eggenhuizen, Esther, Huijs, Lucas, Moorlag, Simone, Netea, Mihai, Pranger, Eva, Taks, Esther, Oever, Jaap ten, Heine, Rob ter, Blauwendraat, Kitty, Meek, Bob, Erkaya, Isil, Harbech, Houda, Roescher, Nienke, Peeters, Rifka, Riele, Menno te, Zhou, Carmen, Calbo, Esther, Marti, Cristina Badia, Palomares, Emma Triviño, Porcuna, Tomás Perez, Barriocanal, Anabel, Barriocanal, Ana Maria, Casas, Irma, Dominguez, Jose, Esteve, Maria, Lacoma, Alicia, Latorre, Irene, Molina, Gemma, Molina, Barbara, Rosell, Antoni, Vidal, Sandra, Barrera, Lydia, Bustos, Natalia, Calderón, Ines Portillo, Campos, David Gutierrez, Carretero, Jose Manuel, Castellano, Angel Dominguez, Compagnone, Renato, Ramirez de Arellano, Encarnacion, Serna, Almudena de la, Dolores del Toro Lopez, Maria, Clement Espindola, Marie-Alix, Martin Gutierrez, Ana Belen, Hernandez, Alvaro Pascual, Jiménez, Virginia Palomo, Moreno, Elisa, Navarrete, Nicolas, Paño, Teresa Rodriguez, Rodríguez-Baño, Jesús, Tristán, Enriqueta, Rios Villegas, Maria Jose, Garces, Atsegiñe Canga, Amo, Erika Castro, Guerrero, Raquel Coya, Goikoetxea, Josune, Jorge, Leticia, Perez, Cristina, Fariñas Álvarez, María Carmen, Cuadra, Manuel Gutierrez, Arnaiz de las Revillas Almajano, Francisco, Garcia, Pilar Bohedo, Poderos, Teresa Giménez, Rico, Claudia González, Sanchez, Blanca, Valero, Olga, Vega, Noelia, Campbell, John, Barnes, Anna, Catterick, Helen, Cranston, Tim, Dawe, Phoebe, Fletcher, Emily, Fouracre, Liam, Gifford, Alison, Kirkwood, John, Martin, Christopher, McAnew, Amy, Mitchell, Marcus, Newman, Georgina, O'Connell, Abby, Onysk, Jakob, Quinn, Lynne, Rhodes, Shelley, Stone, Samuel, Symons, Lorrie, Tripp, Harry, Warris, Adilia, Watkins, Darcy, Whale, Bethany, Harding, Alex, Lockhart, Gemma, Sidaway-Lee, Kate, Hilton, Sam, Manton, Sarah, Webber-Rookes, Daniel, Winder, Rachel, Moore, James, Bateman, Freya, Gibbons, Michael, Knight, Bridget, Moss, Julie, Statton, Sarah, Studham, Josephine, Hall, Lydia, Moyle, Will, Venton, Tamsin, Pittet, Laure F., Moore, Cecilia L., Dalcolmo, Margareth, Douglas, Mark W., Lacerda, Marcus V.G., Lynn, David J., de Oliveira, Roberto D., Perrett, Kirsten P., Richmond, Peter C., Rocha, Jorge L., Rodriguez-Baño, Jesus, Wood, Nicholas J., and Messina, Nicole L.
- Published
- 2023
- Full Text
- View/download PDF
9. Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial
- Author
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Pittet, Laure F., primary, Messina, Nicole L., additional, McDonald, Ellie, additional, Orsini, Francesca, additional, Barry, Simone, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Croda, Mariana G., additional, Dalcolmo, Margareth, additional, Gardiner, Kaya, additional, Gwee, Amanda, additional, Jardim, Bruno, additional, Lacerda, Marcus V.G., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, Perrett, Kirsten P., additional, Post, Jeffrey J., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rocha, Jorge L., additional, Rodriguez-Baño, Jesus, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Davidson, Andrew, additional, Curtis, Nigel, additional, Jamieson, Tenaya, additional, Messina, Nicole, additional, Morawakage, Thilanka, additional, Perlen, Susan, additional, Perrett, Kirsten, additional, Pittet, Laure, additional, Sastry, Amber, additional, Teo, Jia Wei, additional, Lee, Katherine, additional, Moore, Cecilia, additional, Vidmar, Suzanna, additional, Ali, Rashida, additional, Dunn, Ross, additional, Edler, Peta, additional, Gell, Grace, additional, Goodall, Casey, additional, Hall, Richard, additional, Krastev, Ann, additional, La, Nathan, additional, McPhate, Nick, additional, Nguyen, Thao, additional, Ren, Jack, additional, Stevens, Luke, additional, Alamrousi, Ahmed, additional, Bonnici, Rhian, additional, Dang, Thanh, additional, Germano, Susie, additional, Hua, Jenny, additional, McElroy, Rebecca, additional, Razmovska, Monica, additional, Reddiex, Scott, additional, Wang, Xiaofang, additional, Anderson, Jeremy, additional, Azzopardi, Kristy, additional, Bennett-Wood, Vicki, additional, Czajko, Anna, additional, Mazarakis, Nadia, additional, McCafferty, Conor, additional, Oppedisano, Frances, additional, Ortika, Belinda, additional, Pell, Casey, additional, Spry, Leena, additional, Toh, Ryan, additional, Velagapudi, Sunitha, additional, Vlahos, Amanda, additional, Wee-Hee, Ashleigh, additional, Ramos, Pedro, additional, De La Cruz, Karina, additional, Gamage, Dinusha, additional, Karunanayake, Anushka, additional, Mezzetti, Isabella, additional, Ong, Benjamin, additional, Singh, Ronita, additional, Sooriyarachchi, Enoshini, additional, Nicholson, Suellen, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Huang, Han, additional, Abruzzo, Veronica, additional, Bealing, Morgan, additional, Bimboese, Patricia, additional, Bowes, Kirsty, additional, Burrell, Emma, additional, Chan, Joyce, additional, Cushnahan, Jac, additional, Elborough, Hannah, additional, Elkington, Olivia, additional, Fahey, Kieran, additional, Fernandez, Monique, additional, Flynn, Catherine, additional, Fowler, Sarah, additional, Andrit, Marie Gentile, additional, Gladanac, Bojana, additional, Hammond, Catherine, additional, Ma, Norine, additional, Macalister, Sam, additional, Milojevic, Emmah, additional, Mojeed, Jesutofunmi, additional, Nguyen, Jill, additional, O'Donnell, Liz, additional, Olivier, Nadia, additional, Ooi, Isabelle, additional, Reynolds, Stephanie, additional, Shen, Lisa, additional, Sherry, Barb, additional, Spotswood, Judith, additional, Wedderburn, Jamie, additional, Younes, Angela, additional, Legge, Donna, additional, Bell, Jason, additional, Cheah, Jo, additional, Cobbledick, Annie, additional, Lim, Kee, additional, Elia, Sonja, additional, Addlem, Lynne, additional, Bourke, Anna, additional, Brophy, Clare, additional, Henare, Nadine, additional, Jenkins, Narelle, additional, Machingaifa, Francesca, additional, Miller, Skye, additional, Mitchell, Kirsten, additional, Pitkin, Sigrid, additional, Wall, Kate, additional, Villanueva, Paola, additional, Crawford, Nigel, additional, Norton, Wendy, additional, Tan, Niki, additional, Chengodu, Thilakavathi, additional, Dawson, Diane, additional, Gordon, Victoria, additional, Korman, Tony, additional, O'Bryan, Jess, additional, Agius, Sophie, additional, Bannister, Samantha, additional, Bucholc, Jess, additional, Burns, Alison, additional, Camesella, Beatriz, additional, Carlin, John, additional, Ciaverella, Marianna, additional, Curtis, Maxwell, additional, Firth, Stephanie, additional, Guo, Christina, additional, Hannan, Matthew, additional, Hill, Erin, additional, Joshi, Sri, additional, Lieschke, Katherine, additional, Mathers, Megan, additional, Odoi, Sasha, additional, Rak, Ashleigh, additional, Richards, Chris, additional, Steve, Leah, additional, Stewart, Carolyn, additional, Sudbury, Eva, additional, Thomson, Helen, additional, Watts, Emma, additional, Williams, Fiona, additional, Young, Angela, additional, Glenn, Penny, additional, Kaynes, Andrew, additional, De Floy, Amandine Philippart, additional, Buchanan, Sandy, additional, Sondag, Thijs, additional, Xie, Ivy, additional, Edmund, Harriet, additional, Byrne, Bridie, additional, Keeble, Tom, additional, Ngien, Belle, additional, Noonan, Fran, additional, Wearing-Smith, Michelle, additional, Clarke, Alison, additional, Davies, Pemma, additional, Eastwood, Oliver, additional, Ellinghaus, Alric, additional, Ghieh, Rachid, additional, Hilton, Zahra, additional, Jennings, Emma, additional, Kakkos, Athina, additional, Liang, Iris, additional, Nicol, Katie, additional, O'Callaghan, Sally, additional, Osman, Helen, additional, Rajaram, Gowri, additional, Ratcliffe, Sophia, additional, Rayner, Victoria, additional, Salmon, Ashleigh, additional, Scheppokat, Angela, additional, Stevens, Aimee, additional, Street, Rebekah, additional, Toogood, Nicholas, additional, Wood, Nicholas, additional, Bahaduri, Twinkle, additional, Baulman, Therese, additional, Byrne, Jennifer, additional, Carter, Candace, additional, Corbett, Mary, additional, Dao, Aiken, additional, Desylva, Maria, additional, Dunn, Andrew, additional, Gardiner, Evangeline, additional, Joyce, Rosemary, additional, Kandasamy, Rama, additional, Munns, Craig, additional, Pelayo, Lisa, additional, Sharma, Ketaki, additional, Sterling, Katrina, additional, Uren, Caitlin, additional, Colaco, Clinton, additional, Douglas, Mark, additional, Hamilton, Kate, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Palasanthiran, Pamela, additional, Williams, Phoebe, additional, Beardsley, Justin, additional, Bergant, Nikki, additional, Lagunday, Renier, additional, Overton, Kristen, additional, Post, Jeffrey, additional, Al-Hindawi, Yasmeen, additional, Barney, Sarah, additional, Byrne, Anthony, additional, Mead, Lee, additional, Plit, Marshall, additional, Lynn, David, additional, Benson, Saoirse, additional, Blake, Stephen, additional, Botten, Rochelle, additional, Chern, Tee Yee, additional, Eden, Georgina, additional, Griffith, Liddy, additional, James, Jane, additional, Lynn, Miriam, additional, Markow, Angela, additional, Sacca, Domenic, additional, Stevens, Natalie, additional, Wesselingh, Steve, additional, Doran, Catriona, additional, Sawka, Alice, additional, Evans, Sue, additional, Goodchild, Louise, additional, Heath, Christine, additional, Krieg, Meredith, additional, Marshall, Helen, additional, McMillan, Mark, additional, Walker, Mary, additional, Richmond, Peter, additional, Amenyogbe, Nelly, additional, Anthony, Christina, additional, Arnold, Annabelle, additional, Arrowsmith, Beth, additional, Ben-Othman, Rym, additional, Clark, Sharon, additional, Dunnill, Jemma, additional, Eiffler, Nat, additional, Ewe, Krist, additional, Finucane, Carolyn, additional, Flynn, Lorraine, additional, Gibson, Camille, additional, Hartnell, Lucy, additional, Hollams, Elysia, additional, Hutton, Heidi, additional, Jarvis, Lance, additional, Jones, Jane, additional, Jones, Jan, additional, Jones, Karen, additional, Kent, Jennifer, additional, Kollmann, Tobias, additional, Lalich, Debbie, additional, Lee, Wenna, additional, Lim, Rachel, additional, McAlister, Sonia, additional, McDonald, Fiona, additional, Meehan, Andrea, additional, Minhaj, Asma, additional, Montgomery, Lisa, additional, O'Donnell, Melissa, additional, Ong, Jaslyn, additional, Ong, Joanne, additional, Parkin, Kimberley, additional, Perez, Glady, additional, Power, Catherine, additional, Rezazadeh, Shadie, additional, Richmond, Holly, additional, Rogers, Sally, additional, Schultz, Nikki, additional, Shave, Margaret, additional, Skut, Patrycja, additional, Stiglmayer, Lisa, additional, Truelove, Alexandra, additional, Wadia, Ushma, additional, Wallace, Rachael, additional, Waring, Justin, additional, England, Michelle, additional, Latkovic, Erin, additional, Herrmann, Susan, additional, Lacerda, Marcus, additional, Andrade, Paulo Henrique, additional, Barbosa, Fabiane Bianca, additional, Barros, Dayanne, additional, Brasil, Larissa, additional, Capella, Ana Greyce, additional, Castro, Ramon, additional, Costa, Erlane, additional, de Souza, Dilcimar, additional, Dias, Maianne, additional, Dias, José, additional, Ferreira, Klenilson, additional, Figueiredo, Paula, additional, Freitas, Thamires, additional, Furtado, Ana Carolina, additional, Gama, Larissa, additional, Godinho, Vanessa, additional, Gouy, Cintia, additional, Hinojosa, Daniele, additional, Jardim, Tyane, additional, Junior, Joel, additional, Lima, Augustto, additional, Maia, Bernardo, additional, Marins, Adriana, additional, Mazurega, Kelry, additional, Medeiros, Tercilene, additional, Melo, Rosangela, additional, Moraes, Marinete, additional, Nascimento, Elizandra, additional, Neves, Juliana, additional, Oliveira, Maria Gabriela, additional, Oliveira, Thais, additional, Oliveira, Ingrid, additional, Otsuka, Arthur, additional, Paes, Rayssa, additional, Pereira, Handerson, additional, Pereira, Gabrielle, additional, Prado, Christiane, additional, Queiroz, Evelyn, additional, Rodrigues, Laleyska, additional, Rodrigues, Bebeto, additional, Sampaio, Vanderson, additional, Santos, Anna Gabriela, additional, Santos, Daniel, additional, Santos, Tilza, additional, Santos, Evelyn, additional, Sartim, Ariandra, additional, Silva, Ana Beatriz, additional, Silva, Juliana, additional, Silva, Emanuelle, additional, Simão, Mariana, additional, Soares, Caroline, additional, Sousa, Antonny, additional, Trindade, Alexandre, additional, Val, Fernando, additional, Vasconcelos, Adria, additional, Vasconcelos, Heline, additional, Abreu, Carolinne, additional, Almeida, Katya Martinez, additional, Bitencourt de Andrade, Camila, additional, Campos Angelo, Jhenyfer Thalyta, additional, Gonçalvez de Araújo Arcanjo, Ghislaine, additional, Silva Menezes Arruda, Bianca Maria, additional, Ayala, Wellyngthon Espindola, additional, Refosco Barbosa, Adelita Agripina, additional, Vieira Batista, Felipe Zampieri, additional, de Morais Batista, Fabiani, additional, de Jesus Costa, Miriam, additional, Croda, Mariana Garcia, additional, Alves da Cruz, Lais, additional, Pereira Diogo, Roberta Carolina, additional, Dutra Escobar, Rodrigo Cezar, additional, Fernandes, Iara Rodrigues, additional, Figueiredo, Leticia Ramires, additional, Cavalcanti Gonçalves, Leandro Galdino, additional, Lahdo, Sarita, additional, Lencina, Joyce dos Santos, additional, Teodoro de Lima, Guilherme, additional, LEOPOLDINA MEIRELES, Bruna Tayara, additional, Moreira, Debora Quadros, additional, Silva Muranaka, Lilian Batista, additional, de Oliveira, Adriely, additional, Warszawski de Oliveira, Karla Regina, additional, Vieira de Oliveira, Matheus, additional, Dias de Oliveira, Roberto, additional, Pereira, Andrea Antonia Souza de Almeida dos Reis, additional, Puga, Marco, additional, Ramos, Caroliny Veron, additional, Souza da Rosa, Thaynara Haynara, additional, Lopes dos Santos, Karla, additional, Ribeiro dos Santos, Claudinalva, additional, Leopoldina dos Santos, Dyenyffer Stéffany, additional, Santos, Karina Marques, additional, Pereira da Silva, Paulo César, additional, Rocha da Silva, Paulo Victor, additional, Silva, Débora dos Santos, additional, Vieira da Silva, Patricia, additional, Freitas da Rosa Soares, Bruno, additional, Sperotto, Mariana Gazzoni, additional, Tadokoro, Mariana Mayumi, additional, Tsuha, Daniel, additional, Ramos Vieira, Hugo Miguel, additional, Pretti Dalcolmo, Margareth Maria, additional, Lopes Alves da Paixão, Cíntia Maria, additional, Corrêa E Castro, Gabriela, additional, Collopy, Simone Silva, additional, da Costa Silva, Renato, additional, Almeida da Silveira, Samyra, additional, Da-Cruz, Alda Maria, additional, Maria da Silva Passos de Carvalho, Alessandra, additional, de Cássia Batista, Rita, additional, Silva De Freitas, Maria Luciana, additional, Gerhardt de Oliveira Ferreira, Aline, additional, Conceição de Souza, Ana Paula, additional, Doblas, Paola Cerbino, additional, Alcoforado da Silva dos Santos, Ayla, additional, Cristine de Moraes dos Santos, Vanessa, additional, Alves dos Santos Gomes, Dayane, additional, Fortunato, Anderson Lage, additional, Gomes-Silva, Adriano, additional, Gonçalves, Monique Pinto, additional, Garcia Meireless Junior, Paulo Leandro, additional, Martins da Costa Carvalho, Estela, additional, Motta, Fernando do Couto, additional, Olivo de Mendonça, Ligia Maria, additional, Pandine, Girlene dos Santos, additional, Plácido Pereira, Rosa Maria, additional, Maia, Ivan Ramos, additional, Luiz da Rocha, Jorge, additional, Paiva Romano, João Victor, additional, Santos, Glauce dos, additional, Fernandes da Silva, Erica, additional, Mendonça Teixeira de Siqueira, Marilda Agudo, additional, Prudêncio Soares, Ágatha Cristinne, additional, Arroyo, Sandra Franch, additional, Besten, Henny Ophorst-den, additional, Boon, Anna, additional, Brakke, Karin M., additional, Janssen, Axel, additional, Koopmans, Marijke A.H., additional, Lemmens, Toos, additional, Leurink, Titia, additional, Septer-Bijleveld, Engelien, additional, Stadhouders, Kimberly, additional, Troeman, Darren, additional, van der Waal, Marije, additional, van Opdorp, Marjoleine, additional, van Sluis, Nicolette, additional, Wolters, Beatrijs, additional, Kluytmans, Jan, additional, Romme, Jannie, additional, van den Bijllaardt, Wouter, additional, van Mook, Linda, additional, Rijen, M.M.L (Miranda) van, additional, Filius, P.M.G., additional, Gisolf, Jet, additional, Greven, Frances, additional, Huijbens, Danique, additional, Hassing, Robert Jan, additional, Pon, R.C., additional, Preijers, Lieke, additional, van Leusen, J.H., additional, Verheij, Harald, additional, Boersma, Wim, additional, Brans, Evelien, additional, Kloeg, Paul, additional, Molenaar-Groot, Kitty, additional, Nguyen, Nhat Khanh, additional, Paternotte, Nienke, additional, Rol, Anke, additional, Stooper, Lida, additional, Dijkstra, Helga, additional, Eggenhuizen, Esther, additional, Huijs, Lucas, additional, Moorlag, Simone, additional, Netea, Mihai, additional, Pranger, Eva, additional, Taks, Esther, additional, Oever, Jaap ten, additional, Heine, Rob ter, additional, Blauwendraat, Kitty, additional, Meek, Bob, additional, Erkaya, Isil, additional, Harbech, Houda, additional, Roescher, Nienke, additional, Peeters, Rifka, additional, Riele, Menno te, additional, Zhou, Carmen, additional, Calbo, Esther, additional, Marti, Cristina Badia, additional, Palomares, Emma Triviño, additional, Porcuna, Tomás Perez, additional, Barriocanal, Anabel, additional, Barriocanal, Ana Maria, additional, Casas, Irma, additional, Dominguez, Jose, additional, Esteve, Maria, additional, Lacoma, Alicia, additional, Latorre, Irene, additional, Molina, Gemma, additional, Molina, Barbara, additional, Rosell, Antoni, additional, Vidal, Sandra, additional, Barrera, Lydia, additional, Bustos, Natalia, additional, Calderón, Ines Portillo, additional, Campos, David Gutierrez, additional, Carretero, Jose Manuel, additional, Castellano, Angel Dominguez, additional, Compagnone, Renato, additional, Ramirez de Arellano, Encarnacion, additional, Serna, Almudena de la, additional, del Toro Lopez, Maria Dolores, additional, Clement Espindola, Marie-Alix, additional, Martin Gutierrez, Ana Belen, additional, Hernandez, Alvaro Pascual, additional, Jiménez, Virginia Palomo, additional, Moreno, Elisa, additional, Navarrete, Nicolas, additional, Paño, Teresa Rodriguez, additional, Rodríguez-Baño, Jesús, additional, Tristán, Enriqueta, additional, Rios Villegas, Maria Jose, additional, Garces, Atsegiñe Canga, additional, Amo, Erika Castro, additional, Guerrero, Raquel Coya, additional, Goikoetxea, Josune, additional, Jorge, Leticia, additional, Perez, Cristina, additional, Fariñas Álvarez, María Carmen, additional, Cuadra, Manuel Gutierrez, additional, Arnaiz de las Revillas Almajano, Francisco, additional, Garcia, Pilar Bohedo, additional, Poderos, Teresa Giménez, additional, Rico, Claudia González, additional, Sanchez, Blanca, additional, Valero, Olga, additional, Vega, Noelia, additional, Barnes, Anna, additional, Catterick, Helen, additional, Cranston, Tim, additional, Dawe, Phoebe, additional, Fletcher, Emily, additional, Fouracre, Liam, additional, Gifford, Alison, additional, Gow, Neil, additional, Kirkwood, John, additional, Martin, Christopher, additional, McAnew, Amy, additional, Mitchell, Marcus, additional, Newman, Georgina, additional, O'Connell, Abby, additional, Onysk, Jakob, additional, Quinn, Lynne, additional, Rhodes, Shelley, additional, Stone, Samuel, additional, Symons, Lorrie, additional, Tripp, Harry, additional, Watkins, Darcy, additional, Whale, Bethany, additional, Harding, Alex, additional, Lockhart, Gemma, additional, Sidaway-Lee, Kate, additional, Hilton, Sam, additional, Manton, Sarah, additional, Webber-Rookes, Daniel, additional, Winder, Rachel, additional, Moore, James, additional, Bateman, Freya, additional, Gibbons, Michael, additional, Knight, Bridget, additional, Moss, Julie, additional, Statton, Sarah, additional, Studham, Josephine, additional, Hall, Lydia, additional, Moyle, Will, additional, and Venton, Tamsin, additional
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- 2024
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10. No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines
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Stevens, Natalie E., Ryan, Feargal J., Messina, Nicole L., Blake, Stephen J., Norton, Todd S., Germano, Susie, James, Jane, Eden, Georgina L., Tee, Yee C., Lynn, Miriam A., Botten, Rochelle, Barry, Simone E., Curtis, Nigel, and Lynn, David J.
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AstraZeneca PLC ,Messenger RNA -- Analysis -- Health aspects ,Health care industry ,Comirnaty (Vaccine) -- Health aspects - Abstract
To the Editor: Trained immunity (TI) is defined as the long-term metabolic and epigenomic reprogramming of innate immune cells, priming them for enhanced responses to subsequent challenges, including unrelated infections [...]
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- 2023
11. Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination
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Villanueva, Paola, Crawford, Nigel W., Croda, Mariana Garcia, Collopy, Simone, Jardim, Bruno Araújo, de Almeida Pinto Jardim, Tyane, Manning, Laurens, Lucas, Michaela, Marshall, Helen, Prat-Aymerich, Cristina, Sawka, Alice, Sharma, Ketaki, Troeman, Darren, Wadia, Ushma, Warris, Adilia, Wood, Nicholas, Messina, Nicole L., Curtis, Nigel, and Pittet, Laure F.
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- 2023
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12. A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines
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Ryan, Feargal J., Norton, Todd S., McCafferty, Conor, Blake, Stephen J., Stevens, Natalie E., James, Jane, Eden, Georgina L., Tee, Yee C., Benson, Saoirse C., Masavuli, Makutiro G., Yeow, Arthur E.L., Abayasingam, Arunasingam, Agapiou, David, Stevens, Hannah, Zecha, Jana, Messina, Nicole L., Curtis, Nigel, Ignjatovic, Vera, Monagle, Paul, Tran, Huyen, McFadyen, James D., Bull, Rowena A., Grubor-Bauk, Branka, Lynn, Miriam A., Botten, Rochelle, Barry, Simone E., and Lynn, David J.
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- 2023
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13. Factors influencing adverse events following COVID-19 vaccination
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Villanueva, Paola, primary, McDonald, Ellie, additional, Croda, Julio, additional, Croda, Mariana Garcia, additional, Dalcolmo, Margareth, additional, dos Santos, Glauce, additional, Jardim, Bruno, additional, Lacerda, Marcus, additional, Lynn, David J., additional, Marshall, Helen, additional, Oliveira, Roberto D., additional, Rocha, Jorge, additional, Sawka, Alice, additional, Val, Fernando, additional, Pittet, Laure F., additional, Messina, Nicole L., additional, and Curtis, Nigel, additional
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- 2024
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14. Revaccination with Bacille Calmette-Guérin (BCG) is associated with an increased risk of abscess and lymphadenopathy
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Villanueva, Paola, Wadia, Ushma, Crawford, Nigel, Messina, Nicole L., Kollmann, Tobias R., Lucas, Michaela, Manning, Laurens, Richmond, Peter, Pittet, Laure F., and Curtis, Nigel
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- 2022
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15. Neonatal BCG Vaccination for Prevention of Allergy in Infants: The MIS BAIR Randomised Controlled Trial.
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Messina, Nicole L., Gardiner, Kaya, Pittet, Laure F., Forbes, Emily K., Francis, Kate L., Freyne, Bridget, Zufferey, Christel, Abruzzo, Veronica, Morison, Clare, Turner, Hannah, Allen, Katrina J., Flanagan, Katie L., Ponsonby, Anne‐Louise, Robins‐Browne, Roy, Shann, Frank, Vuillermin, Peter, Donath, Susan, Casalaz, Dan, and Curtis, Nigel
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BCG vaccines , *DELIVERY (Obstetrics) , *HEPATITIS B vaccines , *INFANTS , *FOOD allergy - Abstract
ABSTRACT Background Objective Methods Results Conclusions and Clinical Relevance The beneficial off‐target effects of Bacille Calmette–Guérin (BCG) vaccination potentially include protection against allergy.In the MIS BAIR trial, we aimed to determine whether neonatal BCG vaccination reduces atopic sensitisation and clinical food allergy in infants.In this randomised controlled trial, 1272 neonates were allocated to BCG‐Denmark vaccine (0.05 mL intradermal dose) or no BCG at birth. Randomisation was stratified by recruitment site, mode of delivery and plurality of birth. The primary outcome was the incidence of atopic sensitisation determined by skin prick test at 1 year of age. Food allergy was determined by 3‐monthly online questionnaires and oral food challenges. Data were analysed by intention‐to‐treat using binary regression. Clinicaltrials.gov (NCT01906853).Atopic sensitisation during the first year of life was 22.9% among infants in the BCG group and 18.9% in the control group (adjusted risk difference (aRD) 3.8% (95% CI −1.5 to 9.1) after multiple imputation). Clinical food allergy was similar between infants in the BCG and control groups (9.8% vs. 9.6%; aRD 0.2, 95% CI −3.4 to 3.8). An interaction was observed between the primary outcome and maternal history of BCG vaccination. No interaction was observed for the additional prespecified potential effect modifiers tested (sex, delivery mode, family history of any allergy, season of birth, hepatitis B vaccination at randomisation, BCG scar and age at BCG administration).Neonatal BCG‐Denmark vaccination does not protect against atopic sensitisation or clinical food allergy in the first year of life. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Inappropriate prescribing contributes to high antibiotic exposure in young children in Australia.
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Netea, Stejara A, Messina, Nicole L, Gardiner, Kaya, Pittet, Laure F, Curtis, Nigel, and consortium, the MIS BAIR trial
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INAPPROPRIATE prescribing (Medicine) , *ANTIBIOTICS , *RESPIRATORY infections , *CESAREAN section , *DELIVERY (Obstetrics) , *MATERNAL exposure , *WEIGHT gain - Abstract
Background Antibiotic exposure increases antimicrobial resistance and has also been associated with long-term harms, including allergies, inflammatory diseases and weight gain. We assessed antibiotic exposure in the first 2 years of life in Australian children, the factors influencing this and its appropriateness. Methods Data from 1201 participants in the MIS BAIR randomized controlled trial were used. Multivariable logistic regression was used to identify factors associated with antibiotic exposure. Results At 1 and 2 years of age, exposure to at least one course of antibiotics was 43% and 67%, with the highest first antibiotic prescription rate between 9 and 18 months. Amoxicillin was the most frequently used antibiotic (59%), followed by cefalexin (7%). The most common diagnoses for which antibiotics were prescribed were respiratory tract infections from 0 to 6 months of age and otitis media from 6 to 12 months. Factors associated with antibiotic exposure from 0 to 12 months of age were delivery by Caesarean section (adjusted odd-ratio (aOR) 1.5, 95%CI 1.1–1.9), birth in winter (aOR 1.7, 95%CI 1.2–2.4), maternal antibiotic exposure during the last trimester of pregnancy (aOR 1.6, 95%CI 1.1–2.3), cessation of breastfeeding by 6 months of age (aOR 1.5, 95%CI 1.1–2.0) and day-care attendance (aOR 1.4, 95%CI 1.1–1.8). Based on parent-reported questionnaires, 27% of infants were treated in the first year of life for conditions unlikely to need antibiotic treatment. Conclusion At least two-thirds of children were prescribed antibiotics in the first 2 years of life, and more than a quarter of these exposures may have been unnecessary. [ABSTRACT FROM AUTHOR]
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- 2024
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17. The role of antibodies in Bacille Calmette Guérin-mediated immune responses and protection against tuberculosis in humans: A systematic review
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Bright, Matthew R., Curtis, Nigel, and Messina, Nicole L.
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- 2021
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18. Discordance Between Diagnosis Tools for Assessing Eczema in Infants: A Challenge for Intervention Trials
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Pittet, Laure F., Messina, Nicole L., Gardiner, Kaya, Freyne, Bridget, Abruzzo, Veronica, Morrison, Clare, Vuillermin, Peter, Allen, Katrina J., Ponsonby, Anne-Louise, Robins-Browne, Roy, Shann, Frank, Flanagan, Katie L., Donath, Susan, Casalaz, Dan, Phillips, Rod, and Curtis, Nigel
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- 2022
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19. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
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Pittet, Laure F., primary, Moore, Cecilia L., additional, McDonald, Ellie, additional, Barry, Simone, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Davidson, Andrew, additional, Douglas, Mark W., additional, Gardiner, Kaya, additional, Gwee, Amanda, additional, Jardim, Bruno, additional, Lacerda, Marcus V.G., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, de Oliveira, Roberto D., additional, Perrett, Kirsten P., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rocha, Jorge L., additional, Rodriguez-Baño, Jesus, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Messina, Nicole L., additional, Curtis, Nigel, additional, Jamieson, Tenaya, additional, Messina, Nicole, additional, Morawakage, Thilanka, additional, Perlen, Susan, additional, Perrett, Kirsten, additional, Pittet, Laure, additional, Sastry, Amber, additional, Teo, Jia Wei, additional, Orsini, Francesca, additional, Lee, Katherine, additional, Moore, Cecilia, additional, Vidmar, Suzanna, additional, Ali, Rashida, additional, Dunn, Ross, additional, Edler, Peta, additional, Gell, Grace, additional, Goodall, Casey, additional, Hall, Richard, additional, Krastev, Ann, additional, La, Nathan, additional, McPhate, Nick, additional, Nguyen, Thao, additional, Ren, Jack, additional, Stevens, Luke, additional, Alamrousi, Ahmed, additional, Bonnici, Rhian, additional, Dang, Thanh, additional, Germano, Susie, additional, Hua, Jenny, additional, McElroy, Rebecca, additional, Razmovska, Monica, additional, Reddiex, Scott, additional, Wang, Xiaofang, additional, Anderson, Jeremy, additional, Azzopardi, Kristy, additional, Bennett-Wood, Vicki, additional, Czajko, Anna, additional, Mazarakis, Nadia, additional, McCafferty, Conor, additional, Oppedisano, Frances, additional, Ortika, Belinda, additional, Pell, Casey, additional, Spry, Leena, additional, Toh, Ryan, additional, Velagapudi, Sunitha, additional, Vlahos, Amanda, additional, Wee-Hee, Ashleigh, additional, Ramos, Pedro, additional, De La Cruz, Karina, additional, Gamage, Dinusha, additional, Karunanayake, Anushka, additional, Mezzetti, Isabella, additional, Ong, Benjamin, additional, Singh, Ronita, additional, Sooriyarachchi, Enoshini, additional, Nicholson, Suellen, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Huang, Han, additional, Abruzzo, Veronica, additional, Bealing, Morgan, additional, Bimboese, Patricia, additional, Bowes, Kirsty, additional, Burrell, Emma, additional, Chan, Joyce, additional, Cushnahan, Jac, additional, Elborough, Hannah, additional, Elkington, Olivia, additional, Fahey, Kieran, additional, Fernandez, Monique, additional, Flynn, Catherine, additional, Fowler, Sarah, additional, Andrit, Marie Gentile, additional, Gladanac, Bojana, additional, Hammond, Catherine, additional, Ma, Norine, additional, Macalister, Sam, additional, Milojevic, Emmah, additional, Mojeed, Jesutofunmi, additional, Nguyen, Jill, additional, O'Donnell, Liz, additional, Olivier, Nadia, additional, Ooi, Isabelle, additional, Reynolds, Stephanie, additional, Shen, Lisa, additional, Sherry, Barb, additional, Spotswood, Judith, additional, Wedderburn, Jamie, additional, Younes, Angela, additional, Legge, Donna, additional, Bell, Jason, additional, Cheah, Jo, additional, Cobbledick, Annie, additional, Lim, Kee, additional, Elia, Sonja, additional, Addlem, Lynne, additional, Bourke, Anna, additional, Brophy, Clare, additional, Henare, Nadine, additional, Jenkins, Narelle, additional, Machingaifa, Francesca, additional, Miller, Skye, additional, Mitchell, Kirsten, additional, Pitkin, Sigrid, additional, Wall, Kate, additional, Villanueva, Paola, additional, Crawford, Nigel, additional, Norton, Wendy, additional, Tan, Niki, additional, Chengodu, Thilakavathi, additional, Dawson, Diane, additional, Gordon, Victoria, additional, Korman, Tony, additional, O'Bryan, Jess, additional, Agius, Sophie, additional, Bannister, Samantha, additional, Bucholc, Jess, additional, Burns, Alison, additional, Camesella, Beatriz, additional, Carlin, John, additional, Ciaverella, Marianna, additional, Curtis, Maxwell, additional, Firth, Stephanie, additional, Guo, Christina, additional, Hannan, Matthew, additional, Hill, Erin, additional, Joshi, Sri, additional, Lieschke, Katherine, additional, Mathers, Megan, additional, Odoi, Sasha, additional, Rak, Ashleigh, additional, Richards, Chris, additional, Steve, Leah, additional, Stewart, Carolyn, additional, Sudbury, Eva, additional, Thomson, Helen, additional, Watts, Emma, additional, Williams, Fiona, additional, Young, Angela, additional, Glenn, Penny, additional, Kaynes, Andrew, additional, Philippart De Floy, Amandine, additional, Buchanan, Sandy, additional, Sondag, Thijs, additional, Xie, Ivy, additional, Edmund, Harriet, additional, Byrne, Bridie, additional, Keeble, Tom, additional, Ngien, Belle, additional, Noonan, Fran, additional, Wearing-Smith, Michelle, additional, Clarke, Alison, additional, Davies, Pemma, additional, Eastwood, Oliver, additional, Ellinghaus, Alric, additional, Ghieh, Rachid, additional, Hilton, Zahra, additional, Jennings, Emma, additional, Kakkos, Athina, additional, Liang, Iris, additional, Nicol, Katie, additional, O'Callaghan, Sally, additional, Osman, Helen, additional, Rajaram, Gowri, additional, Ratcliffe, Sophia, additional, Rayner, Victoria, additional, Salmon, Ashleigh, additional, Scheppokat, Angela, additional, Stevens, Aimee, additional, Street, Rebekah, additional, Toogood, Nicholas, additional, Wood, Nicholas, additional, Bahaduri, Twinkle, additional, Baulman, Therese, additional, Byrne, Jennifer, additional, Carter, Candace, additional, Corbett, Mary, additional, Dao, Aiken, additional, Desylva, Maria, additional, Dunn, Andrew, additional, Gardiner, Evangeline, additional, Joyce, Rosemary, additional, Kandasamy, Rama, additional, Munns, Craig, additional, Pelayo, Lisa, additional, Sharma, Ketaki, additional, Sterling, Katrina, additional, Uren, Caitlin, additional, Colaco, Clinton, additional, Douglas, Mark, additional, Hamilton, Kate, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Palasanthiran, Pamela, additional, Williams, Phoebe, additional, Beardsley, Justin, additional, Bergant, Nikki, additional, Lagunday, Renier, additional, Overton, Kristen, additional, Post, Jeffrey, additional, Al-Hindawi, Yasmeen, additional, Barney, Sarah, additional, Byrne, Anthony, additional, Mead, Lee, additional, Plit, Marshall, additional, Lynn, David, additional, Benson, Saoirse, additional, Blake, Stephen, additional, Botten, Rochelle, additional, Chern, Tee Yee, additional, Eden, Georgina, additional, Griffith, Liddy, additional, James, Jane, additional, Lynn, Miriam, additional, Markow, Angela, additional, Sacca, Domenic, additional, Stevens, Natalie, additional, Wesselingh, Steve, additional, Doran, Catriona, additional, Sawka, Alice, additional, Evans, Sue, additional, Goodchild, Louise, additional, Heath, Christine, additional, Krieg, Meredith, additional, Marshall, Helen, additional, McMillan, Mark, additional, Walker, Mary, additional, Richmond, Peter, additional, Amenyogbe, Nelly, additional, Anthony, Christina, additional, Arnold, Annabelle, additional, Arrowsmith, Beth, additional, Ben-Othman, Rym, additional, Clark, Sharon, additional, Dunnill, Jemma, additional, Eiffler, Nat, additional, Ewe, Krist, additional, Finucane, Carolyn, additional, Flynn, Lorraine, additional, Gibson, Camille, additional, Hartnell, Lucy, additional, Hollams, Elysia, additional, Hutton, Heidi, additional, Jarvis, Lance, additional, Jones, Jane, additional, Jones, Jan, additional, Jones, Karen, additional, Kent, Jennifer, additional, Kollmann, Tobias, additional, Lalich, Debbie, additional, Lee, Wenna, additional, Lim, Rachel, additional, McAlister, Sonia, additional, McDonald, Fiona, additional, Meehan, Andrea, additional, Minhaj, Asma, additional, Montgomery, Lisa, additional, O'Donnell, Melissa, additional, Ong, Jaslyn, additional, Ong, Joanne, additional, Parkin, Kimberley, additional, Perez, Glady, additional, Power, Catherine, additional, Rezazadeh, Shadie, additional, Richmond, Holly, additional, Rogers, Sally, additional, Schultz, Nikki, additional, Shave, Margaret, additional, Skut, Patrycja, additional, Stiglmayer, Lisa, additional, Truelove, Alexandra, additional, Wadia, Ushma, additional, Wallace, Rachael, additional, Waring, Justin, additional, England, Michelle, additional, Latkovic, Erin, additional, Herrmann, Susan, additional, Lacerda, Marcus, additional, Andrade, Paulo Henrique, additional, Barbosa, Fabiane Bianca, additional, Barros, Dayanne, additional, Brasil, Larissa, additional, Capella, Ana Greyce, additional, Castro, Ramon, additional, Costa, Erlane, additional, de Souza, Dilcimar, additional, Dias, Maianne, additional, Dias, José, additional, Ferreira, Klenilson, additional, Figueiredo, Paula, additional, Freitas, Thamires, additional, Furtado, Ana Carolina, additional, Gama, Larissa, additional, Godinho, Vanessa, additional, Gouy, Cintia, additional, Hinojosa, Daniele, additional, Jardim, Tyane, additional, Junior, Joel, additional, Lima, Augustto, additional, Maia, Bernardo, additional, Marins, Adriana, additional, Mazurega, Kelry, additional, Medeiros, Tercilene, additional, Melo, Rosangela, additional, Moraes, Marinete, additional, Nascimento, Elizandra, additional, Neves, Juliana, additional, Oliveira, Maria Gabriela, additional, Oliveira, Thais, additional, Oliveira, Ingrid, additional, Otsuka, Arthur, additional, Paes, Rayssa, additional, Pereira, Handerson, additional, Pereira, Gabrielle, additional, Prado, Christiane, additional, Queiroz, Evelyn, additional, Rodrigues, Laleyska, additional, Rodrigues, Bebeto, additional, Sampaio, Vanderson, additional, Santos, Anna Gabriela, additional, Santos, Daniel, additional, Santos, Tilza, additional, Santos, Evelyn, additional, Sartim, Ariandra, additional, Silva, Ana Beatriz, additional, Silva, Juliana, additional, Silva, Emanuelle, additional, Simão, Mariana, additional, Soares, Caroline, additional, Sousa, Antonny, additional, Trindade, Alexandre, additional, Val, Fernando, additional, Vasconcelos, Adria, additional, Vasconcelos, Heline, additional, Abreu, Carolinne, additional, Almeida, Katya Martinez, additional, Bitencourt de Andrade, Camila, additional, Campos Angelo, Jhenyfer Thalyta, additional, Gonçalvez de Araújo Arcanjo, Ghislaine, additional, Silva Menezes Arruda, Bianca Maria, additional, Ayala, Wellyngthon Espindola, additional, Refosco Barbosa, Adelita Agripina, additional, Vieira Batista, Felipe Zampieri, additional, de Morais Batista, Fabiani, additional, de Jesus Costa, Miriam, additional, Croda, Mariana Garcia, additional, Alves da Cruz, Lais, additional, Pereira Diogo, Roberta Carolina, additional, Dutra Escobar, Rodrigo Cezar, additional, Fernandes, Iara Rodrigues, additional, Figueiredo, Leticia Ramires, additional, Cavalcanti Gonçalves, Leandro Galdino, additional, Lahdo, Sarita, additional, Lencina, Joyce dos Santos, additional, Teodoro de Lima, Guilherme, additional, Matos, Larissa Santos, additional, Leopoldina Meireles, Bruna Tayara, additional, Moreira, Debora Quadros, additional, Silva Muranaka, Lilian Batista, additional, de Oliveira, Adriely, additional, Warszawski de Oliveira, Karla Regina, additional, Vieira de Oliveira, Matheus, additional, Dias de Oliveira, Roberto, additional, Souza de Almeida dos Reis Pereira, Andrea Antonia, additional, Puga, Marco, additional, Ramos, Caroliny Veron, additional, Souza da Rosa, Thaynara Haynara, additional, Lopes dos Santos, Karla, additional, Ribeiro dos Santos, Claudinalva, additional, Leopoldina dos Santos, Dyenyffer Stéffany, additional, Santos, Karina Marques, additional, Pereira da Silva, Paulo César, additional, Rocha da Silva, Paulo Victor, additional, Silva, Débora dos Santos, additional, Vieira da Silva, Patricia, additional, Freitas da Rosa Soares, Bruno, additional, Sperotto, Mariana Gazzoni, additional, Tadokoro, Mariana Mayumi, additional, Tsuha, Daniel, additional, Ramos Vieira, Hugo Miguel, additional, Pretti Dalcolmo, Margareth Maria, additional, Lopes Alves da Paixão, Cíntia Maria, additional, Corrêa E Castro, Gabriela, additional, Collopy, Simone Silva, additional, da Costa Silva, Renato, additional, Almeida da Silveira, Samyra, additional, Da-Cruz, Alda Maria, additional, Maria da Silva Passos de Carvalho, Alessandra, additional, de Cássia Batista, Rita, additional, Silva De Freitas, Maria Luciana, additional, Gerhardt de Oliveira Ferreira, Aline, additional, Conceição de Souza, Ana Paula, additional, Doblas, Paola Cerbino, additional, Alcoforado da Silva dos Santos, Ayla, additional, Cristine de Moraes dos Santos, Vanessa, additional, Alves dos Santos Gomes, Dayane, additional, Fortunato, Anderson Lage, additional, Gomes-Silva, Adriano, additional, Gonçalves, Monique Pinto, additional, Garcia Meireless Junior, Paulo Leandro, additional, Martins da Costa Carvalho, Estela, additional, Motta, Fernando do Couto, additional, Olivo de Mendonça, Ligia Maria, additional, Pandine, Girlene dos Santos, additional, Plácido Pereira, Rosa Maria, additional, Maia, Ivan Ramos, additional, Luiz da Rocha, Jorge, additional, Paiva Romano, João Victor, additional, Santos, Glauce dos, additional, Fernandes da Silva, Erica, additional, Mendonça Teixeira de Siqueira, Marilda Agudo, additional, Prudêncio Soares, Ágatha Cristinne, additional, Arroyo, Sandra Franch, additional, Besten, Henny Ophorst-den, additional, Boon, Anna, additional, Brakke, Karin M., additional, Janssen, Axel, additional, Koopmans, Marijke A.H., additional, Lemmens, Toos, additional, Leurink, Titia, additional, Septer-Bijleveld, Engelien, additional, Stadhouders, Kimberly, additional, Troeman, Darren, additional, van der Waal, Marije, additional, van Opdorp, Marjoleine, additional, van Sluis, Nicolette, additional, Wolters, Beatrijs, additional, Kluytmans, Jan, additional, Romme, Jannie, additional, van den Bijllaardt, Wouter, additional, van Mook, Linda, additional, Rijen, M.M.L (Miranda) van, additional, Filius, P.M.G., additional, Gisolf, Jet, additional, Greven, Frances, additional, Huijbens, Danique, additional, Hassing, Robert Jan, additional, Pon, R.C., additional, Preijers, Lieke, additional, van Leusen, J.H., additional, Verheij, Harald, additional, Boersma, Wim, additional, Brans, Evelien, additional, Kloeg, Paul, additional, Molenaar-Groot, Kitty, additional, Nguyen, Nhat Khanh, additional, Paternotte, Nienke, additional, Rol, Anke, additional, Stooper, Lida, additional, Dijkstra, Helga, additional, Eggenhuizen, Esther, additional, Huijs, Lucas, additional, Moorlag, Simone, additional, Netea, Mihai, additional, Pranger, Eva, additional, Taks, Esther, additional, Oever, Jaap ten, additional, Heine, Rob ter, additional, Blauwendraat, Kitty, additional, Meek, Bob, additional, Erkaya, Isil, additional, Harbech, Houda, additional, Roescher, Nienke, additional, Peeters, Rifka, additional, Riele, Menno te, additional, Zhou, Carmen, additional, Calbo, Esther, additional, Marti, Cristina Badia, additional, Palomares, Emma Triviño, additional, Porcuna, Tomás Perez, additional, Barriocanal, Anabel, additional, Barriocanal, Ana Maria, additional, Casas, Irma, additional, Dominguez, Jose, additional, Esteve, Maria, additional, Lacoma, Alicia, additional, Latorre, Irene, additional, Molina, Gemma, additional, Molina, Barbara, additional, Rosell, Antoni, additional, Vidal, Sandra, additional, Barrera, Lydia, additional, Bustos, Natalia, additional, Calderón, Ines Portillo, additional, Campos, David Gutierrez, additional, Carretero, Jose Manuel, additional, Castellano, Angel Dominguez, additional, Compagnone, Renato, additional, Ramirez de Arellano, Encarnacion, additional, Serna, Almudena de la, additional, Dolores del Toro Lopez, Maria, additional, Clement Espindola, Marie-Alix, additional, Martin Gutierrez, Ana Belen, additional, Hernandez, Alvaro Pascual, additional, Jiménez, Virginia Palomo, additional, Moreno, Elisa, additional, Navarrete, Nicolas, additional, Paño, Teresa Rodriguez, additional, Rodríguez-Baño, Jesús, additional, Tristán, Enriqueta, additional, Rios Villegas, Maria Jose, additional, Garces, Atsegiñe Canga, additional, Amo, Erika Castro, additional, Guerrero, Raquel Coya, additional, Goikoetxea, Josune, additional, Jorge, Leticia, additional, Perez, Cristina, additional, Fariñas Álvarez, María Carmen, additional, Cuadra, Manuel Gutierrez, additional, Arnaiz de las Revillas Almajano, Francisco, additional, Garcia, Pilar Bohedo, additional, Poderos, Teresa Giménez, additional, Rico, Claudia González, additional, Sanchez, Blanca, additional, Valero, Olga, additional, Vega, Noelia, additional, Barnes, Anna, additional, Catterick, Helen, additional, Cranston, Tim, additional, Dawe, Phoebe, additional, Fletcher, Emily, additional, Fouracre, Liam, additional, Gifford, Alison, additional, Kirkwood, John, additional, Martin, Christopher, additional, McAnew, Amy, additional, Mitchell, Marcus, additional, Newman, Georgina, additional, O'Connell, Abby, additional, Onysk, Jakob, additional, Quinn, Lynne, additional, Rhodes, Shelley, additional, Stone, Samuel, additional, Symons, Lorrie, additional, Tripp, Harry, additional, Watkins, Darcy, additional, Whale, Bethany, additional, Harding, Alex, additional, Lockhart, Gemma, additional, Sidaway-Lee, Kate, additional, Hilton, Sam, additional, Manton, Sarah, additional, Webber-Rookes, Daniel, additional, Winder, Rachel, additional, Moore, James, additional, Bateman, Freya, additional, Gibbons, Michael, additional, Knight, Bridget, additional, Moss, Julie, additional, Statton, Sarah, additional, Studham, Josephine, additional, Hall, Lydia, additional, Moyle, Will, additional, and Venton, Tamsin, additional
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20. BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptor agonists
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Noé, Andrés, primary, Dang, Thanh D., additional, Axelrad, Christine, additional, Burrell, Emma, additional, Germano, Susie, additional, Elia, Sonja, additional, Burgner, David, additional, Perrett, Kirsten P., additional, Curtis, Nigel, additional, and Messina, Nicole L., additional
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- 2023
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21. Interpreting the Results of Trials of BCG Vaccination for Protection Against COVID-19
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Noble, Christie C A, primary, Messina, Nicole L, additional, Pittet, Laure F, additional, and Curtis, Nigel, additional
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- 2023
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22. Safety of BCG vaccination and revaccination in healthcare workers
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Villanueva, Paola, primary, Crawford, Nigel W., additional, Garcia Croda, Mariana, additional, Collopy, Simone, additional, Araújo Jardim, Bruno, additional, de Almeida Pinto Jardim, Tyane, additional, Marshall, Helen, additional, Prat-Aymerich, Cristina, additional, Sawka, Alice, additional, Sharma, Ketaki, additional, Troeman, Darren, additional, Wadia, Ushma, additional, Warris, Adilia, additional, Wood, Nicholas, additional, Messina, Nicole L., additional, Curtis, Nigel, additional, and Pittet, Laure F., additional
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- 2023
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23. Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
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Messina, Nicole L., primary, Sperotto, Mariana G., additional, Puga, Marco A. M., additional, da Silva, Patricia V., additional, de Oliveira, Roberto D., additional, Moore, Cecilia L., additional, Pittet, Laure F., additional, Jamieson, Tenaya, additional, Dalcolmo, Margareth, additional, dos Santos, Glauce, additional, Jardim, Bruno, additional, Lacerda, Marcus V. G., additional, Curtis, Nigel, additional, and Croda, Julio, additional
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- 2023
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24. Metagenomics analysis of the neonatal intestinal resistome
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Leo, Stefano, primary, Cetiner, Omer F., additional, Pittet, Laure F., additional, Messina, Nicole L., additional, Jakob, William, additional, Falquet, Laurent, additional, Curtis, Nigel, additional, and Zimmermann, Petra, additional
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- 2023
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25. Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers
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Pittet, Laure F., primary, Messina, Nicole L., additional, Orsini, Francesca, additional, Moore, Cecilia L., additional, Abruzzo, Veronica, additional, Barry, Simone, additional, Bonnici, Rhian, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Gardiner, Kaya, additional, Gell, Grace, additional, Germano, Susie, additional, Gomes-Silva, Adriano, additional, Goodall, Casey, additional, Gwee, Amanda, additional, Jamieson, Tenaya, additional, Jardim, Bruno, additional, Kollmann, Tobias R., additional, Lacerda, Marcus V.G., additional, Lee, Katherine J., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, Marshall, Helen S., additional, McDonald, Ellie, additional, Munns, Craig F., additional, Nicholson, Suellen, additional, O’Connell, Abby, additional, de Oliveira, Roberto D., additional, Perlen, Susan, additional, Perrett, Kirsten P., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rodriguez-Baño, Jesus, additional, dos Santos, Glauce, additional, da Silva, Patricia V., additional, Teo, Jia Wei, additional, Villanueva, Paola, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Davidson, Andrew, additional, and Curtis, Nigel, additional
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- 2023
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26. The association between the composition of the early-life intestinal microbiome and eczema in the first year of life
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Leo, Stefano, primary, Cetiner, Omer Faruk, additional, Pittet, Laure F., additional, Messina, Nicole L., additional, Jakob, William, additional, Falquet, Laurent, additional, Curtis, Nigel, additional, and Zimmermann, Petra, additional
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- 2023
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27. A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA (BNT162b2/mRNA-1273) and adenovirus vectored vaccines (ChAdOx1-S) after the first, second and third doses
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Ryan, Feargal J., primary, Norton, Todd S., additional, McCafferty, Conor, additional, Blake, Stephen J., additional, Stevens, Natalie E., additional, James, Jane, additional, Eden, Georgina L., additional, Tee, Yee C., additional, Benson, Saoirse C., additional, Masavuli, Makutiro G., additional, Yeow, Arthur EL, additional, Abayasingam, Arunasingam, additional, Agapiou, David, additional, Stevens, Hannah, additional, Zecha, Jana, additional, Messina, Nicole L., additional, Curtis, Nigel, additional, Ignjatovic, Vera, additional, Monagle, Paul, additional, Tran, Huyen, additional, McFadyen, James D., additional, Bull, Rowena A., additional, Grubor-Bauk, Branka, additional, Lynn, Miriam A., additional, Botten, Rochelle, additional, Barry, Simone E., additional, and Lynn, David J., additional
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- 2022
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28. Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes
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Bannister, Samantha, primary, Kim, Bowon, additional, Domínguez-Andrés, Jorge, additional, Kilic, Gizem, additional, Ansell, Brendan R. E., additional, Neeland, Melanie R., additional, Moorlag, Simone J. C. F. M., additional, Matzaraki, Vasiliki, additional, Vlahos, Amanda, additional, Shepherd, Rebecca, additional, Germano, Susie, additional, Bahlo, Melanie, additional, Messina, Nicole L., additional, Saffery, Richard, additional, Netea, Mihai G., additional, Curtis, Nigel, additional, and Novakovic, Boris, additional
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- 2022
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29. The safety of co-administration of Bacille Calmette-Guérin (BCG) and influenza vaccines
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Villanueva, Paola, primary, Wadia, Ushma, additional, Crawford, Nigel W., additional, Messina, Nicole L., additional, Kollmann, Tobias R., additional, Lucas, Michaela, additional, Manning, Laurens, additional, Richmond, Peter, additional, Pittet, Laure F., additional, and Curtis, Nigel, additional
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- 2022
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30. Bacillus Calmette-Guérin Skin Reaction Predicts Enhanced Mycobacteria-Specific T-Cell Responses in Infants: APost HocAnalysis of a Randomized Controlled Trial
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Pittet, Laure F., primary, Fritschi, Nora, additional, Tebruegge, Marc, additional, Dutta, Binita, additional, Donath, Susan, additional, Messina, Nicole L., additional, Casalaz, Dan, additional, Hanekom, Willem A., additional, Britton, Warwick J., additional, Robins-Browne, Roy, additional, Curtis, Nigel, additional, and Ritz, Nicole, additional
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- 2022
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31. Hepatitis B vaccine co-administration influences the heterologous effects of neonatal BCG vaccination in a sex-differential manner
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Pittet, Laure F., primary, Cox, Lianne, additional, Freyne, Bridget, additional, Germano, Susie, additional, Bonnici, Rhian, additional, Gardiner, Kaya, additional, Donath, Susan, additional, Collins, Clare L., additional, Casalaz, Dan, additional, Robins-Browne, Roy, additional, Flanagan, Katie L., additional, Messina, Nicole L., additional, and Curtis, Nigel, additional
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- 2022
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32. BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
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Pittet, Laure F, primary, Messina, Nicole L, additional, Gardiner, Kaya, additional, Orsini, Francesca, additional, Abruzzo, Veronica, additional, Bannister, Samantha, additional, Bonten, Marc, additional, Campbell, John L, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Elia, Sonja, additional, Germano, Susie, additional, Goodall, Casey, additional, Gwee, Amanda, additional, Jamieson, Tenaya, additional, Jardim, Bruno, additional, Kollmann, Tobias R, additional, Guimarães Lacerda, Marcus Vinícius, additional, Lee, Katherine J, additional, Legge, Donna, additional, Lucas, Michaela, additional, Lynn, David J, additional, McDonald, Ellie, additional, Manning, Laurens, additional, Munns, Craig F, additional, Perrett, Kirsten P, additional, Prat Aymerich, Cristina, additional, Richmond, Peter, additional, Shann, Frank, additional, Sudbury, Eva, additional, Villanueva, Paola, additional, Wood, Nicholas J, additional, Lieschke, Katherine, additional, Subbarao, Kanta, additional, Davidson, Andrew, additional, and Curtis, Nigel, additional
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- 2021
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33. 314Data-adaptive methods for high-dimensional mediation analysis: Application to a randomised trial of tuberculosis vaccination
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Moreno-Betancur, Margarita, primary, Messina, Nicole L, additional, Gardiner, Kaya, additional, Curtis, Nigel, additional, and Vansteelandt, Stijn, additional
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- 2021
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34. Prevention of infant eczema by neonatal Bacillus Calmette‐Guérin vaccination: The MIS BAIR randomized controlled trial
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Pittet, Laure F., primary, Messina, Nicole L., additional, Gardiner, Kaya, additional, Freyne, Bridget, additional, Abruzzo, Veronica, additional, Francis, Kate L., additional, Morrison, Clare, additional, Zufferey, Christel, additional, Vuillermin, Peter, additional, Allen, Katrina J., additional, Ponsonby, Anne‐Louise, additional, Robins‐Browne, Roy, additional, Shann, Frank, additional, Flanagan, Katie L., additional, Phillips, Rod, additional, Donath, Susan, additional, Casalaz, Dan, additional, and Curtis, Nigel, additional
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- 2021
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35. Off‐target effects of bacillus Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2: implications for protection against severe COVID‐19.
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Messina, Nicole L, Germano, Susie, McElroy, Rebecca, Rudraraju, Rajeev, Bonnici, Rhian, Pittet, Laure F, Neeland, Melanie R, Nicholson, Suellen, Subbarao, Kanta, Curtis, Nigel, Baena, Adrian Siles, Teo, Jia Wei, de Lima, Guilherme Teodoro, Abreu, Carolinne, Abruzzo, Veronica, Addlem, Lynne, Agius, Sophie, Barbosa, Adelita Agripina Refosco, Alamrousi, Ahmed, and da Silva dos Santos, Ayla Alcoforado
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MEDICAL personnel , *IMMUNE response , *SARS-CoV-2 , *COVID-19 , *BCG vaccines - Abstract
Background and objectives: Because of its beneficial off‐target effects against non‐mycobacterial infectious diseases, bacillus Calmette–Guérin (BCG) vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coronavirus disease 2019 (COVID‐19). Using samples from participants in a placebo‐controlled RCT aiming to determine whether BCG vaccination reduces the incidence and severity of COVID‐19, we investigated the immunomodulatory effects of BCG on in vitro immune responses to SARS‐CoV‐2. Methods: This study used peripheral blood taken from participants in the multicentre RCT and BCG vaccination to reduce the impact of COVID‐19 on healthcare workers (BRACE trial). The whole blood taken from BRACE trial participants was stimulated with γ‐irradiated SARS‐CoV‐2‐infected or mock‐infected Vero cell supernatant. Cytokine responses were measured by multiplex cytokine analysis, and single‐cell immunophenotyping was made by flow cytometry. Results: BCG vaccination, but not placebo vaccination, reduced SARS‐CoV‐2‐induced secretion of cytokines known to be associated with severe COVID‐19, including IL‐6, TNF‐α and IL‐10. In addition, BCG vaccination promoted an effector memory phenotype in both CD4+ and CD8+ T cells, and an activation of eosinophils in response to SARS‐CoV‐2. Conclusions: The immunomodulatory signature of BCG's off‐target effects on SARS‐CoV‐2 is consistent with a protective immune response against severe COVID‐19. [ABSTRACT FROM AUTHOR]
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- 2022
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36. Bacillus Calmette-Guérin Skin Reaction Predicts Enhanced Mycobacteria-Specific T-Cell Responses in Infants: A Analysis of a Randomized Controlled Trial.
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Pittet, Laure F, Fritschi, Nora, Tebruegge, Marc, Dutta, Binita, Donath, Susan, Messina, Nicole L, Casalaz, Dan, Hanekom, Willem A, Britton, Warwick J, Robins-Browne, Roy, Curtis, Nigel, and Ritz, Nicole
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TUBERCULOSIS prevention ,MYCOBACTERIUM ,RESEARCH ,IMMUNIZATION ,RESEARCH methodology ,EVALUATION research ,COMPARATIVE studies ,MYCOBACTERIUM tuberculosis ,BCG vaccines ,RESEARCH funding ,T cells - Abstract
Rationale: Scar formation following bacillus Calmette-Guérin (BCG) vaccination has been associated with lower all-cause mortality; the relation between scar and mycobacteria-specific protection against tuberculosis is debated. Objectives: To evaluate the association between BCG skin reaction and mycobacteria-specific immune responses. Methods: A post hoc analysis was done among 214 infants in Australia randomized to vaccination with one of three BCG vaccine strains (BCG-Denmark, BCG-Japan, or BCG-Russia) given at birth or BCG-Denmark given at 2 months of age. Measurements and Main Results: BCG skin reaction size and characteristics 10 weeks after vaccination were related to the in vitro mycobacteria-specific immune responses measured in stimulated whole blood. The size and characteristics of the skin reaction correlated positively with in vitro immune responses, even after adjusting for BCG vaccine strain and age at vaccination. Specifically, the reaction size and characteristics correlated with the proportion of mycobacteria-specific polyfunctional CD4+ T cells after stimulation with BCG and PPD and, to a lesser extent, after stimulation with Mycobacterium tuberculosis or Mycobacterium ulcerans. A similar correlation was observed with concentrations of IFN-γ, IL-2, tumor necrosis factor, and IL-13 in the supernatant after stimulation with BCG, PPD, and M. tuberculosis and to some degree for the proportions of mycobacteria-specific polyfunctional CD8+ T cells and CD107+ cytotoxic cells. Conclusions: BCG skin reaction correlated with the magnitude of mycobacteria-specific T-cell responses. As T-cell responses play a key role in defense against mycobacteria, the relationship between BCG scar formation and protection against tuberculosis should be revisited. This may also extend to the need for BCG revaccination in scar-negative individuals.Clinical trial registered with www.australianclinicaltrials.gov.au/clinical-trial-registries (ACTRN12608000227392). [ABSTRACT FROM AUTHOR]
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- 2022
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37. Prevention of infant eczema by neonatal Bacillus Calmette‐Guérin vaccination: The MIS BAIR randomized controlled trial.
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Pittet, Laure F., Messina, Nicole L., Gardiner, Kaya, Freyne, Bridget, Abruzzo, Veronica, Francis, Kate L., Morrison, Clare, Zufferey, Christel, Vuillermin, Peter, Allen, Katrina J., Ponsonby, Anne‐Louise, Robins‐Browne, Roy, Shann, Frank, Flanagan, Katie L., Phillips, Rod, Donath, Susan, Casalaz, Dan, and Curtis, Nigel
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ECZEMA , *TUBERCULIN test , *BCG vaccines , *INFANTS , *RANDOMIZED controlled trials , *VACCINATION - Abstract
Background: Bacille Calmette‐Guérin (BCG) vaccine could play a role in counteracting the rising prevalence of atopic diseases, through its beneficial off‐target effects. We aimed to determine whether neonatal BCG vaccination reduces the incidence of eczema in infants. Methods: Randomized controlled trial with 1272 infants allocated to receive BCG‐Denmark or no BCG at birth. The primary outcome was the 12‐month incidence of eczema based on 3‐monthly questionnaires. Eczema was also assessed at a 12‐month clinic visit. ClinicalTrial.gov: NCT01906853. Results: The 12‐month eczema incidence was 32.2% in the BCG group compared with 36.6% in the control group (adjusted risk difference (aRD) −4.3%, 95% CI −9.9% to 1.3%, multiple imputation model). In addition, comparing infants in the BCG group with the control group, 15.7% vs. 19.2% had eczema lesions at the 12‐month visit (aRD −3.5%, 95% CI −8.0% to 1.0%); 35.7% vs. 39.0% reported using topical steroids (aRD −3.3, 95% CI −9.2 to 2.7); and 7.3% vs. 10.2% had severe eczema scores (aRD −3.0%, 95% CI −8.8% to 2.7%). In 344 high‐risk infants (two atopic parents), the 12‐month eczema incidence was 35.3% in the BCG group compared with 46.8% in the control group (aRD −11.5%, 95% CI −21.9% to −1.2%; number needed to treat 8.7, 95% CI 4.6 to 83.3). Conclusion: There is insufficient evidence to recommend neonatal BCG vaccination in all infants for the prevention of eczema in the first year of life; however, a modest beneficial effect was observed among high‐risk infants. A single dose of BCG‐Denmark soon after birth could reduce the incidence of eczema in infants with two atopic parents. [ABSTRACT FROM AUTHOR]
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- 2022
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38. Neonatal Bacille Calmette-Guérin Vaccination and Infections in the First Year of Life: The MIS BAIR Randomized Controlled Trial.
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Messina, Nicole L, Pittet, Laure F, Gardiner, Kaya, Freyne, Bridget, Francis, Kate L, Zufferey, Christel, Abruzzo, Veronica, Morrison, Clare, Allen, Katrina J, Flanagan, Katie L, Ponsonby, Anne-Louise, Robins-Browne, Roy, Shann, Frank, South, Mike, Vuillermin, Peter, Donath, Susan, Casalaz, Dan, and Curtis, Nigel
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BCG vaccines , *RESPIRATORY infections , *VACCINATION , *INFANTS , *COMMUNICABLE diseases - Abstract
Background: Bacille Calmette-Guérin (BCG) vaccination has beneficial off-target effects that may include protecting against non-mycobacterial infectious diseases. We aimed to determine whether neonatal BCG vaccination reduces lower respiratory tract infections (LRTI) in infants in the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) trial.Methods: In this investigator-blinded trial, neonates in Australia were randomized to receive BCG-Denmark vaccination or no BCG at birth. Episodes of LRTI were determined by symptoms reported in parent-completed, 3-month questionnaires over the first year of life. Data were analyzed by intention-to-treat using binary regression.Results: A total of 1272 neonates were randomized to the BCG vaccination (n = 637) or control (n = 635) group. The proportion of participants with an episode of LRTI in the first year of life among BCG-vaccinated infants was 54.8% compared to 58.0% in the control group, resulting in a risk difference of -3.2 (95% confidence interval, -9.0 to 2.6) after multiple imputation. There was no interaction observed between the primary outcome and sex, maternal BCG, or the other prespecified effect modifiers.Conclusions: Based on the findings of this trial, there is insufficient evidence to support the use of neonatal BCG vaccination to prevent LRTI in the first year of life in high-income settings. [ABSTRACT FROM AUTHOR]- Published
- 2021
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39. THE AUTHORS REPLY.
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Pittet, Laure F., Messina, Nicole L., and Curtis, Nigel
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LANGUAGE models , *BCG vaccines , *CHATGPT , *MEDICAL literature , *SIGNAL-to-noise ratio - Abstract
The article presents the authors' reply to comments on their article on BGC vaccination to reduce the Covid-19 impact on healthcare workers in 2023. It states that there is danger in flawed medical studies, and that the effect of BCG vaccination could not be determined on the current definition of severe disease. Also noted is the importance of considering modifying factors in interpreting the outcomes of vaccine trials.
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- 2023
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40. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial.
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Messina NL, Pittet LF, McDonald E, Moore C, Barry S, Bonten M, Byrne A, Campbell J, Croda J, Croda MG, Dalcolmo M, de Almeida E Val FF, de Oliveira RD, Dos Santos G, Douglas MW, Gardiner K, Gwee A, Jardim BA, Kollmann T, Lacerda MV, Lucas M, Lynn DJ, Manning L, Marshall H, O'Connell A, Perrett KP, Post JJ, Prat-Aymerich C, Rocha JL, Rodriguez-Baño J, Wadia U, Warris A, Davidson A, and Curtis N
- Abstract
Objectives: Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to determine whether BCG vaccination protects adults against COVID-19., Design: Phase III double blind randomised controlled trial., Setting: Healthcare centres in Australia, Brazil, the Netherlands, Spain, and the United Kingdom during the COVID-19 pandemic., Participants: 3988 healthcare workers with no prior COVID-19 and no contraindication to BCG., Intervention: Randomised 1:1 using a web-based procedure to receive a single 0.1mL intradermal dose of BCG-Denmark (BCG group, n=1999) or saline (placebo group, n=1989)., Main Outcome Measures: Difference in incidence of (i) symptomatic and (ii) severe COVID-19 during the 12-months following randomisation in the modified intention to treat (mITT) population (confirmed SARS-CoV-2 naïve at inclusion)., Results: Of the 3988 participants randomised, 3386 had a negative baseline SARS-CoV-2 test and were included in the mITT population. The 12-month adjusted estimated risk of symptomatic COVID-19 was higher in the BCG group (22.6%; 95% confidence interval [CI] 20.6% to 24.5%) compared with the placebo group (19.6%; 95%CI 17.6% to 21.5%); adjusted difference +3.0 percentage points (95%CI 0.2% to 5.8%; p=0.04). The 12-month adjusted estimated risk of severe COVID-19 (mainly comprising those reporting being unable to work for ≥3 consecutive days) was 11.0% in the BCG group (95%CI 9.5% to 12.4%) compared with 9.6% in the placebo group (95%CI 8.3% to 11.1%); adjusted difference +1.3 percentage points (95%CI -0.7% to 3.3%, p=0.2). Breakthrough COVID-19 (post COVID-19 vaccination), and asymptomatic SARS-CoV-2 infections were similar in the two groups. There were 18 hospitalisations due to COVID-19 (11 in BCG group, 7 in placebo group; adjusted hazard ratio 1.56, 95%CI 0.60 to 4.02, p=0.4) and two deaths due to COVID-19, both in the placebo group., Conclusions: Compared to placebo, vaccination with BCG-Denmark increased the risk of symptomatic COVID-19 over 12 months among health care workers and did not decrease the risk of severe COVID-19 or post-vaccination breakthrough COVID-19., Trial Registration: ClinicalTrials.gov NCT04327206., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The trial is financially supported by the Foundations listed in the Funding section. Authors disclose funding support over the past 36 months: National Health and Medical Research Council (NHMRC) Ideas Grant (NM), NHMRC Investigator Grant (NC), Melbourne Children’s Clinician-Scientist Fellowship Grant (KPP). Outside of the submitted work, JCr has received grants or contracts from Sanofi, MSD & CEPI; payment or honoraria for presentations from Pfizer and participates on Latin American data safety monitoring/advisory boards for mRNA-1273 (Modern/Zodiac), RSV maternal vaccine (Pfizer), Qdenga vaccine (Takeda) and Nirmatrelvir/Ritonavir-Paxlovid (Pfizer). KG is a member of the Royal Children’s Hospital (RCH) Human Research Ethics Committee (the primary ethics committee providing approval for the BRACE trial) and Director of Research Operations at RCH; she abstained from all discussion, voting, approval and review related to the BRACE trial. All other authors declare no conflict of interest., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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41. Specific and off-target immune responses following COVID-19 vaccination with ChAdOx1-S and BNT162b2 vaccines-an exploratory sub-study of the BRACE trial.
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Messina NL, Germano S, McElroy R, Bonnici R, Grubor-Bauk B, Lynn DJ, McDonald E, Nicholson S, Perrett KP, Pittet LF, Rudraraju R, Stevens NE, Subbarao K, and Curtis N
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- Humans, Female, Male, Adult, Middle Aged, Vaccination, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, Prospective Studies, Health Personnel, Spike Glycoprotein, Coronavirus immunology, BNT162 Vaccine immunology, BNT162 Vaccine administration & dosage, COVID-19 prevention & control, COVID-19 immunology, SARS-CoV-2 immunology, Cytokines metabolism, Antibodies, Viral immunology, Antibodies, Viral blood, ChAdOx1 nCoV-19 immunology
- Abstract
Background: The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on the immune system. We sought to determine and compare the off-target effects of the adenovirus vector ChAdOx1-S (Oxford-AstraZeneca) and modified mRNA BNT162b2 (Pfizer-BioNTech) vaccines on immune responses to unrelated pathogens., Methods: Prospective sub-study within the BRACE trial. Blood samples were collected from 284 healthcare workers before and 28 days after ChAdOx1-S or BNT162b2 vaccination. SARS-CoV-2-specific antibodies were measured using ELISA, and whole blood cytokine responses to specific (SARS-CoV-2) and unrelated pathogen stimulation were measured by multiplex bead array., Findings: Both vaccines induced robust SARS-CoV-2 specific antibody and cytokine responses. ChAdOx1-S vaccination increased cytokine responses to heat-killed (HK) Candida albicans and HK Staphylococcus aureus and decreased cytokine responses to HK Escherichia coli and BCG. BNT162b2 vaccination decreased cytokine response to HK E. coli and had variable effects on cytokine responses to BCG and resiquimod (R848). After the second vaccine dose, BNT162b2 recipients had greater specific and off-target cytokine responses than ChAdOx1-S recipients., Interpretation: ChAdOx1-S and BNT162b2 vaccines alter cytokine responses to unrelated pathogens, indicative of potential off-target effects. The specific and off-target effects of these vaccines differ in their magnitude and breadth. The clinical relevance of these findings is uncertain and needs further study., Funding: Bill & Melinda Gates Foundation, National Health and Medical Research Council, Swiss National Science Foundation and the Melbourne Children's. BRACE trial funding is detailed in acknowledgements., Competing Interests: Declaration of interests All authors declare no conflicts of interest. The BRACE trial consortium funding is detailed in the acknowledgements., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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42. BCG to Protect against Covid-19 in Health Care Workers. Reply.
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Pittet LF, Messina NL, and Curtis N
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- Humans, Health Personnel, BCG Vaccine, COVID-19 prevention & control
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- 2023
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43. Erratum: Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination.
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Villanueva P, Crawford NW, Croda MG, Collopy S, Jardim BA, de Almeida Pinto Jardim T, Manning L, Lucas M, Marshall H, Prat-Aymerich C, Sawka A, Sharma K, Troeman D, Wadia U, Warris A, Wood N, Messina NL, Curtis N, and Pittet LF
- Abstract
[This corrects the article DOI: 10.1016/j.heliyon.2023.e15241.]., (© 2023 The Author(s).)
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- 2023
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44. Bacillus Calmette-Guérin Skin Reaction Predicts Enhanced Mycobacteria-Specific T-Cell Responses in Infants: A Post Hoc Analysis of a Randomized Controlled Trial.
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Pittet LF, Fritschi N, Tebruegge M, Dutta B, Donath S, Messina NL, Casalaz D, Hanekom WA, Britton WJ, Robins-Browne R, Curtis N, and Ritz N
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- BCG Vaccine, CD8-Positive T-Lymphocytes, Humans, Infant, Infant, Newborn, Vaccination, Mycobacterium bovis, Mycobacterium tuberculosis, Tuberculosis prevention & control
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Rationale: Scar formation following bacillus Calmette-Guérin (BCG) vaccination has been associated with lower all-cause mortality; the relation between scar and mycobacteria-specific protection against tuberculosis is debated. Objectives: To evaluate the association between BCG skin reaction and mycobacteria-specific immune responses. Methods: A post hoc analysis was done among 214 infants in Australia randomized to vaccination with one of three BCG vaccine strains (BCG-Denmark, BCG-Japan, or BCG-Russia) given at birth or BCG-Denmark given at 2 months of age. Measurements and Main Results: BCG skin reaction size and characteristics 10 weeks after vaccination were related to the in vitro mycobacteria-specific immune responses measured in stimulated whole blood. The size and characteristics of the skin reaction correlated positively with in vitro immune responses, even after adjusting for BCG vaccine strain and age at vaccination. Specifically, the reaction size and characteristics correlated with the proportion of mycobacteria-specific polyfunctional CD4
+ T cells after stimulation with BCG and PPD and, to a lesser extent, after stimulation with Mycobacterium tuberculosis or Mycobacterium ulcerans . A similar correlation was observed with concentrations of IFN-γ, IL-2, tumor necrosis factor, and IL-13 in the supernatant after stimulation with BCG, PPD, and M. tuberculosis and to some degree for the proportions of mycobacteria-specific polyfunctional CD8+ T cells and CD107+ cytotoxic cells. Conclusions: BCG skin reaction correlated with the magnitude of mycobacteria-specific T-cell responses. As T-cell responses play a key role in defense against mycobacteria, the relationship between BCG scar formation and protection against tuberculosis should be revisited. This may also extend to the need for BCG revaccination in scar-negative individuals.Clinical trial registered with www.australianclinicaltrials.gov.au/clinical-trial-registries (ACTRN12608000227392).- Published
- 2022
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