Search

Your search keyword '"Ming-Qin Lu"' showing total 6 results
Start Over Author "Ming-Qin Lu" Publication Year Range Last 3 years
6 results on '"Ming-Qin Lu"'

1. High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B

Author

Chao Cai, Wen-Xuan Shang, En-Hua Lin, Yu-Chun Jiang, Hong Chen, Ke Xu, Lu Chen, Rui-Cong Chen, Yi-Jing Cai, Ji Lin, Ting-Chen Cai, Xiu-Li Lin, Lei Zhang, Nai-Bin Yang, Hui-Fang Zhang, and Ming-Qin Lu

Subjects
chronic hepatitis B, high-normal alanine aminotransferase, antiviral therapy, liver biopsy, histological disease, HBV DNA clearance, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundEvidence shows people living with CHB even with a normal ALT (40U/L as threshold) suffer histological disease and there is still little research to evaluate the potential benefit of antiviral benefits in them.MethodsWe retrospectively examined 1352 patients who underwent liver biopsy from 2017 to 2021 and then obtained their 1-year follow-up data to analyze.ResultsALT levels were categorized into high and low, with thresholds set at >29 for males and >15 for females through Youden’s Index. The high normal ALT group showed significant histological disease at baseline (56.43% vs 43.82%, p< 0.001), and better HBV DNA clearance from treatment using PSM (p=0.005). Similar results were obtained using 2016 AASLD high normals (male >30, female >19). Further multivariate logistic analysis showed that high normal ALT (both criterias) was an independent predictor of treatment (OR 1.993, 95% CI 1.115-3.560, p=0.020; OR 2.000, 95% CI 1.055-3.793, p=0.034) Both of the models had higher AUC compared with current scoring system, and there was no obvious difference between the two models (AUC:0.8840 vs 0.8835)ConclusionMale >30 or female >19 and Male >29 or female>15 are suggested to be better thresholds for normal ALT. Having a high normal ALT in CHB provides a potential benefit in antiviral therapy.

Published
2024
Full Text
View/download PDF

2. Serum ammonia variation predicts mortality in patients with hepatitis B virus-related acute-on-chronic liver failure

Author

Yi-Jing Cai, Jia-Jia Dong, Rui-Cong Chen, Qian-Qian Xiao, Xu-Mei Li, De-Yuan Chen, Chao Cai, Xiu-Li Lin, Ke-Qing Shi, and Ming-Qin Lu

Subjects
ammonia, AMM, hepatitis B virus, acute-on-chronic liver failure, hepatic encephalopathy (HE), hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), Microbiology, QR1-502
Abstract

BackgroundHyperammonemia is critical to the development of hepatic encephalopathy (HE) and is associated with mortality in end-stage liver disease. This study investigated the clinical value of ammonia variation in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients.MethodsA total of 276 patients with HBV-ACLF were retrospectively recruited. Patients' ammonia levels were serially documented. Baseline ammonia, Peak ammonia (highest level), and Trough ammonia (lowest level) were particularly corrected to the upper limit of normal (AMM-ULN). The primary endpoint was 28-day mortality.ResultsThe 28-day, 3-month, and 12-month mortality rates were 19.2, 25.7, and 28.2%, respectively. A total of 51 (18.4%) patients had overt HE (grade 2/3/4). Peak AMM-ULN was significantly higher in patients with overt HE and non-survivors compared with their counterparts (P < 0.001). Following adjustment for significant confounders, high Peak AMM-ULN was an independent predictor of overt HE (hazard ratio, 1.031, P < 0.001) and 28-day mortality (hazard ratio, 1.026, P < 0.001). The cut-off of Peak AMM-ULN was 1.8, determined by using the X-tile. Patients with Peak AMM-ULN appearing on days 1–3 after admission had a higher proportion of overt HE and mortality compared to other groups. Patients with decreased ammonia levels within 7 days had better clinical outcomes than those with increased ammonia.ConclusionSerum Peak ammonia was independently associated with overt HE and mortality in HBV-ACLF patients. Serial serum ammonia may have prognostic value.

Published
2023
Full Text
View/download PDF

3. Evaluation of Neisseria gonorrhoeae Isolates Susceptibility to Antibiotics in Zhejiang Province Since 2007

Author

Yan Zhang, Li-Hua Hu, Jia Huang, Ming-Qin Lu, Fan-Rong Zeng, and Shao-Chun Chen

Subjects
Pharmacology, Infectious Diseases, Infection and Drug Resistance, Pharmacology (medical)
Abstract

Yan Zhang,1 Li-Hua Hu,2,&ast; Jia Huang,2 Ming-Qin Lu,2 Fan-Rong Zeng,2 Shao-Chun Chen1,3,&ast; 1School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China; 2Zhejiang Provincial Institute of Dermatology, Deqing, People’s Republic of China; 3National Center for Sexually Transmitted Diseases Control, Chinese Center for Disease Control and Prevention, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li-Hua Hu, Email dqhlhua@163.com Shao-Chun Chen, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China, Email chensc@ncstdlc.orgObjective: This study aimed to assess the drug susceptibility of clinical isolates of Neisseria gonorrhoeae to spectinomycin, ceftriaxone and azithromycin. Moreover, the temporal trends in the minimum inhibitory concentration (MIC) of five antibiotics from Zhejiang, China, are also in the scope of this study.Methods: A total of 1710 gonococcal clinical strains were collected between 2007 and 2021 from health-care institutions in Zhejiang. The MICs of ceftriaxone, azithromycin, spectinomycin, penicillin and ciprofloxacin were assessed by agar dilution method on 1710 Neisseria gonorrhoeae isolates. Count data were expressed as strains and rates, and MICs distribution was elucidated using descriptive statistics.Results: The total resistance rates of gonococci to azithromycin, spectinomycin, penicillin and ciprofloxacin in this study were 19.3%, 0.3%, 75.4% and 99.7%, respectively.Conclusion: The in vitro results showed a high prevalence of resistance to ciprofloxacin and penicillin. Azithromycin resistance rate has exceeded 5%, suggested a high prevalence of resistance. Ceftriaxone and spectinomycin are suggested based on this study for the treatment of Neisseria gonorrhoeae in Zhejiang.Keywords: Neisseria gonorrhoeae, agar dilution method, ceftriaxone, spectinomycin

Published
2023
Full Text
View/download PDF

5. High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B

Author

Chao Cai, Wen-Xuan Shang, En-Hua Lin, Yu-Chun Jiang, Ke Xu, Lu Chen, Rui-Cong Chen, Yi-Jing Cai, Ji Lin, Ting-Chen Cai, Xiu-Li Lin, Lei Zhang, Nai-Bin Yang, Hui-Fang Zhang, and Ming-Qin Lu

Abstract

Objective:To investigate liver histologic disease in chronic hepatitis B (CHB) patients with normal ALT (Methods:We retrospectively examined 1352 patients who underwent liver biopsy from 2017 to 2021 and then obtain their 1-year follow up data to establish a predict model of 1-year HBVDNA clearance rate through Logistic regression. Results:The proportion of patient with significant histological disease (significant liver necroinflammation or fibrosis) in the high nALT group was significantly higher than that in the low nALT group (56.43% vs 43.82%, p < 0.001, Table 1). HbeAg negative, GGT and ALT value (OR 0.024, 95% CI 0.011–0.055, p < 0.001; OR 1.027, 95% CI 1.006–1.050, p = 0.013; OR 1.993,95% CI 1.115–3.560, p = 0.020, Table 4) were independent predict factors. High normal ALT is an indicator of 1-year HBVDNA clearance after antiviral treatment. Conclusion: CHB patients with high-normal ALT have significantly higher histological disease rates, and these patients may benefit better from antiviral therapy. We suggest should undergo histological evaluation of liver disease as soon as possible. We also propose these patients should be offered antiviral therapy when feasible.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results