1. A case of development of autoimmune pulmonary alveolar proteinosis during the treatment of hypersensitivity pneumonitis
- Author
-
Maki Asami-Noyama, Kosuke Ito, Misa Harada, Yukari Hisamoto, Yoshie Kunihiro, Eiji Ikeda, Tasuku Yamamoto, Junki Suizu, Ayumi Fukatsu, Syuichiro Ohata, Yoriyuki Murata, Keiji Oishi, Yoshikazu Yamaji, Nobutaka Edakuni, Tomoyuki Kakugawa, Tsunahiko Hirano, and Kazuto Matsunaga
- Subjects
Autoimmune pulmonary alveolar proteinosis ,Fibrotic hypersensitivity pneumonia ,Segmental bronchoalveolar lavage ,Anti-GM-CSF antibody ,Diseases of the respiratory system ,RC705-779 - Abstract
Herein, we report the case of a 73-year-old woman with an occupational history of plaster grinding who developed autoimmune pulmonary alveolar proteinosis (PAP) during the treatment of fibrotic hypersensitivity pneumonitis with steroids and immunosuppressive drugs. Based on the changes in computed tomography imaging findings, poor response to steroid therapy, and markedly elevated KL-6 levels, PAP was suspected and diagnosed by bronchoscopy. Repeated segmental bronchoalveolar lavage under high-flow nasal cannula oxygen therapy resulted in slight improvement. Steroids and immunosuppressive treatments for other interstitial lung diseases may cause PAP or exacerbate latent PAP.
- Published
- 2023
- Full Text
- View/download PDF