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Retinal prostheses partially restore vision in patients blinded by retinitis pigmentosa (RP) and age-related macular degeneration (AMD). One issue that limits the effectiveness of retinal stimulation is the desensitization of the retina response to repeated pulses. Rapid fading of percepts is reported in clinical studies. We studied the retinal output evoked by fixed pulse trains vs. pulse trains that have variable parameters pulse-to-pulse. We used the current clamp to record RGC spiking in the isolated mouse retina. Trains of biphasic current pulses at different frequencies and amplitudes were applied. The main results we report are: (1) RGC desensitization was induced by increasing stimulus frequency, but was unrelated to stimulus amplitude. Desensitization persisted when the 20 Hz stimulation pulses were applied to the retinal ganglion cells at 65 µA, 85 µA, and 105 µA. Subsequent pulses in the train evoked fewer spikes. There was no obvious desensitization when 2 Hz stimulation pulse trains were applied. (2) Blocking inhibitory GABAA receptor increased spontaneous activity but did not reduce desensitization. (3) Pulse trains with constant charge or excitation (based on strengthduration curves) but varying pulse width, amplitude, and shape increased the number of evoked spikes/pulse throughout the pulse train. This suggests that retinal desensitization can be partially overcome by introducing variability into each pulse. [ABSTRACT FROM AUTHOR]

This article presents the heat transfer augmentation in a solar air heater (SAH) using arc-shaped ribs with multiple gaps. Multiple gaps in arc-shaped ribs are used to enhance the heat transfer by interrupting the growth of the boundary layer. Thermal performance analysis of a SAH has been carried out experimentally for the roughness parameters: number of gaps (Ng) ranging from 2 to 5 and flow parameters; Reynolds number (Re) ranging from 3000 to 18000 at a constant heat flux of 1000 W/m2. The data obtained from the experimental investigation are validated and compared with the smooth duct under similar conditions. For roughened SAH duct, the heat transfer and pressure drop are found to be 274% and 169% higher than that for smooth SAH duct at Ng = 3. Thermo-hydraulic performance is determined for considered parameters and maximum value is observed to be 2.75. [ABSTRACT FROM AUTHOR]

Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in children and is characterised by inattention, impulsiveness and hyperactivity. While several studies have analysed the static functional connectivity in the resting-state functional MRI (rs-fMRI) of ADHD patients, detailed investigations are required to characterize the connectivity dynamics in the brain. In an attempt to establish a link between attention instability and the dynamic properties of Functional Connectivity (FC), we investigated the differences in temporal variability of FC between 40 children with ADHD and 40 Typically Developing (TD) children. Using a sliding-window method to segment the rs-fMRI scans in time, we employed seed-to-voxel correlation analysis for each window to obtain time-evolving seed connectivity maps for seeds placed in the posterior cingulate cortex (PCC) and the medial prefrontal cortex (mPFC). For each subject, the standard deviation of the voxel connectivity time series was used as a measure of the temporal variability of FC. Results showed that ADHD patients exhibited significantly higher variability in dFC than TD children in the cingulo-temporal, cingulo-parietal, fronto-temporal, and fronto-parietal networks ( pFW E < 0.05). Atypical temporal variability was observed in the left and right temporal gyri, the anterior cingulate cortex, and lateral regions of the right parietal cortex. The observations are consistent with visual attention issues, executive control deficit, and rightward parietal dysfunction reported in ADHD, respectively. These results help in understanding the disorder with a fresh perspective linking behavioural inattention with instability in FC in the brain.

Damage to the inferior frontal gyrus (Broca's area) can cause agrammatic aphasia wherein patients, although able to comprehend, lack the ability to form complete sentences. This inability leads to communication gaps which cause difficulties in their daily lives. The usage of assistive devices can help in mitigating these issues and enable the patients to communicate effectively. However, due to lack of large scale studies of linguistic deficits in aphasia, research on such assistive technology is relatively limited. In this work, we present two contributions that aim to re-initiate research and development in this field. Firstly, we propose a model that uses linguistic features from small scale studies on aphasia patients and generates large scale datasets of synthetic aphasic utterances from grammatically correct datasets. We show that the mean length of utterance, the noun/verb ratio, and the simple/complex sentence ratio of our synthetic datasets correspond to the reported features of aphasic speech. Further, we demonstrate how the synthetic datasets may be utilized to develop assistive devices for aphasia patients. The pre-trained T5 transformer is fine-tuned using the generated dataset to suggest 5 corrected sentences given an aphasic utterance as input. We evaluate the efficacy of the T5 model using the BLEU and cosine semantic similarity scores. Affirming results with BLEU score of 0.827/1.00 and semantic similarity of 0.904/1.00 were obtained. These results provide a strong foundation for the concept that a synthetic dataset based on small scale studies on aphasia can be used to develop effective assistive technology.Clinical relevance- We demonstrate the utilization of Natural Language Processing (NLP) for developing assistive technology for Aphasia patients. While disorders like Broca's aphasia offer a small sample size of patients and data, synthetic linguistic models like ours offer extensive scope for developing assistive technology and rehabilitation monitoring.