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1. Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study

Author

Alarcón Soto, Yovaninna, Alemany, Andrea, Bailón, Lucía, Benet, Susana, Mitjà, Oriol, Mothe, Beatriz, Paredes, Roger, Sabato, Sofía, Suñer, Clara, Torrano, Pamela, Ubals, Maria, Boreika, Rytis, Brander, Christian, Carabelli, Julieta, Carrillo, Jorge, Gallemí, Marçal, Izquierdo-Useros, Nuria, Molina-Molina, Elisa, Moraes-Cardoso, Igor, Muñoz-Basagoiti, Jordana, Olvera, Alex, Perez-Zsolt, Daniel, Raïch-Regué, Dàlia, Coll, Pep, Fernández, Javier, Mendoza, Adrià, Pérez, Félix, Reguant, Joan, Rivero, Angel, Arando, Maider, Descalzo, Vicente, Néstor Garcia, Jorge, Monforte, Arnau, Álvarez, Patricia, Guedj, Jeremie, Marc, Aurélien, Marks, Michael, Alarcón-Soto, Yovaninna, Grifoni, Alba, Sette, Alessandro, and Moltó, José

Published
2024
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3. Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

Author

Ubals, Maria, Nadal-Baron, Patricia, Arando, Maider, Rivero, Ángel, Mendoza, Adrià, Descalzo Jorro, Vicent, Ouchi, Dan, Pérez-Mañá, Clara, Álvarez, Marlene, Alemany, Andrea, Hoyos-Mallecot, Yannick, Nunley, Ethan, Lieberman, Nicole A P, Greninger, Alexander L, Galván-Casas, Cristina, Suñer, Clara, G-Beiras, Camila, Paredes, Roger, Rodríguez-Gascón, Alicia, Canut, Andrés, García-Patos, Vicente, Farré, Magí, Marks, Michael, Giacani, Lorenzo, Vall-Mayans, Martí, and Mitjà, Oriol

Published
2024
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5. Mpox in people with past infection or a complete vaccination course: a global case series

Author

Creticos, Catherine, Gibbons, Patrick, Maakaroun-Vermesse, Zoha, Faussat, Cathie, Handala, Lynda, Zeggagh, Jeremy, Alemany, Andrea, Galvan, Cristina, Castagna, Antonella, Raccagni, Angelo Roberto, Cruz-Flores, Raul Adrián, Fernandez Pardal, Patricia, Marchetta, Lucila, Hazra, Aniruddha, Zucker, Jason, Bell, Elizabeth, Flores, John, Gordon, Leanna, Mitjà, Oriol, Suñer, Clara, Lemaignen, Adrien, Jamard, Simon, Nozza, Silvia, Nori, Achyuta V, Pérez-Barragán, Edgar, Rodríguez-Aldama, Juan Carlos, Blanco, Jose Louis, Delaugerre, Constance, Turner, Dan, Fuertes, Irene, Leiro, Viviana, Walmsley, Sharon L, and Orkin, Chloe M

Published
2024
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7. Repurposing an integrated national influenza platform for genomic surveillance of SARS-CoV-2 in Ghana: a molecular epidemiological analysis

Author

Asante, Ivy Asantewaa, Hsu, Sharon Nienyun, Boatemaa, Linda, Kwasah, Lorreta, Adusei-Poku, Mildred, Odoom, John Kofi, Awuku-Larbi, Yaw, Foulkes, Benjamin H, Oliver-Commey, Joseph, Asiedu, Ernest Konadu, Parker, Matthew D, Mitja, Oriol, Eggo, Rosalind M, de Oliveira-Martins, Leonardo, Asiedu-Bekoe, Franklin, Laryea, Dennis Odai, Kuma-Aboagye, Patrick, Marks, Michael, de Silva, Thushan I, and Ampofo, William Kwabena

Published
2023
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8. Mpox in people with advanced HIV infection: a global case series

Author

Leiro, Viviana, Marchetta, Lucila, Fernandez Pardal, Patricia, Figueroa, María Inés, Cahn, Pedro, Grabmeier-Pfistershammer, Katharina, Libois, Agnes, Liesenborghs, Laurens, Grinsztejn, Beatriz, Schechter, Mauro, dos Santos de Lemos, Alberto, Furtado Costa, Alvaro, Queiroz Rocha, Simone, Valdez Madruga, José, S. Tan, Darrell H., Mishra, Sharmistha, Shah, Shreya, Jorquera, Camila, Castillo, Alberto, Carrión, Mauricio, Cevallos, Nelson, Palich, Romain, Pourcher, Valerie, Rubenstein, Emma, Migaud, Pascal, Boesecke, Christoph, Hoffmann, Christian, Protopapas, Konstantinos, Nozza, Silvia, Cattelan, Anna Maria, Mussini, Cristina, d'Arminio Monforte, Antonella, Cruz Flores, Raúl Adrian, Pérez Barragán, Edgar, Rodríguez Guzmán, Alma Leticia, Ogoina, Dimie, Chika-Igwenyi, Nneka Marian, Chizaram, Onyeaghala, Valverde López, Jenny, García Tello, Angelica, Ubals, Maria, Vall, Martí, Mendoza, Adrià, Suñer, Clara, Clotet, Bonaventura, Bechini, Jordi, Lepe, Jose A, Navarro-Amuedo, M. Dolores, Bernadino, Jose Ignacio, Català, Alba, Tarín Vicente, Eloy José, González Rodríguez, Borja, Rodriguez-Mercader, Sergi, Sánchez-Martinez, Francisca, Cañas-Ruano, Esperanza, Parra-Navarro, Laura, Filén, Finn, Tallón de Lara, Carmen, Braun, Dominique, Piezzi, Vanja, Burkhard, Michael, Kovari, Helen, Mönch, Anja, Dunning, Jake, Simoes, Pedro, Nori, Achyuta, Keegan, Sarah, Thornhill, John P, Apea, Vanessa, Noori, Teymur, Jones, Joyce L., Judson, Seth, Gilliams, Elizabeth A., Hamill, Matthew M., Keruly, Jeanne, Henao Martínez, Andrés F., Lin, Aung, So, Jessica, Davar, Kusha, Villareal, Diana, Tapia Paredes, Miguel, Mitjà, Oriol, Alemany, Andrea, Marks, Michael, Lezama Mora, Jezer I, Rodríguez-Aldama, Juan Carlos, Torres Silva, Mayara Secco, Corral Herrera, Ever Arturo, Crabtree-Ramirez, Brenda, Blanco, José Luis, Girometti, Nicolo, Mazzotta, Valentina, Hazra, Aniruddha, Silva, Macarena, Montenegro-Idrogo, Juan José, Gebo, Kelly, Ghosn, Jade, Peña Vázquez, María Fernanda, Matos Prado, Eduardo, Unigwe, Uche, Villar-García, Judit, Wald-Dickler, Noah, Zucker, Jason, Paredes, Roger, Calmy, Alexandra, Waters, Laura, Galvan-Casas, Cristina, Walmsley, Sharon, and Orkin, Chloe M

Published
2023
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9. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author

Aguilar-Uroz, Adrià, Rosell-García-Ufano, Adrià, Escudero Planas, Adrián, Baelo, Aida, Villahoz Martín, Ainhoa, Moreno López, Alberto, Roldan Ruiz, Alberto, Santana Briongos, Alberto, Tejera Bodas, Alberto, Alonso-Vallés, Alejandro, Fletes-Pérez, Alejandro, Hueso-Mor, Alejandro, Boluda, Alex, Santamaria, Alex, Diestro, Alicia Santos, Revuelta-Álvarez, Almudena, Moreno Moreno, Álvaro, Ortega de Felipe, Ana, Chen-Ye, Ana, Blázquez Valerón, Ana, Rodríguez Pérez, Ana Belén, Tristán Morgalo, Ana Laura, Fernández-Allende, Ana Luisa, Bagán-Trejo, Andrea, Fernández Juan, Andrés, Zalve-Cano, Ángel, Mateo-Martínez, Anna, Galván, Antonio Valero, Egidos-Plaja, Antonio, Jorge, Ariadna, Fraile Torres, Arturo, Pareja Leal, Azahara Maria, Viader Castro, Bárbara, Fernandez Beato, Barbara, Naveira Menchen, Barbara, Martin Poyatos, Beatriz, García-Martínez, Beatriz, Rodrigo Testillano, Belén, Blanco Tejedor, Belen, López Pérez, Blanca, Mencía Hernanz, Blanca, González-Beiras, Camila, Batres, Carlos, Nuñez Garcia, Carmen, Merino-Rodríguez, Carmen, Rodríguez-Gilabert, Carolina, Bonilla Penedo, Celia, Casado Gomez, Christian, Gonzalez Perez, Claudia, Galindo-Tomás, Claudia, Peral Bolaños, Cristina, Blanco-Montes, Cristina, Lupu-Yakovleva, Cristina, Lopez Ruiz, Cristina, Perez Mayoral, Cristina, Fornes, Cristina, Garcia Corrochano, Cristobal, Gallardo Álvarez, Daniel, Navarro Sanz, Daniel, Sanz Barrio, David, Ramet Meseguer, Debora, Vera-Jurado, Edna Margarita, Perez Costa, Eduardo, Bustillos-Sebastian, Eilen Junet, Palomar Casado, Elena, Guerrero, Elena Dorrego, Medina Mateos, Elena, Aragón Gaspar, Elisa Rebeca, Herrero-Vila, Elisabeth, Paez Herrera, Enriqueta, Rojas Powel, Esmeralda, Robres Medialdea, Esther, Vall-Ribalta, Esther, Lopez Perez, Eva, Mihaela Fer, Felicia, Vazquez Ángeles, Fernanda, Tirado Bejarano, Fernando, Prats-Domenech, Ferran, Borràs Martí, Ferran, Ardila-Mejia, Gabriela, Costes, Gèlia, Gómez Arquero, Gema, Flores Mateo, Gemma, Pintos-Morell, Guillem, Mira-Centelles, Helena, Astola Requena, Ignacio, Ortega Martin, Ignacio, Leivas-Gutierrez, Iker, Escribano Valenciano, Irene, Muñoz Gomez, Irene, Ortega, Irina, Montserrat-Lloan, Isabel, Gamboa, Itziar, Rodríguez de Torres de Paul, Jacobo, Cahís, Jordi, Muñoz-Martinez, Jordi, Bermejo, Jorge Iglesias, Cejas López, Joselvis Virginia, Canudas, Josep, García Lucas, Juan Antonio, Martínez-Pino, Juan Carlos, Torres Martínez, Juana, Pujol-Corney, Judit, González Jiménez, Judith, Gurí, Júlia, Labella Martín, Julio, Garcia-Cano, Laia, Perez Plata, Lara Sonsoles, Muñoz Álvaro, Laura, Rodríguez Andrés, Laura, Vega Ruiz, Laura, Cuevas Valiente, Laura, Díaz Rodríguez, Laura, Puigros, Laura, Cristina Piciorang, Lavinia, Escudero, Leticia, Figueroa Caballero, Liliana, Ferrerfàbrega-Costals, Lluna, Costafreda-Hernández, Lucía, De-Paúl, Lucía, González Fernández-Medina, Luis, Moliner Prada, M<ce:sup loc='post">a</ce:sup> Carmen, Berriochoa Martínez de Pisón, M<ce:sup loc='post">a</ce:sup> Cristina, Blanco Blasco, Maria, Gil Jorge, Maria, Cortijo Caballero, María, Ubals, Maria, Gordillo, Maria, Guilloto López, Maria Alicia, Moreno Calvo, Maria Concepción, Gil García, María del Rosario, Dueñas Román, María Inmaculada, Gonzalez Sanchez, Maria Josefa, Nicolás Campoy, María Luisa, González Velayos, Maria Luz, Zori, Mario Mejías, Maqueda, Mario Oliva, Caño de la Cruz, Mario, Palau-Morral, Mariona, Martín-Muñoz, Marta, Cereceda Meca, Marta, Díaz Urbina, Marta, VerónicaPlazas, Martha, Vall-Mayans, Martí, Blasco, Martí, Jane Chu-Sifuentes, Mary, García de Villasladad Peñaranda, Miguel, Hernanz Sotoca, Miguel, Iglesias Gonzalez, Miguel, Labrador-Galván, Miguel Ángel, Rodrigo de Vivar Azcarate, Miguel, Gil-Fibla, Miquel, Formentí-Pallarés, Miquel, Esteve-Tugues, Mireia, Juanes Perez, Miriam, López Rubio, Miriam, Recuero Renales, Mirian, Hijós-Rullo, Mònica, Lleonart-Abadia, Montserrat, Finelli, Nadia, Rojas-Bertier, Naiara, Reyes-Calderón, Nataly, Casado Larrañaga, Nerea, Zurita Castrosin, Nerea Nuria, Álvarez-Nieto, Noélia, Leiva-Mora, Nuria, Tomillo-Martín, Olga, Belghazi, Omar, Buscà, Oriol, Mendoza Cediel, Pablo, Macedo, Pablo, Rodríguez Barroso, Patricia, Ruiz Álvarez, Patricia, López, Patricia Morales, Vara de Rey, Patricia Jimenez, Ginés, Paz Lozano, Bris Rodriguez, Pilar, Martínez-Alamillo, Pilar, Salmerón Martínez, Rafa, Botello Ariza, Raquel, Vaquero Mena, Raquel, González-Alonso, Raquel, Kaczmarczyk, Raul, Barnadas Vintró, Rita, Hontecillas Martínez, Rodrigo, Ribot-Rodríguez, Rosa, Escobar-Sánchez, Rosa, Montes Trinidad, Rosario Paloma, Martínez Quintana, Rubén, Arnay Arrogante, Ruben, Berjon Sanchez, Ruben, Picazo Navarro, Ruben, Bastos, Rubén, Martín Molinero, Samuel, Israel-Benchaya, Samuel Dan, Muñoz-Burguillo, Sandra, Rodríguez-Salvador, Sandra, Avila, Sara, Corral Gayubas, Sara, Nuñez Sánchez, Sergio, Torres Weber, Sofía, Encabo Lopez, Susana, Torices Rasines, Teresa, Sallas, Valentí, Curto-Vicente, Verónica, Gómez Hijosa, Verónica, Daimiel-Pedrote, Verónica, Gozalo, Verónica, Barrios López, Vicente, Castillo Montoya, Virginia Ivette, Espinoza Pérez, Yuri, CristinaBerriochoa Martínez de Pisón, María, Muñoz Castillo, David, Donato, Carlos, García García, Isabel, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Suñer, Clara, Galvan-Casas, Cristina, Carrera, Caty, Ouchi, Dan, Prat, Núria, Ara, Jordi, Nadal, Nuria, Riel, Ricard, Funollet, Blanca, Ojeda-Ciurana, Carmen, Balague, Lluis Esteve, Salvador-González, Betlem, Arcarons, Anna Forcada, Vidal-Alaball, Josep, Del Cura-González, María Isabel, Barrientos, Ricardo Rodríguez, Ramos-Blanes, Rafel, Bou, Alberto Alum, Mondou, Elsa, Torres, Mireia, Campins, Neus, Sanz, Ana, Tang, Yonggiang, Rodriguez-Arias, Miquel Àngel, Bassat, Quique, Clotet, Bonaventura, and Mitjà, Oriol

Published
2023
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10. Monkeypox

Author

Mitjà, Oriol, Ogoina, Dimie, Titanji, Boghuma K, Galvan, Cristina, Muyembe, Jean-Jacques, Marks, Michael, and Orkin, Chloe M

Published
2023
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11. Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study

Author

Tarín-Vicente, Eloy José, Alemany, Andrea, Agud-Dios, Manuel, Ubals, Maria, Suñer, Clara, Antón, Andrés, Arando, Maider, Arroyo-Andrés, Jorge, Calderón-Lozano, Lorena, Casañ, Cristina, Cabrera, José Miguel, Coll, Pep, Descalzo, Vicente, Folgueira, María Dolores, García-Pérez, Jorge N, Gil-Cruz, Elena, González-Rodríguez, Borja, Gutiérrez-Collar, Christian, Hernández-Rodríguez, Águeda, López-Roa, Paula, de los Ángeles Meléndez, María, Montero-Menárguez, Julia, Muñoz-Gallego, Irene, Palencia-Pérez, Sara Isabel, Paredes, Roger, Pérez-Rivilla, Alfredo, Piñana, María, Prat, Nuria, Ramirez, Aída, Rivero, Ángel, Rubio-Muñiz, Carmen Alejandra, Vall, Martí, Acosta-Velásquez, Kevin Stephen, Wang, An, Galván-Casas, Cristina, Marks, Michael, Ortiz-Romero, Pablo L, and Mitjà, Oriol

Published
2022
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13. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Millat-Martinez, Pere, Gharbharan, Arvind, Alemany, Andrea, Rokx, Casper, Geurtsvankessel, Corine, Papageorgiou, Grigorios, van Geloven, Nan, Jordans, Carlijn, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, Ellen, Corbacho-Monné, Marc, Ouchi, Dan, Piccolo Ferreira, Francini, Malchair, Pierre, Videla, Sebastian, García García, Vanesa, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodriguez Codina, Joana, Amado Simon, Rosa, Grifols, Joan-Ramon, Blanco, Julian, Blanco, Ignacio, Ara, Jordi, Bassat, Quique, Clotet, Bonaventura, Baro, Bàrbara, Troxel, Andrea, Zwaginga, Jaap Jan, Mitjà, Oriol, and Rijnders, Bart J. A.

Published
2022
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14. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, and Mitjà, Oriol

Published
2022
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16. Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series

Author

Thornhill, John P, Palich, Romain, Ghosn, Jade, Walmsley, Sharon, Moschese, Davide, Cortes, Claudia P, Galliez, Rafael Mello, Garlin, Amy B, Nozza, Silvia, Mitja, Oriol, Radix, Asa E, Blanco, Jose Luis, Crabtree-Ramirez, Brenda, Thompson, Melanie, Wiese, Lothar, Schulbin, Hubert, Levcovich, Ariela, Falcone, Marco, Lucchini, Anna, Sendagorta, Elena, Treutiger, Carl-Johan, Byrne, Ruth, Coyne, Katherine, Meyerowitz, Eric A, Grahn, Anna M, Hansen, Ann-Brit Eg, Pourcher, Valerie, DellaPiazza, Michelle, Lee, Rachel, Stoeckle, Marcel, Hazra, Aniruddha, Apea, Vanessa, Rubenstein, Emma, Jones, Joyce, Wilkin, Aimee, Ganesan, Anuradha, Henao-Martínez, Andrés F, Chow, Eric J, Titanji, Boghuma K, Zucker, Jason E, Ogoina, Dimie, and Orkin, Chloe M

Published
2022
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17. Sequence typing of Haemophilus ducreyi isolated from patients in the Namatanai region of Papua New Guinea: Infections by Class I and Class II strain types differ in ulcer duration and resurgence of infection after azithromycin treatment.

Author

Medappa, Monica, Pospíšilová, Petra, John, Lucy N., González-Beiras, Camila, Vall-Mayans, Marti, Mitjà, Oriol, and Šmajs, David

Subjects
GENETIC variation, HAEMOPHILUS, DRUG administration, ULCERS, TREPONEMA pallidum, AZITHROMYCIN
Abstract

Haemophilus ducreyi (HD) is an important cause of cutaneous ulcers in several endemic regions, including the Western Pacific Region, especially among children. An HD sequence typing on swab samples taken from 1,081 ulcers in the Namatanai district of Papua New Guinea, during the pilot study for treatment of yaws, has been performed using the Grant typing system. Of the 363 samples that tested positive for the 16S rDNA of HD, the dsrA sequences of 270 samples were determined. Altogether they revealed 8 HD strain types circulating in Namatanai, including seven strain types of Class I (I.3, I.4, I.5, I.9, I.10, I.11, I.12) and one strain of Class II (II.3); four Class I types (I.9, I.10, I.11, I.12) were novel. The southern region of Namatanai (Matalai Rural) was identified as the region with the lowest genotype diversity and with most infections caused by HD Class II. The middle and northern subdistricts were affected mainly by HD Class I. Analysis of patient characteristics revealed that Class II HD infections were more often represented by longer-lasting ulcers than Class I HD infections. An increase in the prevalence of the I.10 strain was found after azithromycin administration compared to the untreated population at baseline likely reflecting higher infectivity of HD Class I, and more specifically strain type I.10. Author summary: Haemophilus ducreyi (HD) is one of the main causative agents of cutaneous ulcers in children across substantial parts of Africa and the Pacific. A yaws eradication study conducted in the Namatanai district of Papua New Guinea revealed that nearly one-third of all patients were infected with HD. Single locus sequence typing (SLST) of the HD dsrA locus revealed presence of multiple HD strains circulating in the human population of Namatanai region. In contrast to Treponema pallidum subsp. pertenue, the pathogen responsible for yaws, the prevalence of HD strains did not significantly decrease following mass drug administration. In addition, HD strains from patients in Namatanai region revealed a higher genetic diversity compared to the yaws agent present in the same area and the HD strain composition changed following antibiotic treatment. Infections caused by at least some different HD strain types appear to differ in reported ulcer duration and also in resurgence of infection after antibiotic treatment. Therefore, important pathophysiological differences among HD strain types were predicted. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients’ ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes

Author

Medappa, Monica, primary, Pospíšilová, Petra, additional, Madruga, Maria Paula M., additional, John, Lucy N., additional, Beiras, Camila G., additional, Grillová, Linda, additional, Oppelt, Jan, additional, Banerjee, Arka, additional, Vall-Mayans, Marti, additional, Mitjà, Oriol, additional, and Šmajs, David, additional

Published
2024
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21. Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe

Author

Mitjà, Oriol, primary, Padovese, Valeska, additional, Folch, Cinta, additional, Rossoni, Isotta, additional, Marks, Michael, additional, Rodríguez i Arias, Miquel Angel, additional, Telenti, Amalio, additional, Ciuffi, Angela, additional, Blondeel, Karel, additional, Mårdh, Otilia, additional, and Casabona, Jordi, additional

Published
2023
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22. Coverage, determinants of use and repurposing of long-lasting insecticidal nets two years after a mass distribution in Lihir Islands, Papua New Guinea: a cross-sectional study

Author

Millat-Martínez, Pere, Gabong, Rebecca, Balanza, Núria, Luana, Sakaia, Sanz, Sergi, Raulo, Silvia, Elizah, Arthur, Wali, Chilaka, Paivu, Benjamin, Dalmas, Julian, Tabie, Samson, Karl, Stephan, Laman, Moses, Pomat, William, Mitjà, Oriol, Baro, Bàrbara, and Bassat, Quique

Published
2021
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23. Egocentric sexual network analysis among gay and bisexual men who have sex with men with and without mpox infection

Author

Sönmez, İbrahim, primary, Martínez Riveros, Héctor, additional, Folch, Cinta, additional, Suñer, Clara, additional, Díaz, Yesika, additional, Alonso, Lucía, additional, Agusti, Cristina, additional, Mendoza, Adrià, additional, Tarín-Vicente, Eloy José, additional, Oller, Xènia, additional, Alemany, Andrea, additional, Rivero, Àngel, additional, Orviz, Eva, additional, Silva-Klug, Ana, additional, Mitjà, Oriol, additional, and Casabona, Jordi, additional

Published
2023
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24. Mpox in people with past infection or a complete vaccination course: a global case series

Author

Hazra, Aniruddha, primary, Zucker, Jason, additional, Bell, Elizabeth, additional, Flores, John, additional, Gordon, Leanna, additional, Mitjà, Oriol, additional, Suñer, Clara, additional, Lemaignen, Adrien, additional, Jamard, Simon, additional, Nozza, Silvia, additional, Nori, Achyuta V, additional, Pérez-Barragán, Edgar, additional, Rodríguez-Aldama, Juan Carlos, additional, Blanco, Jose Louis, additional, Delaugerre, Constance, additional, Turner, Dan, additional, Fuertes, Irene, additional, Leiro, Viviana, additional, Walmsley, Sharon L, additional, Orkin, Chloe M, additional, Creticos, Catherine, additional, Gibbons, Patrick, additional, Maakaroun-Vermesse, Zoha, additional, Faussat, Cathie, additional, Handala, Lynda, additional, Zeggagh, Jeremy, additional, Alemany, Andrea, additional, Galvan, Cristina, additional, Castagna, Antonella, additional, Raccagni, Angelo Roberto, additional, Cruz-Flores, Raul Adrián, additional, Fernandez Pardal, Patricia, additional, and Marchetta, Lucila, additional

Published
2023
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25. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization

Author

Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart Ja, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, Callaway, Clifton W, Libster, Romina, Marc, Gonzalo Perez, Wappner, Diego, Esteban, Ignacio, Polack, Fernando, Sullivan, David J, Internal Medicine, Surgery, and Medical Microbiology & Infectious Diseases

Subjects
Microbiology (medical), Infectious Diseases
Abstract

Background Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results. Methods We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022. Results Five included studies from 4 countries enrolled and transfused 2620 adult patients. Comorbidities were present in 1795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14 580 in diverse assays. One hundred sixty of 1315 (12.2%) control patients were hospitalized, versus 111 of 1305 (8.5%) CCP-treated patients, yielding a 3.7% (95% confidence interval [CI], 1.3%–6.0%; P = .001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95% CI, 4.0%–11.1%; P = .0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment >5 days after symptom onset or in those receiving CCP with antibody titers below the median titer. Conclusions Among outpatients with COVID-19, treatment with CCP reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher.

Published
2023

28. Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain

Author

Suñer, Clara, primary, Ubals, Maria, additional, Tarín-Vicente, Eloy José, additional, Mendoza, Adrià, additional, Alemany, Andrea, additional, Hernández-Rodríguez, Águeda, additional, Casañ, Cristina, additional, Descalzo, Vicente, additional, Ouchi, Dan, additional, Marc, Aurélien, additional, Rivero, Àngel, additional, Coll, Pep, additional, Oller, Xènia, additional, Miguel Cabrera, José, additional, Vall-Mayans, Martí, additional, Dolores Folgueira, María, additional, Ángeles Melendez, María, additional, Agud-Dios, Manuel, additional, Gil-Cruz, Elena, additional, Paris de Leon, Alexia, additional, Ramírez Marinero, Aída, additional, Buhiichyk, Vira, additional, Galván-Casas, Cristina, additional, Paredes, Roger, additional, Prat, Nuria, additional, Sala Farre, Maria-Rosa, additional, Bonet-Simó, Josep Maria, additional, Farré, Magí, additional, Ortiz-Romero, Pablo L, additional, Clotet, Bonaventura, additional, García-Patos, Vicente, additional, Casabona, Jordi, additional, Guedj, Jeremie, additional, Cardona, Pere-Joan, additional, Blanco, Ignacio, additional, Marks, Michael, additional, Mitjà, Oriol, additional, Ramón Santos, José, additional, Bailón, Lucía, additional, Benet, Susana, additional, Arroyo Andres, Jorge, additional, Calderón Lozano, Lorena, additional, Carrasco Díaz, María, additional, Budria Serrano, Carla, additional, Crespillo Galán, Enola, additional, Parra Manzano, Ana Isabel, additional, Nef Rabadán, Pamela, additional, Muntané, Laura, additional, Sánchez-Lafuente Doncel, Cristina, additional, Marrero Pueo, Yesinei Marina, additional, Muñoz Quinto, Aroa, additional, Acosta, Marlon, additional, Alvarez, Patricia, additional, Arando, Maider, additional, García, Jorge N, additional, Monforte, Arnau, additional, Maltas Hidalgo, Yolanda, additional, Hervas Perez, Ramona, additional, and Clotet Romero, Laura, additional

Published
2023
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29. Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.

Author

Nguyen, Bach Tran, Marc, Aurélien, Suñer, Clara, Marks, Michael, Ubals, Maria, Hernández-Rodríguez, Águeda, Melendez, María Ángeles, Hruby, Dennis E., Russo, Andrew T., Mentré, France, Mitjà, Oriol, Grosenbach, Douglas W., and Guedj, Jérémie

Subjects
MONKEYPOX, BASIC reproduction number, REPRODUCTION, PEAK load, DRUG efficacy, VIRAL load
Abstract

Despite use of tecovirimat since the beginning of the 2022 outbreak, few data have been published on its antiviral effect in humans. We here predict tecovirimat efficacy using a unique set of data in nonhuman primates (NHPs) and humans. We analyzed tecovirimat antiviral activity on viral kinetics in NHP to characterize its concentration–effect relationship in vivo. Next, we used a pharmacological model developed in healthy volunteers to project its antiviral efficacy in humans. Finally, a viral dynamic model was applied to characterize mpox kinetics in skin lesions from 54 untreated patients, and we used this modeling framework to predict the impact of tecovirimat on viral clearance in skin lesions. At human-recommended doses, tecovirimat could inhibit viral replication from infected cells by more than 90% after 3 to 5 days of drug administration and achieved over 97% efficacy at drug steady state. With an estimated mpox within-host basic reproduction number, R0, equal to 5.6, tecovirimat could therefore shorten the time to viral clearance if given before viral peak. We predicted that initiating treatment at symptom onset, which on average occurred 2 days before viral peak, could reduce the time to viral clearance by about 6 days. Immediate postexposure prophylaxis could not only reduce time to clearance but also lower peak viral load by more than 1.0 log10 copies/mL and shorten the duration of positive viral culture by about 7 to 10 days. These findings support the early administration of tecovirimat against mpox infection, ideally starting from the infection day as a postexposure prophylaxis. Despite its use since the beginning of the 2022 mpox outbreak, few data have been published on the antiviral effect of tecovirimat in humans. This study predicts the impact of early tecovirimat administration on the time to viral clearance in patients with mpox infection, using an integrative modeling approach that combines pre-clinical and clinical data. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Comparison of Reverse Transcription (RT)-Quantitative PCR and RT-Droplet Digital PCR for Detection of Genomic and Subgenomic SARS-CoV-2 RNA

Author

Morón-López, Sara, primary, Riveira-Muñoz, Eva, additional, Urrea, Victor, additional, Gutiérrez-Chamorro, Lucia, additional, Ávila-Nieto, Carlos, additional, Noguera-Julian, Marc, additional, Carrillo, Jorge, additional, Mitjà, Oriol, additional, Mateu, Lourdes, additional, Massanella, Marta, additional, Ballana, Ester, additional, and Martinez-Picado, Javier, additional

Published
2023
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31. Mpox in people with advanced HIV infection: a global case series

Author

Mitjà, Oriol, primary, Alemany, Andrea, additional, Marks, Michael, additional, Lezama Mora, Jezer I, additional, Rodríguez-Aldama, Juan Carlos, additional, Torres Silva, Mayara Secco, additional, Corral Herrera, Ever Arturo, additional, Crabtree-Ramirez, Brenda, additional, Blanco, José Luis, additional, Girometti, Nicolo, additional, Mazzotta, Valentina, additional, Hazra, Aniruddha, additional, Silva, Macarena, additional, Montenegro-Idrogo, Juan José, additional, Gebo, Kelly, additional, Ghosn, Jade, additional, Peña Vázquez, María Fernanda, additional, Matos Prado, Eduardo, additional, Unigwe, Uche, additional, Villar-García, Judit, additional, Wald-Dickler, Noah, additional, Zucker, Jason, additional, Paredes, Roger, additional, Calmy, Alexandra, additional, Waters, Laura, additional, Galvan-Casas, Cristina, additional, Walmsley, Sharon, additional, Orkin, Chloe M, additional, Leiro, Viviana, additional, Marchetta, Lucila, additional, Fernandez Pardal, Patricia, additional, Figueroa, María Inés, additional, Cahn, Pedro, additional, Grabmeier-Pfistershammer, Katharina, additional, Libois, Agnes, additional, Liesenborghs, Laurens, additional, Grinsztejn, Beatriz, additional, Schechter, Mauro, additional, dos Santos de Lemos, Alberto, additional, Furtado Costa, Alvaro, additional, Queiroz Rocha, Simone, additional, Valdez Madruga, José, additional, S. Tan, Darrell H., additional, Mishra, Sharmistha, additional, Shah, Shreya, additional, Jorquera, Camila, additional, Castillo, Alberto, additional, Carrión, Mauricio, additional, Cevallos, Nelson, additional, Palich, Romain, additional, Pourcher, Valerie, additional, Rubenstein, Emma, additional, Migaud, Pascal, additional, Boesecke, Christoph, additional, Hoffmann, Christian, additional, Protopapas, Konstantinos, additional, Nozza, Silvia, additional, Cattelan, Anna Maria, additional, Mussini, Cristina, additional, d'Arminio Monforte, Antonella, additional, Cruz Flores, Raúl Adrian, additional, Pérez Barragán, Edgar, additional, Rodríguez Guzmán, Alma Leticia, additional, Ogoina, Dimie, additional, Chika-Igwenyi, Nneka Marian, additional, Chizaram, Onyeaghala, additional, Valverde López, Jenny, additional, García Tello, Angelica, additional, Ubals, Maria, additional, Vall, Martí, additional, Mendoza, Adrià, additional, Suñer, Clara, additional, Clotet, Bonaventura, additional, Bechini, Jordi, additional, Lepe, Jose A, additional, Navarro-Amuedo, M. Dolores, additional, Bernadino, Jose Ignacio, additional, Català, Alba, additional, Tarín Vicente, Eloy José, additional, González Rodríguez, Borja, additional, Rodriguez-Mercader, Sergi, additional, Sánchez-Martinez, Francisca, additional, Cañas-Ruano, Esperanza, additional, Parra-Navarro, Laura, additional, Filén, Finn, additional, Tallón de Lara, Carmen, additional, Braun, Dominique, additional, Piezzi, Vanja, additional, Burkhard, Michael, additional, Kovari, Helen, additional, Mönch, Anja, additional, Dunning, Jake, additional, Simoes, Pedro, additional, Nori, Achyuta, additional, Keegan, Sarah, additional, Thornhill, John P, additional, Apea, Vanessa, additional, Noori, Teymur, additional, Jones, Joyce L., additional, Judson, Seth, additional, Gilliams, Elizabeth A., additional, Hammill, Matthew, additional, Keruly, Jeanne, additional, Henao Martínez, Andrés F., additional, Lin, Aung, additional, So, Jessica, additional, Davar, Kusha, additional, and Villareal, Diana, additional

Published
2023
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32. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author

Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Suñer, Clara, additional, Galvan-Casas, Cristina, additional, Carrera, Caty, additional, Ouchi, Dan, additional, Prat, Núria, additional, Ara, Jordi, additional, Nadal, Nuria, additional, Riel, Ricard, additional, Funollet, Blanca, additional, Ojeda-Ciurana, Carmen, additional, Balague, Lluis Esteve, additional, Salvador-González, Betlem, additional, Arcarons, Anna Forcada, additional, Vidal-Alaball, Josep, additional, Del Cura-González, María Isabel, additional, Barrientos, Ricardo Rodríguez, additional, Ramos-Blanes, Rafel, additional, Bou, Alberto Alum, additional, Mondou, Elsa, additional, Torres, Mireia, additional, Campins, Neus, additional, Sanz, Ana, additional, Tang, Yonggiang, additional, Rodriguez-Arias, Miquel Àngel, additional, Bassat, Quique, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Aguilar-Uroz, Adrià, additional, Rosell-García-Ufano, Adrià, additional, Escudero Planas, Adrián, additional, Baelo, Aida, additional, Villahoz Martín, Ainhoa, additional, Moreno López, Alberto, additional, Roldan Ruiz, Alberto, additional, Santana Briongos, Alberto, additional, Tejera Bodas, Alberto, additional, Alonso-Vallés, Alejandro, additional, Fletes-Pérez, Alejandro, additional, Hueso-Mor, Alejandro, additional, Boluda, Alex, additional, Santamaria, Alex, additional, Diestro, Alicia Santos, additional, Revuelta-Álvarez, Almudena, additional, Moreno Moreno, Álvaro, additional, Ortega de Felipe, Ana, additional, Chen-Ye, Ana, additional, Blázquez Valerón, Ana, additional, Rodríguez Pérez, Ana Belén, additional, Tristán Morgalo, Ana Laura, additional, Fernández-Allende, Ana Luisa, additional, Bagán-Trejo, Andrea, additional, Fernández Juan, Andrés, additional, Zalve-Cano, Ángel, additional, Mateo-Martínez, Anna, additional, Galván, Antonio Valero, additional, Egidos-Plaja, Antonio, additional, Jorge, Ariadna, additional, Fraile Torres, Arturo, additional, Pareja Leal, Azahara Maria, additional, Viader Castro, Bárbara, additional, Fernandez Beato, Barbara, additional, Naveira Menchen, Barbara, additional, Martin Poyatos, Beatriz, additional, García-Martínez, Beatriz, additional, Rodrigo Testillano, Belén, additional, Blanco Tejedor, Belen, additional, López Pérez, Blanca, additional, Mencía Hernanz, Blanca, additional, González-Beiras, Camila, additional, Batres, Carlos, additional, Nuñez Garcia, Carmen, additional, Merino-Rodríguez, Carmen, additional, Rodríguez-Gilabert, Carolina, additional, Bonilla Penedo, Celia, additional, Casado Gomez, Christian, additional, Gonzalez Perez, Claudia, additional, Galindo-Tomás, Claudia, additional, Peral Bolaños, Cristina, additional, Blanco-Montes, Cristina, additional, Lupu-Yakovleva, Cristina, additional, Lopez Ruiz, Cristina, additional, Perez Mayoral, Cristina, additional, Fornes, Cristina, additional, Garcia Corrochano, Cristobal, additional, Gallardo Álvarez, Daniel, additional, Navarro Sanz, Daniel, additional, Sanz Barrio, David, additional, Ramet Meseguer, Debora, additional, Vera-Jurado, Edna Margarita, additional, Perez Costa, Eduardo, additional, Bustillos-Sebastian, Eilen Junet, additional, Palomar Casado, Elena, additional, Guerrero, Elena Dorrego, additional, Medina Mateos, Elena, additional, Aragón Gaspar, Elisa Rebeca, additional, Herrero-Vila, Elisabeth, additional, Paez Herrera, Enriqueta, additional, Rojas Powel, Esmeralda, additional, Robres Medialdea, Esther, additional, Vall-Ribalta, Esther, additional, Lopez Perez, Eva, additional, Mihaela Fer, Felicia, additional, Vazquez Ángeles, Fernanda, additional, Tirado Bejarano, Fernando, additional, Prats-Domenech, Ferran, additional, Borràs Martí, Ferran, additional, Ardila-Mejia, Gabriela, additional, Costes, Gèlia, additional, Gómez Arquero, Gema, additional, Flores Mateo, Gemma, additional, Pintos-Morell, Guillem, additional, Mira-Centelles, Helena, additional, Astola Requena, Ignacio, additional, Ortega Martin, Ignacio, additional, Leivas-Gutierrez, Iker, additional, Escribano Valenciano, Irene, additional, Muñoz Gomez, Irene, additional, Ortega, Irina, additional, Montserrat-Lloan, Isabel, additional, Gamboa, Itziar, additional, Rodríguez de Torres de Paul, Jacobo, additional, Cahís, Jordi, additional, Muñoz-Martinez, Jordi, additional, Bermejo, Jorge Iglesias, additional, Cejas López, Joselvis Virginia, additional, Canudas, Josep, additional, García Lucas, Juan Antonio, additional, Martínez-Pino, Juan Carlos, additional, Torres Martínez, Juana, additional, Pujol-Corney, Judit, additional, González Jiménez, Judith, additional, Gurí, Júlia, additional, Labella Martín, Julio, additional, Garcia-Cano, Laia, additional, Perez Plata, Lara Sonsoles, additional, Muñoz Álvaro, Laura, additional, Rodríguez Andrés, Laura, additional, Vega Ruiz, Laura, additional, Cuevas Valiente, Laura, additional, Díaz Rodríguez, Laura, additional, Puigros, Laura, additional, Cristina Piciorang, Lavinia, additional, Escudero, Leticia, additional, Figueroa Caballero, Liliana, additional, Ferrerfàbrega-Costals, Lluna, additional, Costafreda-Hernández, Lucía, additional, De-Paúl, Lucía, additional, González Fernández-Medina, Luis, additional, Moliner Prada, Ma Carmen, additional, Berriochoa Martínez de Pisón, Ma Cristina, additional, Blanco Blasco, Maria, additional, Gil Jorge, Maria, additional, Cortijo Caballero, María, additional, Ubals, Maria, additional, Gordillo, Maria, additional, Guilloto López, Maria Alicia, additional, Moreno Calvo, Maria Concepción, additional, Gil García, María del Rosario, additional, Dueñas Román, María Inmaculada, additional, Gonzalez Sanchez, Maria Josefa, additional, Nicolás Campoy, María Luisa, additional, González Velayos, Maria Luz, additional, Zori, Mario Mejías, additional, Maqueda, Mario Oliva, additional, Caño de la Cruz, Mario, additional, Palau-Morral, Mariona, additional, Martín-Muñoz, Marta, additional, Cereceda Meca, Marta, additional, Díaz Urbina, Marta, additional, VerónicaPlazas, Martha, additional, Vall-Mayans, Martí, additional, Blasco, Martí, additional, Jane Chu-Sifuentes, Mary, additional, García de Villasladad Peñaranda, Miguel, additional, Hernanz Sotoca, Miguel, additional, Iglesias Gonzalez, Miguel, additional, Labrador-Galván, Miguel Ángel, additional, Rodrigo de Vivar Azcarate, Miguel, additional, Gil-Fibla, Miquel, additional, Formentí-Pallarés, Miquel, additional, Esteve-Tugues, Mireia, additional, Juanes Perez, Miriam, additional, López Rubio, Miriam, additional, Recuero Renales, Mirian, additional, Hijós-Rullo, Mònica, additional, Lleonart-Abadia, Montserrat, additional, Finelli, Nadia, additional, Rojas-Bertier, Naiara, additional, Reyes-Calderón, Nataly, additional, Casado Larrañaga, Nerea, additional, Zurita Castrosin, Nerea Nuria, additional, Álvarez-Nieto, Noélia, additional, Leiva-Mora, Nuria, additional, Tomillo-Martín, Olga, additional, Belghazi, Omar, additional, Buscà, Oriol, additional, Mendoza Cediel, Pablo, additional, Macedo, Pablo, additional, Rodríguez Barroso, Patricia, additional, Ruiz Álvarez, Patricia, additional, López, Patricia Morales, additional, Vara de Rey, Patricia Jimenez, additional, Ginés, Paz Lozano, additional, Bris Rodriguez, Pilar, additional, Martínez-Alamillo, Pilar, additional, Salmerón Martínez, Rafa, additional, Botello Ariza, Raquel, additional, Vaquero Mena, Raquel, additional, González-Alonso, Raquel, additional, Kaczmarczyk, Raul, additional, Barnadas Vintró, Rita, additional, Hontecillas Martínez, Rodrigo, additional, Ribot-Rodríguez, Rosa, additional, Escobar-Sánchez, Rosa, additional, Montes Trinidad, Rosario Paloma, additional, Martínez Quintana, Rubén, additional, Arnay Arrogante, Ruben, additional, Berjon Sanchez, Ruben, additional, Picazo Navarro, Ruben, additional, Bastos, Rubén, additional, Martín Molinero, Samuel, additional, Israel-Benchaya, Samuel Dan, additional, Muñoz-Burguillo, Sandra, additional, Rodríguez-Salvador, Sandra, additional, Avila, Sara, additional, Corral Gayubas, Sara, additional, Nuñez Sánchez, Sergio, additional, Torres Weber, Sofía, additional, Encabo Lopez, Susana, additional, Torices Rasines, Teresa, additional, Sallas, Valentí, additional, Curto-Vicente, Verónica, additional, Gómez Hijosa, Verónica, additional, Daimiel-Pedrote, Verónica, additional, Gozalo, Verónica, additional, Barrios López, Vicente, additional, Castillo Montoya, Virginia Ivette, additional, Espinoza Pérez, Yuri, additional, CristinaBerriochoa Martínez de Pisón, María, additional, Muñoz Castillo, David, additional, Donato, Carlos, additional, and García García, Isabel, additional

Published
2023
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33. Hydroxychloroquine for treatment of non‐hospitalized adults with COVID ‐19: A meta‐analysis of individual participant data of randomized trials

Author

Mitjà, Oriol, primary, Reis, Gilmar, additional, Boulware, David R., additional, Spivak, Adam M., additional, Sarwar, Ammar, additional, Johnston, Christine, additional, Webb, Brandon, additional, Hill, Michael D., additional, Smith, Davey, additional, Kremsner, Peter, additional, Curran, Marla, additional, Carter, David, additional, Alexander, Jim, additional, Corbacho, Marc, additional, Lee, Todd C., additional, Hullsiek, Katherine Huppler, additional, McDonald, Emily G., additional, Hess, Rachel, additional, Hughes, Michael, additional, Baeten, Jared M., additional, Schwartz, Ilan, additional, Metz, Luanne, additional, Richer, Lawrence, additional, Chew, Kara W., additional, Daar, Eric, additional, Wohl, David, additional, and Dunne, Michael, additional

Published
2023
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34. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials

Author

Levine, Adam C., primary, Fukuta, Yuriko, additional, Huaman, Moises A., additional, Ou, Jiangda, additional, Meisenberg, Barry R., additional, Patel, Bela, additional, Paxton, James H., additional, Hanley, Daniel F., additional, Rijnders, Bart JA, additional, Gharbharan, Arvind, additional, Rokx, Casper, additional, Zwaginga, Jaap Jan, additional, Alemany, Andrea, additional, Mitjà, Oriol, additional, Ouchi, Dan, additional, Millat-Martinez, Pere, additional, Durkalski-Mauldin, Valerie, additional, Korley, Frederick K., additional, Dumont, Larry J., additional, Callaway, Clifton W., additional, Libster, Romina, additional, Marc, Gonzalo Perez, additional, Wappner, Diego, additional, Esteban, Ignacio, additional, Polack, Fernando, additional, and Sullivan, David J., additional

Published
2022
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35. Two Streptococcus pyogenes emm types and several anaerobic bacterial species are associated with idiopathic cutaneous ulcers in children after community-based mass treatment with azithromycin

Author

Griesenauer, Brad, primary, Xing, Yue, additional, Fortney, Katherine R., additional, Gao, Xiang, additional, González-Beiras, Camila, additional, Nelson, David E., additional, Ren, Jie, additional, Mitjà, Oriol, additional, Dong, Qunfeng, additional, and Spinola, Stanley M., additional

Published
2022
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36. Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis

Author

Zhang, Ying, primary, Goh, Su Mei, additional, Mello, Maeve B, additional, Baggaley, Rachel C, additional, Wi, Teodora, additional, Johnson, Cheryl C, additional, Asiedu, Kingsley B, additional, Marks, Michael, additional, Pham, Minh D, additional, Fairley, Christopher K, additional, Chow, Eric P F, additional, Mitjà, Oriol, additional, Toskin, Igor, additional, Ballard, Ronald C, additional, and Ong, Jason J, additional

Published
2022
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37. Evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox

Author

Ubals, Maria, primary, Tarín-Vicente, Eloy José, additional, Oller, Xènia, additional, Mendoza, Adrià, additional, Alemany, Andrea, additional, Hernández-Rodríguez, Águeda, additional, Casañ, Cristina, additional, Rivero, Ángel, additional, Coll, Pep, additional, Cabrera, José Miguel, additional, Vall, Martí, additional, Agud-Dios, Manuel, additional, Gil-Cruz, Elena, additional, de Leon, Alexia Paris, additional, Ramírez, Aída, additional, Folgueira, María Dolores, additional, Melendez, María Angeles, additional, Buhiichyk, Vira, additional, Galván-Casas, Cristina, additional, Paredes, Roger, additional, Prat, Nuria, additional, Farre, Maria-Rosa Sala, additional, Bonet-Simó, Josep Maria, additional, Ortiz-Romero, Pablo L, additional, Clotet, Bonaventura, additional, Cardona, Pere-Joan, additional, Blanco, Ignacio, additional, Marks, Michael, additional, Suñer, Clara, additional, and Mitjà, Oriol, additional

Published
2022
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38. Evaluating the yaws diagnostic gap: A survey to determine the capacity of and barriers to improving diagnostics in all yaws-endemic countries

Author

Handley, Becca L., primary, Tchatchouang, Serges, additional, Grout, Lise, additional, Johnson, Roch Christian, additional, Tabah, Earnest Njih, additional, Boua, Bernard, additional, Boock, Alphonse Um, additional, Koffi, Aboa Paul, additional, Phanzu, Delphin Mavinga, additional, Kotey, Nana Konama, additional, Rogers, Emerson, additional, Dofitas, Belen, additional, Jung, Younghee, additional, Maweke, Tchalim, additional, Beiras, Camila G., additional, Maman, Issaka, additional, Basing, Laud Anthony, additional, Ngazoa, Solange Kakou, additional, Houezo, Jean Gabin, additional, Togbey, Kwamy, additional, Telan, Elizabeth Freda, additional, Sarmento, Nevio, additional, Marion, Estelle, additional, Addo, Kwasi Kennedy, additional, Mitjà, Oriol, additional, Asiedu, Kingsley, additional, Harding-Esch, Emma, additional, and Marks, Michael, additional

Published
2022
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39. Piperaquine Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers of Papua New Guinea after Administration of Three-Monthly Doses of Dihydroartemisinin–Piperaquine

Author

Millat-Martínez, Pere, primary, Salman, Sam, additional, Moore, Brioni R., additional, Baro, Bàrbara, additional, Page-Sharp, Madhu, additional, Batty, Kevin T., additional, Robinson, Leanne J., additional, Pomat, William, additional, Karunajeewa, Harin, additional, Laman, Moses, additional, Manning, Laurens, additional, Mitjà, Oriol, additional, and Bassat, Quique, additional

Published
2022
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41. Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials.

Author

Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart J A, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, and Callaway, Clifton W

Subjects
MEDICAL databases, RELATIVE medical risk, META-analysis, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, IMMUNOGLOBULINS, SYSTEMATIC reviews, PREVENTIVE health services, CONVALESCENT plasma, HOSPITAL care, DESCRIPTIVE statistics, MEDLINE, COVID-19 pandemic, OUTPATIENT services in hospitals, COMORBIDITY
Abstract

Background Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results. Methods We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022. Results Five included studies from 4 countries enrolled and transfused 2620 adult patients. Comorbidities were present in 1795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14 580 in diverse assays. One hundred sixty of 1315 (12.2%) control patients were hospitalized, versus 111 of 1305 (8.5%) CCP-treated patients, yielding a 3.7% (95% confidence interval [CI], 1.3%–6.0%; P =.001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95% CI, 4.0%–11.1%; P =.0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment >5 days after symptom onset or in those receiving CCP with antibody titers below the median titer. Conclusions Among outpatients with COVID-19, treatment with CCP reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Population pharmacokinetic model of ivermectin in mass drug administration against lymphatic filariasis.

Author

Alshehri, Abdullah, Chhonker, Yashpal S., Bala, Veenu, Edi, Constant, Bjerum, Catherine M., Koudou, Benjamin G., John, Lucy N., Mitjà, Oriol, Marks, Michael, King, Christopher L., and Murry, Daryl J.

Subjects
FILARIASIS, DRUG administration, PHARMACOKINETICS, IVERMECTIN, POISONS
Abstract

Background: Ivermectin (IVM) is a broad–spectrum anthelmintic drug used to treat diseases caused by filarial worms, such as onchocerciasis and lymphatic filariasis (LF). IVM is part of a triple–drug therapy used by the Mass Drug Administration (MDA) as a preventive strategy to eradicate LF in sub–Saharan Africa. The drug shows high variability in drug exposure in previous pharmacokinetic studies. This study aims to build a population pharmacokinetic (PopPK) model to identify and quantify the possible sources of the variability of IVM exposure after a single–oral dose in LF–infected subjects and healthy individuals. Methodology / Principal findings: In this analysis, 724 samples were collected from treatment–naïve Wuchereria bancrofti–infected (n = 32) and uninfected (n = 24) adults living in Côte d'Ivoire who had received one dose of IVM as a part of triple–drug therapy. PopPK analysis was conducted using Phoenix NLME 8.3 software. The Monte Carlo simulation based on the final model was performed to simulate drug exposure among different dosing groups (200 μg/kg, 18 mg, and 36 mg). A two–compartment model with zero–order dose input into the absorption compartment with a lag time function followed by first–order absorption and linear elimination best described the IVM's pharmacokinetic (PK) parameters. The final model identifies that the PK parameters of IVM are not affected by LF infection. Sex was a significant covariate on the peripheral volume of distribution (Vp/F, 53% lower in men than in women). IVM drug exposure shows linear pharmacokinetic behavior among the simulated dosing groups with similar drug exposure based on sex. Conclusion/Significance: We have developed a PopPk model to describe and identify possible sources of the variability of IVM exposure. To our knowledge, this is the first PopPK study of IVM in patients with LF. Trial registration: NCT02845713; NCT03664063 Author summary: Ivermectin has been shown to be a valuable tool in mass drug administration campaigns against lymphatic filariasis. The drug shows high variability in drug exposure in previous pharmacokinetic studies. Variability in drug exposure can lead to either a higher exposure with the potential for toxic effects or a lower exposure that may result in treatment failure. Identifying and quantifying the source of high variability using non–linear mixed effects modeling is crucial for future dosing recommendations that seek to maximize therapeutic benefit while minimizing toxicity risks. In this study, the variability of IVM exposure after a single oral dose was investigated with a population pharmacokinetic model using data from Lymphatic filariasis infected subjects and healthy individuals. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Rokx, Casper, Lammers, Jolanda, Buitenhuis, Lonneke, Postma, Douwe, Koster, David, Lukens, Michaèl, Scholtens, Thea, Boomgaard, Maartje van den, Kampschreur, Linda, Ubals, Maria, Prat, Núria, Díez Sánchez, Beatriz, Vértiz Guidotti, Thatiana, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, Ancochea, Àgueda, Ferrer, Magí, Videla, Sebas, Gudiol, Carlota, Fernández Rivas, Gema, CoV-Early Study Group, Vonderen, Marit van, Bianco, Andrea Sofia, Bravo, Anna, Otero, Aurema, Ruibal Suarez, Jose Carlos, Benavent, Sergio, Zarauza Pellejero, Alvaro, Línio, Rosa, Malchair, Pierre, Llopis Roca, Ferran, Blanco, Julian, Rodriguez Cortez, Orlando, Casares Gonzalez, Pablo, Arcos Vila, Gemma, García, Yolanda, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Koopmans, Marion, Ara, Jordi, COnV-ert Study Group, Rodríguez Codina, Joana, Tarres García, Silvia, Blanco, Ignacio, Hernández, Águeda, González Soler, Victoria, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Grífols, Joan Ramon, Briones Zambrano, Ney Nicanor, Millan, Anna, Capdevila Jáuregui, Mar, Fornos, Miriam, Casamitjana, Natàlia, Bordoy, Antoni E., Alonso, Eva, Zwet, Erik van, Miedema, Jelle, Martinez, Núria, Ramírez Morros, Anna, Bogers, Susanne, Maglio, Laura Analía, Amado Simon, Rosa, Comellas Fernandez, Laura, Garcia, Nadia, Ruiz Comellas, Anna, Baro, Bàrbara, Hernández, Luis, Viozquez Meya, Maria, Costes, Gèlia, Pradenas, Edwars, Forcada, Anna, Ginneken, Betty van, Harvala, Heli, Marfil, Silvia, Troxel, Andrea, Mooijaart, Simon, Trinité, Benjamin, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Russcher, Henk, Marks, Michael, Zwaginga, Jaap Jan, Torrano Soler, Pamela, Mitjà, Oriol, Rijnders, Bart J. A., Droog, José de, Corbacho Monné, Marc, Scherpenisse, Cees, Hollander, Jan den, Gharbharan, Arvind, Jordans, Carlijn, Geurtsvankessel, Corine, Albersen, Arjan, Papageourgiou, Grigorios, Katsikis, Peter, Vall Mayans, Martí, Müller, Yvonne, Reusken, Chantal, San José, Alba, Ferrer, Susana, Engen, Rene van, Karisli, Ayten, Götz, Hannelore, Struik, Jelle, París, Alexa, Suñer Navarro, Clara, Clotet, Bonaventura, 1953, Reimerink, Johan, Rokx-Niemantsverdriet, Lotte, Rodriguez Arias, Miquel Angel, Jiménez, Zahida, Verstijnen, Jose, Geloven, Nan van, Groeneveld, Geert, Zwaginga, Lisa, Oud, Josine, Meier, Romy, González Beiras, Camila, Swaneveld, Francis, Ramírez Viaplana, Ferran, Schoot, Ellen van der, Vrielink, Hans, Flores Aguilera, Begoña, Vivero Larraza, Ainhoa, Watering, Leo van de, Hogema, Boris, González García, David, Wijngaarden, Peter van, Vidal Alaball, Josep, Etten, Ronald van, Gammeren, Adriaan van, Alemany, Andrea, Puig, Jordi, Maas, Nanda, Berg – Rahman, Juliette van der, Karim, Faiz, Hiddema, Siepke, Elst, Kim van, García García, Vanesa, Casañ Lopez, Cristina, Leeuwen-Segarceanu, Elena van, Nieto, Aroa, Rodríguez Sevilla, Graciela, Reitsma, Annette, Molenkamp, Karin, Soetekouw, Robert, Band, Caterina, Carceles Peiró, Victor, Gallardo, Mireia, Galvan Femenia, Ivan, Comas Leon, Xavier, Millat Martínez, Pere, Bassat Orellana, Quique, González, María Isabel, Verdaguer, Joaquim, Roquer López, Clàudia, Contreras, Enric, Giménez, Montserrat, Ouchi, Dan, Blanco Guillermo, Ignacio, Bonet Papell, Glòria, Dastis Arias, Macarena, Delgado Capel, Maria, Faculteit Medische Wetenschappen/UMCG, Internal Medicine, Medical Microbiology & Infectious Diseases, Virology, and Epidemiology

Subjects
Immunoregulació, Multidisciplinary, SARS-CoV-2, Immunization, Passive, Immunoregulation, COVID-19, General Physics and Astronomy, Bayes Theorem, General Chemistry, Middle Aged, General Biochemistry, Genetics and Molecular Biology, Treatment Outcome, Outpatients, Humans, Multicenter Studies as Topic, COVID-19 Serotherapy, Randomized Controlled Trials as Topic
Abstract

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when Trial registration: Clinicaltrials.gov NCT04621123 and NCT04589949. Registration: NCT04621123 and NCT04589949 on https://www.clinicaltrials.gov

Published
2022

44. Ficus septica exudate, a traditional medicine used in Papua New Guinea for treating infected cutaneous ulcers: in vitro evaluation and clinical efficacy assessment by cluster randomised trial

Author

Deli, John, primary, González-Beiras, Camila, additional, Guldan, Georgia S, additional, Moses, Rachael L., additional, Dally, Jordanna, additional, Moseley, Ryan, additional, Lundy, Fionnuala T., additional, Corbacho-Monne, Marc, additional, Walker, Stephen L, additional, Cazorla, Maria Ubals, additional, Ouchi, Dan, additional, Fang, Rui, additional, Briggs, Marie, additional, Kiapranis, Robert, additional, Yahimbu, Martha, additional, Mitjà, Oriol, additional, and Prescott, Thomas A.K., additional

Published
2022
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45. Virological and Clinical Determinants of the Magnitude of Humoral Responses to SARS-CoV-2 in Mild-Symptomatic Individuals

Author

Pradenas, Edwards, primary, Ubals, Maria, additional, Urrea, Víctor, additional, Suñer, Clara, additional, Trinité, Benjamin, additional, Riveira-Muñoz, Eva, additional, Marfil, Silvia, additional, Ávila-Nieto, Carlos, additional, Rodríguez de la Concepción, María Luisa, additional, Tarrés-Freixas, Ferran, additional, Laporte, Josep, additional, Ballana, Ester, additional, Carrillo, Jorge, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, and Blanco, Julià, additional

Published
2022
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46. Association between two mass-gathering outdoor events and incidence of SARS-CoV-2 infections during the fifth wave of COVID-19 in north-east Spain: A population-based control-matched analysis

Author

Suñer, Clara, primary, Coma, Ermengol, additional, Ouchi, Dan, additional, Hermosilla, Eduardo, additional, Baro, Bàrbara, additional, Rodríguez-Arias, Miquel Àngel, additional, Puig, Jordi, additional, Clotet, Bonaventura, additional, Medina, Manuel, additional, and Mitjà, Oriol, additional

Published
2022
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47. LAMP4yaws: Treponema pallidum, Haemophilus ducreyi loop mediated isothermal amplification - protocol for a cross-sectional, observational, diagnostic accuracy study

Author

Handley, Becca Louise, González-Beiras, Camila, Tchatchouang, Serges, Basing, Laud Antony, Hugues, Kouadio Aboh, Bakheit, Mohammed, Becherer, Lisa, Ries, Christina, Njih Tabah, Earnest, Crucitti, Tania, Borst, Nadine, Lüert, Simone, Frischmann, Sieghard, Haerpfer, Tamara, Landmann, Emelie, Amanor, Ivy, Sylla, Aboubacar, Kouamé-Sina, Mireille S, Ndzomo-Ngono, Jean P, Tano, Adingra, Arhinful, Daniel, Awondo, Patrick, Ngazoa Kakou, Solange, Eyangoh, Sara, Addo, Kennedy Kwasi, Harding-Esch, Emma Michele, Knauf, Sascha, Mitjà, Oriol, and Marks, Michael

Abstract

INTRODUCTION: Yaws, caused by the bacterium Treponema pallidum subsp. pertenue, is a neglected tropical disease targeted for eradication by 2030. Improved diagnostics will be essential to meet this goal. Diagnosis of yaws has relied heavily on clinical and serological tools. However, the presence of coendemic cutaneous skin ulcer diseases, such as lesions caused by Haemophilus ducreyi (HD), means these techniques do not provide a reliable diagnosis. Thus, new diagnostic tools are needed. Molecular tools such as PCR are ideal, but often expensive as they require trained technicians and laboratory facilities, which are often not available to national yaws programmes. METHODS AND ANALYSIS: The LAMP4yaws project is a cross-sectional, observational, diagnostic accuracy study of a combined Treponema pallidum (TP) and HD loop mediated isothermal amplification (TPHD-LAMP) test performed under real world conditions in three endemic countries in West Africa. Individuals with serologically confirmed yaws will be recruited in Cameroon, Côte d'Ivoire and Ghana. Each participant will provide paired swabs, one of which will be sent to the respective national reference laboratory for yaws quantitative PCR and the other will be tested for both TP and HD using the TPHD-LAMP test at local district laboratories. Sensitivity and specificity of the TPHD-LAMP test will be calculated against the reference standard qPCR. We will also assess the acceptability, feasibility and cost-effectiveness of the test. We anticipate that results from this study will support the adoption of the TPHD-LAMP test for use in global yaws eradication efforts. ETHICS AND DISSEMINATION: We have received ethical approval from all relevant institutional and national ethical committees. All participants, or their parents or guardians, must provide written informed consent prior to study enrolment. Study results will be published in an open access journal and disseminated with partners and the World Health Organization. TRIAL REGISTRATION NUMBER: NCT04753788.

Published
2022

48. Association between two mass-gathering outdoor events and incidence of SARS-CoV-2 infections during the fifth wave of COVID-19 in north-east Spain : A population-based control-matched analysis

Author

Suñer, Clara, Coma, Ermengol, Ouchi, Dan, Hermosilla, Eduardo, Baro, Barbara, Rodríguez-Arias, Miquel Àngel, Puig, Jordi, Clotet Sala, Bonaventura, Medina, Manuel, Mitjà, Oriol, and Universitat Autònoma de Barcelona

Subjects
Oncology, Health Policy, Internal Medicine
Abstract

Many countries have resumed mass-gathering events like music festivals, despite the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreading. In this study, we aimed to assess the effect of two mass-gathering outdoor events, held during a peak of SARS-CoV-2 transmission, on COVID-19 incidence.This was a retrospective, population-based control-matched analysis. The study population included attendees to two outdoor music festivals held in Catalonia (North-East Spain). The primary objective was to compare the incidence of COVID-19 within the 3-to-10 days following the event between attendees and a population-based control group.The analysis included 18,275 and 27,347 attendees to the first and second festivals, respectively, and their corresponding controls. The post-festival 7-day cumulative COVID-19 incidence among attendees and controls was 4.14% (95% CI 3.86-4.44) vs. 1.69% (1.51-1.88) for the first festival (RR 2.46; 2.16-2.80), and 2.42% (2.35-2.61) and 1.10% (0.99-1.2) for the second festival (RR 2.19; 1.92-2.51). COVID-19 incidence among immunized individuals was also two-fold higher in attendees than in controls. Previous COVID-19 infection, vaccination, and adequate mask-wearing were significantly associated with a lower risk of COVID-19 infection after the events.Despite the proven effectiveness of preventive measures such as Ag-RDT screening, mask-wearing and vaccination, caution should be taken when holding these events during a period of high community SARS-CoV-2 transmission.Crowdfunding campaign YoMeCorono (https://www.yomecorono.com/) and the Generalitat de Catalunya.

Published
2022

50. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Malchair, Pierre, additional, Ouchi, Dan, additional, Ruiz-Comellas, Anna, additional, Ramírez-Morros, Anna, additional, Rodríguez Codina, Joana, additional, Amado Simon, Rosa, additional, Videla, Sebastian, additional, Costes, Gèlia, additional, Capdevila-Jáuregui, Mar, additional, Torrano-Soler, Pamela, additional, San José, Alba, additional, Bonet Papell, Glòria, additional, Puig, Jordi, additional, Otero, Aurema, additional, Ruibal Suarez, Jose Carlos, additional, Zarauza Pellejero, Alvaro, additional, Llopis Roca, Ferran, additional, Rodriguez Cortez, Orlando, additional, Garcia Garcia, Vanesa, additional, Vidal-Alaball, Josep, additional, Millan, Anna, additional, Contreras, Enric, additional, Grifols, Joan-Ramon, additional, Ancochea, Àgueda, additional, Galvan-Femenia, Ivan, additional, Piccolo Ferreira, Francini, additional, Bonet, Mireia, additional, Cantoni, Jordi, additional, Prat, Núria, additional, Ara, Jordi, additional, Forcada Arcarons, Anna, additional, Farré, Magí, additional, Pradenas, Edwards, additional, Blanco, Julià, additional, Àngel Rodriguez-Arias, Miquel, additional, Fernández Rivas, Gema, additional, Marks, Michael, additional, Bassat, Quique, additional, Blanco, Ignacio, additional, Baro, Bàrbara, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Ferrer, Susana, additional, Gallardo, Mireia, additional, Ubals, Maria, additional, González-Beiras, Camila, additional, Vall-Mayans, Martí, additional, Suñer, Clara, additional, Laporte-Villar, Clàudia, additional, Nieto, Aroa, additional, Comas-Leon, Xavier, additional, Jiménez, Zahida, additional, Ramírez-Viaplana, Ferran, additional, Delgado-Capel, Maria, additional, Díez Sánchez, Beatriz, additional, Pons Barber, Maria, additional, Gonzalez Ruiz, Cristian, additional, Navarrete Gonzalez, Laura, additional, González García, David, additional, Vivero Larraza, Ainhoa, additional, Carceles Peiró, Victor, additional, Roquer López, Clàudia, additional, Robert, Neus, additional, Palet, Carles, additional, Gudiol, Carlota, additional, Casares Gonzalez, Pablo, additional, Arcos Vila, Gemma, additional, Flores Aguilera, Begoña, additional, Rodríguez-Sevilla, Graciela, additional, Dastis Arias, Macarena, additional, Roca Font, Judit, additional, Carrasco Matos, Katherine M., additional, Saüch Valmaña, Glòria, additional, Vidal Obradors, Carla, additional, Tarres García, Silvia, additional, Curriu Sabatès, Margarida, additional, Nieto Rodríguez, Raquel, additional, Línio, Rosa, additional, Fornos, Míriam, additional, Casamitjana, Natàlia, additional, Alonso, Eva, additional, Martínez, Núria, additional, Maglio, Laura Analía, additional, Comellas Fernandez, Laura, additional, Garcia, Nadia, additional, Hernández, Luis, additional, González, Maria Isabel, additional, Bravo, Anna, additional, García, Yolanda, additional, Sauleda Oliveras, Silvia, additional, Vertiz, Tatiana, additional, Benavent, Sergio, additional, Bianco, Andrea Sofia, additional, Verdaguer, Joaquim, additional, Briones Zambrano, Ney Nicanor, additional, Viozquez Meya, Maria, additional, Hernández, Águeda, additional, Casaña Lopez, Cristina, additional, Bordoy, Antoni E., additional, González Soler, Victoria, additional, Giménez, Montserrat, additional, París, Alexa, additional, Marfil, Silvia, additional, Trinité, Benjamin, additional, and Grau, Eulàlia, additional

Published
2022
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