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To compare the visual outcomes and rates of intraoperative complications, in eyes that underwent combined cataract extraction (CE) and pars plana vitrectomy (PPV) (combined group) to those that underwent sequential surgery (sequential group).Multicenter study.A retrospective chart review.CE dataset pooled from 8 UK sites between 2000 and 2015. The main outcome measures were the mean postoperative visual acuity (VA) and the rate of intraoperative complications in both groups.The study included 2236 eyes in the combined group and 2270 eyes in the sequential group. Mean preoperative VA was 1.0 logMAR in both groups. The mean logMAR postoperative VA was worse in the combined group than in the sequential group (P0.0001) at all time points, however, the differences in visual improvement between both groups decreased with longer follow-up time; 1.0±0.7 vs. 0.6±0.6, 0.7±0.6 vs. 0.4±0.5 and 0.7±0.6 vs. 0.5±0.5 at 0-4 weeks, 4-12 weeks and 12-24 weeks, respectively. Proportions of eyes that gained3 logMAR units were 49% in the combined group and 66.2% in the sequential group (P0.0001). Logistic regression analysis showed that sequential surgery (OR = 2.1) was a predictor for reaching 20/40 vision by 6 months. In the combined group, there was a statistically significantly higher rate of posterior capsular rupture.Postoperative visual gain was less in the combined group with a higher rate of posterior capsular rupture as compared to sequential phacovitrectomy. However, we observed small differences in visual improvements between both groups by the 6-month.

To evaluate the accuracy and safety of oral fluorescein angiography (OFA) in differentiating papilledema from pseudopapilledema in pediatric patients.Retrospective evaluation of a diagnostic test.We retrospectively reviewed medical records of all children ≤18 years of age who presented to the Arkansas Children's Hospital between May 2018 and August 2021 with suspected optic disc (OD) swelling that had OFA and images30 minutes after oral ingestion. Two masked specialists interpreted the images as either OD leakage, no leakage, or borderline leakage. Optic disc swelling was graded clinically according to the Frisen grading scale (0-5). We compared OFA images to the final clinical diagnosis and calculated the accuracy of the test as follows: (number of eyes correctly identified as papilledema [true positive] + number of eyes correctly identified as pseudopapilledema [true negative]) / (total number of eyes) × 100%.Forty-five patients (90 eyes) were included, 11 patients with papilledema and 34 with pseudopapilledema. The mean age was 14.1 ± 3.5 years; 66.7% were female. The accuracy of OFA was 62% for reviewer 1 and 69% for reviewer 2. No ocular or systemic side effects after OFA were observed. There was substantial agreement (k = 0.779) between both reviewers in grading the OFA images.OFA cannot definitively distinguish papilledema from pseudopapilledema in children and should be interpreted in conjunction with other clinical findings.